LOCUS       NM_016404                812 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens tRNA methyltransferase activator subunit 11-2
            (TRMT112), transcript variant 1, mRNA.
ACCESSION   NM_016404
VERSION     NM_016404.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 812)
  AUTHORS   Khan,A.A., Huang,H., Zhao,Y., Li,H., Pan,R., Wang,S. and Liu,X.
  TITLE     WBSCR22 and TRMT112 synergistically suppress cell proliferation,
            invasion and tumorigenesis in pancreatic cancer via transcriptional
            regulation of ISG15
  JOURNAL   Int J Oncol 60 (3) (2022)
   PUBMED   35088887
  REMARK    GeneRIF: WBSCR22 and TRMT112 synergistically suppress cell
            proliferation, invasion and tumorigenesis in pancreatic cancer via
            transcriptional regulation of ISG15.
REFERENCE   2  (bases 1 to 812)
  AUTHORS   Sepich-Poore,C., Zheng,Z., Schmitt,E., Wen,K., Zhang,Z.S.,
            Cui,X.L., Dai,Q., Zhu,A.C., Zhang,L., Sanchez Castillo,A., Tan,H.,
            Peng,J., Zhuang,X., He,C. and Nachtergaele,S.
  TITLE     The METTL5-TRMT112 N6-methyladenosine methyltransferase complex
            regulates mRNA translation via 18S rRNA methylation
  JOURNAL   J Biol Chem 298 (3), 101590 (2022)
   PUBMED   35033535
REFERENCE   3  (bases 1 to 812)
  AUTHORS   Brumele,B., Mutso,M., Telanne,L., Ounap,K., Spunde,K., Abroi,A. and
            Kurg,R.
  TITLE     Human TRMT112-Methyltransferase Network Consists of Seven Partners
            Interacting with a Common Co-Factor
  JOURNAL   Int J Mol Sci 22 (24), 13593 (2021)
   PUBMED   34948388
  REMARK    GeneRIF: Human TRMT112-Methyltransferase Network Consists of Seven
            Partners Interacting with a Common Co-Factor.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 812)
  AUTHORS   Yang,W.Q., Xiong,Q.P., Ge,J.Y., Li,H., Zhu,W.Y., Nie,Y., Lin,X.,
            Lv,D., Li,J., Lin,H. and Liu,R.J.
  TITLE     THUMPD3-TRMT112 is a m2G methyltransferase working on a broad range
            of tRNA substrates
  JOURNAL   Nucleic Acids Res 49 (20), 11900-11919 (2021)
   PUBMED   34669960
  REMARK    GeneRIF: THUMPD3-TRMT112 is a m2G methyltransferase working on a
            broad range of tRNA substrates.
REFERENCE   5  (bases 1 to 812)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 812)
  AUTHORS   Ounap,K., Leetsi,L., Matsoo,M. and Kurg,R.
  TITLE     The Stability of Ribosome Biogenesis Factor WBSCR22 Is Regulated by
            Interaction with TRMT112 via Ubiquitin-Proteasome Pathway
  JOURNAL   PLoS One 10 (7), e0133841 (2015)
   PUBMED   26214185
  REMARK    GeneRIF: The localization of the TRMT112 protein is determined by
            WBSCR22, and the WBSCR22-TRMT112 complex is localized in the cell
            nucleus.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 812)
  AUTHORS   Zorbas,C., Nicolas,E., Wacheul,L., Huvelle,E., Heurgue-Hamard,V.
            and Lafontaine,D.L.
  TITLE     The human 18S rRNA base methyltransferases DIMT1L and
            WBSCR22-TRMT112 but not rRNA modification are required for ribosome
            biogenesis
  JOURNAL   Mol Biol Cell 26 (11), 2080-2095 (2015)
   PUBMED   25851604
  REMARK    GeneRIF: DIMT1L and WBSCR22-TRMT112 are required for distinct
            pre-rRNA processing reactions leading to synthesis of 18S rRNA.
            Ribosome biogenesis requires the presence of the modification
            enzyme rather than its RNA-modifying catalytic activity.
REFERENCE   8  (bases 1 to 812)
  AUTHORS   Fu,D., Brophy,J.A., Chan,C.T., Atmore,K.A., Begley,U., Paules,R.S.,
            Dedon,P.C., Begley,T.J. and Samson,L.D.
  TITLE     Human AlkB homolog ABH8 Is a tRNA methyltransferase required for
            wobble uridine modification and DNA damage survival
  JOURNAL   Mol Cell Biol 30 (10), 2449-2459 (2010)
   PUBMED   20308323
REFERENCE   9  (bases 1 to 812)
  AUTHORS   Songe-Moller,L., van den Born,E., Leihne,V., Vagbo,C.B.,
            Kristoffersen,T., Krokan,H.E., Kirpekar,F., Falnes,P.O. and
            Klungland,A.
  TITLE     Mammalian ALKBH8 possesses tRNA methyltransferase activity required
            for the biogenesis of multiple wobble uridine modifications
            implicated in translational decoding
  JOURNAL   Mol Cell Biol 30 (7), 1814-1827 (2010)
   PUBMED   20123966
REFERENCE   10 (bases 1 to 812)
  AUTHORS   Figaro,S., Scrima,N., Buckingham,R.H. and Heurgue-Hamard,V.
  TITLE     HemK2 protein, encoded on human chromosome 21, methylates
            translation termination factor eRF1
  JOURNAL   FEBS Lett 582 (16), 2352-2356 (2008)
   PUBMED   18539146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001453.6 and KF455402.1.
            
            On Aug 7, 2019 this sequence version replaced NM_016404.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP316602.1, AF229068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000544844.6/ ENSP00000438349.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AP001453.6         89631-89741         c
            112-213             AP001453.6         89446-89547         c
            214-303             AP001453.6         89240-89329         c
            304-441             AP001453.6         89013-89150         c
            442-796             KF455402.1         1-355               c
            797-812             AP001453.6         88642-88657         c
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..812
                     /gene="TRMT112"
                     /gene_synonym="HSPC152; HSPC170; hTrm112; TRM112;
                     TRMT11-2"
                     /note="tRNA methyltransferase activator subunit 11-2"
                     /db_xref="GeneID:51504"
                     /db_xref="HGNC:HGNC:26940"
                     /db_xref="MIM:618630"
     exon            1..111
                     /gene="TRMT112"
                     /gene_synonym="HSPC152; HSPC170; hTrm112; TRM112;
                     TRMT11-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..411
                     /gene="TRMT112"
                     /gene_synonym="HSPC152; HSPC170; hTrm112; TRM112;
                     TRMT11-2"
                     /note="isoform 1 is encoded by transcript variant 1; tRNA
                     methyltransferase 112 homolog; TRM112-like protein;
                     multifunctional methyltransferase subunit TRM112-like
                     protein; tRNA methyltransferase 11-2 homolog; tRNA
                     methyltransferase subunit 11-2"
                     /codon_start=1
                     /product="multifunctional methyltransferase subunit
                     TRM112-like protein isoform 1"
                     /protein_id="NP_057488.1"
                     /db_xref="CCDS:CCDS8068.1"
                     /db_xref="GeneID:51504"
                     /db_xref="HGNC:HGNC:26940"
                     /db_xref="MIM:618630"
                     /translation="MKLLTHNLLSSHVRGVGSRGFPLRLQATEVRICPVEFNPNFVAR
                     MIPKVEWSAFLEAADNLRLIQVPKGPVEGYEENEEFLRTMHHLLLEVEVIEGTLQCPE
                     SGRMFPISRGIPNMLLSEEETES"
     exon            112..213
                     /gene="TRMT112"
                     /gene_synonym="HSPC152; HSPC170; hTrm112; TRM112;
                     TRMT11-2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..303
                     /gene="TRMT112"
                     /gene_synonym="HSPC152; HSPC170; hTrm112; TRM112;
                     TRMT11-2"
                     /inference="alignment:Splign:2.1.0"
     exon            304..812
                     /gene="TRMT112"
                     /gene_synonym="HSPC152; HSPC170; hTrm112; TRM112;
                     TRMT11-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      561..566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT112"
                     /gene_synonym="HSPC152; HSPC170; hTrm112; TRM112;
                     TRMT11-2"
                     /note="hexamer: ATTAAA"
     polyA_site      581
                     /gene="TRMT112"
                     /gene_synonym="HSPC152; HSPC170; hTrm112; TRM112;
                     TRMT11-2"
                     /note="major polyA site"
     regulatory      690..695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT112"
                     /gene_synonym="HSPC152; HSPC170; hTrm112; TRM112;
                     TRMT11-2"
                     /note="hexamer: AATAAA"
     polyA_site      691
                     /gene="TRMT112"
                     /gene_synonym="HSPC152; HSPC170; hTrm112; TRM112;
                     TRMT11-2"
ORIGIN      
        1 cggttccggc ctggcgagag tttgtgcggc gacatgaaac tgcttaccca caatctgctg
       61 agctcgcatg tgcggggggt ggggtcccgt ggcttccccc tgcgcctcca ggccaccgag
      121 gtccgtatct gccctgtgga attcaacccc aacttcgtgg cgcgtatgat acctaaagtg
      181 gagtggtcgg cgttcctgga ggcggccgat aacttgcgtc tgatccaggt gccgaaaggg
      241 ccggttgagg gatatgagga gaatgaggag tttctgagga ccatgcacca cctgctgctg
      301 gaggtggaag tgatagaggg caccctgcag tgcccggaat ctggacgtat gttccccatc
      361 agccgcggga tccccaacat gctgctgagt gaagaggaaa ctgagagttg attgtgccag
      421 gcgccagttt ttcttgttat gactgtgtat ttttgttgat ctataccctg tttccgaatt
      481 ctgccgtgtg tatccccaac ccttgaccca atgacaccaa acacagtgtt tttgagctcg
      541 gtattatata tttttttctc attaaaggtt taaaaccaaa agcggtttct ctttgcagca
      601 aatatacatt aaaatagagt ctctgtacag ccaagggctc tgggccctgg cttgccccat
      661 gtccctgcgc ctccctggcc aaacccaaaa ataaatatag tgttattgct ctgcagggca
      721 tagaggcagt gctctcctac cccctgagga ggctcgttgg gagctgatgg ggaagccctg
      781 gccaccccag gggtccaggg gctggagtct gc
//
