LOCUS       NP_057565                441 aa            linear   PRI 29-APR-2025
DEFINITION  tRNA (adenine(37)-N6)-methyltransferase isoform 1 [Homo sapiens].
ACCESSION   NP_057565
VERSION     NP_057565.3
DBSOURCE    REFSEQ: accession NM_016481.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 441)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 441)
  AUTHORS   Kimura,S., Miyauchi,K., Ikeuchi,Y., Thiaville,P.C.,
            Crecy-Lagard,Vd. and Suzuki,T.
  TITLE     Discovery of the beta-barrel-type RNA methyltransferase responsible
            for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs
  JOURNAL   Nucleic Acids Res 42 (14), 9350-9365 (2014)
   PUBMED   25063302
REFERENCE   3  (residues 1 to 441)
  AUTHORS   Eriksson,N., Tung,J.Y., Kiefer,A.K., Hinds,D.A., Francke,U.,
            Mountain,J.L. and Do,C.B.
  TITLE     Novel associations for hypothyroidism include known autoimmune risk
            loci
  JOURNAL   PLoS One 7 (4), e34442 (2012)
   PUBMED   22493691
REFERENCE   4  (residues 1 to 441)
  AUTHORS   Letra,A., Menezes,R., Govil,M., Fonseca,R.F., McHenry,T.,
            Granjeiro,J.M., Castilla,E.E., Orioli,I.M., Marazita,M.L. and
            Vieira,A.R.
  TITLE     Follow-up association studies of chromosome region 9q and
            nonsyndromic cleft lip/palate
  JOURNAL   Am J Med Genet A 152A (7), 1701-1710 (2010)
   PUBMED   20583170
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (residues 1 to 441)
  AUTHORS   Takahashi,M., Saenko,V.A., Rogounovitch,T.I., Kawaguchi,T.,
            Drozd,V.M., Takigawa-Imamura,H., Akulevich,N.M., Ratanajaraya,C.,
            Mitsutake,N., Takamura,N., Danilova,L.I., Lushchik,M.L.,
            Demidchik,Y.E., Heath,S., Yamada,R., Lathrop,M., Matsuda,F. and
            Yamashita,S.
  TITLE     The FOXE1 locus is a major genetic determinant for
            radiation-related thyroid carcinoma in Chernobyl
  JOURNAL   Hum Mol Genet 19 (12), 2516-2523 (2010)
   PUBMED   20350937
REFERENCE   6  (residues 1 to 441)
  AUTHORS   Moreno,L.M., Mansilla,M.A., Bullard,S.A., Cooper,M.E., Busch,T.D.,
            Machida,J., Johnson,M.K., Brauer,D., Krahn,K., Daack-Hirsch,S.,
            L'heureux,J., Valencia-Ramirez,C., Rivera,D., Lopez,A.M.,
            Moreno,M.A., Hing,A., Lammer,E.J., Jones,M., Christensen,K.,
            Lie,R.T., Jugessur,A., Wilcox,A.J., Chines,P., Pugh,E., Doheny,K.,
            Arcos-Burgos,M., Marazita,M.L., Murray,J.C. and Lidral,A.C.
  TITLE     FOXE1 association with both isolated cleft lip with or without
            cleft palate, and isolated cleft palate
  JOURNAL   Hum Mol Genet 18 (24), 4879-4896 (2009)
   PUBMED   19779022
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (residues 1 to 441)
  AUTHORS   Liu,L.X., Margottin,F., Le Gall,S., Schwartz,O., Selig,L.,
            Benarous,R. and Benichou,S.
  TITLE     Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with
            Nef-mediated CD4 down-regulation
  JOURNAL   J Biol Chem 272 (21), 13779-13785 (1997)
   PUBMED   9153233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL499604.9.
            
            On Dec 2, 2006 this sequence version replaced NP_057565.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000213.1, BC002863.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375119.8/ ENSP00000364260.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     Protein         1..441
                     /product="tRNA (adenine(37)-N6)-methyltransferase isoform
                     1"
                     /note="Nef associated protein 1; Nef (lentivirus
                     myristoylated factor) associated protein 1; thioesterase
                     NAP1; nef-associated protein 1; tRNA
                     (adenine(37)-N6)-methyltransferase"
                     /calculated_mol_wt=48456
     Site            order(32..33,73..75,77,84,88,112..117,121,123,125,
                     154..159)
                     /site_type="other"
                     /note="homodimer interaction site [polypeptide binding]"
                     /db_xref="CDD:187753"
     Region          45..164
                     /region_name="TrmO"
                     /note="tRNA-methyltransferase O; pfam01980"
                     /db_xref="CDD:460402"
     Site            order(87,89..90,117,125,127,146,151)
                     /site_type="active"
                     /note="cofactor binding site [active]"
                     /db_xref="CDD:187753"
     Region          179..231
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BU70.2)"
     Region          264..284
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BU70.2)"
     Region          335..403
                     /region_name="TrmO_C"
                     /note="TrmO C-terminal domain; pfam18389"
                     /db_xref="CDD:465738"
     CDS             1..441
                     /gene="TRMO"
                     /gene_synonym="C9orf156; HSPC219; NAP1"
                     /coded_by="NM_016481.5:8..1333"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS6730.1"
                     /db_xref="GeneID:51531"
                     /db_xref="HGNC:HGNC:30967"
ORIGIN      
        1 mrgleesgpr ptatpcgcvk paletgnllt epvgylescf sakngtprqp sicsysracl
       61 rirkrifnnp ehslmgleqf shvwilfvfh knghlsckak vqpprlngak tgvfstrsph
      121 rpnaigltla klekveggai ylsgidmihg tpvldikpyi aeydspqnvm epladfnlqn
      181 nqhtpntvsq sdsktdscdq rqlsgcdepq phhstkrkpk cpedrtseen ylthsdtari
      241 qqafpmhrei avdfglesrr dqsssvaeeq igpycpeksf sekgtdkkle rvegaavlqg
      301 sraetqpmap hcpagradga prsvvpawvt eapvatlevr ftphaemdlg qlssqdvgqa
      361 sfkyfqsaee akraieavls adprsvyrrk lcqdrlfyft vdiahvtcwf gdgfaevlri
      421 kpasepvhmt gpvgslvslg s
//
