LOCUS       NM_001329739             856 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens telomerase RNA component interacting RNase (TRIR),
            transcript variant 3, mRNA.
ACCESSION   NM_001329739
VERSION     NM_001329739.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 856)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 856)
  AUTHORS   Xie,J., Chen,Z., Zhang,X., Chen,H. and Guan,W.
  TITLE     Identification of an RNase that preferentially cleaves A/G
            nucleotides
  JOURNAL   Sci Rep 7, 45207 (2017)
   PUBMED   28322335
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 856)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018761.6.
            
            On May 31, 2019 this sequence version replaced NM_001329739.1.
            
            Transcript Variant: This variant (3) uses an alternate splice site,
            which results in a frameshift, compared to variant 1. The encoded
            protein (isoform 3) has a distinct, shorter C-terminus compared to
            isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.293743.1, BX376854.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155751, SAMEA2162946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               AC018761.6         79055-79403         c
            350-427             AC018761.6         76063-76140         c
            428-856             AC018761.6         75359-75787         c
FEATURES             Location/Qualifiers
     source          1..856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..856
                     /gene="TRIR"
                     /gene_synonym="C19orf43; fSAP18; TERCIR"
                     /note="telomerase RNA component interacting RNase"
                     /db_xref="GeneID:79002"
                     /db_xref="HGNC:HGNC:28424"
     exon            1..349
                     /gene="TRIR"
                     /gene_synonym="C19orf43; fSAP18; TERCIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..426
                     /gene="TRIR"
                     /gene_synonym="C19orf43; fSAP18; TERCIR"
                     /note="isoform 3 is encoded by transcript variant 3;
                     uncharacterized protein C19orf43; My029 protein;
                     exoribonuclease TRIR"
                     /codon_start=1
                     /product="telomerase RNA component interacting RNase
                     isoform 3"
                     /protein_id="NP_001316668.1"
                     /db_xref="CCDS:CCDS86710.1"
                     /db_xref="GeneID:79002"
                     /db_xref="HGNC:HGNC:28424"
                     /translation="MAARGRRAEPQGREAPGPAGGGGGGSRWAESGSGTSPESGDEEV
                     SGAGSSPVSGGVNLFANDGSFLELFKRKMEEEQRQRQEEPPPGPQRPDQSAAAAGPGD
                     PKRKGGGQTQRREQTSPQDGNSSQEAEDGG"
     exon            350..427
                     /gene="TRIR"
                     /gene_synonym="C19orf43; fSAP18; TERCIR"
                     /inference="alignment:Splign:2.1.0"
     exon            428..856
                     /gene="TRIR"
                     /gene_synonym="C19orf43; fSAP18; TERCIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      831..836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIR"
                     /gene_synonym="C19orf43; fSAP18; TERCIR"
                     /note="hexamer: AGTAAA"
     polyA_site      856
                     /gene="TRIR"
                     /gene_synonym="C19orf43; fSAP18; TERCIR"
                     /note="major polyA site"
ORIGIN      
        1 gtcctttgcg cggcacctgg cgacaaaatg gctgcccgag ggagacgggc ggagcctcag
       61 ggccgggagg ctccgggccc cgcgggcggt ggcggtggcg ggagccgttg ggctgagtcg
      121 ggatcgggga cgtcgcccga gagcggggac gaggaggtgt cgggcgcggg ttcgagcccg
      181 gtgtcgggcg gcgtgaactt gttcgccaac gacggcagct tcctggagct gttcaagcgg
      241 aagatggagg aggagcagcg gcagcggcag gaggagccgc ccccgggtcc gcagcgaccc
      301 gaccagtcgg ccgccgccgc tggccccggg gatccgaaga ggaagggcgg tgggcaaacg
      361 cagaggcggg aacaaactag ccctcaagac gggaatagta gccaagaagc agaagacgga
      421 ggatgaggta ttaacaagta aaggtgacgc gtgggccaag tacatggcag aagtgaaaaa
      481 gtacaaagct caccagtgcg gtgacgatga taaaactcgg cccctggtga aatgacgccc
      541 ctcccccacc tgcccatggc ctgggactct ctgcgatgta cataactatt taatgcagcg
      601 gcagcggcga cagccttccc tgagaggact taaaagcaga aggaaaccga gatgcttccc
      661 gcagccgtgg acgattctcc aggactcttt ttttaccttg agcacttgcc tcgtgagact
      721 tcatagaaca gtggtttact gtccccccct tctcacctcc tcattctctc tggctctttc
      781 tgtcttcctc ttctcaccct cctccctccc cttagccatc acttctggga agtaaagaac
      841 ttgacttagt gccgga
//
