LOCUS       NM_001413363            4315 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            C member 1 (TRPC1), transcript variant 5, mRNA.
ACCESSION   NM_001413363
VERSION     NM_001413363.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4315)
  AUTHORS   Skerjanz,J., Bauernhofer,L., Lenk,K., Emmerstorfer-Augustin,A.,
            Leitinger,G., Reichmann,F., Stockner,T., Groschner,K. and Tiapko,O.
  TITLE     TRPC1: The housekeeper of the hippocampus
  JOURNAL   Cell Calcium 123, 102933 (2024)
   PUBMED   39116710
  REMARK    GeneRIF: TRPC1: The housekeeper of the hippocampus.
            Review article
REFERENCE   2  (bases 1 to 4315)
  AUTHORS   Qu,M. and Du,L.
  TITLE     Upregulation of TRPC1 protects against high glucose-induced HUVECs
            dysfunction by inhibiting oxidative stress
  JOURNAL   Biochem Biophys Res Commun 699, 149560 (2024)
   PUBMED   38277724
  REMARK    GeneRIF: Upregulation of TRPC1 protects against high
            glucose-induced HUVECs dysfunction by inhibiting oxidative stress.
REFERENCE   3  (bases 1 to 4315)
  AUTHORS   Shin,S., Gombedza,F.C., Awuah Boadi,E., Yiu,A.J., Roy,S.K. and
            Bandyopadhyay,B.C.
  TITLE     Reduction of TRPC1/TRPC3 mediated Ca2+-signaling protects oxidative
            stress-induced COPD
  JOURNAL   Cell Signal 107, 110681 (2023)
   PUBMED   37062436
  REMARK    GeneRIF: Reduction of TRPC1/TRPC3 mediated Ca[2+]-signaling
            protects oxidative stress-induced COPD.
REFERENCE   4  (bases 1 to 4315)
  AUTHORS   Qi,H., Wu,F. and Wang,H.
  TITLE     Function of TRPC1 in modulating hepatocellular carcinoma
            progression
  JOURNAL   Med Oncol 40 (3), 97 (2023)
   PUBMED   36797544
  REMARK    GeneRIF: Function of TRPC1 in modulating hepatocellular carcinoma
            progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4315)
  AUTHORS   Radoslavova,S., Fels,B., Petho,Z., Gruner,M., Ruck,T., Meuth,S.G.,
            Folcher,A., Prevarskaya,N., Schwab,A. and Ouadid-Ahidouch,H.
  TITLE     TRPC1 channels regulate the activation of pancreatic stellate cells
            through ERK1/2 and SMAD2 pathways and perpetuate their
            pressure-mediated activation
  JOURNAL   Cell Calcium 106, 102621 (2022)
   PUBMED   35905654
  REMARK    GeneRIF: TRPC1 channels regulate the activation of pancreatic
            stellate cells through ERK1/2 and SMAD2 pathways and perpetuate
            their pressure-mediated activation.
REFERENCE   6  (bases 1 to 4315)
  AUTHORS   Zitt,C., Zobel,A., Obukhov,A.G., Harteneck,C., Kalkbrenner,F.,
            Luckhoff,A. and Schultz,G.
  TITLE     Cloning and functional expression of a human Ca2+-permeable cation
            channel activated by calcium store depletion
  JOURNAL   Neuron 16 (6), 1189-1196 (1996)
   PUBMED   8663995
REFERENCE   7  (bases 1 to 4315)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
REFERENCE   8  (bases 1 to 4315)
  AUTHORS   Zhu,X., Chu,P.B., Peyton,M. and Birnbaumer,L.
  TITLE     Molecular cloning of a widely expressed human homologue for the
            Drosophila trp gene
  JOURNAL   FEBS Lett 373 (3), 193-198 (1995)
   PUBMED   7589464
REFERENCE   9  (bases 1 to 4315)
  AUTHORS   Wes,P.D., Chevesich,J., Jeromin,A., Rosenberg,C., Stetten,G. and
            Montell,C.
  TITLE     TRPC1, a human homolog of a Drosophila store-operated channel
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9652-9656 (1995)
   PUBMED   7568191
REFERENCE   10 (bases 1 to 4315)
  AUTHORS   Abdel-Malek,Z., Swope,V., Collins,C., Boissy,R., Zhao,H. and
            Nordlund,J.
  TITLE     Contribution of melanogenic proteins to the heterogeneous
            pigmentation of human melanocytes
  JOURNAL   J Cell Sci 106 (Pt 4), 1323-1331 (1993)
   PUBMED   8126111
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC072028.14 and AC022291.27.
            
            Summary: The protein encoded by this gene is a membrane protein
            that can form a non-selective channel permeable to calcium and
            other cations. The encoded protein appears to be induced to form
            channels by a receptor tyrosine kinase-activated
            phosphatidylinositol second messenger system and also by depletion
            of intracellular calcium stores. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.380494.1,
                                           SRR18074967.462611.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-698               AC072028.14        119662-120359
            699-853             AC072028.14        132007-132161
            854-1056            AC072028.14        143886-144088
            1057-1188           AC072028.14        173260-173391
            1189-1384           AC072028.14        176462-176657
            1385-1721           AC072028.14        180332-180668
            1722-1814           AC072028.14        186647-186739
            1815-1861           AC022291.27        2001-2047
            1862-2037           AC022291.27        13058-13233
            2038-2239           AC022291.27        14866-15067
            2240-2434           AC022291.27        15325-15519
            2435-4315           AC022291.27        16897-18777
FEATURES             Location/Qualifiers
     source          1..4315
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..4315
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="transient receptor potential cation channel
                     subfamily C member 1"
                     /db_xref="GeneID:7220"
                     /db_xref="HGNC:HGNC:12333"
                     /db_xref="MIM:602343"
     exon            1..698
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             527..2662
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="isoform 5 is encoded by transcript variant 5; short
                     transient receptor potential channel 1; transient receptor
                     potential canonical 1; transient receptor protein 1;
                     capacitative calcium channel protein Trp1"
                     /codon_start=1
                     /product="short transient receptor potential channel 1
                     isoform 5"
                     /protein_id="NP_001400292.1"
                     /db_xref="GeneID:7220"
                     /db_xref="HGNC:HGNC:12333"
                     /db_xref="MIM:602343"
                     /translation="MMAALYPSTDLSGASSSSLPSSPSSSSPNEVMALKDVREVKEEN
                     TLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENENLDILQL
                     LLDYGCQKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCE
                     CTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEV
                     EFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRL
                     KLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCY
                     LIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYL
                     LILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKISMGQ
                     MLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGT
                     CFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKS
                     FQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHT
                     SKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNEL
                     RQDLSKFRNEIRDLLGFRTSKYAMFYPRN"
     exon            699..853
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1056
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1188
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1384
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1721
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1861
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2037
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2239
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2434
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..4315
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4290..4295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="hexamer: AATAAA"
     polyA_site      4315
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="major polyA site"
ORIGIN      
        1 gtcgctacag aggagcagag gatgacgtga ggacagagtc gcgaacatct cctcggagcg
       61 cagctgggcc agcggttccc acagccctgg agcccaacgt gcgcagaagc gcctcttgga
      121 gctcctctcc cacagatctc tcgtcctctt cctgggctag gccgccccag gcgcggcccc
      181 tgcgactcct ggcacggccc cgtgctcggc tgccgccctg gcgcgcgcca cactgtcgtc
      241 cccggacggg cgcggaccgg ctcggccggg gcgccggcgg ctggggaggg gtcgctggcc
      301 ccggggccgc gcatgcgccg ccaccaactt ggggctgtca gtggagggcg agtgctggtt
      361 ctcaggggag gcgacgccct tcggggccaa cgggcctcga gccgaggcag cagtgggaac
      421 gactcatcct ttttccagcc ctggggcgtg gctggggtcg gggtcggggt cggggccggt
      481 gggggccccg cccccgtctc ctggcctgcc cccttcatgg gccgcgatga tggcggccct
      541 gtacccgagc acggacctct cgggcgcctc ctcctcctcc ctgccttcct ctccatcctc
      601 ttcctcgccg aacgaggtga tggcgctgaa ggatgtgcgg gaggtgaagg aggagaatac
      661 gctgaatgag aagcttttct tgctggcgtg cgacaagggt gactattata tggttaaaaa
      721 gattttggag gaaaacagtt caggtgactt gaacataaat tgcgtagatg tgcttgggag
      781 aaatgctgtt accataacta ttgaaaacga aaacttggat atactgcagc ttcttttgga
      841 ctacggttgt cagaaactaa tggaacgaat tcagaatcct gagtattcaa caactatgga
      901 tgttgcacct gtcattttag ctgctcatcg taacaactat gaaattctta caatgctctt
      961 aaaacaggat gtatctctac ccaagcccca tgcagttggc tgtgaatgca cattgtgttc
     1021 tgcaaaaaac aaaaaggata gcctccggca ttccaggttt cgtcttgata tatatcgatg
     1081 tttggccagt ccagctctaa taatgttaac agaggaggat ccaattctga gagcatttga
     1141 acttagtgct gatttaaaag aactaagtct tgtggaggtg gaattcagga atgattatga
     1201 ggaactagcc cggcaatgta aaatgtttgc taaggattta cttgcacaag cccggaattc
     1261 tcgtgaattg gaagttattc taaaccatac gtctagtgac gagcctcttg acaaacgggg
     1321 attattagaa gaaagaatga atttaagtcg tctaaaactt gctatcaaat ataaccagaa
     1381 agagtttgtc tcccagtcta actgccagca gttcctgaac actgtttggt ttggacagat
     1441 gtcgggttac cgacgcaagc ccacctgtaa gaagataatg actgttttga cagtaggcat
     1501 cttttggcca gttttgtcac tttgttattt gatagctccc aaatctcagt ttggcagaat
     1561 cattcacaca ccttttatga aatttatcat tcatggagca tcatatttca catttctgct
     1621 gttgcttaat ctatactctc ttgtctacaa tgaggataag aaaaacacaa tggggccagc
     1681 ccttgaaaga atagactatc ttcttattct gtggattatt gggatgattt ggtcagacat
     1741 taaaagactc tggtatgaag ggttggaaga ctttttagaa gaatctcgta atcaactcag
     1801 ttttgtcatg aattctcttt atttggcaac ctttgccctc aaagtggttg ctcacaacaa
     1861 gatttcaatg ggacagatgt tacaagattt tggaaaattt cttgggatgt ttcttcttgt
     1921 tttgttttct ttcacaattg gactgacaca actgtatgat aaaggatata cttcaaagga
     1981 gcagaaggac tgtgtaggca tcttctgtga acagcaaagc aatgatacct tccattcgtt
     2041 cattggcacc tgctttgctt tgttctggta tattttctcc ttagcgcatg tggcaatctt
     2101 tgtcacaaga tttagctatg gagaagaact gcagtccttt gtgggagctg tcattgttgg
     2161 tacatacaat gtcgtggttg tgattgtgct taccaaactg ctggtggcaa tgcttcataa
     2221 aagctttcag ttgatagcaa atcatgaaga caaagaatgg aagtttgctc gagcaaaatt
     2281 atggcttagc tactttgatg acaaatgtac gttacctcca cctttcaaca tcattccctc
     2341 accaaagact atctgctata tgattagtag cctcagtaag tggatttgct ctcatacatc
     2401 aaaaggcaag gtcaaacggc aaaacagttt aaaggaatgg aggaatttga aacagaagag
     2461 agatgaaaac tatcaaaaag tgatgtgctg cctagtgcat cgttacttga cttccatgag
     2521 acagaagatg caaagtacag atcaggcaac tgtggaaaat ctaaacgaac tgcgccaaga
     2581 tctgtcaaaa ttccgaaatg aaataaggga tttacttggc tttcggactt ctaaatatgc
     2641 tatgttttat ccaagaaatt aaccattttc taaatcatgg agcgaataat tttcaataac
     2701 agatccaaaa gactatattg cataacttgc aatgaaatta atgagatata tattgaaata
     2761 aagaattatg taaaagccat tctttaaaat atttatagca taaatatatg ttatgtaaag
     2821 tgtgtatata gaattagttt tttaaacctt ctgttagtgg ctttttgcag aagcaaaaca
     2881 gattaagtag atagattttg ttagcatgct gcttggtttt cttacttagt gctttaaaat
     2941 gttttttttt atgtttaaga ggggcagtta taaatggaca cattgcccag aatgttttgt
     3001 aaaatgaaga ccagcaaatg taggctgatc tccttcacag gatacacttg aaatatagaa
     3061 gttatgtttt aaatatctct gttttaggag ttcacatata gttcagcatt tattgtttag
     3121 gagtataatt ttattttatc taaaataata gtctattttt tcttttgtat tttgttataa
     3181 tcttaagcaa caaagaaaaa accctaatat ttgaatctat ttatgtcttt caatttaaat
     3241 tcacttcagt ttttgttatt gtaatatatt tacttttaca tggttataat cactttatat
     3301 ttttaatgtt tttttcactt aatattttat atatacattt ccatgtattg atgtagttag
     3361 tccacattta aatttttata gaattatata gtttttgaaa aatacagtca gtagatgttt
     3421 tattttttag ctattcagtt atgtttataa gtttgcatag ctacttctcg acatttggtt
     3481 tgttttaatt tttttgtatc ataatagtcc tatttttttt tcaagttgga gtgaatgttt
     3541 ttagttttaa gatagatagg agacactttt ttatcacatg tagtcacaac ctgttttgtt
     3601 tttgtaaaac ataggaagtc tctttaatgc aatgatttgt tttatatttg gactaaggtt
     3661 cttgagctta tctcccaagg tactttccat aatttaacac agcttctata aaagtgactt
     3721 catgcttact tgtggatcat tcttgctgct taagatgaaa agcattggtt ttttaaaatt
     3781 agagaataaa atatgtattt aaatttttgg tgtgttcaca taaagggatg tagctaaaat
     3841 gttttcatag gctattatat attctcgcag catttccagt taagaggata ttaggtatat
     3901 aattctcttc ttaaccgaat gtcagatggt cttacgccac agggtgcagg taacccttgg
     3961 tctgtaagca ccaccgatcc agggatcatt gtctaaatag gttactattg tttgtttcat
     4021 cttgcttttg catttttatt ttttaatttc caaattttaa gtgttccctc tttggggcaa
     4081 attcttataa aaatgtttat tgtaaagtta tatattttgt ctacgatggg attatgcact
     4141 tcccaattgg gattttacat ctggattttt agtcattcta aaaaacacct aattattaaa
     4201 acatttatag agtgcctact gtatgcatga gttgagttgc ttctgaggta cattttgaat
     4261 gacagcatat tgtaagaaaa aaaaaggtga ataaaatttg acattagatt ataaa
//
