LOCUS       NM_005480               2551 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens trophinin associated protein (TROAP), transcript
            variant 1, mRNA.
ACCESSION   NM_005480
VERSION     NM_005480.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2551)
  AUTHORS   Xu,M., Yu,J., Liu,X., Jia,W., Duan,Y., Ma,D., Ma,J., Lei,W. and
            Tai,W.
  TITLE     METTL3 regulatory TROAP can regulate the progression of non-small
            cell lung cancer through PI3K/AKT and EMT signaling pathway
  JOURNAL   Med Oncol 40 (9), 274 (2023)
   PUBMED   37608033
  REMARK    GeneRIF: METTL3 regulatory TROAP can regulate the progression of
            non-small cell lung cancer through PI3K/AKT and EMT signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2551)
  AUTHORS   Wang,J., Wan,H., Mi,Y., Wu,S., Li,J. and Zhu,L.
  TITLE     TROAP Promotes the Proliferation, Migration, and Metastasis of
            Kidney Renal Clear Cell Carcinoma with the Help of STAT3
  JOURNAL   Int J Mol Sci 24 (11), 9658 (2023)
   PUBMED   37298609
  REMARK    GeneRIF: TROAP Promotes the Proliferation, Migration, and
            Metastasis of Kidney Renal Clear Cell Carcinoma with the Help of
            STAT3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2551)
  AUTHORS   Yue,A., Chen,M., Dai,S., Zhang,Y., Wei,W., Fan,L., Wang,F.,
            Zhang,F., Yu,H., Lu,Y. and Lei,Y.
  TITLE     Tastin promotes non-small-cell lung cancer progression through the
            ErbB4, PI3K/AKT, and ERK1/2 pathways
  JOURNAL   Exp Biol Med (Maywood) 248 (6), 519-531 (2023)
   PUBMED   36691332
  REMARK    GeneRIF: Tastin promotes non-small-cell lung cancer progression
            through the ErbB4, PI3K/AKT, and ERK1/2 pathways.
REFERENCE   4  (bases 1 to 2551)
  AUTHORS   Gao,B., Wang,L., Zhang,Y., Zhang,N., Han,M., Liu,H., Sun,D. and
            Liu,Y.
  TITLE     MiR-532-3p suppresses cell viability, migration and invasion of
            clear cell renal cell carcinoma through targeting TROAP
  JOURNAL   Cell Cycle 20 (16), 1578-1588 (2021)
   PUBMED   34287099
  REMARK    GeneRIF: MiR-532-3p suppresses cell viability, migration and
            invasion of clear cell renal cell carcinoma through targeting
            TROAP.
REFERENCE   5  (bases 1 to 2551)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2551)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   7  (bases 1 to 2551)
  AUTHORS   Nadano,D., Nakayama,J., Matsuzawa,S., Sato,T.A., Matsuda,T. and
            Fukuda,M.N.
  TITLE     Human tastin, a proline-rich cytoplasmic protein, associates with
            the microtubular cytoskeleton
  JOURNAL   Biochem J 364 (Pt 3), 669-677 (2002)
   PUBMED   12049630
  REMARK    GeneRIF: plays an important role in mammalian cells by associating
            with the microtubular cytoskeleton
REFERENCE   8  (bases 1 to 2551)
  AUTHORS   Suzuki,N., Nakayama,J., Shih,I.M., Aoki,D., Nozawa,S. and
            Fukuda,M.N.
  TITLE     Expression of trophinin, tastin, and bystin by trophoblast and
            endometrial cells in human placenta
  JOURNAL   Biol Reprod 60 (3), 621-627 (1999)
   PUBMED   10026108
REFERENCE   9  (bases 1 to 2551)
  AUTHORS   Suzuki,N., Zara,J., Sato,T., Ong,E., Bakhiet,N., Oshima,R.G.,
            Watson,K.L. and Fukuda,M.N.
  TITLE     A cytoplasmic protein, bystin, interacts with trophinin, tastin,
            and cytokeratin and may be involved in trophinin-mediated cell
            adhesion between trophoblast and endometrial epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 95 (9), 5027-5032 (1998)
   PUBMED   9560222
REFERENCE   10 (bases 1 to 2551)
  AUTHORS   Fukuda,M.N., Sato,T., Nakayama,J., Klier,G., Mikami,M., Aoki,D. and
            Nozawa,S.
  TITLE     Trophinin and tastin, a novel cell adhesion molecule complex with
            potential involvement in embryo implantation
  JOURNAL   Genes Dev 9 (10), 1199-1210 (1995)
   PUBMED   7758945
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC410015.1, U04810.2 and BC032583.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005480.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U04810.2, SRR1163658.64007.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257909.8/ ENSP00000257909.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DC410015.1         68-91
            25-770              U04810.2           35-780
            771-1626            BC032583.1         750-1605
            1627-2551           U04810.2           1637-2561
FEATURES             Location/Qualifiers
     source          1..2551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..2551
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /note="trophinin associated protein"
                     /db_xref="GeneID:10024"
                     /db_xref="HGNC:HGNC:12327"
                     /db_xref="MIM:603872"
     exon            1..95
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            96..244
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2437
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     trophinin assisting protein; trophinin-assisting protein
                     (tastin)"
                     /codon_start=1
                     /product="tastin isoform 1"
                     /protein_id="NP_005471.3"
                     /db_xref="CCDS:CCDS8784.1"
                     /db_xref="GeneID:10024"
                     /db_xref="HGNC:HGNC:12327"
                     /db_xref="MIM:603872"
                     /translation="MTTRQATKDPLLRGVSPTPSKIPVRSQKRTPFPTVTSCAVDQEN
                     QDPRRWVQKPPLNIQRPLVDSAGPRPKARHQAETSQRLVGISQPRNPLEELRPSPRGQ
                     NVGPGPPAQTEAPGTIEFVADPAALATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGT
                     TQRVQGVRASAYLAPRTPTHRLDPARASCFSRLEGPGPRGRTLCPQRLQALISPSGPS
                     FHPSTRPSFQELRRETAGSSRTSVSQASGLLLETPVQPAFSLPKGEREVVTHSDEGGV
                     ASLGLAQRVPLRENREMSHTRDSHDSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPS
                     PGPPTLTSYSVLRRLTVQPKTRFTPMPSTPRVQQAQWLRGVSPQSCSEDPALPWEQVA
                     VRLFDQESCIRSLEGSGKPPVATPSGPHSNRTPSLQEVKIQRIGILQQLLRQEVEGLV
                     GGQCVPLNGGSSLDMVELQPLLTEISRTLNATEHNSGTSHLPGLLKHSGLPKPCLPEE
                     CGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQEQLEVPEPYPPAEPRPLESCCRSEPEI
                     PESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIPESSRQEQLEVPEPCPPAEPGPLQP
                     STQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPPCCSQWAPATTSLIFSSQHPLCA
                     SPPICSLQSLRPPAGQAGLSNLAPRTLALRERLKSCLTAIHCFHEARLDDECAFYTSR
                     APPSGPTRVCTNPVATLLEWQDALCFIPVGSAAPQGSP"
     exon            245..437
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            438..595
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            596..733
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            734..816
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            817..869
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            870..991
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1120
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1204
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1264
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1399
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..2198
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2392
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2551
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2534..2539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /note="hexamer: AATAAA"
     polyA_site      2551
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /note="major polyA site"
ORIGIN      
        1 gtattttaca aactgagaaa gtagctccag cagcacccga gagggtcagg agaaaagcgg
       61 aggaagctgg gtaggccctg aggggcctcg gtaagccatc atgaccaccc ggcaagccac
      121 gaaggatccc ctcctccggg gtgtatctcc tacccctagc aagattccgg tacgctctca
      181 gaaacgcacg cctttcccca ctgttacatc gtgcgccgtg gaccaggaga accaagatcc
      241 aaggagatgg gtgcagaaac caccgctcaa tattcaacgc cccctcgttg attcagcagg
      301 ccccaggccg aaagccaggc accaggcaga gacatcacaa agattggtgg ggatcagtca
      361 gcctcggaac cccttggaag agctcaggcc tagccctagg ggtcaaaatg tggggcctgg
      421 gccccctgcc cagacagagg ctccagggac catagagttt gtggctgacc ctgcagccct
      481 ggccaccatc ctgtcaggtg agggtgtgaa gagctgtcac ctggggcgcc agcctagtct
      541 ggctaaaaga gtactggttc gaggaagtca gggaggcacc acccagaggg tccagggtgt
      601 tcgggcctct gcatatttgg cccccagaac ccccacccac cgactggacc ctgccagggc
      661 ttcctgcttc tctaggctgg agggaccagg acctcgaggc cggacattgt gcccccagag
      721 gctacaggct ctgatttcac cttcaggacc ttcctttcac ccttccactc gccccagttt
      781 ccaggagcta agaagggaga cagctggcag cagccggact tcagtgagcc aggcctcagg
      841 attgctcctg gagaccccag tccagcctgc tttctctctt cctaaaggag aacgcgaggt
      901 tgtcactcac tcagatgaag gaggtgtggc ctctcttggt ctggcccagc gagtaccatt
      961 aagagaaaac cgagaaatgt cacataccag ggacagccat gactcccacc tgatgccctc
     1021 ccctgcccct gtggcccagc ccttgcctgg ccatgtggtg ccatgtccat caccctttgg
     1081 acgggctcag cgtgtaccct ccccaggccc tccaactctg acctcatatt cagtgttgcg
     1141 gcgtctcacc gttcaaccta aaacccggtt cacacccatg ccatcaaccc ccagagttca
     1201 gcaggcccag tggctgcgtg gtgtctcccc tcagtcctgc tctgaagatc ctgccctgcc
     1261 ctgggagcag gttgccgtcc ggttgtttga ccaggagagt tgtataaggt cactggaggg
     1321 ttctgggaaa ccaccggtgg ccactccttc tggaccccac tctaacagaa cccccagcct
     1381 ccaggaggtg aagattcaac gcatcggtat cctgcaacag ctgttgagac aggaagtaga
     1441 ggggctggta gggggccagt gtgtccctct taatggaggc tcttctctgg atatggttga
     1501 acttcagccc ctgctgactg agatttctag aactctgaat gccacagagc ataactctgg
     1561 gacttcccac cttcctggac tgttaaaaca ctcagggctg ccaaagccct gtcttccaga
     1621 ggagtgcggg gaaccacagc cctgccctcc ggcagagcct gggcccccag aggccttctg
     1681 taggagtgag cctgagatac cagagccctc cctccaggaa cagcttgaag taccagagcc
     1741 ctaccctcca gcagaaccca ggcccctaga gtcctgctgt aggagtgagc ctgagatacc
     1801 ggagtcctct cgccaggaac agcttgaggt acctgagccc tgccctccag cagaacccag
     1861 gcccctagag tcctactgta ggattgagcc tgagataccg gagtcctctc gccaggaaca
     1921 gcttgaggta cctgagccct gccctccagc agaacccggg ccccttcagc ccagcaccca
     1981 ggggcagtct ggacccccag ggccctgccc tagggtagag ctgggggcat cagagccctg
     2041 caccctggaa catagaagtc tagagtccag tctaccaccc tgctgcagtc agtgggctcc
     2101 agcaaccacc agcctgatct tctcttccca acacccgctt tgtgccagcc cccctatctg
     2161 ctcactccag tctttgagac ccccagcagg ccaggcaggc ctcagcaatc tggcccctcg
     2221 aaccctagcc ctgagggagc gcctcaaatc gtgtttaacc gccatccact gcttccacga
     2281 ggctcgtctg gacgatgagt gtgcctttta caccagccga gcccctccct caggccccac
     2341 ccgggtctgc accaaccctg tggctacatt actcgaatgg caggatgccc tgtgtttcat
     2401 tccagttggt tctgctgccc cccagggctc tccatgatga gacaaccact cctgccctgc
     2461 cgtacttctt ccttttagcc cttatttatt gtcggtctgc ccatgggact gggagccgcc
     2521 cacttttgtc ctcaataaag tttctaaagt a
//
