LOCUS       NM_017910               1844 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tRNA methyltransferase 61B (TRMT61B), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_017910
VERSION     NM_017910.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1844)
  AUTHORS   Zeng,D., Zhu,J., Li,J., Liao,F., Yang,Z., Li,Y., Zhang,J.,
            Cheng,J., Li,S., Li,L. and He,J.
  TITLE     TRMT61B rs4563180 G>C variant reduces hepatoblastoma risk: a
            case-control study of seven medical centers
  JOURNAL   Aging (Albany NY) 15 (15), 7583-7592 (2023)
   PUBMED   37531210
  REMARK    GeneRIF: TRMT61B rs4563180 G>C variant reduces hepatoblastoma risk:
            a case-control study of seven medical centers.
REFERENCE   2  (bases 1 to 1844)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1844)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1844)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1844)
  AUTHORS   Hubel,P., Urban,C., Bergant,V., Schneider,W.M., Knauer,B.,
            Stukalov,A., Scaturro,P., Mann,A., Brunotte,L., Hoffmann,H.H.,
            Schoggins,J.W., Schwemmle,M., Mann,M., Rice,C.M. and Pichlmair,A.
  TITLE     A protein-interaction network of interferon-stimulated genes
            extends the innate immune system landscape
  JOURNAL   Nat Immunol 20 (4), 493-502 (2019)
   PUBMED   30833792
REFERENCE   6  (bases 1 to 1844)
  AUTHORS   Li,X., Xiong,X., Zhang,M., Wang,K., Chen,Y., Zhou,J., Mao,Y.,
            Lv,J., Yi,D., Chen,X.W., Wang,C., Qian,S.B. and Yi,C.
  TITLE     Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear-
            and Mitochondrial-Encoded Transcripts
  JOURNAL   Mol Cell 68 (5), 993-1005 (2017)
   PUBMED   29107537
REFERENCE   7  (bases 1 to 1844)
  AUTHORS   Bar-Yaacov,D., Frumkin,I., Yashiro,Y., Chujo,T., Ishigami,Y.,
            Chemla,Y., Blumberg,A., Schlesinger,O., Bieri,P., Greber,B.,
            Ban,N., Zarivach,R., Alfonta,L., Pilpel,Y., Suzuki,T. and
            Mishmar,D.
  TITLE     Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase
            TRMT61B in All Vertebrates
  JOURNAL   PLoS Biol 14 (9), e1002557 (2016)
   PUBMED   27631568
  REMARK    GeneRIF: 16S rRNA RNA-DNA differences result from a
            1-methyladenosine (m1A) modification introduced by TRMT61B.
            Erratum:[PLoS Biol. 2017 Jan 19;15(1):e1002594. doi:
            10.1371/journal.pbio.1002594.. PMID: 28103231]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1844)
  AUTHORS   Lee,S.Y., Kang,M.G., Park,J.S., Lee,G., Ting,A.Y. and Rhee,H.W.
  TITLE     APEX Fingerprinting Reveals the Subcellular Localization of
            Proteins of Interest
  JOURNAL   Cell Rep 15 (8), 1837-1847 (2016)
   PUBMED   27184847
REFERENCE   9  (bases 1 to 1844)
  AUTHORS   Chujo,T. and Suzuki,T.
  TITLE     Trmt61B is a methyltransferase responsible for 1-methyladenosine at
            position 58 of human mitochondrial tRNAs
  JOURNAL   RNA 18 (12), 2269-2276 (2012)
   PUBMED   23097428
  REMARK    GeneRIF: Unlike the cytoplasmic tRNA m(1)A58 methyltransferase that
            consists of an alpha2beta2 heterotetramer formed by Trmt61A and
            Trmt6, Trmt61B formed a homo-oligomer (presumably a homotetramer)
            that resembled the bacterial homotetrameric m(1)A58
            methyltransferase.
REFERENCE   10 (bases 1 to 1844)
  AUTHORS   Li,S., Wang,L., Berman,M., Kong,Y.Y. and Dorf,M.E.
  TITLE     Mapping a dynamic innate immunity protein interaction network
            regulating type I interferon production
  JOURNAL   Immunity 35 (3), 426-440 (2011)
   PUBMED   21903422
  REMARK    Erratum:[Immunity. 2011 Oct 28;35(4):647-8]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC097720.5, AL136689.1 and BC000952.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017910.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000952.1, SRR3476690.735673.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306108.10/ ENSP00000302801.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC097720.5         43010-43026         c
            18-1840             AL136689.1         1-1823
            1841-1844           BC000952.1         1831-1834
FEATURES             Location/Qualifiers
     source          1..1844
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.2"
     gene            1..1844
                     /gene="TRMT61B"
                     /note="tRNA methyltransferase 61B"
                     /db_xref="GeneID:55006"
                     /db_xref="HGNC:HGNC:26070"
                     /db_xref="MIM:619404"
     exon            1..731
                     /gene="TRMT61B"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1466
                     /gene="TRMT61B"
                     /EC_number="2.1.1.220"
                     /note="potential tRNA (adenine-N(1)-)-methyltransferase
                     catalytic subunit TRMT61B; potential tRNA
                     (adenine(58)-N(1))-methyltransferase catalytic subunit
                     TRMT61B; tRNA (adenine(58)-N(1))-methyltransferase,
                     mitochondrial; tRNA methyltransferase 61 homolog B; mRNA
                     methyladenosine-N(1)-methyltransferase"
                     /codon_start=1
                     /product="tRNA (adenine(58)-N(1))-methyltransferase,
                     mitochondrial precursor"
                     /protein_id="NP_060380.3"
                     /db_xref="CCDS:CCDS1768.1"
                     /db_xref="GeneID:55006"
                     /db_xref="HGNC:HGNC:26070"
                     /db_xref="MIM:619404"
                     /translation="MLMAWCRGPVLLCLRQGLGTNSFLHGLGQEPFEGARSLCCRSSP
                     RDLRDGEREHEAAQRKAPGAESCPSLPLSISDIGTGCLSSLENLRLPTLREESSPREL
                     EDSSGDQGRCGPTHQGSEDPSMLSQAQSATEVEERHVSPSCSTSRERPFQAGELILAE
                     TGEGETKFKKLFRLNNFGLLNSNWGAVPFGKIVGKFPGQILRSSFGKQYMLRRPALED
                     YVVLMKRGTAITFPKDINMILSMMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVIS
                     FEVRKDHHDLAKKNYKHWRDSWKLSHVEEWPDNVDFIHKDISGATEDIKSLTFDAVAL
                     DMLNPHVTLPVFYPHLKHGGVCAVYVVNITQVIELLDGIRTCELALSCEKISEVIVRD
                     WLVCLAKQKNGILAQKVESKINTDVQLDSQEKIGVKGELFQEDDHEESHSDFPYGSFP
                     YVARPVHWQPGHTAFLVKLRKVKPQLN"
     exon            732..834
                     /gene="TRMT61B"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1025
                     /gene="TRMT61B"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1117
                     /gene="TRMT61B"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1344
                     /gene="TRMT61B"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1422
                     /gene="TRMT61B"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1844
                     /gene="TRMT61B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1820..1825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT61B"
                     /note="hexamer: AATAAA"
     polyA_site      1844
                     /gene="TRMT61B"
                     /note="major polyA site"
ORIGIN      
        1 actcgtctgc gacggcgcct tcgcgaaaca ctatgctaat ggcatggtgc cgcggtcctg
       61 tcttgctgtg cctgcggcag gggctcggaa ccaattcatt cctgcacggc ctggggcagg
      121 agcccttcga gggagctcgg tcactgtgtt gcaggtcctc gcctagagac ctgcgagatg
      181 gagaaagaga gcacgaggcg gcacaaagga aagccccagg agcagagtct tgcccatctc
      241 tccctctgag catctcggac attgggactg gatgtctttc gtcactggaa aacctcagac
      301 tgccgacgct gcgggaagag tcatcccctc gagagctcga ggactcgagc ggagaccagg
      361 gccggtgcgg tcccacacac cagggatccg aggatccttc gatgctctcg caggcccagt
      421 ccgctaccga ggtcgaagag cgtcacgtct ccccttcttg ttcaacttcc agagagagac
      481 cctttcaggc tggggaactg attttagctg agactgggga gggagaaaca aaatttaaga
      541 aattatttag gttgaacaac ttcggactct taaatagtaa ctggggggca gtcccgttcg
      601 gcaagatcgt ggggaagttc cccggccaga tactgaggag ttccttcggt aagcagtaca
      661 tgctgaggag gccagccttg gaagactatg tagtattgat gaaaagaggg actgccataa
      721 cattcccaaa ggatattaat atgattctct caatgatgga tatcaaccca ggtgatactg
      781 ttttggaagc tggctcaggc tctggtggaa tgagcttatt tttatccaaa gcagttggat
      841 cacaaggacg agtcataagt tttgaggtac gaaaagacca ccatgatctg gctaagaaga
      901 attacaaaca ctggcgtgat tcatggaaat taagtcatgt agaagagtgg ccagacaatg
      961 tggattttat tcataaggac atttcaggag caaccgaaga cataaaatct ttaacatttg
     1021 acgcagtagc tttggatatg ttaaatcctc atgttacttt gcctgttttt tacccacatc
     1081 ttaagcatgg tggtgtatgt gctgtatatg tagtaaacat cacacaggtt attgaacttt
     1141 tagatggaat tcgcacctgt gaacttgctc tttcatgtga aaagataagc gaggtcattg
     1201 tcagagattg gttggtttgc cttgcaaaac agaaaaatgg aattttagct caaaaagtag
     1261 aatctaaaat caacacagat gtacaactag attctcaaga gaaaattgga gttaaaggtg
     1321 agctgtttca agaggatgac catgaagaat cgcattctga ttttccatat ggatcatttc
     1381 cctatgttgc tagaccagta cactggcaac ctggtcatac agcttttctt gtcaagttga
     1441 ggaaggtcaa accacaactt aactgagtac tccagatgac agtaactgac ttgaagatgg
     1501 aaaaatatca aaatagaact ttatattgaa aatcactgct tccatagatt ggcattttta
     1561 gctattacta tgacttatat aacttataca tataattttg aaaataacaa ctaaaagatg
     1621 tataacatag caaaactgct taaacatccc attttgacac ttgtcttgca gttagtttga
     1681 cattttgtag ttaatgattc caaattggtt tagttgggcc atctcattct tcacttcctg
     1741 taaaccactc catagatttg tctttcttca agaaattagt tttctttcct ttatttgatt
     1801 gatggtcatt gactactgaa ataaaatatg cattttaaga taaa
//
