LOCUS       NM_019083               3128 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens tRNA methyltransferase 13 homolog (TRMT13), transcript
            variant 1, mRNA.
ACCESSION   NM_019083
VERSION     NM_019083.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3128)
  AUTHORS   Li,H., Dong,H., Xu,B., Xiong,Q.P., Li,C.T., Yang,W.Q., Li,J.,
            Huang,Z.X., Zeng,Q.Y., Wang,E.D. and Liu,R.J.
  TITLE     A dual role of human tRNA methyltransferase hTrmt13 in regulating
            translation and transcription
  JOURNAL   EMBO J 41 (6), e108544 (2022)
   PUBMED   34850409
  REMARK    GeneRIF: A dual role of human tRNA methyltransferase hTrmt13 in
            regulating translation and transcription.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL445928.8.
            
            On Feb 9, 2021 this sequence version replaced NM_019083.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002081.1, BC075811.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370141.8/ ENSP00000359160.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AL445928.8         28051-28203
            154-200             AL445928.8         31770-31816
            201-267             AL445928.8         31907-31973
            268-330             AL445928.8         34537-34599
            331-400             AL445928.8         35070-35139
            401-507             AL445928.8         35296-35402
            508-675             AL445928.8         35740-35907
            676-748             AL445928.8         38025-38097
            749-823             AL445928.8         38957-39031
            824-1256            AL445928.8         42782-43214
            1257-3128           AL445928.8         43513-45384
FEATURES             Location/Qualifiers
     source          1..3128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.2"
     gene            1..3128
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /note="tRNA methyltransferase 13 homolog"
                     /db_xref="GeneID:54482"
                     /db_xref="HGNC:HGNC:25502"
     exon            1..153
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1452
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /EC_number="2.1.1.225"
                     /note="isoform 1 is encoded by transcript variant 1; tRNA
                     guanosine-2'-O-methyltransferase TRM13 homolog; tRNA [Gm4]
                     methyltransferase; coiled-coil domain-containing protein
                     76; coiled-coil domain containing 76; tRNA:m(4)X
                     modification enzyme TRM13 homolog"
                     /codon_start=1
                     /product="tRNA:m(4)X modification enzyme TRM13 homolog
                     isoform 1"
                     /protein_id="NP_061956.2"
                     /db_xref="CCDS:CCDS765.1"
                     /db_xref="GeneID:54482"
                     /db_xref="HGNC:HGNC:25502"
                     /translation="MATSATSPHAPGFPAEGRCGYYVEKKKRFCRMVVAAGKRFCGEH
                     AGAAEEEDARKRILCPLDPKHTVYEDQLAKHLKKCNSREKPKPDFYIQDINAGLRDET
                     EIPEQLVPISSLSEEQLEKLIKKLRKASEGLNSTLKDHIMSHPALHDALNDPKNGDSA
                     TKHLKQQASILGNIENLKLLGPRRCFVEFGAGKGKLSHWVDIALKDAEKVHFILVEKV
                     TTRFKVDGKHRKKNSVFERLQIDIQHLCLNKIPVLREEKLPVVGIGKHLCGMATDLAL
                     RCLVETYAASFEERNEEPLAKRIKNDKTEKEIYTLAKEGNEKNVPEKWNPVAGIVIAL
                     CCHHRCDWRHYVGKEYFRALGLGAVEFHYFQRMSSWATCGMRKTSLETSNSTTKRQDN
                     QNDDSEEHDDGGYRITDDGADCLPGLLSVEEKKKIGHLCKLLIDQGRIQYLQQKGFSP
                     ALQYYTDPLVSLENVLLTALPNHSSSPETTA"
     exon            154..200
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /inference="alignment:Splign:2.1.0"
     exon            201..267
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /inference="alignment:Splign:2.1.0"
     exon            268..330
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /inference="alignment:Splign:2.1.0"
     exon            331..400
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /inference="alignment:Splign:2.1.0"
     exon            401..507
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /inference="alignment:Splign:2.1.0"
     exon            508..675
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /inference="alignment:Splign:2.1.0"
     exon            676..748
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /inference="alignment:Splign:2.1.0"
     exon            749..823
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1256
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..3128
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1544..1549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /note="hexamer: AATAAT"
     polyA_site      1564
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /note="major polyA site"
     regulatory      2825..2830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /note="hexamer: AATAAA"
     polyA_site      2848
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
     regulatory      3016..3021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /note="hexamer: ATTAAA"
     polyA_site      3033
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
     regulatory      3106..3111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /note="hexamer: AATAAA"
     polyA_site      3128
                     /gene="TRMT13"
                     /gene_synonym="CCDC76"
                     /note="major polyA site"
ORIGIN      
        1 agaattatgg cgacctccgc gacgtcgccg cacgcgcctg gttttccagc tgagggtaga
       61 tgcggttact atgtggaaaa gaagaaacgg ttctgcagga tggtggtggc cgcagggaaa
      121 agattttgtg gtgaacacgc tggagccgcg gaggaagaag atgctcggaa aagaatcctg
      181 tgtcctttag atccaaaaca cacagtatat gaagatcaac tagcaaagca tttgaaaaaa
      241 tgtaactcaa gagagaaacc aaaacctgat ttctatattc aagatattaa tgcaggctta
      301 agagatgaaa cagaaatacc tgaacaatta gttccaattt cttctctatc tgaagagcag
      361 ttggaaaagt taattaagaa attgagaaaa gcaagtgaag gcttgaattc tacacttaaa
      421 gatcatatta tgtcccatcc agcattacac gatgcactta atgaccctaa aaatggcgat
      481 tctgcaacca agcacctgaa acagcaggct tctattttag gtaacattga aaatttaaag
      541 ttacttggtc caagaagatg ctttgttgag tttggagcgg gaaagggaaa attatctcat
      601 tgggttgata ttgccttaaa agatgctgaa aaagttcact tcatcctagt ggaaaaggtg
      661 accacaagat tcaaggtgga tggaaaacac agaaagaaaa attcagtgtt tgaaagactt
      721 caaattgata ttcaacactt gtgtttgaac aagattcctg tgctaagaga agaaaaacta
      781 cctgtggtag gaattggaaa gcatctgtgt ggtatggcaa cagatcttgc attacgatgt
      841 ttggttgaaa cctatgctgc cagttttgag gaaaggaatg aagaaccttt agccaaacgc
      901 ataaagaatg ataaaacaga aaaagaaatt tacactttgg ccaaggaagg aaatgaaaaa
      961 aatgtcccag agaagtggaa ccctgtggct ggcattgtta ttgcactctg ttgtcaccac
     1021 aggtgtgatt ggagacatta tgtgggcaaa gaatatttca gggctctagg ccttggagca
     1081 gtggaattcc attatttcca gcgaatgagt agttgggcaa cttgtgggat gcggaaaaca
     1141 tctttggaaa cctcaaatag taccacaaag aggcaagata atcagaatga tgatagtgaa
     1201 gagcatgatg atggaggata cagaatcaca gatgatggcg ctgattgttt gcctgggctt
     1261 cttagtgttg aagaaaagaa gaaaataggg catctttgta aattgctgat tgaccaaggt
     1321 cgaatccagt atttgcagca gaagggattc agtcctgctt tgcagtacta tacagaccct
     1381 ctggtgtctt tggaaaatgt tttgttaact gctttaccaa atcattcttc atcaccagaa
     1441 acaactgctt aatggaaaag aaatttgagc atcatctgtc ttccaccaaa aaaaattttt
     1501 taattatatt tttatatcaa aaaaatatat actttaaata gcaaataata tgaactttaa
     1561 aaaatgctgt ggcctcatta aactttggta atagcttttc tttttacttc agaaatccaa
     1621 acattagaga attcaccaaa gtaatcctct ttagaagggc atcttgaatt atattatcca
     1681 tccgtattta tggagattgg taaagtagtt gaaccgttga cttggtgatc tgaaacatac
     1741 ataacatgtc aacacataat tagcgtattt ctgtttgtat taattttgga aatttatctt
     1801 cctttgattt tatttaatat tttttatttc ttaagttcaa gaggtagtga ttgattgtaa
     1861 caagggccaa tctgagaatt tgacttatat gtggacattt ttccctacag atctggaaag
     1921 cacaattgtg attttctcaa atgcagacaa ttcagagata ttcacaatta ataaacacaa
     1981 ttaattaatg aagtcacctt caaatttcca gagccataca tgtatatatt gtcagaatct
     2041 gtccatgaca aacacaaaac tgaagagctg ttttcaaaga aaaaagatta tttcacttaa
     2101 ttattttgtt ggataattgt ctagttagaa cttccaaaaa gatacttaca aacataattc
     2161 acaaatttga aataatttct gaagttgatt agctatctca tatcttttat caggtcattt
     2221 tttatatatg taggcacaaa caataagtat gttctcttct gtttgggaaa ataatttgga
     2281 ataaaataga aattagataa tgaaaccaaa aaccttctca aatttaggcc ttatttaact
     2341 catgactggt ttctatgcac aagaaaatac taaaccaaat atatggtagg actgttattc
     2401 tcttctgcat cttatcccta ttttgtttct gcctttattt gtaaaaattg tcttaattga
     2461 tggtacattt gccaagacaa aggttcagaa ttactaattt tagatattat gatattctga
     2521 aataactatt tttatcctgt agttctatga ttatatgatt tgtaaataag aagcctaacc
     2581 aatttaaaat tcctgacttt agtctcatat atcttgtcag actgtctcgg ttcaaattcc
     2641 aaacctacca tcttcagttg tgcgaccttg ggcatgctac ctaatctctt tgtgcctcaa
     2701 tttcctcctt ttaaaatggg gatgatgatg ataacaataa tacctacctc acaaggttgt
     2761 tgtgagcatc aaatgagata acacaagtaa aatgcataga acagttccaa gcacagagta
     2821 attcaataaa tattaactag taatagtagt ggtagtaact cgtgaatctt tttaataaca
     2881 taataggctt tgattttatt atctctttaa gttgttaact tttttccctt gttataagtt
     2941 ttatgtcaag taaggtagtt tgtttaagtt agttacccat gtccccaatc aagggaacct
     3001 aaatgaagat atatcattaa ataattaacc tttttttatt gtgtcaagca atactaattt
     3061 gtgtcataaa atttgttttg catcattcaa caatttatgc ccagaaataa acaatattct
     3121 acaacagg
//
