LOCUS       NM_001251845            4561 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            C member 1 (TRPC1), transcript variant 1, mRNA.
ACCESSION   NM_001251845
VERSION     NM_001251845.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4561)
  AUTHORS   Skerjanz,J., Bauernhofer,L., Lenk,K., Emmerstorfer-Augustin,A.,
            Leitinger,G., Reichmann,F., Stockner,T., Groschner,K. and Tiapko,O.
  TITLE     TRPC1: The housekeeper of the hippocampus
  JOURNAL   Cell Calcium 123, 102933 (2024)
   PUBMED   39116710
  REMARK    GeneRIF: TRPC1: The housekeeper of the hippocampus.
            Review article
REFERENCE   2  (bases 1 to 4561)
  AUTHORS   Qu,M. and Du,L.
  TITLE     Upregulation of TRPC1 protects against high glucose-induced HUVECs
            dysfunction by inhibiting oxidative stress
  JOURNAL   Biochem Biophys Res Commun 699, 149560 (2024)
   PUBMED   38277724
  REMARK    GeneRIF: Upregulation of TRPC1 protects against high
            glucose-induced HUVECs dysfunction by inhibiting oxidative stress.
REFERENCE   3  (bases 1 to 4561)
  AUTHORS   Shin,S., Gombedza,F.C., Awuah Boadi,E., Yiu,A.J., Roy,S.K. and
            Bandyopadhyay,B.C.
  TITLE     Reduction of TRPC1/TRPC3 mediated Ca2+-signaling protects oxidative
            stress-induced COPD
  JOURNAL   Cell Signal 107, 110681 (2023)
   PUBMED   37062436
  REMARK    GeneRIF: Reduction of TRPC1/TRPC3 mediated Ca[2+]-signaling
            protects oxidative stress-induced COPD.
REFERENCE   4  (bases 1 to 4561)
  AUTHORS   Qi,H., Wu,F. and Wang,H.
  TITLE     Function of TRPC1 in modulating hepatocellular carcinoma
            progression
  JOURNAL   Med Oncol 40 (3), 97 (2023)
   PUBMED   36797544
  REMARK    GeneRIF: Function of TRPC1 in modulating hepatocellular carcinoma
            progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4561)
  AUTHORS   Radoslavova,S., Fels,B., Petho,Z., Gruner,M., Ruck,T., Meuth,S.G.,
            Folcher,A., Prevarskaya,N., Schwab,A. and Ouadid-Ahidouch,H.
  TITLE     TRPC1 channels regulate the activation of pancreatic stellate cells
            through ERK1/2 and SMAD2 pathways and perpetuate their
            pressure-mediated activation
  JOURNAL   Cell Calcium 106, 102621 (2022)
   PUBMED   35905654
  REMARK    GeneRIF: TRPC1 channels regulate the activation of pancreatic
            stellate cells through ERK1/2 and SMAD2 pathways and perpetuate
            their pressure-mediated activation.
REFERENCE   6  (bases 1 to 4561)
  AUTHORS   Zitt,C., Zobel,A., Obukhov,A.G., Harteneck,C., Kalkbrenner,F.,
            Luckhoff,A. and Schultz,G.
  TITLE     Cloning and functional expression of a human Ca2+-permeable cation
            channel activated by calcium store depletion
  JOURNAL   Neuron 16 (6), 1189-1196 (1996)
   PUBMED   8663995
REFERENCE   7  (bases 1 to 4561)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
REFERENCE   8  (bases 1 to 4561)
  AUTHORS   Zhu,X., Chu,P.B., Peyton,M. and Birnbaumer,L.
  TITLE     Molecular cloning of a widely expressed human homologue for the
            Drosophila trp gene
  JOURNAL   FEBS Lett 373 (3), 193-198 (1995)
   PUBMED   7589464
REFERENCE   9  (bases 1 to 4561)
  AUTHORS   Wes,P.D., Chevesich,J., Jeromin,A., Rosenberg,C., Stetten,G. and
            Montell,C.
  TITLE     TRPC1, a human homolog of a Drosophila store-operated channel
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9652-9656 (1995)
   PUBMED   7568191
REFERENCE   10 (bases 1 to 4561)
  AUTHORS   Abdel-Malek,Z., Swope,V., Collins,C., Boissy,R., Zhao,H. and
            Nordlund,J.
  TITLE     Contribution of melanogenic proteins to the heterogeneous
            pigmentation of human melanocytes
  JOURNAL   J Cell Sci 106 (Pt 4), 1323-1331 (1993)
   PUBMED   8126111
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC072028.14, X89066.1,
            BC112338.1 and AI280444.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001251845.1.
            
            Summary: The protein encoded by this gene is a membrane protein
            that can form a non-selective channel permeable to calcium and
            other cations. The encoded protein appears to be induced to form
            channels by a receptor tyrosine kinase-activated
            phosphatidylinositol second messenger system and also by depletion
            of intracellular calcium stores. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2144335 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000476941.6/ ENSP00000419313.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               AC072028.14        119662-120051
            391-853             X89066.1           2-464
            854-955             AC072028.14        139113-139214
            956-1545            X89066.1           465-1054
            1546-3674           BC112338.1         973-3101
            3675-4547           X89066.1           3184-4056
            4548-4561           AI280444.1         11-24               c
FEATURES             Location/Qualifiers
     source          1..4561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..4561
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="transient receptor potential cation channel
                     subfamily C member 1"
                     /db_xref="GeneID:7220"
                     /db_xref="HGNC:HGNC:12333"
                     /db_xref="MIM:602343"
     exon            1..698
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             527..2908
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="isoform 1 is encoded by transcript variant 1; short
                     transient receptor potential channel 1; transient receptor
                     potential canonical 1; transient receptor protein 1;
                     capacitative calcium channel protein Trp1"
                     /codon_start=1
                     /product="short transient receptor potential channel 1
                     isoform 1"
                     /protein_id="NP_001238774.1"
                     /db_xref="CCDS:CCDS58856.1"
                     /db_xref="GeneID:7220"
                     /db_xref="HGNC:HGNC:12333"
                     /db_xref="MIM:602343"
                     /translation="MMAALYPSTDLSGASSSSLPSSPSSSSPNEVMALKDVREVKEEN
                     TLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENENLDILQL
                     LLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDV
                     APVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYR
                     CLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQA
                     RNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTV
                     WFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGA
                     SYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDF
                     LEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVL
                     SYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSK
                     EQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAV
                     IVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPF
                     NIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVH
                     RYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN"
     exon            699..853
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..955
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1158
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1290
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1486
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1823
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1963
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2107
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2283
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2485
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2680
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..4561
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4536..4541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="hexamer: AATAAA"
     polyA_site      4561
                     /gene="TRPC1"
                     /gene_synonym="HTRP-1; TRP1"
                     /note="major polyA site"
ORIGIN      
        1 gtcgctacag aggagcagag gatgacgtga ggacagagtc gcgaacatct cctcggagcg
       61 cagctgggcc agcggttccc acagccctgg agcccaacgt gcgcagaagc gcctcttgga
      121 gctcctctcc cacagatctc tcgtcctctt cctgggctag gccgccccag gcgcggcccc
      181 tgcgactcct ggcacggccc cgtgctcggc tgccgccctg gcgcgcgcca cactgtcgtc
      241 cccggacggg cgcggaccgg ctcggccggg gcgccggcgg ctggggaggg gtcgctggcc
      301 ccggggccgc gcatgcgccg ccaccaactt ggggctgtca gtggagggcg agtgctggtt
      361 ctcaggggag gcgacgccct tcggggccaa cgggcctcga gccgaggcag cagtgggaac
      421 gactcatcct ttttccagcc ctggggcgtg gctggggtcg gggtcggggt cggggccggt
      481 gggggccccg cccccgtctc ctggcctgcc cccttcatgg gccgcgatga tggcggccct
      541 gtacccgagc acggacctct cgggcgcctc ctcctcctcc ctgccttcct ctccatcctc
      601 ttcctcgccg aacgaggtga tggcgctgaa ggatgtgcgg gaggtgaagg aggagaatac
      661 gctgaatgag aagcttttct tgctggcgtg cgacaagggt gactattata tggttaaaaa
      721 gattttggag gaaaacagtt caggtgactt gaacataaat tgcgtagatg tgcttgggag
      781 aaatgctgtt accataacta ttgaaaacga aaacttggat atactgcagc ttcttttgga
      841 ctacggttgt cagtctgcag atgcactttt ggtggcaatc gactctgaag tagtgggagc
      901 tgttgatata ctacttaatc atcgaccaaa acgatcatca agaccaacta tagtaaaact
      961 aatggaacga attcagaatc ctgagtattc aacaactatg gatgttgcac ctgtcatttt
     1021 agctgctcat cgtaacaact atgaaattct tacaatgctc ttaaaacagg atgtatctct
     1081 acccaagccc catgcagttg gctgtgaatg cacattgtgt tctgcaaaaa acaaaaagga
     1141 tagcctccgg cattccaggt ttcgtcttga tatatatcga tgtttggcca gtccagctct
     1201 aataatgtta acagaggagg atccaattct gagagcattt gaacttagtg ctgatttaaa
     1261 agaactaagt cttgtggagg tggaattcag gaatgattat gaggaactag cccggcaatg
     1321 taaaatgttt gctaaggatt tacttgcaca agcccggaat tctcgtgaat tggaagttat
     1381 tctaaaccat acgtctagtg acgagcctct tgacaaacgg ggattattag aagaaagaat
     1441 gaatttaagt cgtctaaaac ttgctatcaa atataaccag aaagagtttg tctcccagtc
     1501 taactgccag cagttcctga acactgtttg gtttggacag atgtcgggtt accgacgcaa
     1561 gcccacctgt aagaagataa tgactgtttt gacagtaggc atcttttggc cagttttgtc
     1621 actttgttat ttgatagctc ccaaatctca gtttggcaga atcattcaca caccttttat
     1681 gaaatttatc attcatggag catcatattt cacatttctg ctgttgctta atctatactc
     1741 tcttgtctac aatgaggata agaaaaacac aatggggcca gcccttgaaa gaatagacta
     1801 tcttcttatt ctgtggatta ttgggatgat ttggtcagac attaaaagac tctggtatga
     1861 agggttggaa gactttttag aagaatctcg taatcaactc agttttgtca tgaattctct
     1921 ttatttggca acctttgccc tcaaagtggt tgctcacaac aagtttcatg attttgctga
     1981 tcggaaggat tgggatgcat tccatcctac actggtggca gaagggcttt ttgcatttgc
     2041 aaatgttcta agttatcttc gtctcttttt tatgtataca accagctcta tcttgggtcc
     2101 attacagatt tcaatgggac agatgttaca agattttgga aaatttcttg ggatgtttct
     2161 tcttgttttg ttttctttca caattggact gacacaactg tatgataaag gatatacttc
     2221 aaaggagcag aaggactgtg taggcatctt ctgtgaacag caaagcaatg ataccttcca
     2281 ttcgttcatt ggcacctgct ttgctttgtt ctggtatatt ttctccttag cgcatgtggc
     2341 aatctttgtc acaagattta gctatggaga agaactgcag tcctttgtgg gagctgtcat
     2401 tgttggtaca tacaatgtcg tggttgtgat tgtgcttacc aaactgctgg tggcaatgct
     2461 tcataaaagc tttcagttga tagcaaatca tgaagacaaa gaatggaagt ttgctcgagc
     2521 aaaattatgg cttagctact ttgatgacaa atgtacgtta cctccacctt tcaacatcat
     2581 tccctcacca aagactatct gctatatgat tagtagcctc agtaagtgga tttgctctca
     2641 tacatcaaaa ggcaaggtca aacggcaaaa cagtttaaag gaatggagga atttgaaaca
     2701 gaagagagat gaaaactatc aaaaagtgat gtgctgccta gtgcatcgtt acttgacttc
     2761 catgagacag aagatgcaaa gtacagatca ggcaactgtg gaaaatctaa acgaactgcg
     2821 ccaagatctg tcaaaattcc gaaatgaaat aagggattta cttggctttc ggacttctaa
     2881 atatgctatg ttttatccaa gaaattaacc attttctaaa tcatggagcg aataattttc
     2941 aataacagat ccaaaagact atattgcata acttgcaatg aaattaatga gatatatatt
     3001 gaaataaaga attatgtaaa agccattctt taaaatattt atagcataaa tatatgttat
     3061 gtaaagtgtg tatatagaat tagtttttta aaccttctgt tagtggcttt ttgcagaagc
     3121 aaaacagatt aagtagatag attttgttag catgctgctt ggttttctta cttagtgctt
     3181 taaaatgttt ttttttatgt ttaagagggg cagttataaa tggacacatt gcccagaatg
     3241 ttttgtaaaa tgaagaccag caaatgtagg ctgatctcct tcacaggata cacttgaaat
     3301 atagaagtta tgttttaaat atctctgttt taggagttca catatagttc agcatttatt
     3361 gtttaggagt ataattttat tttatctaaa ataatagtct attttttctt ttgtattttg
     3421 ttataatctt aagcaacaaa gaaaaaaccc taatatttga atctatttat gtctttcaat
     3481 ttaaattcac ttcagttttt gttattgtaa tatatttact tttacatggt tataatcact
     3541 ttatattttt aatgtttttt tcacttaata ttttatatat acatttccat gtattgatgt
     3601 agttagtcca catttaaatt tttatagaat tatatagttt ttgaaaaata cagtcagtag
     3661 atgttttatt ttttagctat tcagttatgt ttataagttt gcatagctac ttctcgacat
     3721 ttggtttgtt ttaatttttt tgtatcataa tagtcctatt tttttttcaa gttggagtga
     3781 atgtttttag ttttaagata gataggagac acttttttat cacatgtagt cacaacctgt
     3841 tttgtttttg taaaacatag gaagtctctt taatgcaatg atttgtttta tatttggact
     3901 aaggttcttg agcttatctc ccaaggtact ttccataatt taacacagct tctataaaag
     3961 tgacttcatg cttacttgtg gatcattctt gctgcttaag atgaaaagca ttggtttttt
     4021 aaaattagag aataaaatat gtatttaaat ttttggtgtg ttcacataaa gggatgtagc
     4081 taaaatgttt tcataggcta ttatatattc tcgcagcatt tccagttaag aggatattag
     4141 gtatataatt ctcttcttaa ccgaatgtca gatggtctta cgccacaggg tgcaggtaac
     4201 ccttggtctg taagcaccac cgatccaggg atcattgtct aaataggtta ctattgtttg
     4261 tttcatcttg cttttgcatt tttatttttt aatttccaaa ttttaagtgt tccctctttg
     4321 gggcaaattc ttataaaaat gtttattgta aagttatata ttttgtctac gatgggatta
     4381 tgcacttccc aattgggatt ttacatctgg atttttagtc attctaaaaa acacctaatt
     4441 attaaaacat ttatagagtg cctactgtat gcatgagttg agttgcttct gaggtacatt
     4501 ttgaatgaca gcatattgta agaaaaaaaa aggtgaataa aatttgacat tagattataa
     4561 a
//
