LOCUS       NM_007332               5191 bp    mRNA    linear   PRI 13-NOV-2024
DEFINITION  Homo sapiens transient receptor potential cation channel subfamily
            A member 1 (TRPA1), mRNA.
ACCESSION   NM_007332
VERSION     NM_007332.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5191)
  AUTHORS   Matsubara,M., Muraki,Y., Suzuki,H., Hatano,N. and Muraki,K.
  TITLE     Critical amino acid residues regulating TRPA1 Zn2+ response: A
            comparative study across species
  JOURNAL   J Biol Chem 300 (6), 107302 (2024)
   PUBMED   38642892
  REMARK    GeneRIF: Critical amino acid residues regulating TRPA1 Zn[2+]
            response: A comparative study across species.
REFERENCE   2  (bases 1 to 5191)
  AUTHORS   Sanchez,J.C., Aleman,A., Henao,J.F., Olaya,J.C. and Ehrlich,B.E.
  TITLE     NCS-1 protein regulates TRPA1 channel through the PI3K pathway in
            breast cancer and neuronal cells
  JOURNAL   J Physiol Biochem 80 (2), 451-463 (2024)
   PUBMED   38564162
  REMARK    GeneRIF: NCS-1 protein regulates TRPA1 channel through the PI3K
            pathway in breast cancer and neuronal cells.
REFERENCE   3  (bases 1 to 5191)
  AUTHORS   Xu,F., Jiang,H., Li,X., Pan,J., Li,H., Wang,L., Zhang,P., Chen,J.,
            Qiu,S., Xie,Y., Li,Y., Zhang,D. and Dong,Z.
  TITLE     Discovery of PRDM16-Mediated TRPA1 Induction as the Mechanism for
            Low Tubulo-Interstitial Fibrosis in Diabetic Kidney Disease
  JOURNAL   Adv Sci (Weinh) 11 (7), e2306704 (2024)
   PUBMED   38072665
  REMARK    GeneRIF: Discovery of PRDM16-Mediated TRPA1 Induction as the
            Mechanism for Low Tubulo-Interstitial Fibrosis in Diabetic Kidney
            Disease.
REFERENCE   4  (bases 1 to 5191)
  AUTHORS   Kim,M.S. and Simons,C.T.
  TITLE     The role of TRPA1 and TRPV1 in the perception of astringency
  JOURNAL   Chem Senses 49 (2024)
   PUBMED   39223911
  REMARK    GeneRIF: The role of TRPA1 and TRPV1 in the perception of
            astringency.
REFERENCE   5  (bases 1 to 5191)
  AUTHORS   Vlachova,V., Barvik,I. and Zimova,L.
  TITLE     Human Transient Receptor Potential Ankyrin 1 Channel: Structure,
            Function, and Physiology
  JOURNAL   Subcell Biochem 104, 207-244 (2024)
   PUBMED   38963489
  REMARK    GeneRIF: Human Transient Receptor Potential Ankyrin 1 Channel:
            Structure, Function, and Physiology.
            Review article
REFERENCE   6  (bases 1 to 5191)
  AUTHORS   Stokes,A., Wakano,C., Koblan-Huberson,M., Adra,C.N., Fleig,A. and
            Turner,H.
  TITLE     TRPA1 is a substrate for de-ubiquitination by the tumor suppressor
            CYLD
  JOURNAL   Cell Signal 18 (10), 1584-1594 (2006)
   PUBMED   16500080
  REMARK    GeneRIF: TRPA1 is a novel substrate for the de-ubiquitinating
            activity of CYLD, and this de-ubiquitination has the net effect of
            increasing the cellular pool of TRPA1 proteins.
REFERENCE   7  (bases 1 to 5191)
  AUTHORS   Clapham,D.E., Julius,D., Montell,C. and Schultz,G.
  TITLE     International Union of Pharmacology. XLIX. Nomenclature and
            structure-function relationships of transient receptor potential
            channels
  JOURNAL   Pharmacol Rev 57 (4), 427-450 (2005)
   PUBMED   16382100
  REMARK    Review article
REFERENCE   8  (bases 1 to 5191)
  AUTHORS   Jordt,S.E., Bautista,D.M., Chuang,H.H., McKemy,D.D., Zygmunt,P.M.,
            Hogestatt,E.D., Meng,I.D. and Julius,D.
  TITLE     Mustard oils and cannabinoids excite sensory nerve fibres through
            the TRP channel ANKTM1
  JOURNAL   Nature 427 (6971), 260-265 (2004)
   PUBMED   14712238
  REMARK    GeneRIF: cellular and molecular target for the pungent action of
            mustard oils; support an emerging role for TRP channel ANKTM1 as an
            ionotropic cannabinoid receptor
REFERENCE   9  (bases 1 to 5191)
  AUTHORS   Jaquemar,D., Schenker,T. and Trueb,B.
  TITLE     An ankyrin-like protein with transmembrane domains is specifically
            lost after oncogenic transformation of human fibroblasts
  JOURNAL   J Biol Chem 274 (11), 7325-7333 (1999)
   PUBMED   10066796
REFERENCE   10 (bases 1 to 5191)
  AUTHORS   Schenker,T. and Trueb,B.
  TITLE     Down-regulated proteins of mesenchymal tumor cells
  JOURNAL   Exp Cell Res 239 (1), 161-168 (1998)
   PUBMED   9511734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016057.6 and AC022867.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007332.2.
            
            Summary: The structure of the protein encoded by this gene is
            highly related to both the protein ankyrin and transmembrane
            proteins.  The specific function of this protein has not yet been
            determined; however, studies indicate the function may involve a
            role in signal transduction and growth control. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y10601.1, SRR14038197.2696851.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262209.5/ ENSP00000262209.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AC016057.6         168507-168792       c
            287-443             AC016057.6         164919-165075       c
            444-619             AC016057.6         162231-162406       c
            620-727             AC016057.6         158659-158766       c
            728-836             AC016057.6         156671-156779       c
            837-982             AC016057.6         156007-156152       c
            983-1119            AC016057.6         154833-154969       c
            1120-1168           AC016057.6         152598-152646       c
            1169-1268           AC016057.6         150925-151024       c
            1269-1369           AC016057.6         150125-150225       c
            1370-1539           AC016057.6         148894-149063       c
            1540-1704           AC016057.6         148644-148808       c
            1705-1819           AC016057.6         146961-147075       c
            1820-1986           AC016057.6         145807-145973       c
            1987-2080           AC016057.6         143986-144079       c
            2081-2140           AC016057.6         140356-140415       c
            2141-2236           AC016057.6         139721-139816       c
            2237-2307           AC016057.6         132935-133005       c
            2308-2470           AC016057.6         132073-132235       c
            2471-2560           AC016057.6         131191-131280       c
            2561-2730           AC016057.6         129496-129665       c
            2731-2860           AC016057.6         127456-127585       c
            2861-3043           AC016057.6         126852-127034       c
            3044-3112           AC022867.10        193800-193868       c
            3113-3226           AC022867.10        189859-189972       c
            3227-3324           AC022867.10        187713-187810       c
            3325-5190           AC022867.10        185150-187015       c
            5191-5191           AC022867.10        185149-185149       c
FEATURES             Location/Qualifiers
     source          1..5191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.11"
     gene            1..5191
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /note="transient receptor potential cation channel
                     subfamily A member 1"
                     /db_xref="GeneID:8989"
                     /db_xref="HGNC:HGNC:497"
                     /db_xref="MIM:604775"
     exon            1..286
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..3535
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /note="ankyrin-like with transmembrane domains 1;
                     transformation-sensitive protein p120; wasabi receptor"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily A member 1"
                     /protein_id="NP_015628.2"
                     /db_xref="CCDS:CCDS34908.1"
                     /db_xref="GeneID:8989"
                     /db_xref="HGNC:HGNC:497"
                     /db_xref="MIM:604775"
                     /translation="MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSA
                     YGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPL
                     HCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNL
                     EGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIIL
                     RFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAI
                     HFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGAD
                     INKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNL
                     RPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPL
                     HFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALF
                     LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVAL
                     LLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPIT
                     EMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYLQCPLEFTKKTPTQDVIYEP
                     LTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNI
                     KPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRN
                     YFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENC
                     GIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSPLLSIIQTFSMMLG
                     DINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHAS
                     LKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIFCFLFCTGEIR
                     QEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETEDDDSHCSFQ
                     DRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP"
     exon            287..443
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            444..619
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            620..727
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            728..836
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            837..982
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1119
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1168
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1268
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1369
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1539
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1704
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1819
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1986
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2080
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2140
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2236
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2307
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2470
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2560
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2730
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2860
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..3043
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3112
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3226
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3324
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..5191
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3843..3848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /note="hexamer: AATAAA"
     polyA_site      3867
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
     regulatory      4219..4224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /note="hexamer: AATAAA"
     polyA_site      4242
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /note="major polyA site"
     regulatory      5171..5176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
                     /note="hexamer: AATAAA"
     polyA_site      5191
                     /gene="TRPA1"
                     /gene_synonym="ANKTM1; FEPS; FEPS1; p120"
ORIGIN      
        1 ccagaagttc tccagggctt ccgcagagcg actttttcgc tgcctgtgag ctgcagcgcg
       61 ggagagctcg ggctcgcgcg gaccccagcg cctggcaggc tgacagcgct ctctcgcccc
      121 aggtgcccgc gcgcgtggtg agcagctgca ccaggtggcg tccggggtgg ggtcaatgaa
      181 gcgcagcctg aggaagatgt ggcgccctgg agaaaagaag gagccccagg gcgttgtcta
      241 tgaggatgtg ccggacgaca cggaggattt caaggaatcg cttaaggtgg tttttgaagg
      301 aagtgcatat ggattacaaa actttaataa gcaaaagaaa ttaaaaagat gtgacgatat
      361 ggacaccttc ttcttgcatt atgctgcagc agaaggccaa attgagctaa tggagaagat
      421 caccagagat tcctctttgg aagtgctgca tgaaatggat gattatggaa atacccctct
      481 gcattgtgct gtagaaaaaa accaaattga aagcgttaag tttcttctca gcagaggagc
      541 aaacccaaat ctccgaaact tcaacatgat ggctcctctc cacatagctg tgcagggcat
      601 gaataatgag gtgatgaagg tcttgcttga gcatagaact attgatgtta atttggaagg
      661 agaaaatgga aacacagctg tgatcattgc gtgcaccaca aataatagcg aagcattgca
      721 gattttgctt aaaaaaggag ctaagccatg taaatcaaat aaatggggat gtttccctat
      781 tcaccaagct gcattttcag gttccaaaga atgcatggaa ataatactaa ggtttggtga
      841 agagcatggg tacagtagac agttgcacat taactttatg aataatggga aagccacccc
      901 tctccacctg gctgtgcaaa atggtgactt ggaaatgatc aaaatgtgcc tggacaatgg
      961 tgcacaaata gacccagtgg agaagggaag gtgcacagcc attcattttg ctgccaccca
     1021 gggagccact gagattgtta aactgatgat atcgtcctat tctggtagcg tggatattgt
     1081 taacacaacc gatggatgtc atgagaccat gcttcacaga gcttcattgt ttgatcacca
     1141 tgagctagca gactatttaa tttcagtggg agcagatatt aataagatcg attctgaagg
     1201 acgctctcca cttatattag caactgcttc tgcatcttgg aatattgtaa atttgctact
     1261 ctctaaaggt gcccaagtag acataaaaga taattttgga cgtaattttc tgcatttaac
     1321 tgtacagcaa ccttatggat taaaaaatct gcgacctgaa tttatgcaga tgcaacagat
     1381 caaagagctg gtaatggatg aagacaacga tgggtgtact cctctacatt atgcatgtag
     1441 acaggggggc cctggttctg taaataacct acttggcttt aatgtgtcca ttcattccaa
     1501 aagcaaagat aagaaatcac ctctgcattt tgcagccagt tatgggcgta tcaatacctg
     1561 tcagaggctc ctacaagaca taagtgatac gaggcttctg aatgaaggtg accttcatgg
     1621 aatgactcct ctccatctgg cagcaaagaa tggacatgat aaagtagttc agcttcttct
     1681 gaaaaaaggt gcattgtttc tcagtgacca caatggctgg acagctttgc atcatgcgtc
     1741 catgggcggg tacactcaga ccatgaaggt cattcttgat actaatttga agtgcacaga
     1801 tcgcctggat gaagacggga acactgcact tcactttgct gcaagggaag gccacgccaa
     1861 agccgttgcg cttcttctga gccacaatgc tgacatagtc ctgaacaagc agcaggcctc
     1921 ctttttgcac cttgcacttc acaataagag gaaggaggtt gttcttacga tcatcaggag
     1981 caaaagatgg gatgaatgtc ttaagatttt cagtcataat tctccaggca ataaatgtcc
     2041 aattacagaa atgatagaat acctccctga atgcatgaag gtacttttag atttctgcat
     2101 gttgcattcc acagaagaca agtcctgccg agactattat atcgagtata atttcaaata
     2161 tcttcaatgt ccattagaat tcaccaaaaa aacacctaca caggatgtta tatatgaacc
     2221 gcttacagcc ctcaacgcaa tggtacaaaa taaccgcata gagcttctca atcatcctgt
     2281 gtgtaaagaa tatttactca tgaaatggtt ggcttatgga tttagagctc atatgatgaa
     2341 tttaggatct tactgtcttg gtctcatacc tatgaccatt ctcgttgtca atataaaacc
     2401 aggaatggct ttcaactcaa ctggcatcat caatgaaact agtgatcatt cagaaatact
     2461 agataccacg aattcatatc taataaaaac ttgtatgatt ttagtgtttt tatcaagtat
     2521 atttgggtat tgcaaagaag cggggcaaat tttccaacag aaaaggaatt attttatgga
     2581 tataagcaat gttcttgaat ggattatcta cacgacgggc atcatttttg tgctgccctt
     2641 gtttgttgaa ataccagctc atctgcagtg gcaatgtgga gcaattgctg tttacttcta
     2701 ttggatgaat ttcttattgt atcttcaaag atttgaaaat tgtggaattt ttattgttat
     2761 gttggaggta attttgaaaa ctttgttgag gtctacagtt gtatttatct tccttcttct
     2821 ggcttttgga ctcagctttt acatcctcct gaatttacag gatcccttca gctctccatt
     2881 gctttctata atccagacct tcagcatgat gctaggagat atcaattatc gagagtcctt
     2941 cctagaacca tatctgagaa atgaattggc acatccagtt ctgtcctttg cacaacttgt
     3001 ttccttcaca atatttgtcc caattgtcct catgaattta cttattggtt tggcagttgg
     3061 cgacattgct gaggtccaga aacatgcatc attgaagagg atagctatgc aggtggaact
     3121 tcataccagc ttagagaaga agctgccact ttggtttcta cgcaaagtgg atcagaaatc
     3181 caccatcgtg tatcccaaca aacccagatc tggtgggatg ttattccata tattctgttt
     3241 tttattttgc actggggaaa taagacaaga aataccaaat gctgataaat ctttagaaat
     3301 ggaaatatta aagcagaaat accggctgaa ggatcttact tttctcctgg aaaaacagca
     3361 tgagctcatt aaactgatca ttcagaagat ggagatcatc tctgagacag aggatgatga
     3421 tagccattgt tcttttcaag acaggtttaa gaaagagcag atggaacaaa ggaatagcag
     3481 atggaatact gtgttgagag cagtcaaggc aaaaacacac catcttgagc cttagctcct
     3541 cagaccttca gtgaggcttc taatgggggg tgcatgactt gctggttcta actttcaatt
     3601 taaaaagagt gaggaagaag cagaatgatt cattttgctg cgtgtgaaat catggttcct
     3661 gcatgctgta taaaagtaaa ccatctttta tcctctattc atattttcta ccaatcacta
     3721 tgtattgggg atatctttgc agatatgttc aaattggact ggactttgat gagatataat
     3781 ctcattattt gaatgggtag aaaatgaatt tgctagaaca cacattttta atgaaaagaa
     3841 gtaataaatg taactattaa gctaaaatgc aaatgtcagt actgaattcc tgcttgttaa
     3901 ttacataata tgtgatgctc tagaaaatag tcacaagtat taataatgcc ttagatgata
     3961 gtcttaaata ttaggttgag gtctacctaa cctaagctgc ttcctggaaa gcttcatgtt
     4021 gaaagaacct atgggtggca ccatgtggac ttttctgtcc ctactgtgat gaatagcccc
     4081 acccttcttg ctgtccccaa cacacctgat gtcactttga gccatatagt tgaagtacaa
     4141 attaataggc cttatgatat gcacgaattt tactatagat aatatatgtt gtttctggtt
     4201 ttgtttgcca atgagcataa taaatgtaaa acctatatag tatccctgtg attattgtat
     4261 gagcctttgt ttgagatttg aaaacaacat ggctccatca catattccct tttttctttt
     4321 gatgtctact caaatcatga attaatcaca tacctcatca ttaatctttt caaggtcctt
     4381 ctattgtttt gtctgatttt ctccatcatc ctgattagca tgtttattcc ctcactaccc
     4441 ccaggagata ttcactgtaa tgaatatgtc tttggctatg tatgtgtcct tgtgttatgt
     4501 tgtacagtgt tgttttgagt ctgttattat ttacacagat gttattatgc tatagcttct
     4561 atttctgttt ttgcttctta tttctcttat aattctcact tatttcctat tttttctact
     4621 catttctatt tgttactcct ttttactgga catgatgttt acaagataca actgtgttac
     4681 tgtattccat ctagtacggg gcctttggtg tggcttacta tttcattgtg tgcacccacc
     4741 cacccaccac actggacttt tctagagatg gacagcttgg ttacctccac cttcctgcac
     4801 tcattctcaa acatactgat gttcatacaa accagcagag tgctgaggga cgatatgtac
     4861 tattacaaaa ccagacactt ttacattcat ggtccaacag atcacatggc ctagaggcaa
     4921 tgttgcatat accttaatct ttgatatgaa taatatcttt gttctttata tttcttaaaa
     4981 cagaaagggt ggaaaatcac tatacagaag caatatccaa agatctcctg atcataaaga
     5041 caaggggtct tttcagtctt ccctctcctc aaaccttgtg tagcattgca caatatagat
     5101 ctcagtcaac attcactgag tgccaagaat gtgagaaaca ctgtaccatg cctgtcatgc
     5161 gaaatattta aataaacaga ttgtcttaca a
//
