LOCUS       NM_001135957            7556 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            C member 4 (TRPC4), transcript variant 4, mRNA.
ACCESSION   NM_001135957
VERSION     NM_001135957.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7556)
  AUTHORS   Chen,X., Yan,Y., Liu,Z., Yang,S., Li,W., Wang,Z., Wang,M., Guo,J.,
            Li,Z., Zhu,W., Yang,J., Yin,J., Dai,Q., Li,Y., Wang,C., Zhao,L.,
            Yang,X., Guo,X., Leng,L., Xu,J., Obukhov,A.G., Cao,R. and Zhong,W.
  TITLE     In vitro and in vivo inhibition of the host TRPC4 channel
            attenuates Zika virus infection
  JOURNAL   EMBO Mol Med 16 (8), 1817-1839 (2024)
   PUBMED   39009885
  REMARK    GeneRIF: In vitro and in vivo inhibition of the host TRPC4 channel
            attenuates Zika virus infection.
REFERENCE   2  (bases 1 to 7556)
  AUTHORS   Chen,Z., Zhao,Y., Tian,Y., Cao,R. and Shang,D.
  TITLE     Pan-Cancer Analysis of the TRP Family, Especially TRPV4 and TRPC4,
            and Its Expression Correlated with Prognosis, Tumor
            Microenvironment, and Treatment Sensitivity
  JOURNAL   Biomolecules 13 (2), 282 (2023)
   PUBMED   36830651
  REMARK    GeneRIF: Pan-Cancer Analysis of the TRP Family, Especially TRPV4
            and TRPC4, and Its Expression Correlated with Prognosis, Tumor
            Microenvironment, and Treatment Sensitivity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7556)
  AUTHORS   Gotz,V., Qiao,S., Beck,A. and Boehm,U.
  TITLE     Transient receptor potential (TRP) channel function in the
            reproductive axis
  JOURNAL   Cell Calcium 67, 138-147 (2017)
   PUBMED   28522036
  REMARK    Review article
REFERENCE   4  (bases 1 to 7556)
  AUTHORS   Dietrich,A., Steinritz,D. and Gudermann,T.
  TITLE     Transient receptor potential (TRP) channels as molecular targets in
            lung toxicology and associated diseases
  JOURNAL   Cell Calcium 67, 123-137 (2017)
   PUBMED   28499580
  REMARK    Review article
REFERENCE   5  (bases 1 to 7556)
  AUTHORS   Zeng,B., Yuan,C., Yang,X., Atkin,S.L. and Xu,S.Z.
  TITLE     TRPC channels and their splice variants are essential for promoting
            human ovarian cancer cell proliferation and tumorigenesis
  JOURNAL   Curr Cancer Drug Targets 13 (1), 103-116 (2013)
   PUBMED   22920441
REFERENCE   6  (bases 1 to 7556)
  AUTHORS   von Spiczak,S., Muhle,H., Helbig,I., de Kovel,C.G., Hampe,J.,
            Gaus,V., Koeleman,B.P., Lindhout,D., Schreiber,S., Sander,T. and
            Stephani,U.
  TITLE     Association study of TRPC4 as a candidate gene for generalized
            epilepsy with photosensitivity
  JOURNAL   Neuromolecular Med 12 (3), 292-299 (2010)
   PUBMED   20574736
  REMARK    GeneRIF: Results showed a trend toward association of TRPC4
            variants and photoparoxysmal response/idiopathic generalized
            epilepsies.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 7556)
  AUTHORS   Schaefer,M., Plant,T.D., Stresow,N., Albrecht,N. and Schultz,G.
  TITLE     Functional differences between TRPC4 splice variants
  JOURNAL   J Biol Chem 277 (5), 3752-3759 (2002)
   PUBMED   11713258
REFERENCE   8  (bases 1 to 7556)
  AUTHORS   Mery,L., Magnino,F., Schmidt,K., Krause,K.H. and Dufour,J.F.
  TITLE     Alternative splice variants of hTrp4 differentially interact with
            the C-terminal portion of the inositol 1,4,5-trisphosphate
            receptors
  JOURNAL   FEBS Lett 487 (3), 377-383 (2001)
   PUBMED   11163362
REFERENCE   9  (bases 1 to 7556)
  AUTHORS   McKay,R.R., Szymeczek-Seay,C.L., Lievremont,J.P., Bird,G.S.,
            Zitt,C., Jungling,E., Luckhoff,A. and Putney,J.W. Jr.
  TITLE     Cloning and expression of the human transient receptor potential 4
            (TRP4) gene: localization and functional expression of human TRP4
            and TRP3
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 735-746 (2000)
   PUBMED   11042129
REFERENCE   10 (bases 1 to 7556)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356495.15, AL354802.15 and
            AL138679.11.
            
            On Aug 6, 2019 this sequence version replaced NM_001135957.2.
            
            Summary: This gene encodes a member of the canonical subfamily of
            transient receptor potential cation channels. The encoded protein
            forms a non-selective calcium-permeable cation channel that is
            activated by Gq-coupled receptors and tyrosine kinases, and plays a
            role in multiple processes including endothelial permeability,
            vasodilation, neurotransmitter release and cell proliferation.
            Single nucleotide polymorphisms in this gene may be associated with
            generalized epilepsy with photosensitivity. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Aug 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF063824.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AL356495.15        14744-14921         c
            179-583             AL354802.15        99189-99593         c
            584-1102            AL354802.15        62170-62688         c
            1103-1439           AL354802.15        8232-8568           c
            1440-1579           AL138679.11        94386-94525         c
            1580-1893           AL138679.11        83574-83887         c
            1894-2089           AL138679.11        75246-75441         c
            2090-2284           AL138679.11        71423-71617         c
            2285-2326           AL138679.11        59416-59457         c
            2327-2393           AL138679.11        59221-59287         c
            2394-7556           AL138679.11        52221-57383         c
FEATURES             Location/Qualifiers
     source          1..7556
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.3"
     gene            1..7556
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="transient receptor potential cation channel
                     subfamily C member 4"
                     /db_xref="GeneID:7223"
                     /db_xref="HGNC:HGNC:12336"
                     /db_xref="MIM:603651"
     exon            1..178
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            179..583
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2716
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="isoform delta is encoded by transcript variant 4;
                     short transient receptor potential channel 4; trp-related
                     protein 4"
                     /codon_start=1
                     /product="short transient receptor potential channel 4
                     isoform delta"
                     /protein_id="NP_001129429.1"
                     /db_xref="CCDS:CCDS45039.1"
                     /db_xref="GeneID:7223"
                     /db_xref="HGNC:HGNC:12336"
                     /db_xref="MIM:603651"
                     /translation="MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGD
                     YASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLH
                     AIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKL
                     LVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFL
                     TAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNS
                     LIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCF
                     IIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDL
                     NRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATIS
                     LKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQIS
                     LGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFE
                     TLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSY
                     QLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKM
                     RRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEVARQQAAGPLE
                     RNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVED
                     TVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL"
     exon            584..1102
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1439
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1579
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1893
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2089
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2284
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2326
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2393
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..7556
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2943..2948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: AATAAA"
     polyA_site      2961
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="major polyA site"
     regulatory      5697..5702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: AATAAA"
     polyA_site      5716
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
     regulatory      5727..5732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: AATAAA"
     polyA_site      5747
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="major polyA site"
     regulatory      5909..5914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: ATTAAA"
     polyA_site      5930
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
     regulatory      7301..7306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: AATATA"
     polyA_site      7319
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
     regulatory      7532..7537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /note="hexamer: ATTAAA"
     polyA_site      7556
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
ORIGIN      
        1 agttcggtgc cagctgcgtg ggctccagct tcgatcgttt tccttggaat gctccaaaac
       61 tcagcagcga ctaagggaat tccattggaa tttgccgggc gtgctctcac cccgcacggc
      121 acccgcgccg tcagtcctcg gatcccatca cttcagcccg aagattgcaa ctttgcagag
      181 acgaagaaat agcatggcat gaaacatggc tcagttctat tacaaaagaa atgttaatgc
      241 tccctataga gaccgcatcc ctctaaggat agtaagagca gaatcagaac tctcgccatc
      301 agaaaaagcc tacttgaatg ctgtggaaaa gggagattat gccagtgtca agaaatccct
      361 agaggaagct gaaatttatt ttaaaatcaa tattaattgc attgatcctc tcggaagaac
      421 tgctctcctc attgcaattg aaaatgagaa cttggagctc atcgaactac tcttaagctt
      481 taatgtctat gttggagatg ctctattaca tgctatcaga aaagaagtcg tcggagctgt
      541 tgagctgtta ttgaaccaca aaaaacctag tggagaaaaa caggtgcctc ctatactcct
      601 tgataagcag ttctctgaat tcactccaga cattacacca atcattttgg cagcccatac
      661 aaataattat gagataataa aactcttggt tcagaaagga gtctcagtgc ctcgacccca
      721 cgaggtccgc tgtaactgtg tggaatgcgt gtccagttca gatgtggaca gcctccgtca
      781 ctcacgctcc agactcaaca tctacaaggc cttggccagt ccctctctca ttgcactgtc
      841 aagcgaagat ccttttctca cagcctttca gttaagttgg gaacttcagg aactgagcaa
      901 ggtggaaaat gaattcaagt cggagtatga agagctgtca cggcagtgca aacaatttgc
      961 taaggaccta ctggatcaga cgagaagttc cagagaactg gaaatcattc ttaattaccg
     1021 agatgacaat agtctcatag aagaacaaag tggaaatgat cttgcaagac taaaattggc
     1081 cattaagtac cgtcaaaaag agtttgttgc ccagcccaat tgtcaacagc tgctggcatc
     1141 tcgctggtac gatgagtttc caggctggag gagaagacac tgggcagtga agatggtgac
     1201 atgtttcata ataggacttc tttttcctgt cttctctgtg tgctacctga tagctcccaa
     1261 aagcccactt ggactgttca tcaggaagcc atttatcaag tttatctgcc acacagcctc
     1321 ctatttgact tttttgttcc tgctgctgct tgcctctcag cacatcgaca ggtcagactt
     1381 gaacaggcaa ggtccaccac caaccatcgt cgagtggatg atattaccgt gggtcctggg
     1441 cttcatatgg ggagaaatta aacagatgtg ggatggcgga cttcaggact acatccatga
     1501 ttggtggaat ctaatggact ttgtaatgaa ctccttatat ttagcaacaa tctccttgaa
     1561 aattgttgca tttgtaaagt acagtgccct taatccacga gaatcatggg acatgtggca
     1621 tcccactctg gtggcagagg ctttatttgc tattgcaaac atcttcagtt ctctgcgtct
     1681 gatctcactg tttactgcaa attctcacct gggacctctg caaatatctc tgggaagaat
     1741 gctcctggac attttgaagt ttctattcat atactgcctt gtgttgctag catttgcaaa
     1801 tggcctaaat caattgtact tctattatga agaaacgaaa gggttaacct gcaaaggcat
     1861 aagatgtgaa aagcagaata atgcattttc aacgttattt gagacactgc agtccctgtt
     1921 ttggtcaata tttgggctca tcaatttata tgtgaccaat gtcaaagcac agcatgaatt
     1981 tactgagttt gttggtgcca ccatgtttgg gacatacaat gtcatctctc tggttgttct
     2041 actcaacatg ttaatagcta tgatgaataa ttcttaccaa ctgattgctg accatgcaga
     2101 tatagaatgg aaatttgcac gaacaaagct ttggatgagt tattttgaag aaggaggtac
     2161 tctgcctact cccttcaatg tcatcccgag ccccaagtct ctctggtacc tgatcaaatg
     2221 gatctggaca cacttgtgca agaaaaagat gagaagaaag ccagaaagtt ttggaacaat
     2281 agggaggcga gctgctgata acttgagaag acatcaccaa taccaagaag ttatgaggaa
     2341 cctggtgaag cgatacgttg ctgcaatgat tagagatgct aaaactgaag aagttgctcg
     2401 tcaacaggct gcaggaccac ttgagagaaa tattcaactg gaatctcgag gattagcttc
     2461 acggggtgac ctgagcattc ccggtctcag tgaacaatgt gtgttagtag accatagaga
     2521 aaggaatacg gacacactgg ggttacaggt aggaaagaga gtgtgtccat tcaagtcaga
     2581 gaaggtggtg gtggaggaca cggttcctat aataccaaag gagaaacatg caaaagaaga
     2641 ggactctagt atagactatg atctaaacct cccagacaca gtcacccacg aagattacgt
     2701 gaccacaaga ttgtgatact tgaaggagga agcgtttacc atacacatac gtattttccg
     2761 tagtgctctg ggtgggggaa aatgtttaaa ttgtattagc aaatgctaac ttacacttta
     2821 tagcgtttat cagctgtggc atattacctg taacatgttt aaataaggca aaggcaatca
     2881 aaaacctttt tgttttgtag cctgcttttg ctttcacaat ttgtcttaca attgtttttg
     2941 ttaataaata aatgcacctt gtattcttgt actgttgcaa taacccacag aaacatttta
     3001 gctatctttt tcaattaaaa caaatgcaat ttatttcatg tggtagttga ctcctaaaat
     3061 agatattttt atattcaaaa accaatgtgg ctgaaatatt atagcttttc ataatttttt
     3121 agggtcttta gagagggtta ctcaccaagg acttttcacc tagtcctaca gtttggcttt
     3181 aaaacacaaa tattaccaaa ttatttctta acgacatgta aataattatt gtacacaaag
     3241 caaacaagtc ttcttctcat ggagtcatat ctaaactccc tcaaattcag aaaaactttg
     3301 tagtgtttta ggttgttcca gggtttcctt tcagtaagta aaagaagtgt ttgtcttaat
     3361 acattttgat gactgatgat ttttaacgac attttgtcag gaaaaaaact cgcccctcca
     3421 gtttttttaa ttacctattt cagattcaac tgcttatcag tataaatatg agtctttatg
     3481 aataactgaa tttcaaaaat atggcaagat ttctgttata aaaaaataat aaaccataat
     3541 attgtaagta tcttaaacaa gcaagatgat tacatactaa taatatccaa atgaaaatga
     3601 atttattcta acaatctaaa tctaagtaaa gttgaattcc agtattttca atcaacgcaa
     3661 tattgtaatc aattcaaaag aagtacaaaa aaactagcag tctcctcttt tcaccagtaa
     3721 tctttatata tttctttaaa attaaatcac tcaaaaatca ttattaattt tatcagcaga
     3781 tatagatata tagttttgcc tataggaaaa acattcttat ttcttgtttt tctttctatt
     3841 gtttgcaagg taatttagct tataacaatt cactgaacta ttacaaggaa agtgttcgca
     3901 acttacataa aattgatact agaaacttaa agcttaaatt ttacattgct tgtgtctatt
     3961 taagccacta cgggaagttt cttcaccaca taaaattagc atttatttca aatcaataga
     4021 aaaatgctaa gttcatttta tttcaaaaat tactctgcga acctcagaaa ttgcatgtga
     4081 tttatcattg gccccaaact gaataatgtt atggcactca gtttctcatt accaaacatc
     4141 aaaaataagg aataacagca ataacaatgc cagcctctgt tctattccta tacacctgtt
     4201 aacatttatg tactgctctt tacagccctc tgaagtagct cctgttttta tccccatttc
     4261 acatatgatg aaactgagac cagcactaac tggctaaggt aatacagctc atgatggagc
     4321 tgtgatgtgt ccatcagagc cattcccttc accactgcat tgtaactgcc tttcagaaca
     4381 taaaaagagc aagttataaa acatgcatat acaggggtta caattgccac ttctgaagtc
     4441 ctataccttg agagagaatg agtttggtat gcttcataag agtcccttct tctaaagcaa
     4501 gagaagtgtg caaaatataa aatgtgctgt atttgattct ttagactaaa ttacattaaa
     4561 gttagtagat tttaaaaaca tatttattat gtgatctcag aactcaattt gaaatactag
     4621 attttaattt tcagaaaagc caggagcact aagcccctgt tcactcctaa acctggtttt
     4681 tgggaattta ggaatgggcc agatagattt ggagaaacac aagcctaaat gaatgcattt
     4741 actgtttcaa gaacaccttt atctcaagta tattaggact cagagcaaat cctggggcta
     4801 ctgaaatact catttttttc taaatcatac ctacagtagt agagaaattg taggcctatt
     4861 gttaatattt gggatatttt ctattaattt ctttttgcct ctcttgtgcg ttgttgtttt
     4921 attttgtttt ttcccaaagt aaggacacta tacataacca ttttacatac tttaccagaa
     4981 tttaatttca aattctctct gttccgtcaa gcaacaccaa taacagtaca agcaacaaaa
     5041 ccttttttcc cccagtagct tatttatatc aggggttaag gtgctgacat tttatagggg
     5101 gacatgatgg taatagagga atgtatttgg agcaagtaag accctccttt tcagtgccct
     5161 agaaaggatg attctaacaa cccccagatg ttgctgacag atgtgtttat gagtatgaac
     5221 aaagtgctgg atattattag tacccgatgt tactaatatc actagaattg aatgctattc
     5281 taaatacgta gtgacattat gtagcattaa tgaagatgag gagtagggat aaaataagaa
     5341 aagtcaaaca acagcaggat agcaagcaaa gaaatactgt ttctttgagg tttgtaagtg
     5401 cgtacttcag ggtgttcgtt tctattcata tttctatcca cagaaatttc taaatgctac
     5461 agagaacttt gaaattacct tcatttacat aaataatgtt tctcattttt cgtactctct
     5521 taatcttaaa aaatctgttt ttcttaaatt ttgtgtctga gttaggtgaa ggagtgtgtt
     5581 gaaaattcag tttaatagac tagcaggtaa gtttaaaaca ctttgtttat cacaattgta
     5641 ttttggaagt cccatttata agaaagtatg ctataaagat gtacctcatt attcgtaata
     5701 aaggttttcc ttaaaatttc tgtgcaaata aatctatatt aacttcagta aggaaattgg
     5761 ctatattttt taaaatgggg tgaattattt tataaaatca tgagtaattt ttcaaagtgc
     5821 taaacatcct caaaatgtat ctgtttcatg aattgaatat ttgtatatca aattttctta
     5881 aattagttac tctatttact ggatggcaat taaactaatg caaaaacata ctcactttct
     5941 tgccttgacg tagacagcaa cttgaaatac tttagtgatg aaacaaattg atgaaaagtc
     6001 aaggatagta gactcaccat gctgttctca aagaagcaaa gtcaattttc tagcaaaggt
     6061 ggaggaaaca taagtaacaa tagcataaga atatattctt ctaacattca ataatcctta
     6121 ataactctgg gatttagctg agtaaatgac tatccagtct cacagctctt tattgaagag
     6181 aggccaccaa gttttgaaat ctgtccattc ttagtcctca tgcattgtat ttttagctgt
     6241 cttctatggt gtatacagct gccttccatg ctcagtgtcc ttaaaactca acctagtaag
     6301 aaccatccat tgtggccctg taaatatgct tacaatatat ttttctttct ctgtattatc
     6361 tgaaattctg acttaaaact aaccatagaa tttagaaatt taatattact ggcattcctc
     6421 ttaacttcaa aaccattatt ctgattttac aatgtctgaa aagacatttt atttatacag
     6481 tgttatcaca tgcctttttt aatttgaatt ttagaatcat gttaaataag ttcactgtag
     6541 ataactgggg aaagtaaagc ccagggaatt tatggaaatt atctaaattt acccatgtgt
     6601 ttggtggtca agttggggct taaacaaaaa cctcctcatc tagatatttg gatgaggcat
     6661 cacattataa atgccttgac cactgacttt ttatttgggg aacattttgt cttctttgcc
     6721 cttgtagaaa atatagttgt ccaaacattc aagttaaaat tcagaattaa taccatatta
     6781 tcttttgttt ttctacaaag ttgtgttaag agaattttta aaaagctggt ttcttactgt
     6841 tttcagaaaa tacactgttc attttcactg gaagtgtaga ttttatgata acctgtatgc
     6901 atactggtaa taataaaatg tattaaatta tatcaaagct tctcaactga aaaacattag
     6961 agatggacaa tgtacagttg aactaagatt gggacaatgg gaccaagcct ggatacagtc
     7021 acaccgttac taggctgaca gtgaagacgt ctctgcaagt caaattcacc agtagcaaaa
     7081 ccgttaattt cctctagagc tgcactgttc agtaacgtag ctcctatact catacggcta
     7141 ttaatcactt gtaagtgtga caagtctgaa ttaagatgtg ctgtaagtgt gaaacacaca
     7201 ccagatttct aggacagtat gaaaataatg taaactagct cataaatatt ttatgttggc
     7261 tacatattga actgatagta tttatgaagt attgatttaa aatatactaa gtaaatgagt
     7321 ttgatgtttc tttttccttt tacaatgtgg ctactagaaa actgaaaaat acgtatgtgg
     7381 cttgcatttg tgccttgcaa tacatttcta ttggacagtg ctgctcagga acatttgtat
     7441 ttgtttcagt cagctcatgt atctccatca tctgaattgc aaaggtagaa aattctatct
     7501 ttaattactc aaaaaagttt tgtgtagctc tattaaagtt tgcagtctct ccttga
//
