LOCUS       NM_001413382            3683 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            C member 1 (TRPC1), transcript variant 13, mRNA.
ACCESSION   NM_001413382
VERSION     NM_001413382.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3683)
  AUTHORS   Skerjanz,J., Bauernhofer,L., Lenk,K., Emmerstorfer-Augustin,A.,
            Leitinger,G., Reichmann,F., Stockner,T., Groschner,K. and Tiapko,O.
  TITLE     TRPC1: The housekeeper of the hippocampus
  JOURNAL   Cell Calcium 123, 102933 (2024)
   PUBMED   39116710
  REMARK    GeneRIF: TRPC1: The housekeeper of the hippocampus.
            Review article
REFERENCE   2  (bases 1 to 3683)
  AUTHORS   Qu,M. and Du,L.
  TITLE     Upregulation of TRPC1 protects against high glucose-induced HUVECs
            dysfunction by inhibiting oxidative stress
  JOURNAL   Biochem Biophys Res Commun 699, 149560 (2024)
   PUBMED   38277724
  REMARK    GeneRIF: Upregulation of TRPC1 protects against high
            glucose-induced HUVECs dysfunction by inhibiting oxidative stress.
REFERENCE   3  (bases 1 to 3683)
  AUTHORS   Shin,S., Gombedza,F.C., Awuah Boadi,E., Yiu,A.J., Roy,S.K. and
            Bandyopadhyay,B.C.
  TITLE     Reduction of TRPC1/TRPC3 mediated Ca2+-signaling protects oxidative
            stress-induced COPD
  JOURNAL   Cell Signal 107, 110681 (2023)
   PUBMED   37062436
  REMARK    GeneRIF: Reduction of TRPC1/TRPC3 mediated Ca[2+]-signaling
            protects oxidative stress-induced COPD.
REFERENCE   4  (bases 1 to 3683)
  AUTHORS   Qi,H., Wu,F. and Wang,H.
  TITLE     Function of TRPC1 in modulating hepatocellular carcinoma
            progression
  JOURNAL   Med Oncol 40 (3), 97 (2023)
   PUBMED   36797544
  REMARK    GeneRIF: Function of TRPC1 in modulating hepatocellular carcinoma
            progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3683)
  AUTHORS   Radoslavova,S., Fels,B., Petho,Z., Gruner,M., Ruck,T., Meuth,S.G.,
            Folcher,A., Prevarskaya,N., Schwab,A. and Ouadid-Ahidouch,H.
  TITLE     TRPC1 channels regulate the activation of pancreatic stellate cells
            through ERK1/2 and SMAD2 pathways and perpetuate their
            pressure-mediated activation
  JOURNAL   Cell Calcium 106, 102621 (2022)
   PUBMED   35905654
  REMARK    GeneRIF: TRPC1 channels regulate the activation of pancreatic
            stellate cells through ERK1/2 and SMAD2 pathways and perpetuate
            their pressure-mediated activation.
REFERENCE   6  (bases 1 to 3683)
  AUTHORS   Zitt,C., Zobel,A., Obukhov,A.G., Harteneck,C., Kalkbrenner,F.,
            Luckhoff,A. and Schultz,G.
  TITLE     Cloning and functional expression of a human Ca2+-permeable cation
            channel activated by calcium store depletion
  JOURNAL   Neuron 16 (6), 1189-1196 (1996)
   PUBMED   8663995
REFERENCE   7  (bases 1 to 3683)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
REFERENCE   8  (bases 1 to 3683)
  AUTHORS   Zhu,X., Chu,P.B., Peyton,M. and Birnbaumer,L.
  TITLE     Molecular cloning of a widely expressed human homologue for the
            Drosophila trp gene
  JOURNAL   FEBS Lett 373 (3), 193-198 (1995)
   PUBMED   7589464
REFERENCE   9  (bases 1 to 3683)
  AUTHORS   Wes,P.D., Chevesich,J., Jeromin,A., Rosenberg,C., Stetten,G. and
            Montell,C.
  TITLE     TRPC1, a human homolog of a Drosophila store-operated channel
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9652-9656 (1995)
   PUBMED   7568191
REFERENCE   10 (bases 1 to 3683)
  AUTHORS   Abdel-Malek,Z., Swope,V., Collins,C., Boissy,R., Zhao,H. and
            Nordlund,J.
  TITLE     Contribution of melanogenic proteins to the heterogeneous
            pigmentation of human melanocytes
  JOURNAL   J Cell Sci 106 (Pt 4), 1323-1331 (1993)
   PUBMED   8126111
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC072028.14 and AC022291.27.
            
            Summary: The protein encoded by this gene is a membrane protein
            that can form a non-selective channel permeable to calcium and
            other cations. The encoded protein appears to be induced to form
            channels by a receptor tyrosine kinase-activated
            phosphatidylinositol second messenger system and also by depletion
            of intracellular calcium stores. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.551285.1,
                                           SRR14038196.36137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146982, SAMN03267761
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-698               AC072028.14        119662-120359
            699-901             AC072028.14        143886-144088
            902-1033            AC072028.14        173260-173391
            1034-1229           AC072028.14        176462-176657
            1230-1405           AC022291.27        13058-13233
            1406-1607           AC022291.27        14866-15067
            1608-1802           AC022291.27        15325-15519
            1803-3683           AC022291.27        16897-18777
FEATURES             Location/Qualifiers
     source          1..3683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..3683
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="transient receptor potential cation channel
                     subfamily C member 1"
                     /db_xref="GeneID:7220"
                     /db_xref="HGNC:HGNC:12333"
                     /db_xref="MIM:602343"
     exon            1..698
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             666..2030
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="isoform 13 is encoded by transcript variant 13;
                     short transient receptor potential channel 1; transient
                     receptor potential canonical 1; transient receptor protein
                     1; capacitative calcium channel protein Trp1"
                     /codon_start=1
                     /product="short transient receptor potential channel 1
                     isoform 13"
                     /protein_id="NP_001400311.1"
                     /db_xref="GeneID:7220"
                     /db_xref="HGNC:HGNC:12333"
                     /db_xref="MIM:602343"
                     /translation="MRSFSCWRATRKLMERIQNPEYSTTMDVAPVILAAHRNNYEILT
                     MLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPI
                     LRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSD
                     EPLDKRGLLEERMNLSRLKLAIKYNQKEISMGQMLQDFGKFLGMFLLVLFSFTIGLTQ
                     LYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGE
                     ELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFD
                     DKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENY
                     QKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMF
                     YPRN"
     exon            699..901
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1033
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1229
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1405
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1607
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1802
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..3683
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3658..3663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="hexamer: AATAAA"
     polyA_site      3683
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="major polyA site"
ORIGIN      
        1 gtcgctacag aggagcagag gatgacgtga ggacagagtc gcgaacatct cctcggagcg
       61 cagctgggcc agcggttccc acagccctgg agcccaacgt gcgcagaagc gcctcttgga
      121 gctcctctcc cacagatctc tcgtcctctt cctgggctag gccgccccag gcgcggcccc
      181 tgcgactcct ggcacggccc cgtgctcggc tgccgccctg gcgcgcgcca cactgtcgtc
      241 cccggacggg cgcggaccgg ctcggccggg gcgccggcgg ctggggaggg gtcgctggcc
      301 ccggggccgc gcatgcgccg ccaccaactt ggggctgtca gtggagggcg agtgctggtt
      361 ctcaggggag gcgacgccct tcggggccaa cgggcctcga gccgaggcag cagtgggaac
      421 gactcatcct ttttccagcc ctggggcgtg gctggggtcg gggtcggggt cggggccggt
      481 gggggccccg cccccgtctc ctggcctgcc cccttcatgg gccgcgatga tggcggccct
      541 gtacccgagc acggacctct cgggcgcctc ctcctcctcc ctgccttcct ctccatcctc
      601 ttcctcgccg aacgaggtga tggcgctgaa ggatgtgcgg gaggtgaagg aggagaatac
      661 gctgaatgag aagcttttct tgctggcgtg cgacaaggaa actaatggaa cgaattcaga
      721 atcctgagta ttcaacaact atggatgttg cacctgtcat tttagctgct catcgtaaca
      781 actatgaaat tcttacaatg ctcttaaaac aggatgtatc tctacccaag ccccatgcag
      841 ttggctgtga atgcacattg tgttctgcaa aaaacaaaaa ggatagcctc cggcattcca
      901 ggtttcgtct tgatatatat cgatgtttgg ccagtccagc tctaataatg ttaacagagg
      961 aggatccaat tctgagagca tttgaactta gtgctgattt aaaagaacta agtcttgtgg
     1021 aggtggaatt caggaatgat tatgaggaac tagcccggca atgtaaaatg tttgctaagg
     1081 atttacttgc acaagcccgg aattctcgtg aattggaagt tattctaaac catacgtcta
     1141 gtgacgagcc tcttgacaaa cggggattat tagaagaaag aatgaattta agtcgtctaa
     1201 aacttgctat caaatataac cagaaagaga tttcaatggg acagatgtta caagattttg
     1261 gaaaatttct tgggatgttt cttcttgttt tgttttcttt cacaattgga ctgacacaac
     1321 tgtatgataa aggatatact tcaaaggagc agaaggactg tgtaggcatc ttctgtgaac
     1381 agcaaagcaa tgataccttc cattcgttca ttggcacctg ctttgctttg ttctggtata
     1441 ttttctcctt agcgcatgtg gcaatctttg tcacaagatt tagctatgga gaagaactgc
     1501 agtcctttgt gggagctgtc attgttggta catacaatgt cgtggttgtg attgtgctta
     1561 ccaaactgct ggtggcaatg cttcataaaa gctttcagtt gatagcaaat catgaagaca
     1621 aagaatggaa gtttgctcga gcaaaattat ggcttagcta ctttgatgac aaatgtacgt
     1681 tacctccacc tttcaacatc attccctcac caaagactat ctgctatatg attagtagcc
     1741 tcagtaagtg gatttgctct catacatcaa aaggcaaggt caaacggcaa aacagtttaa
     1801 aggaatggag gaatttgaaa cagaagagag atgaaaacta tcaaaaagtg atgtgctgcc
     1861 tagtgcatcg ttacttgact tccatgagac agaagatgca aagtacagat caggcaactg
     1921 tggaaaatct aaacgaactg cgccaagatc tgtcaaaatt ccgaaatgaa ataagggatt
     1981 tacttggctt tcggacttct aaatatgcta tgttttatcc aagaaattaa ccattttcta
     2041 aatcatggag cgaataattt tcaataacag atccaaaaga ctatattgca taacttgcaa
     2101 tgaaattaat gagatatata ttgaaataaa gaattatgta aaagccattc tttaaaatat
     2161 ttatagcata aatatatgtt atgtaaagtg tgtatataga attagttttt taaaccttct
     2221 gttagtggct ttttgcagaa gcaaaacaga ttaagtagat agattttgtt agcatgctgc
     2281 ttggttttct tacttagtgc tttaaaatgt ttttttttat gtttaagagg ggcagttata
     2341 aatggacaca ttgcccagaa tgttttgtaa aatgaagacc agcaaatgta ggctgatctc
     2401 cttcacagga tacacttgaa atatagaagt tatgttttaa atatctctgt tttaggagtt
     2461 cacatatagt tcagcattta ttgtttagga gtataatttt attttatcta aaataatagt
     2521 ctattttttc ttttgtattt tgttataatc ttaagcaaca aagaaaaaac cctaatattt
     2581 gaatctattt atgtctttca atttaaattc acttcagttt ttgttattgt aatatattta
     2641 cttttacatg gttataatca ctttatattt ttaatgtttt tttcacttaa tattttatat
     2701 atacatttcc atgtattgat gtagttagtc cacatttaaa tttttataga attatatagt
     2761 ttttgaaaaa tacagtcagt agatgtttta ttttttagct attcagttat gtttataagt
     2821 ttgcatagct acttctcgac atttggtttg ttttaatttt tttgtatcat aatagtccta
     2881 tttttttttc aagttggagt gaatgttttt agttttaaga tagataggag acactttttt
     2941 atcacatgta gtcacaacct gttttgtttt tgtaaaacat aggaagtctc tttaatgcaa
     3001 tgatttgttt tatatttgga ctaaggttct tgagcttatc tcccaaggta ctttccataa
     3061 tttaacacag cttctataaa agtgacttca tgcttacttg tggatcattc ttgctgctta
     3121 agatgaaaag cattggtttt ttaaaattag agaataaaat atgtatttaa atttttggtg
     3181 tgttcacata aagggatgta gctaaaatgt tttcataggc tattatatat tctcgcagca
     3241 tttccagtta agaggatatt aggtatataa ttctcttctt aaccgaatgt cagatggtct
     3301 tacgccacag ggtgcaggta acccttggtc tgtaagcacc accgatccag ggatcattgt
     3361 ctaaataggt tactattgtt tgtttcatct tgcttttgca tttttatttt ttaatttcca
     3421 aattttaagt gttccctctt tggggcaaat tcttataaaa atgtttattg taaagttata
     3481 tattttgtct acgatgggat tatgcacttc ccaattggga ttttacatct ggatttttag
     3541 tcattctaaa aaacacctaa ttattaaaac atttatagag tgcctactgt atgcatgagt
     3601 tgagttgctt ctgaggtaca ttttgaatga cagcatattg taagaaaaaa aaaggtgaat
     3661 aaaatttgac attagattat aaa
//
