LOCUS       NM_003302               1693 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens thyroid hormone receptor interactor 6 (TRIP6), mRNA.
ACCESSION   NM_003302
VERSION     NM_003302.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1693)
  AUTHORS   Liu,X.S., Chen,Y.X., Wan,H.B., Wang,Y.L., Wang,Y.Y., Gao,Y.,
            Wu,L.B. and Pei,Z.J.
  TITLE     TRIP6 a potential diagnostic marker for colorectal cancer with
            glycolysis and immune infiltration association
  JOURNAL   Sci Rep 14 (1), 4042 (2024)
   PUBMED   38369589
  REMARK    GeneRIF: TRIP6 a potential diagnostic marker for colorectal cancer
            with glycolysis and immune infiltration association.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1693)
  AUTHORS   Daniel,P., Balusikova,K., Vaclavikova,R., Seborova,K.,
            Ransdorfova,S., Valerianova,M., Wei,L., Jelinek,M., Tlapakova,T.,
            Fleischer,T., Kristensen,V.N., Soucek,P., Ojima,I. and Kovar,J.
  TITLE     ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6
            Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines
  JOURNAL   Genes (Basel) 14 (2), 296 (2023)
   PUBMED   36833223
  REMARK    GeneRIF: ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven
            TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1693)
  AUTHORS   Seborova,K., Kloudova-Spalenkova,A., Koucka,K., Holy,P.,
            Ehrlichova,M., Wang,C., Ojima,I., Voleska,I., Daniel,P.,
            Balusikova,K., Jelinek,M., Kovar,J., Rob,L., Hruda,M., Mrhalova,M.,
            Soucek,P. and Vaclavikova,R.
  TITLE     The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of
            Ovarian Cancer to Taxanes
  JOURNAL   Int J Mol Sci 23 (1), 73 (2021)
   PUBMED   35008510
  REMARK    GeneRIF: The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance
            of Ovarian Cancer to Taxanes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1693)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1693)
  AUTHORS   Yang,F., Li,L., Zhang,J., Zhang,J. and Yang,L.
  TITLE     TRIP6 accelerates the proliferation and invasion of cervical cancer
            by upregulating oncogenic YAP signaling
  JOURNAL   Exp Cell Res 396 (1), 112248 (2020)
   PUBMED   32853630
  REMARK    GeneRIF: TRIP6 accelerates the proliferation and invasion of
            cervical cancer by upregulating oncogenic YAP signaling.
REFERENCE   6  (bases 1 to 1693)
  AUTHORS   Murthy,K.K., Clark,K., Fortin,Y., Shen,S.H. and Banville,D.
  TITLE     ZRP-1, a zyxin-related protein, interacts with the second PDZ
            domain of the cytosolic protein tyrosine phosphatase hPTP1E
  JOURNAL   J Biol Chem 274 (29), 20679-20687 (1999)
   PUBMED   10400701
REFERENCE   7  (bases 1 to 1693)
  AUTHORS   Zhao,M.K., Wang,Y., Murphy,K., Yi,J., Beckerle,M.C. and
            Gilmore,T.D.
  TITLE     LIM domain-containing protein trip6 can act as a coactivator for
            the v-Rel transcription factor
  JOURNAL   Gene Expr 8 (4), 207-217 (1999)
   PUBMED   10794523
REFERENCE   8  (bases 1 to 1693)
  AUTHORS   Yi,J. and Beckerle,M.C.
  TITLE     The human TRIP6 gene encodes a LIM domain protein and maps to
            chromosome 7q22, a region associated with tumorigenesis
  JOURNAL   Genomics 49 (2), 314-316 (1998)
   PUBMED   9598321
REFERENCE   9  (bases 1 to 1693)
  AUTHORS   Williams,J.M., Chen,G.C., Zhu,L. and Rest,R.F.
  TITLE     Using the yeast two-hybrid system to identify human epithelial cell
            proteins that bind gonococcal Opa proteins: intracellular gonococci
            bind pyruvate kinase via their Opa proteins and require host
            pyruvate for growth
  JOURNAL   Mol Microbiol 27 (1), 171-186 (1998)
   PUBMED   9466265
REFERENCE   10 (bases 1 to 1693)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM800083.1 and BC004999.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003302.2.
            
            Summary: This gene is a member of the zyxin family and encodes a
            protein with three LIM zinc-binding domains. This protein localizes
            to focal adhesion sites and along actin stress fibers. Recruitment
            of this protein to the plasma membrane occurs in a lysophosphatidic
            acid (LPA)-dependent manner and it regulates LPA-induced cell
            migration. Alternatively spliced variants which encode different
            protein isoforms have been described; however, not all variants
            have been fully characterized. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.193113.1,
                                           SRR3476690.676481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000200457.9/ ENSP00000200457.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BM800083.1         60-101
            43-1693             BC004999.1         1-1651
FEATURES             Location/Qualifiers
     source          1..1693
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1693
                     /gene="TRIP6"
                     /gene_synonym="OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1"
                     /note="thyroid hormone receptor interactor 6"
                     /db_xref="GeneID:7205"
                     /db_xref="HGNC:HGNC:12311"
                     /db_xref="MIM:602933"
     exon            1..220
                     /gene="TRIP6"
                     /gene_synonym="OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1542
                     /gene="TRIP6"
                     /gene_synonym="OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1"
                     /note="OPA-interacting protein 1; zyxin related protein 1;
                     thyroid hormone receptor interacting protein 6;
                     TR-interacting protein 6"
                     /codon_start=1
                     /product="thyroid receptor-interacting protein 6"
                     /protein_id="NP_003293.2"
                     /db_xref="CCDS:CCDS5708.1"
                     /db_xref="GeneID:7205"
                     /db_xref="HGNC:HGNC:12311"
                     /db_xref="MIM:602933"
                     /translation="MSGPTWLPPKQPEPARAPQGRAIPRGTPGPPPAHGAALQPHPRV
                     NFCPLPSEQCYQAPGGPEDRGPAWVGSHGVLQHTQGLPADRGGLRPGSLDAEIDLLSS
                     TLAELNGGRGHASRRPDRQAYEPPPPPAYRTGSLKPNPASPLPASPYGGPTPASYTTA
                     STPAGPAFPVQVKVAQPVRGCGPPRRGASQASGPLPGPHFPLPGRGEVWGPGYRSQRE
                     PGPGAKEEAAGVSGPAGRGRGGEHGPQVPLSQPPEDELDRLTKKLVHDMNHPPSGEYF
                     GQCGGCGEDVVGDGAGVVALDRVFHVGCFVCSTCRAQLRGQHFYAVERRAYCEGCYVA
                     TLEKCATCSQPILDRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCIEDFH
                     RKFAPRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYP
                     LDGHILCKACSAWRIQELSATVTTDC"
     exon            221..348
                     /gene="TRIP6"
                     /gene_synonym="OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..474
                     /gene="TRIP6"
                     /gene_synonym="OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..846
                     /gene="TRIP6"
                     /gene_synonym="OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..940
                     /gene="TRIP6"
                     /gene_synonym="OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1110
                     /gene="TRIP6"
                     /gene_synonym="OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1289
                     /gene="TRIP6"
                     /gene_synonym="OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1410
                     /gene="TRIP6"
                     /gene_synonym="OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1693
                     /gene="TRIP6"
                     /gene_synonym="OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1669..1674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIP6"
                     /gene_synonym="OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1"
                     /note="hexamer: AATAAT"
     polyA_site      1693
                     /gene="TRIP6"
                     /gene_synonym="OIP-1; OIP1; TRIP-6; TRIP6i2; ZRP-1"
                     /note="major polyA site"
ORIGIN      
        1 agaaaaagtt ttcttttctg gagtcccaaa cgaggtgcgg gacggaagag ggggtgaagg
       61 ccagaggctc ggggcttcaa gaccgctgtc tggagtcccc ctttccaggc catgtcgggg
      121 cccacctggc tgcccccgaa gcagccggag cccgccagag cccctcaggg gagggcgatc
      181 ccccgcggca ccccggggcc accaccggcc cacggagcag cactccagcc ccaccccagg
      241 gtcaattttt gcccccttcc atctgagcag tgttaccagg ccccaggggg accggaggat
      301 cgggggccgg cgtgggtggg gtcccatgga gtactccagc acacgcaggg gctccctgca
      361 gacagggggg gccttcgccc tggaagcctg gacgccgaga tagacttgct gagcagcacg
      421 ctggccgagc tgaatggggg tcggggtcat gcgtcacggc gaccagaccg acaggcatat
      481 gagcccccgc cacctcctgc ctaccgcacg ggctccctga agccaaatcc agcctcgccg
      541 ctcccagcgt ctccctatgg gggccccact ccagcctctt acactaccgc cagcaccccg
      601 gctggcccag ccttccccgt gcaagtgaag gtggcacagc cagtgagggg ctgcggccca
      661 cccaggcggg gagcctctca ggcctctggg cccctcccgg gcccccactt tcctctccca
      721 ggccgaggtg aagtctgggg gcctggctat aggagccaga gagagccagg gccaggggcc
      781 aaagaggaag ctgctggggt ctctggccct gcaggaagag gaagaggagg cgagcacggg
      841 ccccaggtgc ccctgagcca gcctccagag gatgagctgg ataggctgac gaagaagctg
      901 gttcacgaca tgaaccaccc gcccagcggg gagtactttg gccagtgtgg tggctgcgga
      961 gaagatgtgg ttggggatgg ggctggggtt gtggcccttg atcgcgtctt tcacgtgggc
     1021 tgctttgtat gttctacatg ccgggcccag cttcgcggcc agcatttcta cgccgtggag
     1081 aggagggcat attgcgaggg ctgctacgtg gccaccctgg agaaatgtgc cacgtgctcc
     1141 cagcccatcc tggaccggat cctgcgggct atggggaagg cctaccaccc tggctgcttc
     1201 acctgcgtgg tgtgtcaccg cggcctcgac ggcatcccct tcacagtgga tgctacgagc
     1261 cagatccact gcattgagga ctttcacagg aagtttgccc caagatgctc agtgtgcggt
     1321 ggggccataa tgcctgagcc aggtcaggag gagactgtga gaattgttgc tctggatcga
     1381 agttttcaca ttggctgtta caagtgcgag gagtgtgggc tgctgctctc ctctgagggc
     1441 gagtgtcagg gctgctaccc gctggatggg cacatcttgt gcaaggcctg cagcgcctgg
     1501 cgcatccagg agctctcagc caccgtcacc actgactgct gagtcttcct agaagtacct
     1561 gctgggttct cagttccagt tcccatcctt tgattgatca ctctccctga catccacctg
     1621 tatgactttg tcaccaaatg ctgtcttctc tttctccaat caagaaataa taatccctcg
     1681 agtttacaaa aca
//
