LOCUS       NM_024038                879 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens telomerase RNA component interacting RNase (TRIR),
            transcript variant 1, mRNA.
ACCESSION   NM_024038
VERSION     NM_024038.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 879)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 879)
  AUTHORS   Xie,J., Chen,Z., Zhang,X., Chen,H. and Guan,W.
  TITLE     Identification of an RNase that preferentially cleaves A/G
            nucleotides
  JOURNAL   Sci Rep 7, 45207 (2017)
   PUBMED   28322335
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 879)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC000216.2.
            
            On Nov 22, 2018 this sequence version replaced NM_024038.3.
            
            Transcript Variant: This variant (1) encodes the longest protein
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000216.2, BM925747.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242784.5/ ENSP00000242784.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-879               BC000216.2         32-910
FEATURES             Location/Qualifiers
     source          1..879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..879
                     /gene="TRIR"
                     /gene_synonym="C19orf43; fSAP18; TERCIR"
                     /note="telomerase RNA component interacting RNase"
                     /db_xref="GeneID:79002"
                     /db_xref="HGNC:HGNC:28424"
     exon            1..372
                     /gene="TRIR"
                     /gene_synonym="C19orf43; fSAP18; TERCIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..558
                     /gene="TRIR"
                     /gene_synonym="C19orf43; fSAP18; TERCIR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C19orf43; My029 protein;
                     exoribonuclease TRIR"
                     /codon_start=1
                     /product="telomerase RNA component interacting RNase
                     isoform 1"
                     /protein_id="NP_076943.1"
                     /db_xref="CCDS:CCDS12279.1"
                     /db_xref="GeneID:79002"
                     /db_xref="HGNC:HGNC:28424"
                     /translation="MAARGRRAEPQGREAPGPAGGGGGGSRWAESGSGTSPESGDEEV
                     SGAGSSPVSGGVNLFANDGSFLELFKRKMEEEQRQRQEEPPPGPQRPDQSAAAAGPGD
                     PKRKGGPGSTLSFVGKRRGGNKLALKTGIVAKKQKTEDEVLTSKGDAWAKYMAEVKKY
                     KAHQCGDDDKTRPLVK"
     exon            373..450
                     /gene="TRIR"
                     /gene_synonym="C19orf43; fSAP18; TERCIR"
                     /inference="alignment:Splign:2.1.0"
     exon            451..879
                     /gene="TRIR"
                     /gene_synonym="C19orf43; fSAP18; TERCIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      854..859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIR"
                     /gene_synonym="C19orf43; fSAP18; TERCIR"
                     /note="hexamer: AGTAAA"
     polyA_site      879
                     /gene="TRIR"
                     /gene_synonym="C19orf43; fSAP18; TERCIR"
                     /note="major polyA site"
ORIGIN      
        1 gtcctttgcg cggcacctgg cgacaaaatg gctgcccgag ggagacgggc ggagcctcag
       61 ggccgggagg ctccgggccc cgcgggcggt ggcggtggcg ggagccgttg ggctgagtcg
      121 ggatcgggga cgtcgcccga gagcggggac gaggaggtgt cgggcgcggg ttcgagcccg
      181 gtgtcgggcg gcgtgaactt gttcgccaac gacggcagct tcctggagct gttcaagcgg
      241 aagatggagg aggagcagcg gcagcggcag gaggagccgc ccccgggtcc gcagcgaccc
      301 gaccagtcgg ccgccgccgc tggccccggg gatccgaaga ggaagggcgg tccgggctcc
      361 acacttagct tcgtgggcaa acgcagaggc gggaacaaac tagccctcaa gacgggaata
      421 gtagccaaga agcagaagac ggaggatgag gtattaacaa gtaaaggtga cgcgtgggcc
      481 aagtacatgg cagaagtgaa aaagtacaaa gctcaccagt gcggtgacga tgataaaact
      541 cggcccctgg tgaaatgacg cccctccccc acctgcccat ggcctgggac tctctgcgat
      601 gtacataact atttaatgca gcggcagcgg cgacagcctt ccctgagagg acttaaaagc
      661 agaaggaaac cgagatgctt cccgcagccg tggacgattc tccaggactc tttttttacc
      721 ttgagcactt gcctcgtgag acttcataga acagtggttt actgtccccc ccttctcacc
      781 tcctcattct ctctggctct ttctgtcttc ctcttctcac cctcctccct ccccttagcc
      841 atcacttctg ggaagtaaag aacttgactt agtgccgga
//
