LOCUS       NM_001013642            1961 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens TMF1 regulated nuclear protein 1 (TRNP1), mRNA.
ACCESSION   NM_001013642 XM_371238
VERSION     NM_001013642.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1961)
  AUTHORS   Stahl,R., Walcher,T., De Juan Romero,C., Pilz,G.A., Cappello,S.,
            Irmler,M., Sanz-Aquela,J.M., Beckers,J., Blum,R., Borrell,V. and
            Gotz,M.
  TITLE     Trnp1 regulates expansion and folding of the mammalian cerebral
            cortex by control of radial glial fate
  JOURNAL   Cell 153 (3), 535-549 (2013)
   PUBMED   23622239
  REMARK    GeneRIF: TRNP1 expression levels exhibit regional differences in
            the cerebral cortex of human fetuses, anticipating radial or
            tangential expansion.
REFERENCE   2  (bases 1 to 1961)
  AUTHORS   Volpe,M., Shpungin,S., Barbi,C., Abrham,G., Malovani,H., Wides,R.
            and Nir,U.
  TITLE     trnp: A conserved mammalian gene encoding a nuclear protein that
            accelerates cell-cycle progression
  JOURNAL   DNA Cell Biol 25 (6), 331-339 (2006)
   PUBMED   16792503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356390.24.
            
            On Nov 22, 2018 this sequence version replaced NM_001013642.2.
            
            CCDS Note: This CCDS ID represents the protein described in PMID:
            16792503 and is supported by the mRNA BC069216.1. It should be
            noted that this transcript is predicted to undergo
            nonsense-mediated mRNA decay (NMD). However, the protein is
            represented because it was detected endogenously in mouse as shown
            in PMID: 16792503. It is likely that the majority of transcripts
            representing this variant will undergo NMD, while some low level of
            NMD escape may allow for the expression of this protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069216.1, ERR279828.1168.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000522111.3/ ENSP00000429216.2
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-921               AL356390.24        39827-40747         c
            922-1961            AL356390.24        33553-34592         c
FEATURES             Location/Qualifiers
     source          1..1961
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..1961
                     /gene="TRNP1"
                     /gene_synonym="C1orf225; TNRP; TRNP"
                     /note="TMF1 regulated nuclear protein 1"
                     /db_xref="GeneID:388610"
                     /db_xref="HGNC:HGNC:34348"
                     /db_xref="MIM:616824"
     exon            1..921
                     /gene="TRNP1"
                     /gene_synonym="C1orf225; TNRP; TRNP"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..779
                     /gene="TRNP1"
                     /gene_synonym="C1orf225; TNRP; TRNP"
                     /codon_start=1
                     /product="TMF-regulated nuclear protein 1"
                     /protein_id="NP_001013664.2"
                     /db_xref="CCDS:CCDS41289.1"
                     /db_xref="GeneID:388610"
                     /db_xref="HGNC:HGNC:34348"
                     /db_xref="MIM:616824"
                     /translation="MPGCRISACGPGAQEGTAEQRSPPPPWDPMPSSQPPPPTPTLTP
                     TPTPGQSPPLPDAAGASAGAAEDQELQRWRQGASGIAGLAGPGGGSGAAAGAGGRALE
                     LAEARRRLLEVEGRRRLVSELESRVLQLHRVFLAAELRLAHRAESLSRLSGGVAQAEL
                     YLAAHGSRLKKGPRRGRRGRPPALLASALGLGGCVPWGAGRLRRGHGPEPDSPFRRSP
                     PRGPASPQR"
     exon            922..1961
                     /gene="TRNP1"
                     /gene_synonym="C1orf225; TNRP; TRNP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1706..1711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRNP1"
                     /gene_synonym="C1orf225; TNRP; TRNP"
                     /note="hexamer: AATAAA"
     polyA_site      1731
                     /gene="TRNP1"
                     /gene_synonym="C1orf225; TNRP; TRNP"
                     /note="major polyA site"
     regulatory      1941..1946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRNP1"
                     /gene_synonym="C1orf225; TNRP; TRNP"
                     /note="hexamer: ATTAAA"
     polyA_site      1961
                     /gene="TRNP1"
                     /gene_synonym="C1orf225; TNRP; TRNP"
ORIGIN      
        1 ggggtggggg ctgtggccgt gtctagctgt tcgggtgtgc tgtggtcatc ctccctgcgc
       61 acctacagcc gcagaccgcc ggtggggggc gggggatgcc gggctgccgc atcagcgcct
      121 gcggcccggg ggcccaggag gggacggcag agcagaggtc gccgccgccg ccctgggatc
      181 ccatgccgtc ctctcagccc ccgcccccaa ctccgacctt gactcctacc ccgaccccgg
      241 gtcagtcccc gccgctgccg gacgcagctg gggcttcagc aggcgcggcc gaggaccagg
      301 agctgcagcg ctggcgccag ggcgctagcg ggatcgcggg gctcgccggc cccggagggg
      361 gctctggcgc ggctgcgggg gcggggggcc gcgcgctgga gctggccgaa gcacggcggc
      421 ggctgctgga ggtggagggc cgccggcgcc tggtgtcgga gctggagagc cgcgtgctgc
      481 agctgcaccg cgttttcttg gcggccgagc tgcgcctggc gcaccgcgcg gagagcctga
      541 gccgcctgag cggcggcgtg gcgcaggccg agctctacct ggcggctcac gggtcgcgcc
      601 tcaagaaggg cccgcgccgc ggccgccgcg gccgaccccc cgcgctgctg gcctcggcgc
      661 tgggcctggg cggctgcgtg ccctggggtg ccgggcgact gcggcgcggc cacggccccg
      721 agcccgactc gcccttccgc cgcagcccgc cccgcggccc cgcctccccg cagcgctgac
      781 ctccacgccc ggacccctgg ccaccccgac aagcttcgcc gaggtgccga ccgaccgact
      841 gatcgcggac gccggctgga aggactacgg atccgcagga agaggcagtt gggggccagg
      901 ggcccagtag aggaggctga gctccttcca actcctcaga acctccactc tatggatctg
      961 gacctctgga ttcggctttc tccctgggca ctgccttcag gaagacgttg agaattgacc
     1021 ttacacaatc ccagcgccct cctcacagga gcctttcact ttacagtggc aaggggctgg
     1081 ttctggagaa ctggctgatg ctctgaattt cttcatatac cccacatttg actttggctt
     1141 acactgtaca attggagatg ttgctacagg tccctgagat gcaatcagat taagcgtagc
     1201 aagcattgcc aatgggaaag tcaaaataat ttattttttt tccctttccc cctaccccat
     1261 ccccagccaa gaatttcttt tcaagatatc gtcatcattc ttaaacaaca ttcttaaccc
     1321 ccagctgggg tccccatttt aatagatgtc attgcttcaa gtctaacggc gccgggaggc
     1381 ctgtttgagg gaaaacatta gtttgaaaaa tccccgttcc cttcatccac tgcccttgtt
     1441 ctccacgtgg gagtgtgctt gtggcccctc agaaagatag tctgctggct cctaggggtt
     1501 ggggtggggg acacaccttt ttctcaggaa gaggtgatgg caatgtaaaa catctaagca
     1561 aagttttaaa tgaaaaaaag gaaacacatt taaacatcct gataatggag ggaagggggg
     1621 cacatttaca catagcccag aacttgtaga attctgcata gtgaatgtat attgaattag
     1681 tctcctgcct tatacattca ggaggaataa atttccataa tgtaaggcaa atgcatgggg
     1741 ttctgaggtt cactttgcaa gtgcccttgc tgcctttcct ctgtgtctat tatggctctt
     1801 taagttgacg gttcctggag cagcttgtat ttagtttcgt ttggcagtct ggccctgttg
     1861 actttgattt gcagaccaat tctcccttga cctgactcac agccgcctgc tcttaccccc
     1921 ctcctcagga agtcttcctc attaaaggat gtgatgacgg a
//
