LOCUS       NM_152307               3217 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens tRNA methyltransferase 61A (TRMT61A), mRNA.
ACCESSION   NM_152307
VERSION     NM_152307.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3217)
  AUTHORS   Wang,Y., Wang,J., Li,X., Xiong,X., Wang,J., Zhou,Z., Zhu,X., Gu,Y.,
            Dominissini,D., He,L., Tian,Y., Yi,C. and Fan,Z.
  TITLE     N1-methyladenosine methylation in tRNA drives liver tumourigenesis
            by regulating cholesterol metabolism
  JOURNAL   Nat Commun 12 (1), 6314 (2021)
   PUBMED   34728628
  REMARK    GeneRIF: N(1)-methyladenosine methylation in tRNA drives liver
            tumourigenesis by regulating cholesterol metabolism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3217)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3217)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3217)
  AUTHORS   Li,X., Xiong,X., Zhang,M., Wang,K., Chen,Y., Zhou,J., Mao,Y.,
            Lv,J., Yi,D., Chen,X.W., Wang,C., Qian,S.B. and Yi,C.
  TITLE     Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear-
            and Mitochondrial-Encoded Transcripts
  JOURNAL   Mol Cell 68 (5), 993-1005 (2017)
   PUBMED   29107537
REFERENCE   5  (bases 1 to 3217)
  AUTHORS   Safra,M., Sas-Chen,A., Nir,R., Winkler,R., Nachshon,A.,
            Bar-Yaacov,D., Erlacher,M., Rossmanith,W., Stern-Ginossar,N. and
            Schwartz,S.
  TITLE     The m1A landscape on cytosolic and mitochondrial mRNA at
            single-base resolution
  JOURNAL   Nature 551 (7679), 251-255 (2017)
   PUBMED   29072297
REFERENCE   6  (bases 1 to 3217)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 3217)
  AUTHORS   Macari,F., El-Houfi,Y., Boldina,G., Xu,H., Khoury-Hanna,S.,
            Ollier,J., Yazdani,L., Zheng,G., Bieche,I., Legrand,N., Paulet,D.,
            Durrieu,S., Bystrom,A., Delbecq,S., Lapeyre,B., Bauchet,L.,
            Pannequin,J., Hollande,F., Pan,T., Teichmann,M., Vagner,S.,
            David,A., Choquet,A. and Joubert,D.
  TITLE     TRM6/61 connects PKCalpha with translational control through
            tRNAi(Met) stabilization: impact on tumorigenesis
  JOURNAL   Oncogene 35 (14), 1785-1796 (2016)
   PUBMED   26234676
  REMARK    GeneRIF: we suggest that PKCA tightly controls TRM6/61 activity to
            prevent translation deregulation that would favor neoplastic
            development.
REFERENCE   8  (bases 1 to 3217)
  AUTHORS   Finer-Moore,J., Czudnochowski,N., O'Connell,J.D. 3rd, Wang,A.L. and
            Stroud,R.M.
  TITLE     Crystal Structure of the Human tRNA m(1)A58
            Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA
            Allows Access to the Methylation Target
  JOURNAL   J Mol Biol 427 (24), 3862-3876 (2015)
   PUBMED   26470919
  REMARK    GeneRIF: The TRM61 heterotetramer is the only active species, both
            subunits are required for orientating tRNA for catalysis at Trm61.
REFERENCE   9  (bases 1 to 3217)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   10 (bases 1 to 3217)
  AUTHORS   Ozanick,S., Krecic,A., Andersland,J. and Anderson,J.T.
  TITLE     The bipartite structure of the tRNA m1A58 methyltransferase from S.
            cerevisiae is conserved in humans
  JOURNAL   RNA 11 (8), 1281-1290 (2005)
   PUBMED   16043508
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL133367.4 and AL139300.6.
            
            On Nov 23, 2018 this sequence version replaced NM_152307.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279830.519.1, SRR1660807.51968.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389749.9/ ENSP00000374399.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AL133367.4         7029-7094           c
            67-426              AL133367.4         5981-6340           c
            427-693             AL133367.4         3442-3708           c
            694-2433            AL133367.4         1-1740              c
            2434-3217           AL139300.6         144261-145044       c
FEATURES             Location/Qualifiers
     source          1..3217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..3217
                     /gene="TRMT61A"
                     /gene_synonym="C14orf172; GCD14; Gcd14p; hTRM61; TRM61"
                     /note="tRNA methyltransferase 61A"
                     /db_xref="GeneID:115708"
                     /db_xref="HGNC:HGNC:23790"
                     /db_xref="MIM:620885"
     exon            1..66
                     /gene="TRMT61A"
                     /gene_synonym="C14orf172; GCD14; Gcd14p; hTRM61; TRM61"
                     /inference="alignment:Splign:2.1.0"
     exon            67..426
                     /gene="TRMT61A"
                     /gene_synonym="C14orf172; GCD14; Gcd14p; hTRM61; TRM61"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..965
                     /gene="TRMT61A"
                     /gene_synonym="C14orf172; GCD14; Gcd14p; hTRM61; TRM61"
                     /EC_number="2.1.1.220"
                     /note="tRNA (adenine-N(1)-)-methyltransferase catalytic
                     subunit TRM61; tRNA(m1A58)-methyltransferase subunit
                     TRM61; tRNA(m1A58)MTase subunit TRM61; tRNA
                     (adenine-N(1)-)-methyltransferase catalytic subunit
                     TRMT61A; tRNA(m1A58)MTase subunit TRMT61A;
                     tRNA(m1A58)-methyltransferase subunit TRMT61A; tRNA
                     methyltransferase 61 homolog A; mRNA
                     methyladenosine-N(1)-methyltransferase catalytic subunit
                     TRMT61A"
                     /codon_start=1
                     /product="tRNA (adenine(58)-N(1))-methyltransferase
                     catalytic subunit TRMT61A"
                     /protein_id="NP_689520.2"
                     /db_xref="CCDS:CCDS41994.1"
                     /db_xref="GeneID:115708"
                     /db_xref="HGNC:HGNC:23790"
                     /db_xref="MIM:620885"
                     /translation="MSFVAYEELIKEGDTAILSLGHGAMVAVRVQRGAQTQTRHGVLR
                     HSVDLIGRPFGSKVTCGRGGWVYVLHPTPELWTLNLPHRTQILYSTDIALITMMLELR
                     PGSVVCESGTGSGSVSHAIIRTIAPTGHLHTVEFHQQRAEKAREEFQEHRVGRWVTVR
                     TQDVCRSGFGVSHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQ
                     ALAARGFSELSTLEVLPQVYNVRTVSLPPPDLGTGTDGPAGSDTSPFRSGTPMKEAVG
                     HTGYLTFATKTPG"
     exon            427..693
                     /gene="TRMT61A"
                     /gene_synonym="C14orf172; GCD14; Gcd14p; hTRM61; TRM61"
                     /inference="alignment:Splign:2.1.0"
     exon            694..3217
                     /gene="TRMT61A"
                     /gene_synonym="C14orf172; GCD14; Gcd14p; hTRM61; TRM61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2169..2174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT61A"
                     /gene_synonym="C14orf172; GCD14; Gcd14p; hTRM61; TRM61"
                     /note="hexamer: AATAAA"
     polyA_site      2189
                     /gene="TRMT61A"
                     /gene_synonym="C14orf172; GCD14; Gcd14p; hTRM61; TRM61"
                     /note="major polyA site"
     regulatory      3194..3199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT61A"
                     /gene_synonym="C14orf172; GCD14; Gcd14p; hTRM61; TRM61"
                     /note="hexamer: ATTAAA"
     polyA_site      3217
                     /gene="TRMT61A"
                     /gene_synonym="C14orf172; GCD14; Gcd14p; hTRM61; TRM61"
ORIGIN      
        1 gttgtggccg ccgccgccgc gcgtcgcgga ggcacgtgtg gagccccggc agcaggagcg
       61 tcgcaggtcc ttggcccttg ccagacatta gcaccatgag cttcgtggca tacgaggagc
      121 tgatcaagga gggtgacacg gccatcctgt cactgggcca tggtgcaatg gtggcggtgc
      181 gtgtgcagcg tggggcacag acccagaccc ggcatggtgt cctgcggcac tcagttgacc
      241 ttatcggccg ccccttcggc tccaaggtga cgtgcggccg aggtggctgg gtgtatgtgc
      301 tgcaccccac gcccgagctc tggacgctga acctgccgca ccgcacgcag atcctctact
      361 ccacagacat cgccctcatc accatgatgt tggagcttcg gcccggctct gtggtctgtg
      421 agtctggcac cggcagtggc tctgtgtccc acgccatcat ccgcaccatt gcacccacgg
      481 gtcacctgca cacggtggag ttccaccagc agcgggcaga gaaggcccgg gaggagttcc
      541 aggagcaccg tgtgggccgc tgggtgactg tgcgcaccca ggacgtgtgc cgcagtggct
      601 ttggcgtgag ccacgtggcc gacgccgtct tcctggacat cccatcaccc tgggaggccg
      661 tgggccacgc ctgggacgcc ctcaaggtcg aaggcgggcg cttctgctcc ttctcaccgt
      721 gcatcgagca ggtgcaacgc acatgccagg cgctggcagc gcgcggcttc tcagagctga
      781 gcaccctgga ggtgctgcca caggtctaca acgtgcgcac tgtcagcctg ccaccgcccg
      841 acctgggcac aggcacagat ggccctgccg gctccgacac cagccccttc cgcagcggca
      901 cgcccatgaa ggaggccgtg ggccacaccg gctacctgac cttcgccacc aagaccccag
      961 gctagggggc cgcctcccag ggcaccaggg agctgggagc actgaagggc tgggcaggga
     1021 ggccagaggc accttatatg gtcagcgatg cctgccagac acagacggtg gggtggggct
     1081 tgggggcctc ctgggtggcc agagtgggac agcaggaagg gcggctgtga tggaggagca
     1141 gtgctggggc tgggcctcag ccattcctgt ccagccctgt ggcccatccc agctgctgtt
     1201 tgttgccaat atgaagtatc cactgccaca ggctcccctg ggtgttgaag ccaaagggtg
     1261 caggtggggg agtctgaccc cctcccaggt gggcctaagc aggaaggggg tggaggaggg
     1321 aggggggcat tgaccctgag accacgctgc gtctgacccc tgggccccca cggccctggc
     1381 tgccccacgg ggcctgagac catctcgtgc ttctccagtc cccgggccga ggctccagcc
     1441 ttggccagaa gctggggtga gctgacccag aatccctgcc ctgctctccc cagcgctagg
     1501 agaccaggcc agcccaggaa ccagggaggt gaccctgctc tctggcctcc tggctgatgt
     1561 cacagcactg agctcagccc aggccttcgt ccactcatgt ccaagaggcg gggcatcccc
     1621 cacccagcca gagcccctga catgggctgc actcgctgag gccaggcagc gctgcggaga
     1681 ggagcggcag agtgggttgt ctgccgcagg caaccaggca agtgtgtcgg ggctggggtg
     1741 tgaatgccag cctgtgagtc ccggaactat gtgggtaccc ctacccctca cagaagccaa
     1801 gggcatggag gaggtccctc cacagtgaca acggtgtggg gtaggggagg tgcattcagg
     1861 acaccaccca gggacagtgc ctatgtgatc acctcttaaa ggctaagctt aggggcattt
     1921 cccaaagtgg ggacagaggg caggacgccc aggctggggg ctctcctcgc ccgccctggt
     1981 gtctgacagc ctcaaggaag gagcagtgcc tgtgtcagcc atggggccct tggagctgcc
     2041 gctggtgcct agggggcctg ggtttctgcc caggcagcca gtggctgttg ggagcctctg
     2101 tttcccctgt gctgggggcc ttgagtgcta tgctagcagg ggcctggccc caagtgtgag
     2161 tgatgagcaa taaacgtacc gtccccctct gttctgagtg atccctagca gccaaggcca
     2221 cccccagctg ctgtctaggc cagccctacc tgcgctctgc ccctggtccc tgctcctccc
     2281 tgtcctggtt tggcatgata ggcgctccag tctccaggac aaaggggcaa atgtgtggcc
     2341 acccccatct ggctgcagaa aaggccactc cttcctgggg ttggggtggt ccaggagtgc
     2401 tgggccttct tccacagtcc tgggctggaa ttcagtgtgg ctgcctgggt tacttgtatg
     2461 cgcccctgaa ggaagggtcc actccaggcc gcctggtccc tgcgaagtgt cacactgtgg
     2521 gtcaccgggg gctgtggcta atgtggtccg ggaggcctgt gtccctgaga gttgctcagc
     2581 cctgctccga gggcttgtcc tctccttcca ggacccagct tcccttctaa ccttgttact
     2641 cacctggggc acagaggagg ggcccccagt caggttcaac atggaagtgg gtgaccctaa
     2701 tgccaggagc tttggggtca ggctgtccct ggggtgtcat gaactgggtg acgcacaccc
     2761 ctgagatctc agttccccca agcctgccct gcccctcctg gccacagcaa aggcctgcat
     2821 ggtgtctgat gggtggacac cgggaggtgt ttctttgagg cgcagctcca tggtttatag
     2881 gacacatagg cctcaggcac cgtagggtcc aggttgtgcc cattttccag ccggggctgg
     2941 ttgccctggt ggcagccctg ggtgagtcac cagggtccgc acatggagag cgggaggtcc
     3001 cagcccaccc ttagttgtca catgggacag agttgctgtg tcaatcccct cggccctgct
     3061 gctctgccct gcacacaggc ccccatgatg accttgagcc tccaggcatc cacccccacc
     3121 gtatggccct ctagacccag ctgggcctca ccccactccc tcagcttgga tcctcacgtg
     3181 gcctggagcc agcattaaac tcctgtatgt ccttcaa
//
