LOCUS       NM_001130698            8401 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            C member 3 (TRPC3), transcript variant 1, mRNA.
ACCESSION   NM_001130698
VERSION     NM_001130698.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8401)
  AUTHORS   Li,Y., Shataer,R., Chen,Y., Zhu,X. and Sun,X.
  TITLE     Protective Role of TRPC3 Gene Polymorphism (rs10518289) in
            Obstructive Sleep Apnea Hypopnea Syndrome Among Hypertensive
            Patients
  JOURNAL   Med Sci Monit 30, e942667 (2024)
   PUBMED   38771735
  REMARK    GeneRIF: Protective Role of TRPC3 Gene Polymorphism (rs10518289) in
            Obstructive Sleep Apnea Hypopnea Syndrome Among Hypertensive
            Patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8401)
  AUTHORS   Kirstein,E., Schaudien,D., Wagner,M., Diebolt,C.M., Bozzato,A.,
            Tschernig,T. and Englisch,C.N.
  TITLE     TRPC3 Is Downregulated in Primary Hyperparathyroidism
  JOURNAL   Int J Mol Sci 25 (8), 4392 (2024)
   PUBMED   38673977
  REMARK    GeneRIF: TRPC3 Is Downregulated in Primary Hyperparathyroidism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8401)
  AUTHORS   Diebolt,C.M., Schaudien,D., Junker,K., Krasteva-Christ,G.,
            Tschernig,T. and Englisch,C.N.
  TITLE     New insights in the renal distribution profile of TRPC3 - Of mice
            and men
  JOURNAL   Ann Anat 252, 152192 (2024)
   PUBMED   37977270
  REMARK    GeneRIF: New insights in the renal distribution profile of TRPC3 -
            Of mice and men.
REFERENCE   4  (bases 1 to 8401)
  AUTHORS   Cole,B.A. and Becker,E.B.E.
  TITLE     Modulation and Regulation of Canonical Transient Receptor Potential
            3 (TRPC3) Channels
  JOURNAL   Cells 12 (18), 2215 (2023)
   PUBMED   37759438
  REMARK    GeneRIF: Modulation and Regulation of Canonical Transient Receptor
            Potential 3 (TRPC3) Channels.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8401)
  AUTHORS   Yildirim,E., Kawasaki,B.T. and Birnbaumer,L.
  TITLE     Molecular cloning of TRPC3a, an N-terminally extended,
            store-operated variant of the human C3 transient receptor potential
            channel
  JOURNAL   Proc Natl Acad Sci U S A 102 (9), 3307-3311 (2005)
   PUBMED   15728370
REFERENCE   6  (bases 1 to 8401)
  AUTHORS   Boulay,G., Zhu,X., Peyton,M., Jiang,M., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     Cloning and expression of a novel mammalian homolog of Drosophila
            transient receptor potential (Trp) involved in calcium entry
            secondary to activation of receptors coupled by the Gq class of G
            protein
  JOURNAL   J Biol Chem 272 (47), 29672-29680 (1997)
   PUBMED   9368034
REFERENCE   7  (bases 1 to 8401)
  AUTHORS   Xu,X.Z., Li,H.S., Guggino,W.B. and Montell,C.
  TITLE     Coassembly of TRP and TRPL produces a distinct store-operated
            conductance
  JOURNAL   Cell 89 (7), 1155-1164 (1997)
   PUBMED   9215637
REFERENCE   8  (bases 1 to 8401)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
REFERENCE   9  (bases 1 to 8401)
  AUTHORS   Wes,P.D., Chevesich,J., Jeromin,A., Rosenberg,C., Stetten,G. and
            Montell,C.
  TITLE     TRPC1, a human homolog of a Drosophila store-operated channel
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9652-9656 (1995)
   PUBMED   7568191
REFERENCE   10 (bases 1 to 8401)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108930.3, AY865574.1,
            Y13758.1 and AC079341.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001130698.1.
            
            Summary: The protein encoded by this gene is a membrane protein
            that can form a non-selective channel permeable to calcium and
            other cations. The encoded protein appears to be induced to form
            channels by a receptor tyrosine kinase-activated
            phosphatidylinositol second messenger system and also by depletion
            of intracellular calcium stores. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.33198.1,
                                           SRR1803617.260164.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153307, SAMEA2163459
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379645.8/ ENSP00000368966.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               AC108930.3         63775-64080         c
            307-598             AY865574.1         1-292
            599-3605            Y13758.1           424-3430
            3606-3650           AY865574.1         3298-3342
            3651-3854           AY865574.1         3344-3547
            3855-8401           AC079341.6         134320-138866       c
FEATURES             Location/Qualifiers
     source          1..8401
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q27"
     gene            1..8401
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /note="transient receptor potential cation channel
                     subfamily C member 3"
                     /db_xref="GeneID:7222"
                     /db_xref="HGNC:HGNC:12335"
                     /db_xref="MIM:602345"
     exon            1..595
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             381..3146
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /note="isoform a is encoded by transcript variant 1; short
                     transient receptor potential channel 3; hTrp-3; transient
                     receptor protein 3"
                     /codon_start=1
                     /product="short transient receptor potential channel 3
                     isoform a"
                     /protein_id="NP_001124170.1"
                     /db_xref="CCDS:CCDS47130.1"
                     /db_xref="GeneID:7222"
                     /db_xref="HGNC:HGNC:12335"
                     /db_xref="MIM:602345"
                     /translation="MSTKVRKCKEQARVTFPAPEEEEDEGEDEGAEPQRRRRGWRGVN
                     GGLEPRSAPSQREPHGYCPPPFSHGPDLSMEGSPSLRRMTVMREKGRRQAVRGPAFMF
                     NDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHL
                     EVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDD
                     DFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQ
                     RHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRK
                     LSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKK
                     FVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGK
                     ILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFT
                     WTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQ
                     ATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFS
                     RIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNA
                     AFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLI
                     AMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVN
                     FPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLI
                     KRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLN
                     PSMLRCE"
     exon            596..1367
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1556
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1721
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1938
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2172
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2437
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2633
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2843
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..2927
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3003
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..8401
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3579..3584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /note="hexamer: AATAAA"
     polyA_site      3605
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /note="major polyA site"
     regulatory      3833..3838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /note="hexamer: ATTAAA"
     polyA_site      3855
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /note="major polyA site"
     regulatory      4775..4780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /note="hexamer: AATAAA"
     polyA_site      4794
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /note="major polyA site"
     regulatory      8377..8382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /note="hexamer: AATAAA"
     polyA_site      8401
                     /gene="TRPC3"
                     /gene_synonym="SCA41; TRP3"
                     /note="major polyA site"
ORIGIN      
        1 gagtaacgat gctgtcctag caagtgatgc tgtcggagac aggagacggg cgccgaggag
       61 gcatcgccgc cgccgcgggg ctggagagcc tctcccagca ccagagcccc gctcggcccc
      121 gggcttcctc gtcgcagcca cggccgcggc agctgctccc acggtttgat ggtgggcggc
      181 ggcagctcgg cttcggcgct agcctctaac tgctggatcg cgggccgcga cgctctccgc
      241 tcctgccttc ccgccctggg ccgcccgggg ccccggaagc cgcgggaggt ggtgaagggg
      301 cgccgcggga agactgcact gccgcgaagg cggaggaggc cggcagccgg cacccccaca
      361 ctcggaccgc agccggcgcg atgtccacca aggtcaggaa gtgcaaagaa caagcaaggg
      421 tgaccttccc ggcgccggag gaggaggaag acgagggcga ggacgagggc gcggagccgc
      481 agcgccgccg ccggggctgg aggggcgtca acggggggct ggagccgcgc tcggcgccct
      541 cgcagcggga gccgcacggc tactgcccgc cgcccttctc ccacgggccg gacctgtcca
      601 tggagggaag cccatccctg agacgcatga cagtgatgcg ggagaagggc cggcgccagg
      661 ctgtcagggg cccggccttc atgttcaatg accgcggcac cagcctcacc gccgaggagg
      721 agcgcttcct cgacgccgcc gagtacggca acatcccagt ggtgcgcaag atgctggagg
      781 agtccaagac gctgaacgtc aactgcgtgg actacatggg ccagaacgcg ctgcagctgg
      841 ctgtgggcaa cgagcacctg gaggtgaccg agctgctgct caagaaggag aacctggcgc
      901 gcattggcga cgccctgctg ctcgccatca gcaagggcta cgtgcgcatc gtagaggcca
      961 tcctcaacca ccctggcttc gcggccagca agcgtctcac tctgagcccc tgtgagcagg
     1021 agctgcagga cgacgacttc tacgcttacg acgaggacgg cacgcgcttc tcgccggaca
     1081 tcacccccat catcctggcg gcgcactgcc agaaatacga agtggtgcac atgctgctga
     1141 tgaagggtgc caggatcgag cggccgcacg actatttctg caagtgcggg gactgcatgg
     1201 agaagcagag gcacgactcc ttcagccact cacgctcgag gatcaatgcc tacaaggggc
     1261 tggccagccc ggcttacctc tcattgtcca gcgaggaccc ggtgcttacg gccctagagc
     1321 tcagcaacga gctggccaag ctggccaaca tagagaagga gttcaagaat gactatcgga
     1381 agctctccat gcaatgcaaa gactttgtag tgggtgtgct ggatctctgc cgagactcag
     1441 aagaggtaga agccattctg aatggagatc tggaatcagc agagcctctg gaggtacaca
     1501 ggcacaaagc ttcattaagt cgtgtcaaac ttgccattaa gtatgaagtc aaaaagtttg
     1561 tggctcatcc caactgccag cagcagctct tgacgatctg gtatgagaac ctctcaggcc
     1621 taagggagca gaccatagct atcaagtgtc tcgttgtgct ggtcgtggcc ctgggccttc
     1681 cattcctggc cattggctac tggatcgcac cttgcagcag gctggggaaa attctgcgaa
     1741 gcccttttat gaagtttgta gcacatgcag cttctttcat catcttcctg ggtctgcttg
     1801 tgttcaatgc ctcagacagg ttcgaaggca tcaccacgct gcccaatatc acagttactg
     1861 actatcccaa acagatcttc agggtgaaaa ccacccagtt tacatggact gaaatgctaa
     1921 ttatggtctg ggttcttgga atgatgtggt ctgaatgtaa agagctctgg ctggaaggac
     1981 ctagggaata cattttgcag ttgtggaatg tgcttgactt tgggatgctg tccatcttca
     2041 ttgctgcttt cacagccaga ttcctagctt tccttcaggc aacgaaggca caacagtatg
     2101 tggacagtta cgtccaagag agtgacctca gtgaagtgac actcccacca gagatacagt
     2161 atttcactta tgctagagat aaatggctcc cttctgaccc tcagattata tctgaaggcc
     2221 tttatgccat agctgttgtg ctcagcttct ctcggattgc gtacatcctc cctgcaaatg
     2281 agagctttgg ccccctgcag atctctcttg gaaggactgt aaaggacata ttcaagttca
     2341 tggtcctctt tattatggtg ttttttgcct ttatgattgg catgttcata ctttattctt
     2401 actaccttgg ggctaaagtt aatgctgctt ttaccactgt agaagaaagt ttcaagactt
     2461 tattttggtc aatatttggg ttgtctgaag tgacttccgt tgtgctcaaa tatgatcaca
     2521 aattcataga aaatattgga tacgttcttt atggaatata caatgtaact atggtggtcg
     2581 ttttactcaa catgctaatt gctatgatta atagctcata tcaagaaatt gaggatgaca
     2641 gtgatgtaga atggaagttt gctcgttcaa aactttggtt atcctatttt gatgatggaa
     2701 aaacattacc tccacctttc agtctagttc ctagtccaaa atcatttgtt tatttcatca
     2761 tgcgaattgt taactttccc aaatgcagaa ggagaaggct tcagaaggat atagaaatgg
     2821 gaatgggtaa ctcaaagtcc aggttaaacc tcttcactca gtctaactca agagtttttg
     2881 aatcacacag ttttaacagc attctcaatc agccaacacg ttatcagcag ataatgaaaa
     2941 gacttataaa gcggtatgtt ttgaaagcac aagtagacaa agaaaatgat gaagttaatg
     3001 aaggtgaatt aaaagaaatc aagcaagata tctccagcct tcgttatgaa cttttggaag
     3061 acaagagcca agcaactgag gaattagcca ttctaattca taaacttagt gagaaactga
     3121 atcccagcat gctgagatgt gaatgatgca gcaacctgga tttggctttg actatagcac
     3181 aaatgtgggc aataatattt ctaagtatga aatacttgaa aaactatgat gtaaattttt
     3241 agtattaact acctttatca tgtgaacctt taaaagttag ctcttaatgg ttttattgtt
     3301 ttatcacatg aaaatgcatt ttatttgtct gctttgacat tacagtggca taccattgtg
     3361 ttgaaaagcc caatattact atattattga aacttttatt cattttagag taaactccac
     3421 atctttgcac tacctgtttg cctccaagag actatcagtt ccttggggac agggaccatg
     3481 tcttattcat ctttgtgtct ccagcatcta gtacagtgcc tggtatatag taggtgctca
     3541 ataaatgttg aaaccaactg aactgccaac aaaataaaaa taaaaagtct tcactatgta
     3601 gcataccttc ccttgtccaa gttctgaaga ggtttttttt tttttttttt aatagaaact
     3661 gaagacattt tacaaccagc tatgacttgg taagacattc ttagaatttt aggtgtcact
     3721 gataatccta gaaccactga gccccaagtg aagaatttaa caacaaaatg ggttaatgaa
     3781 aaatataatt acattgtata tttaagtttc atagaattat ttaaaacaac acattaaaga
     3841 tttttctaaa atatagactg cttgctttct gtcttagact tacgtttgtt gtttttcagt
     3901 aatgtgattt tcttttaagt tgggggttat gcagggttgt cattttgtta taaccatcta
     3961 atttctgcct ctgctgcttt aatgctaaat gagatatcaa cagctgactt catatctcac
     4021 ctgtgagctc cctgctgagt tttggagggt ctgctcatgg gaagaaatag gaaagagcag
     4081 tgactatggg cgtacttgga aagacatggc caagcatccc caggtgtgtt tcagttcctt
     4141 ttggggcatt tattgccatc gttgcttaca atgattgaca tctttgtttc ttatcaaagg
     4201 attccagttc cactttctat ataaaatata ttgtgatata tctacatatg ccttattaca
     4261 taattgtgct gaatgctggt aatatccgca atgcctcttg actttaatgg gaaaaggcat
     4321 gcagaccagt aagttcccca gtcacttcag agactataaa acactcaaag cattttttaa
     4381 ccagctaggt ttaaatctct catagagtta tgtttaacat cctgagtctg cagtcagttg
     4441 ctgtcaagtc gtataggaat acgaattgtg atcatagatc aaagattttc agaggtcctt
     4501 aaaaccaact aaatacatgc tactttaaaa tcattgctat catgcagaaa agctctttag
     4561 acatgaagac agaaataagt gttaaatgga actacataaa gctctttaaa gattatttct
     4621 taatttctac tttttgggag ttaaattaag aaaggaactt tataaatgtt ttgctaccat
     4681 tgtagaacac ttcattaact tttgtgccat gctaagagta ttcgtcttaa acatttttca
     4741 aactttatgt actttatgtt gtgtctcaga actgaataaa atattgaatt tttccattgt
     4801 tatatgttac catatgttaa gatagtaaag atacaaagtt tctataatag atgtttctga
     4861 tagttttata gtatggtcca ggattccaag tgtgaaaagt ttttgcttat agctatggaa
     4921 ctgaatattt tgtaattttc ttctttgcgg ttggaaaaaa tgttgaatga aaaagtggca
     4981 gattcagctg gggacattca gcctaagatt cttggaatct gaagatcaga gaagtatgaa
     5041 gataagcctc atggtatcca caccatgtgg ataaaaagct gacttttttt tttttttttt
     5101 tttgtccatg cccctcacaa ctgtagagct cttaacaggc attttttctt tatttactat
     5161 gtacaaactg gtatagtttt aatatttcat ctttttcctt attcatcatt tcaaggtgtt
     5221 gtttcagaag aaggtgtgat gacaaggtgt agtgagtgtg gttgatgttt ttgatgccct
     5281 gcccagatgc cctctactgg accagtgcac ctgtctccca gattctcctg tgcagttcct
     5341 agccaatcac ttcccctgga gaattgccct cagctaaaaa gaagaagcct tgctcgggat
     5401 gtgatgcctc cgcctcccca tggccagtga ctgatgggtg ggggcacaaa gggctggccc
     5461 cttgtctcaa gatggggcca actattcagt gcagttcatg ctccagagct cctgaaagga
     5521 ttagggtgat gccagactca agctgagatg aaatcctggt ttagattctt cctctgcctt
     5581 ttccagtttc cttccttccc tttctccaga gagcatcccc ttaatgagtc accacatcca
     5641 aatcttatta ggttttgctt ttagggaact cacactaagc cataaggtat taatgtggta
     5701 gcatacggtt gagatgagga ttagtcgagg ggattgctgt cagaattagt ccttcacttg
     5761 aggataaaga tagctctggg tcagcaagtc ttttccctag tcacttttaa caggtacctt
     5821 tgggaaaaca aacctcaaag aagttgttgg ggcaactcag agaagggagc atttaaacag
     5881 gaccaaaaac aactttatag aaaaaaacat taattaaagg attgtcaaag ccccaggact
     5941 cttttttcct taggacatct ctcatttttt acctctttgc tattcttatt tttttctcat
     6001 ttacagataa agaaaagaaa gcaacactca aagtgcttct tagacttatt gttcgaaaag
     6061 ttgggtactt tgtaagtgcc tgctgtattg aatttacaga gcacccatga ctttatggaa
     6121 gtcacaatct gttgaaaagt ttgggttctt agacttgaaa taatgagaaa actttgaaaa
     6181 atggtacaga gtatctttac agagtttatg cacaataaaa acaaaaatga tatgttgtga
     6241 ttattaaaag caaatttggt acaatttagg ataactatct tacccaatat gtcaatatat
     6301 ttatatttca aatgtgcaag ccaagtgaaa gcagcttttg taaatgggaa gataaattgt
     6361 ctgatggaca atgtctaaag agaactgaag ccacactaat gactgtggta tgggacaaac
     6421 catttaactt ctctggtctt cataaatggt tcaggcaaac agggttatgc tacatcaggg
     6481 gttcctagtc cctggagctc atagaggtgt tttaggaggt taatgtcatc atccaaggtg
     6541 gtaatctttc tttccatgtc tttttaaatt ttttaaataa agtttttaaa atacattttt
     6601 agaggcgggt ctcactatgt tgtccaggct agtctttaac ttttggcctc aagcgatcct
     6661 cctgcctcag cctcccaaaa tcaggctggg cacagtggtg cacacctgta atcgcagcac
     6721 tttgggacgt tgaagcaggt cgatggcttc agttcaggag ttcgagacca gcagggcaac
     6781 atggtgaaac tgtctctaca aaaaatacaa aaaaaattag ccgggcatgg tggcatgtgt
     6841 ctgtggttcc agttactcag gaggctgggg tgagaggata acttgagccc aggaagttga
     6901 ggctgcagtg agctggttca cgccactgca ctccagcctg ggtgacaaag tgaaccaccc
     6961 cccacaaaaa aaaaaaaaaa aaaaaaaaaa aatctaaaat gggtatttat aactttgttc
     7021 agtttaaaaa agagtttgag aatttctaaa tttataccat gtgttagggg aaactaatgt
     7081 ttttactcat gactcagtca ctcagctgac caccactagc gtgttgatgg ttttaacttt
     7141 aatgcagttt aaattgcttt tatttttagc cataagttgt ttaacttata ctcataatgg
     7201 ttgctttagc accataacat aaggttataa attactgagg tgcatggtaa ttctgcaaat
     7261 ttgtctctaa agtggtcttt gtcacatctg agaggcagcc atcttctgtt gagttttata
     7321 aagaccacca agatgtctct gataccctaa aacatcttta aaaagaggac acacagtggt
     7381 aatttaactt gacattttct ttattgtgaa taaaaattcc ttaccctgct aattaattat
     7441 ttgaggaata cttaaaatta gtaggttgaa atctttacta atcatttaga aacaaaacat
     7501 agtatgtact ttaaaaataa taaattgcat ttttagatgc aaaatcaaag aattccaaat
     7561 atcatattat gcaaactttt tgtattgttt tgatgctata tcatagcctc atttcactgt
     7621 tttaaaataa atttgagctt caaaataaac ttttactttc cttctacaca attaattgaa
     7681 cagtggacat cacttgctaa atggaaagta agcactgcca gcattgtctg tctttggtgt
     7741 tttttttttt acctatttat tagaaccata gtatttcttc attattaatt tgtatgaact
     7801 attttttaag atattaactc ttttctccta tatttttgtt ttcatttaaa cattgttgtg
     7861 acatattgaa atgtttatct ttacttttca ttttttttaa gttagttttt tgtttgtttt
     7921 ttagagatgg ggccttgcta ttttgcccag gctggattgt tgggctcaag caatcttgag
     7981 cctcagcctt caaatagctg agactacagg catgtaacac catatctgct tttttccttt
     8041 gtggtttctt ctattccttt tgagatcagt ttccttctgt tatgggctga attgtgtccc
     8101 ctcaaaactc atgttaaagt cctcgccttc agtatctcag actataacta tagttggaga
     8161 tagggtcttt aaagaggtaa ttaatttaaa atgagataat atgactggtg tgcttataaa
     8221 aagacaagat gagacacaga cagacataga gggaggacca cgtgaagaca cggagaagat
     8281 gacgatctat aagccaagaa gagaggcctc tgaagatcgg ttttattccc tgctgacacc
     8341 ttgatctatg acttctagac tccaagactg tgagaaaata aatttctgtt gttgaaaagc
     8401 c
//
