LOCUS       NM_020844               9591 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens tRNA methyltransferase 9B (putative) (TRMT9B),
            transcript variant 1, mRNA.
ACCESSION   NM_020844
VERSION     NM_020844.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9591)
  AUTHORS   Hogan,C.A., Gratz,S.J., Dumouchel,J.L., Thakur,R.S., Delgado,A.,
            Lentini,J.M., Madhwani,K.R., Fu,D. and O'Connor-Giles,K.M.
  TITLE     Expanded tRNA methyltransferase family member TRMT9B regulates
            synaptic growth and function
  JOURNAL   EMBO Rep 24 (10), e56808 (2023)
   PUBMED   37642556
REFERENCE   2  (bases 1 to 9591)
  AUTHORS   Chen,H., Wang,J., Zhang,Y. and Gao,Y.
  TITLE     [Overexpression of KIAA1456 inhibits the proliferation of HO8910PM
            cells]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 32 (9), 1183-1187 (2016)
   PUBMED   27609572
  REMARK    GeneRIF: Over-expression of KIAA1456 inhibits the proliferation of
            HO8910PM ovarian cancer cells and arrests the cell cycle in G1
            phase.
REFERENCE   3  (bases 1 to 9591)
  AUTHORS   Figueiredo,J.C., Hsu,L., Hutter,C.M., Lin,Y., Campbell,P.T.,
            Baron,J.A., Berndt,S.I., Jiao,S., Casey,G., Fortini,B., Chan,A.T.,
            Cotterchio,M., Lemire,M., Gallinger,S., Harrison,T.A., Le
            Marchand,L., Newcomb,P.A., Slattery,M.L., Caan,B.J., Carlson,C.S.,
            Zanke,B.W., Rosse,S.A., Brenner,H., Giovannucci,E.L., Wu,K.,
            Chang-Claude,J., Chanock,S.J., Curtis,K.R., Duggan,D., Gong,J.,
            Haile,R.W., Hayes,R.B., Hoffmeister,M., Hopper,J.L., Jenkins,M.A.,
            Kolonel,L.N., Qu,C., Rudolph,A., Schoen,R.E., Schumacher,F.R.,
            Seminara,D., Stelling,D.L., Thibodeau,S.N., Thornquist,M.,
            Warnick,G.S., Henderson,B.E., Ulrich,C.M., Gauderman,W.J.,
            Potter,J.D., White,E. and Peters,U.
  CONSRTM   CCFR; GECCO
  TITLE     Genome-wide diet-gene interaction analyses for risk of colorectal
            cancer
  JOURNAL   PLoS Genet 10 (4), e1004228 (2014)
   PUBMED   24743840
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9591)
  AUTHORS   Wolf,E.J., Rasmusson,A.M., Mitchell,K.S., Logue,M.W., Baldwin,C.T.
            and Miller,M.W.
  TITLE     A genome-wide association study of clinical symptoms of
            dissociation in a trauma-exposed sample
  JOURNAL   Depress Anxiety 31 (4), 352-360 (2014)
   PUBMED   24677629
REFERENCE   5  (bases 1 to 9591)
  AUTHORS   Anttila,V., Winsvold,B.S., Gormley,P., Kurth,T., Bettella,F.,
            McMahon,G., Kallela,M., Malik,R., de Vries,B., Terwindt,G.,
            Medland,S.E., Todt,U., McArdle,W.L., Quaye,L., Koiranen,M.,
            Ikram,M.A., Lehtimaki,T., Stam,A.H., Ligthart,L., Wedenoja,J.,
            Dunham,I., Neale,B.M., Palta,P., Hamalainen,E., Schurks,M.,
            Rose,L.M., Buring,J.E., Ridker,P.M., Steinberg,S., Stefansson,H.,
            Jakobsson,F., Lawlor,D.A., Evans,D.M., Ring,S.M., Farkkila,M.,
            Artto,V., Kaunisto,M.A., Freilinger,T., Schoenen,J., Frants,R.R.,
            Pelzer,N., Weller,C.M., Zielman,R., Heath,A.C., Madden,P.A.F.,
            Montgomery,G.W., Martin,N.G., Borck,G., Gobel,H., Heinze,A.,
            Heinze-Kuhn,K., Williams,F.M.K., Hartikainen,A.L., Pouta,A., van
            den Ende,J., Uitterlinden,A.G., Hofman,A., Amin,N., Hottenga,J.J.,
            Vink,J.M., Heikkila,K., Alexander,M., Muller-Myhsok,B.,
            Schreiber,S., Meitinger,T., Wichmann,H.E., Aromaa,A.,
            Eriksson,J.G., Traynor,B., Trabzuni,D., Rossin,E., Lage,K.,
            Jacobs,S.B.R., Gibbs,J.R., Birney,E., Kaprio,J., Penninx,B.W.,
            Boomsma,D.I., van Duijn,C., Raitakari,O., Jarvelin,M.R.,
            Zwart,J.A., Cherkas,L., Strachan,D.P., Kubisch,C., Ferrari,M.D.,
            van den Maagdenberg,A.M.J.M., Dichgans,M., Wessman,M., Smith,G.D.,
            Stefansson,K., Daly,M.J., Nyholt,D.R., Chasman,D. and Palotie,A.
  CONSRTM   North American Brain Expression Consortium; UK Brain Expression
            Consortium
  TITLE     Genome-wide meta-analysis identifies new susceptibility loci for
            migraine
  JOURNAL   Nat Genet 45 (8), 912-917 (2013)
   PUBMED   23793025
REFERENCE   6  (bases 1 to 9591)
  AUTHORS   Begley,U., Sosa,M.S., Avivar-Valderas,A., Patil,A., Endres,L.,
            Estrada,Y., Chan,C.T., Su,D., Dedon,P.C., Aguirre-Ghiso,J.A. and
            Begley,T.
  TITLE     A human tRNA methyltransferase 9-like protein prevents tumour
            growth by regulating LIN9 and HIF1-alpha
  JOURNAL   EMBO Mol Med 5 (3), 366-383 (2013)
   PUBMED   23381944
  REMARK    GeneRIF: Study links hTRM9L and tRNA modifications to inhibition of
            tumour growth via LIN9 and HIF1-alpha-dependent mechanisms.
REFERENCE   7  (bases 1 to 9591)
  AUTHORS   Lunetta,K.L., D'Agostino,R.B. Sr., Karasik,D., Benjamin,E.J.,
            Guo,C.Y., Govindaraju,R., Kiel,D.P., Kelly-Hayes,M., Massaro,J.M.,
            Pencina,M.J., Seshadri,S. and Murabito,J.M.
  TITLE     Genetic correlates of longevity and selected age-related
            phenotypes: a genome-wide association study in the Framingham Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S13 (2007)
   PUBMED   17903295
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135352.6, DA390356.1, DC334299.1, AB040889.1 and AW295329.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020844.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2151119,
                              SAMEA2155550 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000524591.7/ ENSP00000432695.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC135352.6         39384-39384
            2-141               DA390356.1         1-140
            142-691             DC334299.1         1-550
            692-941             AB040889.1         465-714
            942-9173            AC135352.6         114839-123070
            9174-9591           AW295329.1         14-431              c
FEATURES             Location/Qualifiers
     source          1..9591
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..9591
                     /gene="TRMT9B"
                     /gene_synonym="C8orf79; hTRM9L; KIAA1456; TRM9L"
                     /note="tRNA methyltransferase 9B (putative)"
                     /db_xref="GeneID:57604"
                     /db_xref="HGNC:HGNC:26725"
                     /db_xref="MIM:615666"
     exon            1..294
                     /gene="TRMT9B"
                     /gene_synonym="C8orf79; hTRM9L; KIAA1456; TRM9L"
                     /inference="alignment:Splign:2.1.0"
     exon            295..492
                     /gene="TRMT9B"
                     /gene_synonym="C8orf79; hTRM9L; KIAA1456; TRM9L"
                     /inference="alignment:Splign:2.1.0"
     exon            493..647
                     /gene="TRMT9B"
                     /gene_synonym="C8orf79; hTRM9L; KIAA1456; TRM9L"
                     /inference="alignment:Splign:2.1.0"
     CDS             494..1858
                     /gene="TRMT9B"
                     /gene_synonym="C8orf79; hTRM9L; KIAA1456; TRM9L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable tRNA methyltransferase 9-like protein; probable
                     tRNA methyltransferase 9B"
                     /codon_start=1
                     /product="probable tRNA methyltransferase 9B isoform 1"
                     /protein_id="NP_065895.2"
                     /db_xref="CCDS:CCDS47808.1"
                     /db_xref="GeneID:57604"
                     /db_xref="HGNC:HGNC:26725"
                     /db_xref="MIM:615666"
                     /translation="MDHEAAQLEKQHVHNVYESTAPYFSDLQSKAWPRVRQFLQEQKP
                     GSLIADIGCGTGKYLKVNSQVHTVGCDYCGPLVEIARNRGCEAMVCDNLNLPFRDEGF
                     DAIISIGVIHHFSTKQRRIRAIKEMARVLVPGGQLMIYVWAMEQKNRHFEKQDVLVPW
                     NRALCSQLFSESSQSGRKRQCGYPERGHPYHPPCSECSCSVCFKEQCGSKRSHSVGYE
                     PAMARTCFANISKEGEEEYGFYSTLGKSFRSWFFSRSLDESTLRKQIERVRPLKNTEV
                     WASSTVTVQPSRHSSLDFDHQEPFSTKGQSLDEEVFVESSSGKHLEWLRAPGTLKHLN
                     GDHQGEMRRNGGGNFLDSTNTGVNCVDAGNIEDDNPSASKILRRISAVDSTDFNPDDT
                     MSVEDPQTDVLDSTAFMRYYHVFREGELCSLLKENVSELRILSSGNDHGNWCIIAEKK
                     RGCD"
     exon            648..821
                     /gene="TRMT9B"
                     /gene_synonym="C8orf79; hTRM9L; KIAA1456; TRM9L"
                     /inference="alignment:Splign:2.1.0"
     exon            822..9591
                     /gene="TRMT9B"
                     /gene_synonym="C8orf79; hTRM9L; KIAA1456; TRM9L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4554..4559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT9B"
                     /gene_synonym="C8orf79; hTRM9L; KIAA1456; TRM9L"
                     /note="hexamer: AATAAA"
     polyA_site      4575
                     /gene="TRMT9B"
                     /gene_synonym="C8orf79; hTRM9L; KIAA1456; TRM9L"
                     /note="major polyA site"
     regulatory      9565..9570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT9B"
                     /gene_synonym="C8orf79; hTRM9L; KIAA1456; TRM9L"
                     /note="hexamer: AATAAA"
     polyA_site      9591
                     /gene="TRMT9B"
                     /gene_synonym="C8orf79; hTRM9L; KIAA1456; TRM9L"
                     /note="major polyA site"
ORIGIN      
        1 attcagtatt gtgtagtaca gaaaagatca cacatgtata tgtcagaagt agatgcacat
       61 gttcttttgg ctttttttct ttgttttatt cttttttcat tttttgtgtt ttttgttagt
      121 ttgttttgaa ttttttttct tgatgcatat gttccttcaa cttattcagt acttccatgt
      181 gcagggctct ggactagact ttcaggatct aaggctgaat cctacacagt cctccctctg
      241 ggaaagtgat gaaacctgtg agctctccta gcaactctgc agtcttcctt caagggcctg
      301 tgcttccttc agagactcac acaagaggtt tatcatgaga aggaccgcac tatttcattt
      361 cactcctaca agttttcatt tacgttacac attgagaaag ttatgagaag caactgtcac
      421 tctctggagg tggagactgc cgtgattcac aaagacaaga ggtaattttc ctgtaatcac
      481 aggatgactc aggatggatc atgaagccgc ccagctggag aagcagcatg tgcacaatgt
      541 gtacgagagc acagcccctt acttcagcga cctgcagagc aaagcctggc ctcgtgtccg
      601 ccagttcctg caagagcaga agccaggcag cctcatcgct gacataggtt gtgggactgg
      661 aaaatatctt aaagtgaaca gccaggtaca taccgtgggc tgtgactact gtgggccact
      721 ggtagagatt gcccggaata gaggatgtga agccatggta tgtgacaacc ttaatctccc
      781 ctttagggat gagggcttcg atgccatcat ctccatagga gtcatacatc atttttctac
      841 aaaacaaaga agaatcagag caataaaaga aatggccagg gtcttagttc ccggaggcca
      901 actgatgatt tacgtttggg caatggaaca aaagaaccgt cactttgaga agcaagacgt
      961 gcttgttcca tggaacaggg ctctgtgttc ccagctcttc tcagagtcca gccagtctgg
     1021 gaggaagagg cagtgtggat acccagaaag aggccatccc taccatcctc cttgctctga
     1081 gtgtagctgt tctgtttgtt ttaaagagca gtgtggttca aaacggtccc acagcgtggg
     1141 ctatgaacct gctatggcaa gaacctgttt tgcaaatatt tctaaggaag gcgaggaaga
     1201 atatggattt tacagcacat taggaaaatc gtttcgttcc tggtttttct ccagatcttt
     1261 ggatgaatcg actctgagga agcaaattga aagagtaaga cccttgaaaa acacagaagt
     1321 ttgggccagt agcactgtaa cagtccagcc ttccagacac tctagtttag actttgatca
     1381 ccaagagcca ttttcaacaa aagggcaaag tttagatgag gaagtgtttg tggaatcttc
     1441 ttctggaaaa cacttggagt ggctgagagc accaggcact ctgaaacatt taaatggaga
     1501 ccatcaaggg gaaatgagga gaaatggagg gggaaatttt ctggatagca ctaatactgg
     1561 tgtgaattgt gtggatgcag gcaacataga agatgataat ccttctgcta gtaaaatatt
     1621 gagaaggatt tctgcagttg attccacaga tttcaaccca gatgatacaa tgtctgtcga
     1681 agatccacag actgatgttt tggactccac agcctttatg cgctactacc atgtgtttcg
     1741 agaaggggag ctctgcagtc tgctcaagga gaatgtgtca gagctccgta tcctgagttc
     1801 tgggaatgat catggtaact ggtgtatcat tgcagagaaa aagagaggtt gtgattgatt
     1861 ggatcctttt agacaactcc tccaaaagat gaaccacatt ctttcctctt ggtttgatat
     1921 ggttacctga atttgcattc agtgttattt gttaatccat ttacgctttg gtctgcagag
     1981 actattaatt atttggttgt tttgttttca tttttgaata agcacagatt ctggcattga
     2041 aagcacttga caaagggtat ttgtgcttaa atgttaatat acaagatctg aagaagcaac
     2101 agaaagtacc cttcagtaca cctcagactt ttttttaacc ccagagagat aaaatacatg
     2161 tatagtgttt ttcagtatta cacattgatt taaaaagatt atgctgttaa ataatctttt
     2221 aaaacggtat ttttataaag tgaggggata atttctggtt ctcaggttat aactgagagc
     2281 agtgtgcaag ataataggta aatttgatcc attgcacaga tatactttga accatgtgat
     2341 gagttatctt gttgccaagg ccttgcttct acttaaagtt ttcagaaaac tgagtgacag
     2401 tggagagaaa caagaagttt tacaaggact ttactaaatt ataagcaaac ttgcttcaaa
     2461 ataagttgac atgtgataat aaggttttca atgtagccca ggaggttttt aaaggcactg
     2521 ttaggctgag catggtggct catgcctgta atcccagcac tttgggaggc caaggcagaa
     2581 ggatcacttg aacccaggag ttcaagaata gcctgggcaa catagcaaga ccccatctct
     2641 ataaaaatta gcaagatgtg gtggtgcatg cctgtcatcc aagctactca agagactgag
     2701 gcaggaggat cacgtgagcc caggaattca aggctgcagt gaactatgat tgcatcactg
     2761 cactgcagcc tgggcaacat agcaagactc tgtctcaaaa taataataat aataataata
     2821 aaggcgttgt tagcttgtaa ggagtggagt atgtaggtag taggagttat atgcaagtac
     2881 ccaagtggta ttcttccaat cttattagaa gcatgaatat tcaagattga tattactatt
     2941 gcttattagc aagattgtta tcaatcatgc ttattagaag gatgaatatc caagaccaag
     3001 attgactaat gatgagtctg catcaagaac taggcatttc ttctgagttg acggactctt
     3061 taggaaagga gaatctaagt gaagcactga ttttagctct gagaacaaac aaattaaggt
     3121 acagcatagt tagccttggt agaggtatga cttggatttg ctgtatcctt taaaatagta
     3181 tctgggcatt tattttattg aaggtgacta cattttatta gttatattag gaatttaggt
     3241 agaatcaact tctactgatt acaggttgaa tttctgtcac tttgtagaga aacgaataga
     3301 ctggacactg tgtggtcact gtttagattt gcccatgggt ctctttaaat ctatgtcatg
     3361 gatcctgaga cacaaatata attaagacag gtctagagac aggagaagca gaaataagtt
     3421 gacccaggag tacagtctca agtagttcat taatgagaaa attgacatct gacaagagtc
     3481 tttttacttt atgctggatg aaaatccaaa tcttgtttta ttttttccac taaaagtgac
     3541 taaaataata acgaatttca tttgttcttg ggttcttttt tcctttaatg attgtgctat
     3601 aacttaaaat aatgatgtta cttttgaaca aacttaaaga aatattttta aagcgtatct
     3661 gaaaacgatt gatgtttata actctctttt ggcttcaaaa taagattgtg ttatcaccat
     3721 tttggtagat gaggttgtct ggtgaaaatg atgcatatga gttgtactgt tcagtgtaca
     3781 tcctgcagta gtggatgatt gaaaacatat ataagtggag tataaattaa aaattaattt
     3841 ggtttcttct atttcttttt tttttttttt tttttgagac agagtctcgc tctgtcgccc
     3901 aggctggagt gcactggcgc gatctcggct cactgtaagc tccgcctccc gggttcacgc
     3961 catcctcctg cctcagcctc ccaagtagct gggactactg gcacccacca cgacgcccgg
     4021 ctgttttttt gtatttttag gagagacggg gtttcaccgt gttagccagg atggtctcga
     4081 tctcctgacg tcgtgatcca cccgcctcgg ccccccacag tgctgggatt acaggcgtga
     4141 gccaccgcgc ccggcctgtt ccttttattt cttaattcag gacactaaac catgactgca
     4201 agggatttcc ttggtaaaaa gaaaagattc tcagagtcaa aatggtctta caactcgggc
     4261 ttgacggcct ttgaattatg aatggattgt tcctctctct gaagcctatt gtcacatggg
     4321 tttttaatcc tggccttgct gctagaaatc tgtgcttgaa gtcctctctt tctgctgcta
     4381 gcctaccagt taaaagtcaa gacttggtgg aactcagttt accagactct ttagcctttg
     4441 agctaaactg tctgagcaac ctcttagatg tgcacacacc actttgtatg aaagggttct
     4501 ctagaacggt tctttggaga gaaatatttt catgtacgtt tgacaggggt gtaaataaag
     4561 catgctgact aataagtctt ttactcttca tctaatgaac ataagaatct atgcatccag
     4621 atattatttt gtatacaaat atttaatttg gtgattgata atctctcttt ggggtagtca
     4681 catggaaagc tcttttaaat ttaacttccg cctttggatt ttttttaaaa agccattgaa
     4741 gagcaaaact aatgtaaacg tcttgatcat ttaaaaagct tgcttgtcct cgaaaggaaa
     4801 cacaggtcat cagtgagtat aaacgtagac agttgatttg tgaatgctgt cggcctcaac
     4861 ttgcttgatg atagattcta ctgacctagc tggagtaatc tgatcactta cttccttatt
     4921 aatactagat cacacagtgt ctttcttatt ccttcttctt tacttactgg catcagcaca
     4981 gagtcccact atctgaaata gaagggagag tttgggggtt tattggagga gtcttaaaaa
     5041 cttggttggc agctgggtac gatgactcac acctgtactc ccagcacttc aggaagctga
     5101 ggtgggtgga tcagctgagg tcaggagttt gagaccagcc tgaccaacat ggtgaaaccc
     5161 cgtctttatt aaatacaaaa aattagccag gttggtggcg catgcctgta atcccagcta
     5221 cttgggaggc tgaggcagga gaatcgcttg aacctgggag gcggaggttg cagtgagccg
     5281 agattgtgcc attgcactcc aacctgggca acaagagtga aactccatct ccaacaaaac
     5341 aaaactttgc tggcttcctg atgcctcact gtctatttga ggaattccac agaatcttca
     5401 aaggatttgg gggaaagcgc attaacatgg acaaaggatg gaatcaaaat aatgttatag
     5461 tgagaatcat tcaagcacct atttaaattt tttccaattg ccagtatagt gatgatatga
     5521 caccagcata tcaaagtaac taacaaacta gctacacaaa cgtcttggag tttggtttcg
     5581 ttctcttttc tcatcataga tctccgtgca gaatagtgct aattcttatt tctcgtttgc
     5641 ctttctattt ccttccaaat tctacatgcc agtaattcct ctgtctttta agtgaccatc
     5701 aattcaatag gcaaaaattt ggagtaatcc agagaaaaaa ccatccaaat ataaaccagc
     5761 taggaacatg aatgcccctg attattaatg gccaaaaaaa aagcactggt ggattttaaa
     5821 ttaaattaat acatatatac gagtttggag gagaacagaa gttctaactc agtacttgaa
     5881 cttggtgggg gagggcacag gttaaatatg agctgtgagc ccccagtttt ggaggaagga
     5941 ggaaatggga accaaccacc agacaagcag ctgcagtcta agaaaaacaa attagggcag
     6001 gcctcagcat ctctttccta ttacatagaa aatctgaaat gagaatagct gtgaactttt
     6061 ctaaatatgc aacattcaac tatcgcaagg acaaaaaacc aaacaccgca tgttctcact
     6121 cataggtggg aattgaacaa tgagaacaca tggacacagt aaggggaaca tcacacactg
     6181 ggacctgttg tgaccccgct gagggagttc ctcttgccct ctacccccgg ggcttgtata
     6241 tagattataa atatataagg gggaaagggg tgggggggag gggttgtgcg gctggggcct
     6301 cacttcccct ccttcccctt ctcctggtcc cctgtcccag gggctgtttg ttaaaaaaga
     6361 gtaataaagg atttttgttt ttaaaaaaag caacgttcat taatttatat gcagtcctca
     6421 ccacagccct ccaagataac tatacttatt gttcccattt tgcagatgag gaaaactgag
     6481 gcagaaagaa attaaattgc ttaaggttac acacatagta ggtatcacac atttagttag
     6541 aggcagagct gggattcaaa cccaggtctg gctcctagtc tctgctctta accacaacac
     6601 catatactcc cacccctggg cccagctcat gtgcttggcg gagtattaga gcctttcaag
     6661 gtaagtgtga ttatcccctt tccaaatgag ctttggaaaa gtttaagcaa agattacaca
     6721 gctagacaat aattcaatag tagtctctta catattttcc cttttatctt tttttcattt
     6781 gtaaatctgt ttcgatttga tttgaattaa aaaatagttc ttggttgcaa aatattctgg
     6841 gaccactttt ctccaactct tcaacctttc aacaattata ttattgtttt cccattttat
     6901 aagtaaggca actgaggact attcagatat ttcattcact ccatttgttt actaagccct
     6961 gctgtgtgct ggatacacag tctgctgtgt gctggataca tatgatacaa ggtaatgact
     7021 atctggcatc ttgaaggtac ccagaatatt agaattaact gacccacagg tgccaagctg
     7081 aaacattctt cgtattccct gtgtgcctat taccaagtta tattgtttag tttgaggaaa
     7141 acaacaaaca accctccctt agagaatcat gatgcatatt agcatattta aggagtaccc
     7201 taaagcttgg acttaatcta gcttacccta gacgtattaa catcctatag cgcacgtgtt
     7261 ctgtgggata tatttcagaa aataatatgt cttacagaat aaatgcagac tcctttggat
     7321 ggcattcagg cccttcataa agtaactctg aattattttt cagtctcatt tcctgcagtt
     7381 gcacccgatt ttttctgttc tgcaatctgc tattttagac aaagctttca taagaaatta
     7441 cataatgaca agtaattccc acattcccta gatatatact tggatttcaa atgccataat
     7501 tgtaatcttt ctccaaagaa aaatgcacga tacaggcttc attctatcaa gaggcatatg
     7561 aggtaagcgt tattatacac ccgtccagca gatgggaaaa ccacggaagt gggagggaat
     7621 caagaagcat taacagaccc tccaccaacc gtaatgctta actcctcttg ttccaatctt
     7681 aactcaaaat tatgattatt ttgattattt aatgattgtt ttgatagtat aaactccata
     7741 tctgcaacct cagttatcta caacactgag gtgcaaacat ttaaaaagat ctctcaccaa
     7801 acaaggattg aaattgtatt gcaaatgaaa gagctcagca tgagagcaca atcagaaact
     7861 gaagagagtt gatcaaagag aagattctag ctgaattgtt ctatttttaa ttccccaggg
     7921 atcctacggt ctatgacaca ttaacagggg tgtgaatcat ttcagttaca tcacatactc
     7981 tgtcctcttg tggtgcgggt cttccccagt tgattataca cagataatca atgactttat
     8041 ttgggaggga ttggagctat agaataatct atcttaccaa tctgatggac catttgtaag
     8101 agctgtttgt caaattggat cttcatttga caaataaata ctagagctgc agaaagtaaa
     8161 gtttactcca acccaattaa tcattaatac atccacagga aaaatacatt ttctccacat
     8221 ggaatattga tttttctatg aatattacct ccacattgaa aaacgagtga gtcactgcag
     8281 ttaagccagt gtaccttgat gttgaattcc ctgaagaagg tacaattata tttacattcc
     8341 cttagcaaga atttggctaa gtgataagca cttttctctt ttcttttctt tttttttttt
     8401 tttttttgag acagtgtctc actctgtcac ccaggctgga gggcagtagt gcagtctcag
     8461 ctcattgcaa cctctgcctc ccaggtttaa gcaattctcg tgcctcagcc tcctgaatag
     8521 ctgggattac aggaacatgc caccactcct ggctaatttt tgtatttttt tttaagtaaa
     8581 gacaaacttt caccatgttg gccaggctgg tcttgaactc ctgacctctt acgagctaat
     8641 cataccactt ctaactagat tttctattaa tgtacaagga gggactccac tactaaagtt
     8701 tgttttactt ctctggttat ttacacaaaa cgctggcaat acattaaggc tcactaatgt
     8761 ggacctaagt gagtatctga gaggctttga atatgtatgt gcaaactgtc ctattttctt
     8821 tatatgctct cttaaatatg tatgtctgta aatatatata taacacacat atatatatat
     8881 tcctagacat ctagtgtttg ctgtcattag tgaccaagaa aaagtagttc ttttgtgcac
     8941 gcgtgaatac atcaaattag caattaccat agaaatgtat ttcattgaat aaatagcttt
     9001 tgtttgtttg tttgtttgtt tcagggaaat ttagaacaat tattagatgt tatagtgcct
     9061 cttctcgtgt tgatacgtgt atttgggtca aaagtgcaaa aacttttttc tacaatgtac
     9121 agttattttg acttttccca ggggaagcta gcaatagttt taaaagcaca aagtgatgta
     9181 aaatattttg acttttataa taatgcgaag tagttttatt tgcattaatc aataatgttc
     9241 aggatctttt tgtagtaagt atattttaaa tggtgtaatt tgtgtgttta tgatatgtat
     9301 tcaattattt aagttaagta tcagtgtatt tttaaaaagt gttcccaggt gaacaaaagt
     9361 ttgcttttct tcaccattct gtacaggaca agcattattc agttcacata gtcagctctc
     9421 actacacttc aacagaacgg ggcaagttcg tatttgaatt ctgttatatt tatctaaggg
     9481 aagcaaaatt aaccttttaa taatagatta tctttaatgg ttattaaaag aatgttattg
     9541 accaaaaaga catattttga gattaataaa gatgtattag attatccaaa a
//
