LOCUS       NM_030934               4361 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tRNA methyltransferase 1L (TRMT1L), transcript variant
            1, mRNA.
ACCESSION   NM_030934
VERSION     NM_030934.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4361)
  AUTHORS   Hwang,S.P., Liao,H., Barondeau,K., Han,X., Herbert,C., McConie,H.,
            Shekar,A., Pestov,D.G., Limbach,P.A., Chang,J.T. and Denicourt,C.
  TITLE     TRMT1L-catalyzed m22G27 on tyrosine tRNA is required for efficient
            mRNA translation and cell survival under oxidative stress
  JOURNAL   Cell Rep 44 (1), 115167 (2025)
   PUBMED   39786998
REFERENCE   2  (bases 1 to 4361)
  AUTHORS   Zhang,K., Manning,A.C., Lentini,J.M., Howard,J., Dalwigk,F.,
            Maroofian,R., Efthymiou,S., Chan,P., Eliseev,S.I., Yang,Z.,
            Chang,H., Karimiani,E.G., Bakhshoodeh,B., Houlden,H., Kaiser,S.M.,
            Lowe,T.M. and Fu,D.
  TITLE     Human TRMT1 and TRMT1L paralogs ensure the proper modification
            state, stability, and function of tRNAs
  JOURNAL   Cell Rep 44 (1), 115092 (2025)
   PUBMED   39786990
REFERENCE   3  (bases 1 to 4361)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4361)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 4361)
  AUTHORS   Vauti,F., Goller,T., Beine,R., Becker,L., Klopstock,T.,
            Holter,S.M., Wurst,W., Fuchs,H., Gailus-Durner,V., de Angelis,M.H.
            and Arnold,H.H.
  TITLE     The mouse Trm1-like gene is expressed in neural tissues and plays a
            role in motor coordination and exploratory behaviour
  JOURNAL   Gene 389 (2), 174-185 (2007)
   PUBMED   17198746
  REMARK    GeneRIF: Functional characterization of the mouse C1orf25 ortholog
            and comparison to the human protein.
REFERENCE   6  (bases 1 to 4361)
  AUTHORS   Sood,R., Bonner,T.I., Makalowska,I., Stephan,D.A., Robbins,C.M.,
            Connors,T.D., Morgenbesser,S.D., Su,K., Faruque,M.U., Pinkett,H.,
            Graham,C., Baxevanis,A.D., Klinger,K.W., Landes,G.M., Trent,J.M.
            and Carpten,J.D.
  TITLE     Cloning and characterization of 13 novel transcripts and the human
            RGS8 gene from the 1q25 region encompassing the hereditary prostate
            cancer (HPC1) locus
  JOURNAL   Genomics 73 (2), 211-222 (2001)
   PUBMED   11318611
  REMARK    GeneRIF: Includes the identification of the C1orf25 gene.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB093548.1, BC045535.1,
            AK226103.1 and AF288399.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030934.4.
            
            Summary: This gene encodes a protein that has some similarity to
            N2,N2-dimethylguanosine tRNA methyltransferase from other
            organisms. Studies of the mouse ortholog have shown that this
            protein plays a role in motor coordination and exploratory
            behavior, and it may also be involved in modulating postnatal
            neuronal functions. Alternatively spliced transcripts have been
            identified for this gene. [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.205757.1,
                                           SRR1660807.101521.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367506.10/ ENSP00000356476.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DB093548.1         32-51
            21-3415             BC045535.1         1-3395
            3416-3959           AK226103.1         3162-3705
            3960-3996           AF288399.1         3905-3941
            3997-4361           AK226103.1         3743-4107
FEATURES             Location/Qualifiers
     source          1..4361
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..4361
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /note="tRNA methyltransferase 1L"
                     /db_xref="GeneID:81627"
                     /db_xref="HGNC:HGNC:16782"
                     /db_xref="MIM:611673"
     exon            1..476
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..2443
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TRM1-like protein; TRMT1-like protein; TRM1 tRNA
                     methyltransferase 1-like; tRNA methyltransferase 1
                     homolog-like; tRNA methyltransferase 1 like"
                     /codon_start=1
                     /product="TRMT1-like protein isoform 1"
                     /protein_id="NP_112196.3"
                     /db_xref="CCDS:CCDS1366.1"
                     /db_xref="GeneID:81627"
                     /db_xref="HGNC:HGNC:16782"
                     /db_xref="MIM:611673"
                     /translation="MENMAEEELLPLEKEEVEVAQVQVPTPARDSAGVPAPAPDSALD
                     SAPTPASAPAPAPALAQAPALSPSLASAPEEAKSKRHISIQRQLADLENLAFVTDGNF
                     DSASSLNSDNLDAGNRQACPLCPKEKFRACNSHKLRRHLQNLHWKVSVEFEGYRMCIC
                     HLPCRPVKPNIIGEQITSKMGAHYHCIICSATITRRTDMLGHVRRHMNKGETKSSYIA
                     ASTAKPPKEILKEADTDVQVCPNYSIPQKTDSYFNPKMKLNRQLIFCTLAALAEERKP
                     LECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQENCHLNKLKVVVDSKEK
                     EKSDDILEEGEKNLGNIKVTKMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNIRNL
                     GIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGI
                     EVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPY
                     RQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESLHHGLDDIQTLIKTLIFE
                     SECTPQSQFSIHASSNVNKQEENGVFIKTTDDTTTDNYIAQGKRKSNEMITNLGKKQK
                     TDVSTEHPPFYYNIHRHSIKGMNMPKLKKFLCYLSQAGFRVSRTHFDPMGVRTDAPLM
                     QFKSILLKYSTPTYTGGQSESHVQSASEDTVTERVEMSVNDKAEASGCRRW"
     exon            477..587
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            588..701
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            702..766
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            767..896
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1020
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1100
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1350
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1563
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1754
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1833
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2000
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2063
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2190
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..4361
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4341..4346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /note="hexamer: ATTAAA"
     polyA_site      4361
                     /gene="TRMT1L"
                     /gene_synonym="bG120K12.3; C1orf25; MST070; MSTP070;
                     TRM1L"
                     /note="major polyA site"
ORIGIN      
        1 gtaacgcctc ggggaaaggg aagcggacgg gcatctggaa tcgctgcctc tggctttctg
       61 ttttctacta acaggatttg gtcactggtt cttcatcttt tgtctgttgc acgcatcccg
      121 ccctccccac ttgcttcccc actccttgga tccagccctg tgggcattca cgtcagttct
      181 ctgaccccgc cgtgagcccc gctccgggtc cccgggcggg cttggcacgg aggcggtaac
      241 tatggagaat atggcggagg aggagctgct gcccctggag aaggaggagg tggaggtggc
      301 ccaggtccag gtcccgaccc cggcccggga ctcggctggg gtcccagctc cggccccgga
      361 ttcggctctg gactcggctc cgactccggc ctcggctcca gccccagccc ctgccctggc
      421 ccaggctccg gccctgtccc cgtccctagc ctctgcccct gaggaggcta aaagcaagag
      481 acacatctca attcaaaggc agcttgctga tctagagaat ttagcttttg taactgatgg
      541 aaattttgac tctgccagct cattgaactc agataatctt gatgcaggca acagacaggc
      601 ttgtccattg tgccctaagg aaaaattcag agcttgtaat agccataagc ttcgtcgtca
      661 cctccagaat ttacactgga aagtctcagt tgaatttgaa ggttacagga tgtgcatctg
      721 tcacttacct tgtcgaccag tgaaaccaaa cattattgga gaacagataa ccagtaaaat
      781 gggagcccat tatcattgta tcatttgttc agcaacaatc accagaagaa ctgatatgct
      841 aggacatgtt aggcgccaca tgaataaagg agagactaaa tctagttata ttgcagcttc
      901 cactgctaaa ccacctaagg aaattttgaa agaggcagac acggatgtac aagtttgtcc
      961 caactattct atacctcaga aaacagattc ctattttaac cccaaaatga aactaaatcg
     1021 gcagctaata ttctgtacat tggctgcttt ggctgaggaa cgaaaacctt tggaatgtct
     1081 agatgctttt ggagccactg ggataatggg attacagtgg gcaaaacatc ttggaaatgc
     1141 agtcaaagtt acaatcaatg acttgaatga aaattctgtg acactgattc aggaaaactg
     1201 ccatttaaac aaattgaaag tggtggtgga cagtaaggaa aaggaaaaga gtgatgatat
     1261 tcttgaagaa ggagagaaaa atcttggtaa tattaaggtg accaaaatgg atgccaatgt
     1321 actgatgcat ttgagatctt ttgatttcat acatctagac ccttttggaa catcagtgaa
     1381 ttatctagat tctgcattca gaaatataag aaaccttggc atagtgtcag tgacttctac
     1441 agatatcagt tctttatatg ccaaggcaca gcatgttgcc cggcgtcact acggatgtaa
     1501 cattgtccga actgaatatt acaaggaact agcagccaga attgttgtag ctgcagtggc
     1561 aagagctgca gcccgatgca acaaaggcat agaagtactg tttgcagtgg ctctggaaca
     1621 ttttgtgttg gtagttgtga gagttttgag gggacctact tcagcagatg aaacagccaa
     1681 gaagattcaa tacctgatcc attgtcagtg gtgtgaagag agaatttttc agaaggatgg
     1741 taatatggta gaagaaaacc catatagaca gctgccttgt aactgtcatg gaagcatgcc
     1801 tggaaagaca gcaatagaac ttggacctct gtggtcaagt tcccttttca atactggatt
     1861 cctcaaaaga atgctatttg aatctcttca ccatggtttg gatgacattc agaccctaat
     1921 aaagacatta atctttgaat cagagtgtac gcctcaaagt cagttttcaa ttcatgcatc
     1981 ttcaaatgtc aacaagcaag aagaaaatgg tgtatttatt aaaactacag atgacaccac
     2041 aacagataat tacattgcac aaggaaagag aaaaagtaat gaaatgatca caaatttagg
     2101 caagaagcaa aagactgatg tcagtactga acatcctccc ttttattaca acattcacag
     2161 acacagcatt aaaggaatga atatgccaaa gttaaaaaag tttttgtgct atttatctca
     2221 agcaggcttt cgagtaagcc gaactcattt tgacccaatg ggtgtacgca cagatgcacc
     2281 tctgatgcag tttaaatcta tccttttaaa gtacagcacc cccacctaca ctggaggaca
     2341 gtcagaaagc catgtccagt cagcatctga agatacagta actgaaagag ttgaaatgtc
     2401 agtgaatgac aaagcagaag caagtggctg cagaagatgg taaacgtaga gaagaattgg
     2461 ttctcaggtg tctgtataga tggcctaata gttctctata ccaactgtag ttctttttct
     2521 gttctttcaa ttcagtagag taaaaataaa aaacagtgtc attttcattc agaaactgag
     2581 cagtttctaa cttagctggt ttgggagctt tgctttccaa gttttttttt gttttaaggc
     2641 aaacttaaaa ttttaatgga aacatttcat atgaagccaa gtctcactga gatcacccta
     2701 ctgcttaata attcagaaaa ttttcacatg caaagtgttt ggaattttat gtatgttatg
     2761 aaagccatct tttacaattc ttaatcacat ctctgcctaa actgattcat gatgtttatg
     2821 ttttcctgtt tgtagtgtac aaaatgaagc tgaaggctca catgttaaaa tgaccctgaa
     2881 tagaatagga agaacaatgt tcttacaggt cataatgtat ttcacaatta aaaaactaaa
     2941 atatgtaccc atttttaaga aatcatactt ctctccacat tgatcttttc atttcttact
     3001 agcttttaag aaattaaata cttgcctgag atagaaatac tttatttttg taactttaag
     3061 gtctaaatga ctaaacttca aagtaagatt ttgtcagaat aaattgagac cattaatcta
     3121 atataatact tgttcatgag cactgaaatc ctgaagagga gagatttggt tataaattaa
     3181 aaaggttggg tgatcttaag tgcctcagtt aatgcacgta cagtattcat ttggttggtt
     3241 gtactacctc tcagaagtaa aatttgtcac cttatggaat gagagttttt gggtttgggg
     3301 gttgtttttt tgttgttgct tggtttggta tttttggttt tgtgtgtatt tgtataaatt
     3361 ttctgtataa ttagcccagg ctgatgtaac tataaaaatt agttgaaaaa aaaaatattg
     3421 tttccttaat ggaattctca cttcatttga atataagatt ttggatgaaa ggatttggta
     3481 taaagtttgg gtttttgtct caaggatttg atccatattt atccctaaat atttcttaag
     3541 ggatgtaact ttttataacc attaagtggg gggaaggggg tggagggggt ggtaataatt
     3601 ataactgaaa ggtttaaata tactacctaa gaaaaaagta cttctgtgac atatacaaaa
     3661 aaatctagtg gataggcatt agatgaatag agaatattaa ttttgcagaa atgaaggaaa
     3721 atctcttcgt gctagtacag cgtattccca agagagttta ttttcctttc tccaattaat
     3781 gtggtcataa atttcggtaa aatcaagaaa taggtgaagt gcaagctagt ttctataatg
     3841 accattaaaa aaattctgct gtgtaattct tgccagttaa aattataact tgcaaatgag
     3901 cagaataaat gaggtttttt tcaattaaaa attactataa atccaggagg caaactattt
     3961 tagcactcag attatctgat ttaatacata ttattgaata tcagtctcaa attttgctaa
     4021 atgcttatca gcatgaaata tgttgatcag tgatgagttg ggcttaatgc aaagatccta
     4081 atttaataaa gaaacctgta aattactgtt acctaaaata tatgtgtata ttaatttcac
     4141 atataaaggt agatttttca aagaaaaatt tggtaggcgg tagtttagaa ctctgatcag
     4201 gtactacatc aaccaaaaga ggaaatactt taaaaattcc ttttagcaac ctgagcaatc
     4261 ttattctcgt aacaatagta gtaatttggg acattgcaaa tgtttatcat gttgtaaagt
     4321 agcatcagtt gtatcctttc attaaaactt gataaacaaa a
//
