LOCUS       NM_001413376            5948 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            C member 1 (TRPC1), transcript variant 6, mRNA.
ACCESSION   NM_001413376
VERSION     NM_001413376.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5948)
  AUTHORS   Skerjanz,J., Bauernhofer,L., Lenk,K., Emmerstorfer-Augustin,A.,
            Leitinger,G., Reichmann,F., Stockner,T., Groschner,K. and Tiapko,O.
  TITLE     TRPC1: The housekeeper of the hippocampus
  JOURNAL   Cell Calcium 123, 102933 (2024)
   PUBMED   39116710
  REMARK    GeneRIF: TRPC1: The housekeeper of the hippocampus.
            Review article
REFERENCE   2  (bases 1 to 5948)
  AUTHORS   Qu,M. and Du,L.
  TITLE     Upregulation of TRPC1 protects against high glucose-induced HUVECs
            dysfunction by inhibiting oxidative stress
  JOURNAL   Biochem Biophys Res Commun 699, 149560 (2024)
   PUBMED   38277724
  REMARK    GeneRIF: Upregulation of TRPC1 protects against high
            glucose-induced HUVECs dysfunction by inhibiting oxidative stress.
REFERENCE   3  (bases 1 to 5948)
  AUTHORS   Shin,S., Gombedza,F.C., Awuah Boadi,E., Yiu,A.J., Roy,S.K. and
            Bandyopadhyay,B.C.
  TITLE     Reduction of TRPC1/TRPC3 mediated Ca2+-signaling protects oxidative
            stress-induced COPD
  JOURNAL   Cell Signal 107, 110681 (2023)
   PUBMED   37062436
  REMARK    GeneRIF: Reduction of TRPC1/TRPC3 mediated Ca[2+]-signaling
            protects oxidative stress-induced COPD.
REFERENCE   4  (bases 1 to 5948)
  AUTHORS   Qi,H., Wu,F. and Wang,H.
  TITLE     Function of TRPC1 in modulating hepatocellular carcinoma
            progression
  JOURNAL   Med Oncol 40 (3), 97 (2023)
   PUBMED   36797544
  REMARK    GeneRIF: Function of TRPC1 in modulating hepatocellular carcinoma
            progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5948)
  AUTHORS   Radoslavova,S., Fels,B., Petho,Z., Gruner,M., Ruck,T., Meuth,S.G.,
            Folcher,A., Prevarskaya,N., Schwab,A. and Ouadid-Ahidouch,H.
  TITLE     TRPC1 channels regulate the activation of pancreatic stellate cells
            through ERK1/2 and SMAD2 pathways and perpetuate their
            pressure-mediated activation
  JOURNAL   Cell Calcium 106, 102621 (2022)
   PUBMED   35905654
  REMARK    GeneRIF: TRPC1 channels regulate the activation of pancreatic
            stellate cells through ERK1/2 and SMAD2 pathways and perpetuate
            their pressure-mediated activation.
REFERENCE   6  (bases 1 to 5948)
  AUTHORS   Zitt,C., Zobel,A., Obukhov,A.G., Harteneck,C., Kalkbrenner,F.,
            Luckhoff,A. and Schultz,G.
  TITLE     Cloning and functional expression of a human Ca2+-permeable cation
            channel activated by calcium store depletion
  JOURNAL   Neuron 16 (6), 1189-1196 (1996)
   PUBMED   8663995
REFERENCE   7  (bases 1 to 5948)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
REFERENCE   8  (bases 1 to 5948)
  AUTHORS   Zhu,X., Chu,P.B., Peyton,M. and Birnbaumer,L.
  TITLE     Molecular cloning of a widely expressed human homologue for the
            Drosophila trp gene
  JOURNAL   FEBS Lett 373 (3), 193-198 (1995)
   PUBMED   7589464
REFERENCE   9  (bases 1 to 5948)
  AUTHORS   Wes,P.D., Chevesich,J., Jeromin,A., Rosenberg,C., Stetten,G. and
            Montell,C.
  TITLE     TRPC1, a human homolog of a Drosophila store-operated channel
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9652-9656 (1995)
   PUBMED   7568191
REFERENCE   10 (bases 1 to 5948)
  AUTHORS   Abdel-Malek,Z., Swope,V., Collins,C., Boissy,R., Zhao,H. and
            Nordlund,J.
  TITLE     Contribution of melanogenic proteins to the heterogeneous
            pigmentation of human melanocytes
  JOURNAL   J Cell Sci 106 (Pt 4), 1323-1331 (1993)
   PUBMED   8126111
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC072028.14 and AC022291.27.
            
            Summary: The protein encoded by this gene is a membrane protein
            that can form a non-selective channel permeable to calcium and
            other cations. The encoded protein appears to be induced to form
            channels by a receptor tyrosine kinase-activated
            phosphatidylinositol second messenger system and also by depletion
            of intracellular calcium stores. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3622791.1,
                                           SRR14038191.1114744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2342              AC072028.14        129820-132161
            2343-2545           AC072028.14        143886-144088
            2546-2677           AC072028.14        173260-173391
            2678-2873           AC072028.14        176462-176657
            2874-3210           AC072028.14        180332-180668
            3211-3303           AC072028.14        186647-186739
            3304-3350           AC022291.27        2001-2047
            3351-3494           AC022291.27        3713-3856
            3495-3670           AC022291.27        13058-13233
            3671-3872           AC022291.27        14866-15067
            3873-4067           AC022291.27        15325-15519
            4068-5948           AC022291.27        16897-18777
FEATURES             Location/Qualifiers
     source          1..5948
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..5948
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="transient receptor potential cation channel
                     subfamily C member 1"
                     /db_xref="GeneID:7220"
                     /db_xref="HGNC:HGNC:12333"
                     /db_xref="MIM:602343"
     exon            1..2342
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             2166..4295
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="isoform 6 is encoded by transcript variant 6; short
                     transient receptor potential channel 1; transient receptor
                     potential canonical 1; transient receptor protein 1;
                     capacitative calcium channel protein Trp1"
                     /codon_start=1
                     /product="short transient receptor potential channel 1
                     isoform 6"
                     /protein_id="NP_001400305.1"
                     /db_xref="GeneID:7220"
                     /db_xref="HGNC:HGNC:12333"
                     /db_xref="MIM:602343"
                     /translation="MFVYCYLGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIEN
                     ENLDILQLLLDYGCQKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLP
                     KPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADL
                     KELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLE
                     ERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIF
                     WPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGP
                     ALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVA
                     HNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQML
                     QDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCF
                     ALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQ
                     LIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSK
                     GKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQ
                     DLSKFRNEIRDLLGFRTSKYAMFYPRN"
     exon            2343..2545
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2677
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2873
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3210
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3350
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3494
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3495..3670
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3872
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..4067
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4068..5948
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5923..5928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="hexamer: AATAAA"
     polyA_site      5948
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="major polyA site"
ORIGIN      
        1 aaattaatac tactttcaga taattaaact gtcatacagc gactacaaaa taattatgtt
       61 taaaatgatg agaaagttaa aataaggaaa tgaaaacata agaaaataag agagttggaa
      121 agaaatctgg taaaacttat gcaaataaaa aatacagtca ttaaattttt aagaaatcag
      181 tgaatgggtt aaaggaggaa tgtgaatgga agctaaagga gaaataagtg agtggaagaa
      241 atatgtgaag aaattaccca gaatgcagga aagagagagg aaaaaaagaa aaaacaggaa
      301 atcttgagag acacagatgt tgaaatggga aggtctaact taatgtctaa tggaagttga
      361 caagagaaaa agcaatatgg agatgaagca atatttgaag agagaatggc tgaaaatact
      421 gaagaattaa tgaagggtag aagtccttag atttagaaag cctaggccag atgtggtggc
      481 tcatgcctat aatcccagca cttttggagg ccgaggcgag aggattgctt gaggccagga
      541 atttgagaca agcctgggca acatagcgag acctcatctc tataaaaaat aaaaataaaa
      601 aaaaaaattg aaagcctaat gagtcctaag cagaataaat aaaaaattac ttttcacctg
      661 gacacatcac gataacaaag tatagcagaa tttttatgtg tagcattcta ctactaagat
      721 gttgaaatag agtcacctga aataagattt taaatgtcac tttccagtaa tagcgataaa
      781 ttttcactgg tctatctttg gtcactattg gttcaacttg tgacttagag tatcactttg
      841 tgaagtgtct gtctgataag gttttcccag ggagcatttg tgtctaacta ttaactacta
      901 gtactatggg gaaaatattt ctttttgtga ctagttttct tcttgaggga cctaaggaaa
      961 tacattgtca agaaaactat cacccagctt ccttcaaaag aagttgtatg tgtgaggcag
     1021 ggagtttaag gccatagatt aaaaatagta gcaaatttac ttgaaatttt aataaataaa
     1081 atatgttacc tgtctttctt actcacttat ttagcccagt ttcagtattt tctttttctg
     1141 tatcatgaaa tcatttcttt ttctattttc tatgctgatt gttctttccc tgtttattta
     1201 tagacttcta atgagcaact gtatttgcac atcacgtaaa atgacttatt tatctattgt
     1261 ttaacaagtc aaatgaaaca aaacaagcaa aacccacctt ggcttttttt ctctatttaa
     1321 ttagcatttc tcttgattta ttccccatat tcctgtacca tctggtcagc agacaaatac
     1381 agtggggcct tgctgaaaat aattactgct gtaattgttg tcatttcctc acatgggaca
     1441 actgttttgt tgtgggctac agtcacacag aaggcaattt gcctgctcct aacaggtcag
     1501 gcactaatcc tagtcctgcc ttaagagttt tgtgaactga atgttccctg gccatttaat
     1561 ctaatcagct tcattaatga gatggtgtgt gtgtgtgtgt gttgggaggg tgggaagtag
     1621 ggaagaggat tttcagacat ctttcccttt actatacata tccttgaata tatatgtatt
     1681 tatactgctt ttccaaagtg ttttctcctg taaaacctct ttataatatc ctctgcttat
     1741 tactagatct catttttaac tctatgttat gtaagtaaat atctatgtat atttgaggta
     1801 taaaacttaa ttctttaagc tttttccatc taatttttct agtgtccagt ctgtgccttt
     1861 gggcatcctt tattaaattg ctttaaatat cttccaaaag tttctcctct tatgatcatt
     1921 cagttattaa ttttaaacta ataattttta ttttattctg tacatttaaa aattttctac
     1981 tttttatgtc tgctgctgat gtacgtatta ttttattaag gtataaattt tcatcaagga
     2041 aatgttcaca ttctctgtgt acattttctt atacaaaaat gagtttaggc ttttaatctt
     2101 ttaattcaac aagctaagtt tttctttaca gtcatcctta cttgatatgt cacggatatt
     2161 aaattatgtt tgtatattgt tatttaggtg actattatat ggttaaaaag attttggagg
     2221 aaaacagttc aggtgacttg aacataaatt gcgtagatgt gcttgggaga aatgctgtta
     2281 ccataactat tgaaaacgaa aacttggata tactgcagct tcttttggac tacggttgtc
     2341 agaaactaat ggaacgaatt cagaatcctg agtattcaac aactatggat gttgcacctg
     2401 tcattttagc tgctcatcgt aacaactatg aaattcttac aatgctctta aaacaggatg
     2461 tatctctacc caagccccat gcagttggct gtgaatgcac attgtgttct gcaaaaaaca
     2521 aaaaggatag cctccggcat tccaggtttc gtcttgatat atatcgatgt ttggccagtc
     2581 cagctctaat aatgttaaca gaggaggatc caattctgag agcatttgaa cttagtgctg
     2641 atttaaaaga actaagtctt gtggaggtgg aattcaggaa tgattatgag gaactagccc
     2701 ggcaatgtaa aatgtttgct aaggatttac ttgcacaagc ccggaattct cgtgaattgg
     2761 aagttattct aaaccatacg tctagtgacg agcctcttga caaacgggga ttattagaag
     2821 aaagaatgaa tttaagtcgt ctaaaacttg ctatcaaata taaccagaaa gagtttgtct
     2881 cccagtctaa ctgccagcag ttcctgaaca ctgtttggtt tggacagatg tcgggttacc
     2941 gacgcaagcc cacctgtaag aagataatga ctgttttgac agtaggcatc ttttggccag
     3001 ttttgtcact ttgttatttg atagctccca aatctcagtt tggcagaatc attcacacac
     3061 cttttatgaa atttatcatt catggagcat catatttcac atttctgctg ttgcttaatc
     3121 tatactctct tgtctacaat gaggataaga aaaacacaat ggggccagcc cttgaaagaa
     3181 tagactatct tcttattctg tggattattg ggatgatttg gtcagacatt aaaagactct
     3241 ggtatgaagg gttggaagac tttttagaag aatctcgtaa tcaactcagt tttgtcatga
     3301 attctcttta tttggcaacc tttgccctca aagtggttgc tcacaacaag tttcatgatt
     3361 ttgctgatcg gaaggattgg gatgcattcc atcctacact ggtggcagaa gggctttttg
     3421 catttgcaaa tgttctaagt tatcttcgtc tcttttttat gtatacaacc agctctatct
     3481 tgggtccatt acagatttca atgggacaga tgttacaaga ttttggaaaa tttcttggga
     3541 tgtttcttct tgttttgttt tctttcacaa ttggactgac acaactgtat gataaaggat
     3601 atacttcaaa ggagcagaag gactgtgtag gcatcttctg tgaacagcaa agcaatgata
     3661 ccttccattc gttcattggc acctgctttg ctttgttctg gtatattttc tccttagcgc
     3721 atgtggcaat ctttgtcaca agatttagct atggagaaga actgcagtcc tttgtgggag
     3781 ctgtcattgt tggtacatac aatgtcgtgg ttgtgattgt gcttaccaaa ctgctggtgg
     3841 caatgcttca taaaagcttt cagttgatag caaatcatga agacaaagaa tggaagtttg
     3901 ctcgagcaaa attatggctt agctactttg atgacaaatg tacgttacct ccacctttca
     3961 acatcattcc ctcaccaaag actatctgct atatgattag tagcctcagt aagtggattt
     4021 gctctcatac atcaaaaggc aaggtcaaac ggcaaaacag tttaaaggaa tggaggaatt
     4081 tgaaacagaa gagagatgaa aactatcaaa aagtgatgtg ctgcctagtg catcgttact
     4141 tgacttccat gagacagaag atgcaaagta cagatcaggc aactgtggaa aatctaaacg
     4201 aactgcgcca agatctgtca aaattccgaa atgaaataag ggatttactt ggctttcgga
     4261 cttctaaata tgctatgttt tatccaagaa attaaccatt ttctaaatca tggagcgaat
     4321 aattttcaat aacagatcca aaagactata ttgcataact tgcaatgaaa ttaatgagat
     4381 atatattgaa ataaagaatt atgtaaaagc cattctttaa aatatttata gcataaatat
     4441 atgttatgta aagtgtgtat atagaattag ttttttaaac cttctgttag tggctttttg
     4501 cagaagcaaa acagattaag tagatagatt ttgttagcat gctgcttggt tttcttactt
     4561 agtgctttaa aatgtttttt tttatgttta agaggggcag ttataaatgg acacattgcc
     4621 cagaatgttt tgtaaaatga agaccagcaa atgtaggctg atctccttca caggatacac
     4681 ttgaaatata gaagttatgt tttaaatatc tctgttttag gagttcacat atagttcagc
     4741 atttattgtt taggagtata attttatttt atctaaaata atagtctatt ttttcttttg
     4801 tattttgtta taatcttaag caacaaagaa aaaaccctaa tatttgaatc tatttatgtc
     4861 tttcaattta aattcacttc agtttttgtt attgtaatat atttactttt acatggttat
     4921 aatcacttta tatttttaat gtttttttca cttaatattt tatatataca tttccatgta
     4981 ttgatgtagt tagtccacat ttaaattttt atagaattat atagtttttg aaaaatacag
     5041 tcagtagatg ttttattttt tagctattca gttatgttta taagtttgca tagctacttc
     5101 tcgacatttg gtttgtttta atttttttgt atcataatag tcctattttt ttttcaagtt
     5161 ggagtgaatg tttttagttt taagatagat aggagacact tttttatcac atgtagtcac
     5221 aacctgtttt gtttttgtaa aacataggaa gtctctttaa tgcaatgatt tgttttatat
     5281 ttggactaag gttcttgagc ttatctccca aggtactttc cataatttaa cacagcttct
     5341 ataaaagtga cttcatgctt acttgtggat cattcttgct gcttaagatg aaaagcattg
     5401 gttttttaaa attagagaat aaaatatgta tttaaatttt tggtgtgttc acataaaggg
     5461 atgtagctaa aatgttttca taggctatta tatattctcg cagcatttcc agttaagagg
     5521 atattaggta tataattctc ttcttaaccg aatgtcagat ggtcttacgc cacagggtgc
     5581 aggtaaccct tggtctgtaa gcaccaccga tccagggatc attgtctaaa taggttacta
     5641 ttgtttgttt catcttgctt ttgcattttt attttttaat ttccaaattt taagtgttcc
     5701 ctctttgggg caaattctta taaaaatgtt tattgtaaag ttatatattt tgtctacgat
     5761 gggattatgc acttcccaat tgggatttta catctggatt tttagtcatt ctaaaaaaca
     5821 cctaattatt aaaacattta tagagtgcct actgtatgca tgagttgagt tgcttctgag
     5881 gtacattttg aatgacagca tattgtaaga aaaaaaaagg tgaataaaat ttgacattag
     5941 attataaa
//
