LOCUS       NM_017819               1813 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens tRNA methyltransferase 10C, mitochondrial RNase P
            subunit (TRMT10C), mRNA.
ACCESSION   NM_017819
VERSION     NM_017819.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1813)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1813)
  AUTHORS   Bhatta,A., Dienemann,C., Cramer,P. and Hillen,H.S.
  TITLE     Structural basis of RNA processing by human mitochondrial RNase P
  JOURNAL   Nat Struct Mol Biol 28 (9), 713-723 (2021)
   PUBMED   34489609
  REMARK    GeneRIF: Structural basis of RNA processing by human mitochondrial
            RNase P.
REFERENCE   3  (bases 1 to 1813)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1813)
  AUTHORS   Karasik,A., Wilhelm,C.A., Fierke,C.A. and Koutmos,M.
  TITLE     Disease-associated mutations in mitochondrial precursor tRNAs
            affect binding, m1R9 methylation, and tRNA processing by mtRNase P
  JOURNAL   RNA 27 (4), 420-432 (2021)
   PUBMED   33380464
  REMARK    GeneRIF: Disease-associated mutations in mitochondrial precursor
            tRNAs affect binding, m1R9 methylation, and tRNA processing by
            mtRNase P.
REFERENCE   5  (bases 1 to 1813)
  AUTHORS   Wang,Q., Zhang,Q., Huang,Y. and Zhang,J.
  TITLE     m1A Regulator TRMT10C Predicts Poorer Survival and Contributes to
            Malignant Behavior in Gynecological Cancers
  JOURNAL   DNA Cell Biol 39 (10), 1767-1778 (2020)
   PUBMED   32833542
  REMARK    GeneRIF: m(1)A Regulator TRMT10C Predicts Poorer Survival and
            Contributes to Malignant Behavior in Gynecological Cancers.
REFERENCE   6  (bases 1 to 1813)
  AUTHORS   Sanchez,M.I., Mercer,T.R., Davies,S.M., Shearwood,A.M.,
            Nygard,K.K., Richman,T.R., Mattick,J.S., Rackham,O. and
            Filipovska,A.
  TITLE     RNA processing in human mitochondria
  JOURNAL   Cell Cycle 10 (17), 2904-2916 (2011)
   PUBMED   21857155
  REMARK    GeneRIF: MRPP1 is essential for transcript processing, RNA
            modification, translation and mitochondrial respiration.
REFERENCE   7  (bases 1 to 1813)
  AUTHORS   Brzezniak,L.K., Bijata,M., Szczesny,R.J. and Stepien,P.P.
  TITLE     Involvement of human ELAC2 gene product in 3' end processing of
            mitochondrial tRNAs
  JOURNAL   RNA Biol 8 (4), 616-626 (2011)
   PUBMED   21593607
REFERENCE   8  (bases 1 to 1813)
  AUTHORS   Holzmann,J., Frank,P., Loffler,E., Bennett,K.L., Gerner,C. and
            Rossmanith,W.
  TITLE     RNase P without RNA: identification and functional reconstitution
            of the human mitochondrial tRNA processing enzyme
  JOURNAL   Cell 135 (3), 462-474 (2008)
   PUBMED   18984158
REFERENCE   9  (bases 1 to 1813)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 1813)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC035967.1 and BU619586.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017819.3.
            
            Summary: This gene encodes the precursor of a subunit of the
            mitochondrial ribonuclease P, which is involved in 5' processing of
            mitochondrial tRNAs. The encoded protein may confer RNA-binding
            capacity to mitochondrial ribonuclease P and may be essential for
            transcript processing, RNA modification, translation and
            mitochondrial respiration. [provided by RefSeq, Nov 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF226052.1, BC035967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000309922.7/
                                                  ENSP00000312356.6
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1608              BC035967.1         7-1614
            1609-1813           BU619586.1         17-221              c
FEATURES             Location/Qualifiers
     source          1..1813
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.3"
     gene            1..1813
                     /gene="TRMT10C"
                     /gene_synonym="COXPD30; HNYA; MRPP1; RG9MTD1"
                     /note="tRNA methyltransferase 10C, mitochondrial RNase P
                     subunit"
                     /db_xref="GeneID:54931"
                     /db_xref="HGNC:HGNC:26022"
                     /db_xref="MIM:615423"
     exon            1..136
                     /gene="TRMT10C"
                     /gene_synonym="COXPD30; HNYA; MRPP1; RG9MTD1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..1813
                     /gene="TRMT10C"
                     /gene_synonym="COXPD30; HNYA; MRPP1; RG9MTD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1360
                     /gene="TRMT10C"
                     /gene_synonym="COXPD30; HNYA; MRPP1; RG9MTD1"
                     /EC_number="2.1.1.218"
                     /EC_number="2.1.1.221"
                     /note="mitochondrial ribonuclease P protein 1; renal
                     carcinoma antigen NY-REN-49; HBV pre-S2 trans-regulated
                     protein 2; RNA (guanine-9-) methyltransferase domain
                     containing 1; mitochondrial RNase P subunit 1; tRNA
                     methyltransferase 10 homolog C; tRNA
                     (adenine(9)-N(1))-methyltransferase; tRNA
                     (guanine(9)-N(1))-methyltransferase; mRNA
                     methyladenosine-N(1)-methyltransferase"
                     /codon_start=1
                     /product="tRNA methyltransferase 10 homolog C precursor"
                     /protein_id="NP_060289.2"
                     /db_xref="CCDS:CCDS43122.1"
                     /db_xref="GeneID:54931"
                     /db_xref="HGNC:HGNC:26022"
                     /db_xref="MIM:615423"
                     /translation="MAAFLKMSVSVNFFRPFTRFLVPFTLHRKRNNLTILQRYMSSKI
                     PAVTYPKNESTPPSEELELDKWKTTMKSSVQEECVSTISSSKDEDPLAATREFIEMWR
                     LLGREVPEHITEEELKTLMECVSNTAKKKYLKYLYTKEKVKKARQIKKEMKAAAREEA
                     KNIKLLETTEEDKQKNFLFLRLWDRNMDIAMGWKGAQAMQFGQPLVFDMAYENYMKRK
                     ELQNTVSQLLESEGWNRRNVDPFHIYFCNLKIDGALHRELVKRYQEKWDKLLLTSTEK
                     SHVDLFPKDSIIYLTADSPNVMTTFRHDKVYVIGSFVDKSMQPGTSLAKAKRLNLATE
                     CLPLDKYLQWEIGNKNLTLDQMIRILLCLKNNGNWQEALQFVPKRKHTGFLEISQHSQ
                     EFINRLKKAKT"
     regulatory      1594..1599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT10C"
                     /gene_synonym="COXPD30; HNYA; MRPP1; RG9MTD1"
                     /note="hexamer: AATAAA"
     polyA_site      1612
                     /gene="TRMT10C"
                     /gene_synonym="COXPD30; HNYA; MRPP1; RG9MTD1"
                     /note="major polyA site"
     regulatory      1626..1631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT10C"
                     /gene_synonym="COXPD30; HNYA; MRPP1; RG9MTD1"
                     /note="hexamer: AATAAT"
     polyA_site      1647
                     /gene="TRMT10C"
                     /gene_synonym="COXPD30; HNYA; MRPP1; RG9MTD1"
     regulatory      1786..1791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMT10C"
                     /gene_synonym="COXPD30; HNYA; MRPP1; RG9MTD1"
                     /note="hexamer: AGTAAA"
     polyA_site      1813
                     /gene="TRMT10C"
                     /gene_synonym="COXPD30; HNYA; MRPP1; RG9MTD1"
ORIGIN      
        1 ggtcggctgt gtagactgtt gggtaggctg cgtgctagct tcggcgcgga tccctgggcg
       61 tccgtacgtc ggagtccttc gtcctccagg gtccctgttc tttgcgccag cgggaaccac
      121 tatctctgca ctcctggggt tttgttacat ggctgctttc ctcaaaatga gtgttagtgt
      181 caatttcttc agacctttca ccaggttttt ggtgccattt acccttcata ggaagagaaa
      241 taacttaaca attttgcaga gatacatgtc ttccaaaata ccagctgtta cttatcctaa
      301 aaatgagagt acaccccctt ctgaagagct agagttggat aagtggaaaa ctaccatgaa
      361 atctagtgtg caagaagaat gtgtttcaac aatctcaagc agtaaggatg aagatcctct
      421 agctgccacc agagagttca ttgagatgtg gagattgctt ggcagagaag taccagaaca
      481 catcactgaa gaagagctca aaacccttat ggaatgtgtt tctaacacag caaaaaaaaa
      541 atatttaaaa tatttatata cgaaggaaaa agtgaaaaaa gctaggcaaa taaaaaagga
      601 aatgaaagca gcagcaaggg aagaagcaaa aaatatcaag ctgctagaaa ccactgagga
      661 agataaacag aaaaactttc tatttttacg actttgggat aggaatatgg acatagcaat
      721 gggctggaag ggtgcccagg ccatgcagtt tggacaacct ttggtttttg acatggctta
      781 cgaaaattat atgaaacgaa aagaattgca gaatactgtt tcccagcttt tagaaagtga
      841 aggatggaac agaagaaatg ttgatccttt ccatatttat ttctgcaatc taaaaataga
      901 tggtgctttg cacagagagt tagttaaacg gtatcaagaa aaatgggaca aattgctttt
      961 aacatcaaca gaaaagtctc atgtagattt atttccaaag gacagtatta tctatttaac
     1021 tgcagattct cccaatgtta tgactacttt caggcatgac aaagtttatg taattgggtc
     1081 ttttgttgat aagagtatgc agccaggcac atccctagcc aaggcaaaac ggctgaacct
     1141 ggcaactgaa tgccttccat tagataaata tttacaatgg gaaattggta acaaaaatct
     1201 caccttagat caaatgatac gtattttgtt atgtctgaaa aacaatggta attggcaaga
     1261 ggctctgcaa ttcgttccca agagaaaaca tactggtttt ctggagattt ctcagcattc
     1321 tcaagagttt atcaacagac taaagaaggc aaagacttaa ttcattttca aaaggttctc
     1381 tgaatgtgca cagaacacgt ggctcaaatg agaacatttg atggcttaaa aagtaaatgc
     1441 gttagaaata cagttctgtt aatgtatttc ttcccaaaca attcattttt ctcttctaaa
     1501 ggtagtcttt cccaactgac tgtagggttg tgtcttttcc caattaaata tctgcagaac
     1561 tttgggatta tactttgttt actgtagaaa gataataaaa agagttgtcc aagattgttg
     1621 aacagaataa tctttatccc agttaaatag ttgtaccatt ggtagacttt tttatggagg
     1681 ttcctagagg gtggtgccct ggggtgggct tggaagctct gcaccccttc ccccatagct
     1741 ttccccgtgc atctctttgt ctgtatgttt tgtaatatct tttacagtaa actggtaaat
     1801 gtgtttcctt caa
//
