LOCUS       NM_001039705            4634 bp    mRNA    linear   PRI 09-APR-2024
DEFINITION  Homo sapiens trophinin (TRO), transcript variant 6, mRNA.
ACCESSION   NM_001039705
VERSION     NM_001039705.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4634)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 4634)
  AUTHORS   Dolanbay,E.G., Yardimoglu,M., Yalcinkaya,E., Yazir,Y., Aksoy,A.,
            Karaoz,E. and Caliskan,E.
  TITLE     Expression of trophinin and dipeptidyl peptidase IV in endometrial
            co-culture in the presence of an embryo: A comparative
            immunocytochemical study
  JOURNAL   Mol Med Rep 13 (5), 3961-3968 (2016)
   PUBMED   27035766
  REMARK    GeneRIF: Expression of trophinin and dipeptidyl peptidase IV in
            endometrial co-culture in the presence of an embryo: A comparative
            immunocytochemical study.
REFERENCE   3  (bases 1 to 4634)
  AUTHORS   Kim,S.W., Yang,H.G., Kang,M.C., Lee,S., Namkoong,H., Lee,S.W. and
            Sung,Y.C.
  TITLE     KIAA1114, a full-length protein encoded by the trophinin gene, is a
            novel surface marker for isolating tumor-initiating cells of
            multiple hepatocellular carcinoma subtypes
  JOURNAL   Oncotarget 5 (5), 1226-1240 (2014)
   PUBMED   24713374
REFERENCE   4  (bases 1 to 4634)
  AUTHORS   Fukuda,M.N. and Sugihara,K.
  TITLE     Trophinin in cell adhesion and signal transduction
  JOURNAL   Front Biosci (Elite Ed) 4 (1), 342-350 (2012)
   PUBMED   22201876
  REMARK    GeneRIF: report dual roles for trophinin in human cancers in terms
            of promoting malignancy in some tumor types and suppressing it in
            others
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4634)
  AUTHORS   Aoyama,J., Akazawa,Y., Kasahara,K., Higashiyama,Y., Kikuchi,I.,
            Fukumoto,Y., Saburi,S., Nakayama,Y., Fukuda,M.N. and Yamaguchi,N.
  TITLE     Nuclear localization of magphinins, alternative splicing products
            of the human trophinin gene
  JOURNAL   J Cell Biochem 103 (3), 765-777 (2008)
   PUBMED   17559068
  REMARK    GeneRIF: When magphinin-gamma was expressed in NIH3T3 cells, cells
            underwent G1 arrest. These results suggest that human
            magphinin-gamma inhibits cell cycle progression through nuclear
            activity.
            GeneRIF: Confocal microscopy analysis of ectopically expressed
            magphinins revealed that magphinin-alpha and -beta localize in the
            cytoplasm, whereas magphinin-gamma lacking the peptide encoded by
            exon-3 is nuclear.
REFERENCE   6  (bases 1 to 4634)
  AUTHORS   Chomez,P., De Backer,O., Bertrand,M., De Plaen,E., Boon,T. and
            Lucas,S.
  TITLE     An overview of the MAGE gene family with the identification of all
            human members of the family
  JOURNAL   Cancer Res 61 (14), 5544-5551 (2001)
   PUBMED   11454705
REFERENCE   7  (bases 1 to 4634)
  AUTHORS   Suzuki,N., Nakayama,J., Shih,I.M., Aoki,D., Nozawa,S. and
            Fukuda,M.N.
  TITLE     Expression of trophinin, tastin, and bystin by trophoblast and
            endometrial cells in human placenta
  JOURNAL   Biol Reprod 60 (3), 621-627 (1999)
   PUBMED   10026108
REFERENCE   8  (bases 1 to 4634)
  AUTHORS   Suzuki,N., Zara,J., Sato,T., Ong,E., Bakhiet,N., Oshima,R.G.,
            Watson,K.L. and Fukuda,M.N.
  TITLE     A cytoplasmic protein, bystin, interacts with trophinin, tastin,
            and cytokeratin and may be involved in trophinin-mediated cell
            adhesion between trophoblast and endometrial epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 95 (9), 5027-5032 (1998)
   PUBMED   9560222
REFERENCE   9  (bases 1 to 4634)
  AUTHORS   Pack,S.D., Tanigami,A., Ledbetter,D.H., Sato,T. and Fukuda,M.N.
  TITLE     Assignment of trophoblast/endometrial epithelium cell adhesion
            molecule trophinin gene TRO to human chromosome bands
            Xp11.22-->p11.21 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 123-124 (1997)
   PUBMED   9533028
REFERENCE   10 (bases 1 to 4634)
  AUTHORS   Fukuda,M.N., Sato,T., Nakayama,J., Klier,G., Mikami,M., Aoki,D. and
            Nozawa,S.
  TITLE     Trophinin and tastin, a novel cell adhesion molecule complex with
            potential involvement in embryo implantation
  JOURNAL   Genes Dev 9 (10), 1199-1210 (1995)
   PUBMED   7758945
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB177388.1, AB029037.2 and
            AF349719.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001039705.2.
            
            Summary: This gene encodes a membrane protein that mediates cell
            adhesion between trophoblastic cells and the epithelial cells of
            the endometrium. The encoded protein participates in cell
            signalling during embryo implantation, and may also be involved in
            cancer formation. This gene is located near several other closely
            related genes on chromosome X. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2012].
            
            Transcript Variant: This variant (6) represents the longest
            transcript and encodes the longest isoform (5).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.55688.1,
                                           SRR1660803.107329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000173898.12/ ENSP00000173898.7
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DB177388.1         262-279
            19-4632             AB029037.2         1-4614
            4633-4634           AF349719.1         2596-2597
FEATURES             Location/Qualifiers
     source          1..4634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.21"
     gene            1..4634
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /note="trophinin"
                     /db_xref="GeneID:7216"
                     /db_xref="HGNC:HGNC:12326"
                     /db_xref="MIM:300132"
     exon            1..55
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /inference="alignment:Splign:2.1.0"
     exon            56..144
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..4395
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /note="isoform 5 is encoded by transcript variant 6; MAGE
                     superfamily protein; magphinin; MAGE-D3 antigen; melanoma
                     antigen, family D, 3"
                     /codon_start=1
                     /product="trophinin isoform 5"
                     /protein_id="NP_001034794.1"
                     /db_xref="CCDS:CCDS43959.1"
                     /db_xref="GeneID:7216"
                     /db_xref="HGNC:HGNC:12326"
                     /db_xref="MIM:300132"
                     /translation="MDRRNDYGYRVPLFQGPLPPPGSLGLPFPPDIQTETTEEDSVLL
                     MHTLLAATKDSLAMDPPVVNRPKKSKTKKAPIKTITKAAPAAPPVPAANEIATNKPKI
                     TWQALNLPVITQISQALPTTEVTNTQASSVTAQPKKANKMKRVTAKAAQGSQSPTGHE
                     GGTIQLKSPLQVLKLPVISQNIHAPIANESASSQALITSIKPKKASKAKKAANKAIAS
                     ATEVSLAATATHTATTQGQITNETASIHTTAASIRTKKASKARKTIAKVINTDTEHIE
                     ALNVTDAATRQIEASVVAIRPKKSKGKKAASRGPNSVSEISEAPLATQIVTNQALAAT
                     LRVKRGSRARKAATKARATESQTPNADQGAQAKIASAQTNVSALETQVAAAVQALADD
                     YLAQLSLEPTTRTRGKRNRKSKHLNGDERSGSNYRRIPWGRRPAPPRDVAILQERANK
                     LVKYLLVKDQTKIPIKRSDMLRDVIQEYDEYFPEIIERASYTLEKMFRVNLKEIDKQS
                     SLYILISTQESSAGILGTTKDTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLRP
                     GVRHSLFGEVRKLITDEFVKQKYLEYKRVPNSRPPEYEFFWGLRSYHETSKMKVLKFA
                     CRVQKKDPKDWAVQYREAVEMEVQAAAVAVAEAEARAEARAQMGIGEEAVAGPWNWDD
                     MDIDCLTREELGDDAQAWSRFSFEIEARAQENADASTNVNFSRGASTRAGFSDGASIS
                     FNGAPSSSGGFSGGPGITFGVAPSTSASFSNTASISFGGTLSTSSSFSSAASISFGCA
                     HSTSTSFSSEASISFGGMPCTSASFSGGVSSSFSGPLSTSATFSGGASSGFGGTLSTT
                     AGFSGVLSTSTSFGSAPTTSTVFSSALSTSTGFGGILSTSVCFGGSPSSSGSFGGTLS
                     TSICFGGSPCTSTGFGGTLSTSVSFGGSSSTSANFGGTLSTSICFDGSPSTGAGFGGA
                     LNTSASFGSVLNTSTGFGGAMSTSADFGGTLSTSVCFGGSPGTSVSFGSALNTNAGYG
                     GAVSTNTDFGGTLSTSVCFGGSPSTSAGFGGALNTNASFGCAVSTSASFSGAVSTSAC
                     FSGAPITNPGFGGAFSTSAGFGGALSTAADFGGTPSNSIGFGAAPSTSVSFGGAHGTS
                     LCFGGAPSTSLCFGSASNTNLCFGGPPSTSACFSGATSPSFCDGPSTSTGFSFGNGLS
                     TNAGFGGGLNTSAGFGGGLGTSAGFSGGLSTSSGFDGGLGTSAGFGGGPGTSTGFGGG
                     LGTSAGFSGGLGTSAGFGGGLVTSDGFGGGLGTNASFGSTLGTSAGFSGGLSTSDGFG
                     SRPNASFDRGLSTIIGFGSGSNTSTGFTGEPSTSTGFSSGPSSIVGFSGGPSTGVGFC
                     SGPSTSGFSGGPSTGAGFGGGPNTGAGFGGGPSTSAGFGSGAASLGACGFSYG"
     exon            145..1335
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1440
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1504
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1584
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1676
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1756
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1799
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1862
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1977
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..4406
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /inference="alignment:Splign:2.1.0"
     exon            4407..4634
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4616..4621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /note="hexamer: ATTAAA"
     polyA_site      4634
                     /gene="TRO"
                     /gene_synonym="MAGE-d3; MAGED3"
                     /note="major polyA site"
ORIGIN      
        1 agacacaagg agaggcttgg agagagcaga cgccttctgg attcaagaag acgaggccca
       61 ttcccctcag gctcacctgt tactcggcct cccagaaaga tggataggag aaatgactac
      121 ggatataggg tgcctctatt tcagggccct ctgcctcccc cggggagcct ggggcttccc
      181 ttccctccag atatacagac tgagaccaca gaagaggaca gtgtcctgct gatgcatacc
      241 ctgttggcgg caaccaagga ctccctggcc atggacccac cagttgtcaa ccggcctaag
      301 aaaagcaaga ccaagaaggc ccctataaag actattacta aggctgcacc tgctgcccct
      361 ccagtcccag ctgccaatga gattgccacc aacaagccca aaataacttg gcaggcttta
      421 aacctgccag tcattaccca gatcagccag gctttaccta ccactgaggt aaccaatact
      481 caggcttctt cagtcactgc tcagcctaag aaagccaaca agatgaagag agttactgcc
      541 aaggcagccc aaggctccca atccccaact ggccatgagg gtggcactat acagctgaag
      601 tcacccttgc aggtcctaaa gctaccagtc atctcacaga atattcacgc tccaattgcc
      661 aatgagtcag ccagttccca agccttgata acctctatca agcctaagaa agcttccaag
      721 gctaagaagg ctgcaaataa ggccatagct agtgccaccg aggtctcgct ggctgcaact
      781 gccacccata cagctaccac ccaaggccaa attaccaatg agacagccag tatccacacc
      841 acagcagcct ccatccgaac caagaaagcc tccaaagcca ggaagacaat tgctaaggtc
      901 ataaatactg acactgagca tatagaggct ctaaatgtca ctgacgcagc taccaggcag
      961 attgaggcct cagtagtggc tatcaggccc aaaaaatcca agggcaagaa ggctgccagc
     1021 aggggcccaa attctgtctc tgagatctct gaggccccac ttgccactca gatagtcaca
     1081 aaccaagccc tggcagccac cctgcgggtc aagagagggt ctagggctcg gaaggctgcc
     1141 actaaggctc gggcaactga aagccagact ccaaatgctg accaaggggc ccaggccaag
     1201 atagcctctg ctcagaccaa cgtaagtgcc cttgagactc aggttgctgc tgctgtccag
     1261 gccctggcag atgactatct ggctcagttg agcctggagc ccacaaccag gacccggggc
     1321 aaaagaaacc gaaagtccaa gcatctgaat ggggatgaga gaagtggcag taattacagg
     1381 cggatcccat ggggccggag gcctgcacca ccgcgagatg tggccatttt acaagaaagg
     1441 gctaataagt tggtgaaata cctgttggtt aaggaccaga caaagatccc catcaaacgc
     1501 tcagacatgc tgagggatgt catccaagaa tatgatgaat atttcccaga aatcattgaa
     1561 cgagcaagct acactctgga gaagatgttt cgagtcaatc tgaaagaaat tgataagcaa
     1621 agtagcttgt atattctcat cagcactcag gaatcctctg caggcatact gggaacgacc
     1681 aaggacacac ccaagctggg tctcctcatg gtgattctga gtgtcatttt tatgaatggc
     1741 aacaaggcca gtgaggctgt catctgggag gtgctgcgca agttggggct gcgccctggg
     1801 gtgaggcatt cactctttgg ggaagtgagg aagctcatca cagacgagtt tgtgaagcag
     1861 aagtacctgg agtacaagag ggtccctaac agcagaccac ctgaatatga gttcttctgg
     1921 ggcttgcgct cctaccacga gactagcaag atgaaagtcc tcaagtttgc atgcagggtg
     1981 cagaagaaag accccaagga ctgggctgtg cagtaccgcg aggcagtgga gatggaagtc
     2041 caagctgcag ctgtggctgt ggctgaggct gaagccaggg ctgaggcaag agcccaaatg
     2101 gggattggag aggaagctgt ggctgggccc tggaattggg atgacatgga tatcgactgc
     2161 ctaacaaggg aagagttagg cgatgatgct caggcctgga gcagattttc atttgaaatt
     2221 gaggccagag cccaagaaaa tgcagatgcc agcaccaacg tcaacttcag cagaggagct
     2281 agtaccaggg ctggcttcag cgatggtgct agtattagct tcaatggtgc acccagctcc
     2341 agtggtggct tcagtggtgg acctggcatt acctttggtg ttgcacccag caccagtgcc
     2401 agcttcagca atacagccag cattagcttt ggtggtacac tgagcactag ctccagcttc
     2461 agcagcgcag ccagcattag ctttggttgt gcacacagca ccagcactag tttcagcagt
     2521 gaagccagca ttagctttgg tggcatgcct tgtaccagtg ccagctttag tggtggagtc
     2581 agctctagtt ttagtggccc actcagcacc agtgccactt tcagtggtgg agccagctct
     2641 ggctttggag gcacactcag caccacggct ggctttagtg gtgtactcag cactagcacc
     2701 agctttggca gtgcacccac aacgagcaca gtcttcagta gtgcgcttag caccagcact
     2761 ggctttggag gcatactcag caccagtgtc tgttttggtg gctctcccag ctccagtggt
     2821 agctttggtg gtacactcag taccagtatc tgcttcggtg gctctccctg caccagcact
     2881 ggctttggag gcacacttag caccagtgtc tcctttggtg gctcttccag caccagtgcc
     2941 aattttggtg gtacactaag taccagcatc tgctttgatg gctctcccag cactggtgct
     3001 ggctttggtg gtgctctcaa caccagtgcc agctttggca gtgtgctcaa caccagtact
     3061 ggttttggtg gtgctatgag caccagtgct gactttggcg gtacactaag caccagtgtc
     3121 tgctttggtg gctctcctgg caccagtgtc agctttggca gtgcactcaa caccaatgct
     3181 ggttatggtg gtgctgtcag caccaacact gactttggtg gtacactaag caccagcgtc
     3241 tgttttggtg gctctcccag caccagtgct ggctttggtg gtgcactcaa caccaatgcc
     3301 agctttggct gtgccgtcag caccagtgcc agcttcagtg gtgctgtcag caccagtgct
     3361 tgcttcagtg gtgcaccaat caccaaccct ggctttggcg gtgcatttag caccagtgct
     3421 ggcttcggtg gggcacttag taccgctgct gacttcggtg gtactcccag caacagcatt
     3481 ggctttggtg ctgctcccag caccagtgtc agctttggtg gtgctcatgg caccagcctc
     3541 tgttttggtg gagctcccag caccagcctc tgctttggca gtgcatctaa tactaaccta
     3601 tgctttggtg gccctcctag caccagtgcc tgctttagtg gtgctaccag ccctagtttt
     3661 tgtgatggac ccagcaccag taccggtttc agctttggca atgggttaag caccaatgct
     3721 ggatttggtg gtggactgaa caccagtgct ggctttggtg gtggcctagg caccagtgct
     3781 ggcttcagtg gtggcctaag cacaagttct ggctttgatg gtgggctagg taccagcgct
     3841 ggcttcggtg gaggaccagg caccagcact ggttttggtg gtggactggg caccagtgct
     3901 ggcttcagtg gcggactggg caccagtgct ggctttggtg gtggactggt cactagtgat
     3961 ggctttggtg gtggactggg caccaatgct agtttcggca gcacacttgg caccagtgct
     4021 ggctttagtg gtggcctcag caccagcgat ggctttggca gtaggcctaa tgccagcttc
     4081 gacagaggac tgagtaccat cattggcttt ggcagtggtt ccaacaccag cactggcttt
     4141 actggcgaac ccagcaccag cacgggcttc agtagtggac ccagttctat tgttggcttc
     4201 agcggtggac caagcactgg tgttggcttc tgcagtggac caagcaccag tggcttcagc
     4261 ggtggaccga gcacaggagc tggcttcggc ggtggaccaa acactggtgc tggctttggt
     4321 ggtggaccga gcaccagtgc tggctttggc agtggagccg ccagtcttgg tgcctgtggc
     4381 ttctcgtatg gctagtgagg tttcagattt attccccatg tttacagata ccgctaataa
     4441 attgcagtag tccttcccat ggagccaaag tacatccttg gaatctttgt ccacacagca
     4501 gtcaaggcag ttatggccaa tcagctgagg gtgtcatgtg atggaaaaat ctgtttgctg
     4561 ttcctgcttt attgtttgct ttctgtgtgc tgtcatattt tggtatcaga gttacattaa
     4621 atttgcaaaa tgaa
//
