LOCUS       NM_015939               2929 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens tRNA methyltransferase 6 non-catalytic subunit
            (TRMT6), transcript variant 1, mRNA.
ACCESSION   NM_015939
VERSION     NM_015939.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2929)
  AUTHORS   Ma,L., Zhu,J., Zhang,J., Zhang,W., Li,Y., Yang,Z., Li,S., Cheng,J.,
            Li,L., He,J. and Liu,P.
  TITLE     Identification of hepatoblastoma susceptibility loci in the TRMT6
            gene from a seven-center case-control study
  JOURNAL   J Cell Mol Med 28 (1), e18006 (2024)
   PUBMED   37850543
  REMARK    GeneRIF: Identification of hepatoblastoma susceptibility loci in
            the TRMT6 gene from a seven-center case-control study.
REFERENCE   2  (bases 1 to 2929)
  AUTHORS   Chang,X., Zhu,J., Hua,R.X., Deng,C., Zhang,J., Cheng,J., Li,S.,
            Zhou,H., He,J. and Wang,H.
  TITLE     TRMT6 gene rs236110 C > A polymorphism increases the risk of Wilms
            tumor
  JOURNAL   Gene 882, 147646 (2023)
   PUBMED   37473973
  REMARK    GeneRIF: TRMT6 gene rs236110 C > A polymorphism increases the risk
            of Wilms tumor.
REFERENCE   3  (bases 1 to 2929)
  AUTHORS   Wang,Y., Wang,J., Li,X., Xiong,X., Wang,J., Zhou,Z., Zhu,X., Gu,Y.,
            Dominissini,D., He,L., Tian,Y., Yi,C. and Fan,Z.
  TITLE     N1-methyladenosine methylation in tRNA drives liver tumourigenesis
            by regulating cholesterol metabolism
  JOURNAL   Nat Commun 12 (1), 6314 (2021)
   PUBMED   34728628
  REMARK    GeneRIF: N(1)-methyladenosine methylation in tRNA drives liver
            tumourigenesis by regulating cholesterol metabolism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2929)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2929)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2929)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 2929)
  AUTHORS   Finer-Moore,J., Czudnochowski,N., O'Connell,J.D. 3rd, Wang,A.L. and
            Stroud,R.M.
  TITLE     Crystal Structure of the Human tRNA m(1)A58
            Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA
            Allows Access to the Methylation Target
  JOURNAL   J Mol Biol 427 (24), 3862-3876 (2015)
   PUBMED   26470919
REFERENCE   8  (bases 1 to 2929)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   9  (bases 1 to 2929)
  AUTHORS   He,C., Kraft,P., Chen,C., Buring,J.E., Pare,G., Hankinson,S.E.,
            Chanock,S.J., Ridker,P.M., Hunter,D.J. and Chasman,D.I.
  TITLE     Genome-wide association studies identify loci associated with age
            at menarche and age at natural menopause
  JOURNAL   Nat Genet 41 (6), 724-728 (2009)
   PUBMED   19448621
REFERENCE   10 (bases 1 to 2929)
  AUTHORS   Ozanick,S., Krecic,A., Andersland,J. and Anderson,J.T.
  TITLE     The bipartite structure of the tRNA m1A58 methyltransferase from S.
            cerevisiae is conserved in humans
  JOURNAL   RNA 11 (8), 1281-1290 (2005)
   PUBMED   16043508
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC348968.1, BC001262.1,
            AI291549.1 and AL035461.11.
            
            On Nov 22, 2018 this sequence version replaced NM_015939.4.
            
            Summary: This gene encodes a member of the tRNA methyltransferase 6
            protein family. A similar protein in yeast is part of a two
            component methyltransferase, which is involved in the
            posttranslational modification that produces the modified
            nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine
            influences initiator methionine stability and may be involved in
            the replication of human immunodeficiency virus type 1. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.146100.1,
                                           SRR1660803.103337.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000203001.7/ ENSP00000203001.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                DC348968.1         26-81
            57-2309             BC001262.1         1-2253
            2310-2324           AI291549.1         5-19                c
            2325-2929           AL035461.11        30491-31095         c
FEATURES             Location/Qualifiers
     source          1..2929
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.3"
     gene            1..2929
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /note="tRNA methyltransferase 6 non-catalytic subunit"
                     /db_xref="GeneID:51605"
                     /db_xref="HGNC:HGNC:20900"
                     /db_xref="MIM:620886"
     exon            1..256
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1622
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tRNA(m1A58)MTase subunit TRM6; tRNA methyltransferase 6
                     homolog; tRNA (adenine(58)-N(1))-methyltransferase
                     non-catalytic subunit TRM6; mRNA
                     methyladenosine-N(1)-methyltransferase non-catalytic
                     subunit TRM6"
                     /codon_start=1
                     /product="tRNA (adenine(58)-N(1))-methyltransferase
                     non-catalytic subunit TRM6 isoform 1"
                     /protein_id="NP_057023.2"
                     /db_xref="CCDS:CCDS13093.1"
                     /db_xref="GeneID:51605"
                     /db_xref="HGNC:HGNC:20900"
                     /db_xref="MIM:620886"
                     /translation="MEGSGEQPGPQPQHPGDHRIRDGDFVVLKREDVFKAVQVQRRKK
                     VTFEKQWFYLDNVIGHSYGTAFEVTSGGSLQPKKKREEPTAETKEAGTDNRNIVDDGK
                     SQKLTQDDIKALKDKGIKGEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAIITV
                     VKPSTRILSIMYYAREPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCAGLVLGAMM
                     ERMGGFGSIIQLYPGGGPVRAATACFGFPKSFLSGLYEFPLNKVDSLLHGTFSAKMLS
                     SEPKDSALVEESNGTLEEKQASEQENEDSMAEAPESNHPEDQETMETISQDPEHKGPK
                     ERGSKKDYIQEKQRRQEEQRKRHLEAAALLSERNADGLIVASRFHPTPLLLSLLDFVA
                     PSRPFVVYCQYKEPLLECYTKLRERGGVINLRLSETWLRNYQVLPDRSHPKLLMSGGG
                     GYLLSGFTVAMDNLKADTSLKSNASTLESHETEEPAAKKRKCPESDS"
     exon            257..384
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /inference="alignment:Splign:2.1.0"
     exon            385..494
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /inference="alignment:Splign:2.1.0"
     exon            495..586
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /inference="alignment:Splign:2.1.0"
     exon            671..795
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1154
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1240
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1343
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1430
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..2929
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2266..2271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /note="hexamer: AATAAA"
     regulatory      2299..2304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /note="hexamer: ATTAAA"
     polyA_site      2299
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /note="major polyA site"
     polyA_site      2317
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
     regulatory      2690..2695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /note="hexamer: AAGAAA"
     polyA_site      2708
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
     regulatory      2911..2916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
                     /note="hexamer: AATAAA"
     polyA_site      2929
                     /gene="TRMT6"
                     /gene_synonym="CGI-09; GCD10; Gcd10p; TRM6"
ORIGIN      
        1 gcaacacgtg ggggcggtgc cggtcggagg gctcctagtg cgccaggttg tgggaagtga
       61 ggctggcggt ggcgacaacc gaggaggagg ggcgggacgc cgtggagcac ggcgaccggc
      121 tgagcgtcat ggagggctca ggggagcagc cgggcccaca accacagcat cccggagacc
      181 accgcatccg cgacggcgac ttcgtggtgc tgaaacgtga agatgtgttt aaagcagtac
      241 aagtccagcg gagaaaaaaa gtaactttcg aaaaacagtg gttctacctg gataacgtca
      301 ttggccatag ttatggaact gcatttgaag tgaccagtgg aggaagtcta cagcccaaga
      361 agaagaggga agagcctact gcagagacta aagaagcggg cactgataat cgaaatatag
      421 ttgatgatgg gaaatctcag aaacttactc aagatgacat aaaagctttg aaggacaagg
      481 gcattaaagg agaggaaata gttcagcagt taattgaaaa tagtacaaca ttccgagaca
      541 agacagaatt tgcccaagat aaatatatta aaaagaagaa aaaaaaatat gaagccatca
      601 ttactgttgt gaagccatcc acccgtattc tttcaattat gtattatgca agagaacctg
      661 gaaaaattaa ccacatgaga tacgatacac tagcccagat gttgacgttg ggaaatatcc
      721 gtgctggcaa caaaatgatt gtgatggaaa cgtgtgcagg cttggtgctg ggtgcaatga
      781 tggaacgaat gggaggtttt ggctccatta ttcagctata ccctggagga ggacctgttc
      841 gggcagcaac agcatgtttt ggatttccca aatcttttct cagtggtctt tatgaattcc
      901 ctctcaacaa agtggacagt cttctacatg gaacattttc tgccaagatg ttatcttcag
      961 agccaaaaga cagtgctttg gttgaagaaa gtaatggcac actggaggaa aaacaggctt
     1021 ctgaacaaga gaatgaagac agcatggcag aggccccaga gagcaaccac ccagaagacc
     1081 aggaaacaat ggaaacaatt tctcaagatc cagaacataa ggggcctaaa gagagaggaa
     1141 gcaaaaaaga ttatattcag gaaaaacaga ggagacaaga agagcagagg aaaagacatt
     1201 tagaggctgc cgctctgctg agtgaaagaa acgcagatgg tttaattgta gctagtcgtt
     1261 tccaccccac tcccctgctg ctgtctttgc tggactttgt ggccccttca aggccgtttg
     1321 tggtctactg tcagtacaaa gagcctctgt tggaatgcta cacaaaactg cgggagaggg
     1381 gaggggtcat caacctcagg ctgtctgaaa cctggctcag aaattatcag gttttgccag
     1441 atcgaagtca tcctaaactg ctgatgagtg gaggtggggg ttatcttctc tccggcttca
     1501 ccgttgccat ggacaacctt aaagcagaca ccagcctcaa atctaatgca agcactttag
     1561 aatcacacga gactgaggag cctgcagcta aaaaacgaaa atgcccagag tctgactctt
     1621 aacccttttg agaattgctc tgaattttgt tctcaggcat tatacagtta gtaattaaac
     1681 tttaaatgcc attactactt gttttttcat atcccaagaa taagaacatg tctatgtacc
     1741 cgtttctagg aaggaggagt atatgccttt tgtctatttc tgacacagat gcatttggtc
     1801 tgtcaaaact gcaaccatgg ggtatgtagt atgaccaact gcatttaaca aaactcctct
     1861 aagtacttct aaatattctg tgcaaatatc ttgagaactt caacatccta aaaatgtgtt
     1921 tctacaagac tttatatttt aagctaagtg gaataataca acgtaactaa aacatggcgg
     1981 gtaccgaaag gagggcaatt catggaagaa atttcctctg ttcattccgt tctcttcaac
     2041 ctaagcaata tggatgtgtg agtgtgtgat ttattatggt accaaaaatg tccaccttct
     2101 ttcctgcagc ggaataagct tttttgaaat gctgaggttt tattttaata gttgacaacc
     2161 tgggaaagtt ctgagtattt attttactgc tcttttttgt gcatagaaag gtttagtagg
     2221 gtactttttt gcattaattt gccaatactc ttattctttg ttctaaataa agtgactaga
     2281 atttttgtgt actattcaat taaaggaaac aaatgtcttt tccccctcta tggtcttatg
     2341 gatacacatt tgcacacaca cacatatgta tatagatgtt ggtatatata cacacatata
     2401 tttatatata cacagatata tacatacaca tgcaagtgga gacatagatt gtaccacctg
     2461 tatgaatatg tatgtacaca tggggacaga aagagtgtgc agtctatttg aactgtatca
     2521 aagtcttgtg caggacttag accaattctc attgtattag tgtcattcct tgtcaaatgt
     2581 ccctaaagtg cctttcttga ttattaatgc tgaagaactc tgtcatgatt agatggttac
     2641 cctttctaag ctctgaaaaa ctctaatcat ttgatcatgt gctgtagcaa agaaagtgtt
     2701 tagaatcagc caaggctctt gttcatttga gagattgagt cttgctcact ggaacatggt
     2761 catcgtttgc gttgctcctg tcatagaata ggcctgtatc atacagcaag gaacatctca
     2821 gaaaaaaaat tttttttcca aatagcatgt gctatgccaa tgtgattact aagtacaatt
     2881 ttgagtcctt tatcctaatt gctattaaag aataaaaatg tcggccggg
//
