LOCUS       NM_001413380            4028 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            C member 1 (TRPC1), transcript variant 11, mRNA.
ACCESSION   NM_001413380
VERSION     NM_001413380.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4028)
  AUTHORS   Skerjanz,J., Bauernhofer,L., Lenk,K., Emmerstorfer-Augustin,A.,
            Leitinger,G., Reichmann,F., Stockner,T., Groschner,K. and Tiapko,O.
  TITLE     TRPC1: The housekeeper of the hippocampus
  JOURNAL   Cell Calcium 123, 102933 (2024)
   PUBMED   39116710
  REMARK    GeneRIF: TRPC1: The housekeeper of the hippocampus.
            Review article
REFERENCE   2  (bases 1 to 4028)
  AUTHORS   Qu,M. and Du,L.
  TITLE     Upregulation of TRPC1 protects against high glucose-induced HUVECs
            dysfunction by inhibiting oxidative stress
  JOURNAL   Biochem Biophys Res Commun 699, 149560 (2024)
   PUBMED   38277724
  REMARK    GeneRIF: Upregulation of TRPC1 protects against high
            glucose-induced HUVECs dysfunction by inhibiting oxidative stress.
REFERENCE   3  (bases 1 to 4028)
  AUTHORS   Shin,S., Gombedza,F.C., Awuah Boadi,E., Yiu,A.J., Roy,S.K. and
            Bandyopadhyay,B.C.
  TITLE     Reduction of TRPC1/TRPC3 mediated Ca2+-signaling protects oxidative
            stress-induced COPD
  JOURNAL   Cell Signal 107, 110681 (2023)
   PUBMED   37062436
  REMARK    GeneRIF: Reduction of TRPC1/TRPC3 mediated Ca[2+]-signaling
            protects oxidative stress-induced COPD.
REFERENCE   4  (bases 1 to 4028)
  AUTHORS   Qi,H., Wu,F. and Wang,H.
  TITLE     Function of TRPC1 in modulating hepatocellular carcinoma
            progression
  JOURNAL   Med Oncol 40 (3), 97 (2023)
   PUBMED   36797544
  REMARK    GeneRIF: Function of TRPC1 in modulating hepatocellular carcinoma
            progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4028)
  AUTHORS   Radoslavova,S., Fels,B., Petho,Z., Gruner,M., Ruck,T., Meuth,S.G.,
            Folcher,A., Prevarskaya,N., Schwab,A. and Ouadid-Ahidouch,H.
  TITLE     TRPC1 channels regulate the activation of pancreatic stellate cells
            through ERK1/2 and SMAD2 pathways and perpetuate their
            pressure-mediated activation
  JOURNAL   Cell Calcium 106, 102621 (2022)
   PUBMED   35905654
  REMARK    GeneRIF: TRPC1 channels regulate the activation of pancreatic
            stellate cells through ERK1/2 and SMAD2 pathways and perpetuate
            their pressure-mediated activation.
REFERENCE   6  (bases 1 to 4028)
  AUTHORS   Zitt,C., Zobel,A., Obukhov,A.G., Harteneck,C., Kalkbrenner,F.,
            Luckhoff,A. and Schultz,G.
  TITLE     Cloning and functional expression of a human Ca2+-permeable cation
            channel activated by calcium store depletion
  JOURNAL   Neuron 16 (6), 1189-1196 (1996)
   PUBMED   8663995
REFERENCE   7  (bases 1 to 4028)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
REFERENCE   8  (bases 1 to 4028)
  AUTHORS   Zhu,X., Chu,P.B., Peyton,M. and Birnbaumer,L.
  TITLE     Molecular cloning of a widely expressed human homologue for the
            Drosophila trp gene
  JOURNAL   FEBS Lett 373 (3), 193-198 (1995)
   PUBMED   7589464
REFERENCE   9  (bases 1 to 4028)
  AUTHORS   Wes,P.D., Chevesich,J., Jeromin,A., Rosenberg,C., Stetten,G. and
            Montell,C.
  TITLE     TRPC1, a human homolog of a Drosophila store-operated channel
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9652-9656 (1995)
   PUBMED   7568191
REFERENCE   10 (bases 1 to 4028)
  AUTHORS   Abdel-Malek,Z., Swope,V., Collins,C., Boissy,R., Zhao,H. and
            Nordlund,J.
  TITLE     Contribution of melanogenic proteins to the heterogeneous
            pigmentation of human melanocytes
  JOURNAL   J Cell Sci 106 (Pt 4), 1323-1331 (1993)
   PUBMED   8126111
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC072028.14 and AC022291.27.
            
            Summary: The protein encoded by this gene is a membrane protein
            that can form a non-selective channel permeable to calcium and
            other cations. The encoded protein appears to be induced to form
            channels by a receptor tyrosine kinase-activated
            phosphatidylinositol second messenger system and also by depletion
            of intracellular calcium stores. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1992251.1,
                                           SRR18074967.3453194.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-698               AC072028.14        119662-120359
            699-901             AC072028.14        143886-144088
            902-1097            AC072028.14        176462-176657
            1098-1434           AC072028.14        180332-180668
            1435-1527           AC072028.14        186647-186739
            1528-1574           AC022291.27        2001-2047
            1575-1750           AC022291.27        13058-13233
            1751-1952           AC022291.27        14866-15067
            1953-2147           AC022291.27        15325-15519
            2148-4028           AC022291.27        16897-18777
FEATURES             Location/Qualifiers
     source          1..4028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..4028
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="transient receptor potential cation channel
                     subfamily C member 1"
                     /db_xref="GeneID:7220"
                     /db_xref="HGNC:HGNC:12333"
                     /db_xref="MIM:602343"
     exon            1..698
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             666..2375
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="isoform 11 is encoded by transcript variant 11;
                     short transient receptor potential channel 1; transient
                     receptor potential canonical 1; transient receptor protein
                     1; capacitative calcium channel protein Trp1"
                     /codon_start=1
                     /product="short transient receptor potential channel 1
                     isoform 11"
                     /protein_id="NP_001400309.1"
                     /db_xref="GeneID:7220"
                     /db_xref="HGNC:HGNC:12333"
                     /db_xref="MIM:602343"
                     /translation="MRSFSCWRATRKLMERIQNPEYSTTMDVAPVILAAHRNNYEILT
                     MLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRNDYEELARQCKMFAKDLLAQARN
                     SRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWF
                     GQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASY
                     FTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLE
                     ESRNQLSFVMNSLYLATFALKVVAHNKISMGQMLQDFGKFLGMFLLVLFSFTIGLTQL
                     YDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEE
                     LQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDD
                     KCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQ
                     KVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFY
                     PRN"
     exon            699..901
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1097
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1434
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1574
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1750
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1952
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2147
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..4028
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4003..4008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="hexamer: AATAAA"
     polyA_site      4028
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="major polyA site"
ORIGIN      
        1 gtcgctacag aggagcagag gatgacgtga ggacagagtc gcgaacatct cctcggagcg
       61 cagctgggcc agcggttccc acagccctgg agcccaacgt gcgcagaagc gcctcttgga
      121 gctcctctcc cacagatctc tcgtcctctt cctgggctag gccgccccag gcgcggcccc
      181 tgcgactcct ggcacggccc cgtgctcggc tgccgccctg gcgcgcgcca cactgtcgtc
      241 cccggacggg cgcggaccgg ctcggccggg gcgccggcgg ctggggaggg gtcgctggcc
      301 ccggggccgc gcatgcgccg ccaccaactt ggggctgtca gtggagggcg agtgctggtt
      361 ctcaggggag gcgacgccct tcggggccaa cgggcctcga gccgaggcag cagtgggaac
      421 gactcatcct ttttccagcc ctggggcgtg gctggggtcg gggtcggggt cggggccggt
      481 gggggccccg cccccgtctc ctggcctgcc cccttcatgg gccgcgatga tggcggccct
      541 gtacccgagc acggacctct cgggcgcctc ctcctcctcc ctgccttcct ctccatcctc
      601 ttcctcgccg aacgaggtga tggcgctgaa ggatgtgcgg gaggtgaagg aggagaatac
      661 gctgaatgag aagcttttct tgctggcgtg cgacaaggaa actaatggaa cgaattcaga
      721 atcctgagta ttcaacaact atggatgttg cacctgtcat tttagctgct catcgtaaca
      781 actatgaaat tcttacaatg ctcttaaaac aggatgtatc tctacccaag ccccatgcag
      841 ttggctgtga atgcacattg tgttctgcaa aaaacaaaaa ggatagcctc cggcattcca
      901 ggaatgatta tgaggaacta gcccggcaat gtaaaatgtt tgctaaggat ttacttgcac
      961 aagcccggaa ttctcgtgaa ttggaagtta ttctaaacca tacgtctagt gacgagcctc
     1021 ttgacaaacg gggattatta gaagaaagaa tgaatttaag tcgtctaaaa cttgctatca
     1081 aatataacca gaaagagttt gtctcccagt ctaactgcca gcagttcctg aacactgttt
     1141 ggtttggaca gatgtcgggt taccgacgca agcccacctg taagaagata atgactgttt
     1201 tgacagtagg catcttttgg ccagttttgt cactttgtta tttgatagct cccaaatctc
     1261 agtttggcag aatcattcac acacctttta tgaaatttat cattcatgga gcatcatatt
     1321 tcacatttct gctgttgctt aatctatact ctcttgtcta caatgaggat aagaaaaaca
     1381 caatggggcc agcccttgaa agaatagact atcttcttat tctgtggatt attgggatga
     1441 tttggtcaga cattaaaaga ctctggtatg aagggttgga agacttttta gaagaatctc
     1501 gtaatcaact cagttttgtc atgaattctc tttatttggc aacctttgcc ctcaaagtgg
     1561 ttgctcacaa caagatttca atgggacaga tgttacaaga ttttggaaaa tttcttggga
     1621 tgtttcttct tgttttgttt tctttcacaa ttggactgac acaactgtat gataaaggat
     1681 atacttcaaa ggagcagaag gactgtgtag gcatcttctg tgaacagcaa agcaatgata
     1741 ccttccattc gttcattggc acctgctttg ctttgttctg gtatattttc tccttagcgc
     1801 atgtggcaat ctttgtcaca agatttagct atggagaaga actgcagtcc tttgtgggag
     1861 ctgtcattgt tggtacatac aatgtcgtgg ttgtgattgt gcttaccaaa ctgctggtgg
     1921 caatgcttca taaaagcttt cagttgatag caaatcatga agacaaagaa tggaagtttg
     1981 ctcgagcaaa attatggctt agctactttg atgacaaatg tacgttacct ccacctttca
     2041 acatcattcc ctcaccaaag actatctgct atatgattag tagcctcagt aagtggattt
     2101 gctctcatac atcaaaaggc aaggtcaaac ggcaaaacag tttaaaggaa tggaggaatt
     2161 tgaaacagaa gagagatgaa aactatcaaa aagtgatgtg ctgcctagtg catcgttact
     2221 tgacttccat gagacagaag atgcaaagta cagatcaggc aactgtggaa aatctaaacg
     2281 aactgcgcca agatctgtca aaattccgaa atgaaataag ggatttactt ggctttcgga
     2341 cttctaaata tgctatgttt tatccaagaa attaaccatt ttctaaatca tggagcgaat
     2401 aattttcaat aacagatcca aaagactata ttgcataact tgcaatgaaa ttaatgagat
     2461 atatattgaa ataaagaatt atgtaaaagc cattctttaa aatatttata gcataaatat
     2521 atgttatgta aagtgtgtat atagaattag ttttttaaac cttctgttag tggctttttg
     2581 cagaagcaaa acagattaag tagatagatt ttgttagcat gctgcttggt tttcttactt
     2641 agtgctttaa aatgtttttt tttatgttta agaggggcag ttataaatgg acacattgcc
     2701 cagaatgttt tgtaaaatga agaccagcaa atgtaggctg atctccttca caggatacac
     2761 ttgaaatata gaagttatgt tttaaatatc tctgttttag gagttcacat atagttcagc
     2821 atttattgtt taggagtata attttatttt atctaaaata atagtctatt ttttcttttg
     2881 tattttgtta taatcttaag caacaaagaa aaaaccctaa tatttgaatc tatttatgtc
     2941 tttcaattta aattcacttc agtttttgtt attgtaatat atttactttt acatggttat
     3001 aatcacttta tatttttaat gtttttttca cttaatattt tatatataca tttccatgta
     3061 ttgatgtagt tagtccacat ttaaattttt atagaattat atagtttttg aaaaatacag
     3121 tcagtagatg ttttattttt tagctattca gttatgttta taagtttgca tagctacttc
     3181 tcgacatttg gtttgtttta atttttttgt atcataatag tcctattttt ttttcaagtt
     3241 ggagtgaatg tttttagttt taagatagat aggagacact tttttatcac atgtagtcac
     3301 aacctgtttt gtttttgtaa aacataggaa gtctctttaa tgcaatgatt tgttttatat
     3361 ttggactaag gttcttgagc ttatctccca aggtactttc cataatttaa cacagcttct
     3421 ataaaagtga cttcatgctt acttgtggat cattcttgct gcttaagatg aaaagcattg
     3481 gttttttaaa attagagaat aaaatatgta tttaaatttt tggtgtgttc acataaaggg
     3541 atgtagctaa aatgttttca taggctatta tatattctcg cagcatttcc agttaagagg
     3601 atattaggta tataattctc ttcttaaccg aatgtcagat ggtcttacgc cacagggtgc
     3661 aggtaaccct tggtctgtaa gcaccaccga tccagggatc attgtctaaa taggttacta
     3721 ttgtttgttt catcttgctt ttgcattttt attttttaat ttccaaattt taagtgttcc
     3781 ctctttgggg caaattctta taaaaatgtt tattgtaaag ttatatattt tgtctacgat
     3841 gggattatgc acttcccaat tgggatttta catctggatt tttagtcatt ctaaaaaaca
     3901 cctaattatt aaaacattta tagagtgcct actgtatgca tgagttgagt tgcttctgag
     3961 gtacattttg aatgacagca tattgtaaga aaaaaaaagg tgaataaaat ttgacattag
     4021 attataaa
//
