LOCUS       NM_001371661            1402 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens tRNA methyltransferase O (TRMO), transcript variant 7,
            mRNA.
ACCESSION   NM_001371661 XM_005252049
VERSION     NM_001371661.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1402)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1402)
  AUTHORS   Kimura,S., Miyauchi,K., Ikeuchi,Y., Thiaville,P.C.,
            Crecy-Lagard,Vd. and Suzuki,T.
  TITLE     Discovery of the beta-barrel-type RNA methyltransferase responsible
            for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs
  JOURNAL   Nucleic Acids Res 42 (14), 9350-9365 (2014)
   PUBMED   25063302
REFERENCE   3  (bases 1 to 1402)
  AUTHORS   Eriksson,N., Tung,J.Y., Kiefer,A.K., Hinds,D.A., Francke,U.,
            Mountain,J.L. and Do,C.B.
  TITLE     Novel associations for hypothyroidism include known autoimmune risk
            loci
  JOURNAL   PLoS One 7 (4), e34442 (2012)
   PUBMED   22493691
REFERENCE   4  (bases 1 to 1402)
  AUTHORS   Letra,A., Menezes,R., Govil,M., Fonseca,R.F., McHenry,T.,
            Granjeiro,J.M., Castilla,E.E., Orioli,I.M., Marazita,M.L. and
            Vieira,A.R.
  TITLE     Follow-up association studies of chromosome region 9q and
            nonsyndromic cleft lip/palate
  JOURNAL   Am J Med Genet A 152A (7), 1701-1710 (2010)
   PUBMED   20583170
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1402)
  AUTHORS   Takahashi,M., Saenko,V.A., Rogounovitch,T.I., Kawaguchi,T.,
            Drozd,V.M., Takigawa-Imamura,H., Akulevich,N.M., Ratanajaraya,C.,
            Mitsutake,N., Takamura,N., Danilova,L.I., Lushchik,M.L.,
            Demidchik,Y.E., Heath,S., Yamada,R., Lathrop,M., Matsuda,F. and
            Yamashita,S.
  TITLE     The FOXE1 locus is a major genetic determinant for
            radiation-related thyroid carcinoma in Chernobyl
  JOURNAL   Hum Mol Genet 19 (12), 2516-2523 (2010)
   PUBMED   20350937
REFERENCE   6  (bases 1 to 1402)
  AUTHORS   Moreno,L.M., Mansilla,M.A., Bullard,S.A., Cooper,M.E., Busch,T.D.,
            Machida,J., Johnson,M.K., Brauer,D., Krahn,K., Daack-Hirsch,S.,
            L'heureux,J., Valencia-Ramirez,C., Rivera,D., Lopez,A.M.,
            Moreno,M.A., Hing,A., Lammer,E.J., Jones,M., Christensen,K.,
            Lie,R.T., Jugessur,A., Wilcox,A.J., Chines,P., Pugh,E., Doheny,K.,
            Arcos-Burgos,M., Marazita,M.L., Murray,J.C. and Lidral,A.C.
  TITLE     FOXE1 association with both isolated cleft lip with or without
            cleft palate, and isolated cleft palate
  JOURNAL   Hum Mol Genet 18 (24), 4879-4896 (2009)
   PUBMED   19779022
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1402)
  AUTHORS   Liu,L.X., Margottin,F., Le Gall,S., Schwartz,O., Selig,L.,
            Benarous,R. and Benichou,S.
  TITLE     Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with
            Nef-mediated CD4 down-regulation
  JOURNAL   J Biol Chem 272 (21), 13779-13785 (1997)
   PUBMED   9153233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL499604.9.
            
            On Jul 19, 2019 this sequence version replaced XM_005252049.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2636178.1,
                                           DRR138512.280772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AL499604.9         140702-140784       c
            84-241              AL499604.9         131685-131842       c
            242-898             AL499604.9         128244-128900       c
            899-1402            AL499604.9         122773-123276       c
FEATURES             Location/Qualifiers
     source          1..1402
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..1402
                     /gene="TRMO"
                     /gene_synonym="C9orf156; HSPC219; NAP1"
                     /note="tRNA methyltransferase O"
                     /db_xref="GeneID:51531"
                     /db_xref="HGNC:HGNC:30967"
     exon            1..83
                     /gene="TRMO"
                     /gene_synonym="C9orf156; HSPC219; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            84..241
                     /gene="TRMO"
                     /gene_synonym="C9orf156; HSPC219; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            242..898
                     /gene="TRMO"
                     /gene_synonym="C9orf156; HSPC219; NAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1158
                     /gene="TRMO"
                     /gene_synonym="C9orf156; HSPC219; NAP1"
                     /note="isoform 2 is encoded by transcript variant 7; Nef
                     associated protein 1; Nef (lentivirus myristoylated
                     factor) associated protein 1; thioesterase NAP1;
                     nef-associated protein 1; tRNA
                     (adenine(37)-N6)-methyltransferase"
                     /codon_start=1
                     /product="tRNA (adenine(37)-N6)-methyltransferase isoform
                     2"
                     /protein_id="NP_001358590.1"
                     /db_xref="CCDS:CCDS83387.1"
                     /db_xref="GeneID:51531"
                     /db_xref="HGNC:HGNC:30967"
                     /translation="MIHGTPVLDIKPYIAEYDSPQNVMEPLADFNLQNNQHTPNTVSQ
                     SDSKTDSCDQRQLSGCDEPQPHHSTKRKPKCPEDRTSEENYLTHSDTARIQQAFPMHR
                     EIAVDFGLESRRDQSSSVAEEQIGPYCPEKSFSEKGTDKKLERVEGAAVLQGSRAETQ
                     PMAPHCPAGRADGAPRSVVPAWVTEAPVATLEVRFTPHAEMDLGQLSSQDVGQASFKY
                     FQSAEEAKRAIEAVLSADPRSVYRRKLCQDRLFYFTVDIAHVTCWFGDGFAEVLRIKP
                     ASEPVHMTGPVGSLVSLGS"
     exon            899..1402
                     /gene="TRMO"
                     /gene_synonym="C9orf156; HSPC219; NAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1329..1334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMO"
                     /gene_synonym="C9orf156; HSPC219; NAP1"
                     /note="hexamer: AACAAA"
     regulatory      1339..1344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMO"
                     /gene_synonym="C9orf156; HSPC219; NAP1"
                     /note="hexamer: TATAAA"
     regulatory      1344..1349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMO"
                     /gene_synonym="C9orf156; HSPC219; NAP1"
                     /note="hexamer: AATACA"
     polyA_site      1345
                     /gene="TRMO"
                     /gene_synonym="C9orf156; HSPC219; NAP1"
                     /note="major polyA site"
     polyA_site      1358
                     /gene="TRMO"
                     /gene_synonym="C9orf156; HSPC219; NAP1"
     polyA_site      1363
                     /gene="TRMO"
                     /gene_synonym="C9orf156; HSPC219; NAP1"
     regulatory      1383..1388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRMO"
                     /gene_synonym="C9orf156; HSPC219; NAP1"
                     /note="hexamer: ATTAAA"
     polyA_site      1402
                     /gene="TRMO"
                     /gene_synonym="C9orf156; HSPC219; NAP1"
                     /note="major polyA site"
ORIGIN      
        1 agtagccatg cgcggcttgg aggagtcggg gcctcggcct acagcgaccc cgtgcggctg
       61 cgttaagccg gctctggaga caggattttg tttgtttttc acaaaaatgg tcatttgagc
      121 tgtaaggcaa aagtgcagcc tcctaggctg aatggtgcaa agactggagt tttttccaca
      181 aggagccctc atcgtcccaa tgcaatagga ctgaccctgg ccaagctgga aaaggtagaa
      241 ggtggagcta tatacctttc tggaattgac atgatacatg gcacacccgt actagacatc
      301 aagccctaca tagctgagta tgactcaccg caaaatgtga tggagccttt agcagacttt
      361 aatttacaga ataaccaaca tacaccaaac actgtgtccc agtctgacag caagactgac
      421 agctgtgacc agcgacagct ctcagggtgt gatgagccac aaccccacca tagcactaag
      481 aggaaaccta aatgtcctga agacagaact tcagaagaaa actacctgac acacagtgac
      541 acagccagaa ttcagcaagc atttcctatg cacagggaga tagcagtgga ttttggtttg
      601 gaatcaagac gtgatcagag ttccagcgtg gcagaagaac aaattggccc atattgccca
      661 gagaagagct tttcagagaa aggtacagac aagaagctag aaagagtgga aggagcagca
      721 gtcttgcaag gaagcagggc agagacacag cccatggccc ctcactgccc tgctggaagg
      781 gctgatggag ctccccgcag cgtggttcct gcctgggtga cagaggctcc tgtggccact
      841 ttagaagtgc ggtttactcc tcatgccgag atggaccttg ggcagctcag ttcacaagat
      901 gttggtcagg cgtcatttaa atattttcag tcagcagagg aagcaaagcg tgccattgag
      961 gctgtgctgt cagcggatcc tcggtctgtg taccgccgga agctttgcca ggaccgcctt
     1021 ttctacttta ctgtagacat agcgcatgtc acttgctggt ttggtgatgg ctttgcagag
     1081 gtgctgagga tcaagccggc ttctgagcct gttcatatga ctggccctgt ggggtccttg
     1141 gtgtctctag ggtcttaagg agcctccctc atgtctttaa ggtagcatca ttgatctttg
     1201 gatgtggctt ttggattttc tgaacaagct aatgttgtgt cgagaagcaa cactttgtga
     1261 tctcatggct ttgattgatt tgggctgttc aaaatgttta tttgaaaaac gtatacatta
     1321 ataaacttaa caaagagata taaaatacag agaaatcacc aaatgctttt tgatctgttg
     1381 atattaaaga atcaaaaggt ga
//
