LOCUS       NM_016213               2013 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens thyroid hormone receptor interactor 4 (TRIP4),
            transcript variant 1, mRNA.
ACCESSION   NM_016213
VERSION     NM_016213.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2013)
  AUTHORS   Rullo-Tubau,J., Martinez-Molledo,M., Bartoccioni,P., Puch-Giner,I.,
            Arias,A., Saen-Oon,S., Stephan-Otto Attolini,C., Artuch,R.,
            Diaz,L., Guallar,V., Errasti-Murugarren,E., Palacin,M. and
            Llorca,O.
  TITLE     Structure and mechanisms of transport of human Asc1/CD98hc amino
            acid transporter
  JOURNAL   Nat Commun 15 (1), 2986 (2024)
   PUBMED   38582862
  REMARK    GeneRIF: Structure and mechanisms of transport of human Asc1/CD98hc
            amino acid transporter.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2013)
  AUTHORS   Lu,Z., Xiao,Z., Wang,Q., Pan,C., Xia,Y., Wu,W. and Chen,L.
  TITLE     LINC00668 promoted non-small lung cancer progression by
            miR-518c-3p/TRIP4 axis
  JOURNAL   Cancer Biomark 38 (3), 379-391 (2023)
   PUBMED   37718780
  REMARK    GeneRIF: LINC00668 promoted non-small lung cancer progression by
            miR-518c-3p/TRIP4 axis.
REFERENCE   3  (bases 1 to 2013)
  AUTHORS   Narita,M., Denk,T., Matsuo,Y., Sugiyama,T., Kikuguchi,C., Ito,S.,
            Sato,N., Suzuki,T., Hashimoto,S., Machova,I., Tesina,P.,
            Beckmann,R. and Inada,T.
  TITLE     A distinct mammalian disome collision interface harbors K63-linked
            polyubiquitination of uS10 to trigger hRQT-mediated subunit
            dissociation
  JOURNAL   Nat Commun 13 (1), 6411 (2022)
   PUBMED   36302773
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2013)
  AUTHORS   Dembour,A., Destree,A., Deprez,M., Kadhim,H., Karadurmus,D.,
            Froment,O., Deconinck,N. and Lederer,D.
  TITLE     ASC1 complex related conditions: Two novel paediatric patients with
            TRIP4 pathogenic variants and review of literature
  JOURNAL   Eur J Med Genet 65 (4), 104469 (2022)
   PUBMED   35276412
  REMARK    GeneRIF: ASC1 complex related conditions: Two novel paediatric
            patients with TRIP4 pathogenic variants and review of literature.
            Review article
REFERENCE   5  (bases 1 to 2013)
  AUTHORS   Meunier,J., Villar-Quiles,R.N., Duband-Goulet,I. and Ferreiro,A.
  TITLE     Inherited Defects of the ASC-1 Complex in Congenital Neuromuscular
            Diseases
  JOURNAL   Int J Mol Sci 22 (11), 6039 (2021)
   PUBMED   34204919
  REMARK    GeneRIF: Inherited Defects of the ASC-1 Complex in Congenital
            Neuromuscular Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2013)
  AUTHORS   Knierim,E., Hirata,H., Wolf,N.I., Morales-Gonzalez,S.,
            Schottmann,G., Tanaka,Y., Rudnik-Schoneborn,S., Orgeur,M.,
            Zerres,K., Vogt,S., van Riesen,A., Gill,E., Seifert,F., Zwirner,A.,
            Kirschner,J., Goebel,H.H., Hubner,C., Stricker,S., Meierhofer,D.,
            Stenzel,W. and Schuelke,M.
  TITLE     Mutations in Subunits of the Activating Signal Cointegrator 1
            Complex Are Associated with Prenatal Spinal Muscular Atrophy and
            Congenital Bone Fractures
  JOURNAL   Am J Hum Genet 98 (3), 473-489 (2016)
   PUBMED   26924529
REFERENCE   7  (bases 1 to 2013)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   8  (bases 1 to 2013)
  AUTHORS   Jung,D.J., Sung,H.S., Goo,Y.W., Lee,H.M., Park,O.K., Jung,S.Y.,
            Lim,J., Kim,H.J., Lee,S.K., Kim,T.S., Lee,J.W. and Lee,Y.C.
  TITLE     Novel transcription coactivator complex containing activating
            signal cointegrator 1
  JOURNAL   Mol Cell Biol 22 (14), 5203-5211 (2002)
   PUBMED   12077347
REFERENCE   9  (bases 1 to 2013)
  AUTHORS   Kim,H.J., Yi,J.Y., Sung,H.S., Moore,D.D., Jhun,B.H., Lee,Y.C. and
            Lee,J.W.
  TITLE     Activating signal cointegrator 1, a novel transcription coactivator
            of nuclear receptors, and its cytosolic localization under
            conditions of serum deprivation
  JOURNAL   Mol Cell Biol 19 (9), 6323-6332 (1999)
   PUBMED   10454579
REFERENCE   10 (bases 1 to 2013)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG166305.1, AK314319.1 and
            BC012448.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_016213.4.
            
            Summary: This gene encodes a subunit of the tetrameric nuclear
            activating signal cointegrator 1 (ASC-1) complex, which associates
            with transcriptional coactivators, nuclear receptors and basal
            transcription factors to facilitate nuclear receptors-mediated
            transcription. This protein is localized in the nucleus and
            contains an E1A-type zinc finger domain, which mediates interaction
            with transcriptional coactivators and ligand-bound nuclear
            receptors, such as thyroid hormone receptor and retinoid X receptor
            alpha, but not glucocorticoid receptor. Mutations in this gene are
            associated with spinal muscular atrophy with congenital bone
            fractures-1 (SMABF1). [provided by RefSeq, Apr 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012448.1, SRR1660803.207503.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261884.8/ ENSP00000261884.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BG166305.1         33-57
            26-1624             AK314319.1         1-1599
            1625-2013           BC012448.1         1640-2028
FEATURES             Location/Qualifiers
     source          1..2013
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..2013
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /note="thyroid hormone receptor interactor 4"
                     /db_xref="GeneID:9325"
                     /db_xref="HGNC:HGNC:12310"
                     /db_xref="MIM:604501"
     exon            1..129
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1774
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     activating signal cointegrator 1; TRIP-4; TR-interacting
                     protein 4; thyroid receptor-interacting protein 4; zinc
                     finger, C2HC5-type"
                     /codon_start=1
                     /product="activating signal cointegrator 1 isoform 1"
                     /protein_id="NP_057297.2"
                     /db_xref="CCDS:CCDS10194.1"
                     /db_xref="GeneID:9325"
                     /db_xref="HGNC:HGNC:12310"
                     /db_xref="MIM:604501"
                     /translation="MAVAGAVSGEPLVHWCTQQLRKTFGLDVSEEIIQYVLSIESAEE
                     IREYVTDLLQGNEGKKGQFIEELITKWQKNDQELISDPLQQCFKKDEILDGQKSGDHL
                     KRGRKKGRNRQEVPAFTEPDTTAEVKTPFDLAKAQENSNSVKKKTKFVNLYTREGQDR
                     LAVLLPGRHPCDCLGQKHKLINNCLICGRIVCEQEGSGPCLFCGTLVCTHEEQDILQR
                     DSNKSQKLLKKLMSGVENSGKVDISTKDLLPHQELRIKSGLEKAIKHKDKLLEFDRTS
                     IRRTQVIDDESDYFASDSNQWLSKLERETLQKREEELRELRHASRLSKKVTIDFAGRK
                     ILEEENSLAEYHSRLDETIQAIANGTLNQPLTKLDRSSEEPLGVLVNPNMYQSPPQWV
                     DHTGAASQKKAFRSSGFGLEFNSFQHQLRIQDQEFQEGFDGGWCLSVHQPWASLLVRG
                     IKRVEGRSWYTPHRGRLWIAATAKKPSPQEVSELQATYRLLRGKDVEFPNDYPSGCLL
                     GCVDLIDCLSQKQFKEQFPDISQESDSPFVFICKNPQEMVVKFPIKGNPKIWKLDSKI
                     HQGAKKGLMKQNKAV"
     exon            130..299
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            300..433
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            434..646
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            647..725
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            726..855
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1071
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1198
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1386
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1511
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1603
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1706
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..2013
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1988..1993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /note="hexamer: TATAAA"
     polyA_site      2013
                     /gene="TRIP4"
                     /gene_synonym="ASC-1; ASC1; HsT17391; MDCDC; SMABF1;
                     ZC2HC5"
                     /note="major polyA site"
ORIGIN      
        1 gcagctcagc tggttccggc tggggaagat ggcggtggct ggggcggtgt ccggggagcc
       61 gctggtgcac tggtgcaccc agcagttgcg gaagactttc ggcctggatg tcagcgagga
      121 gatcattcag tacgttttgt caattgagag tgctgaagag atacgagaat atgttactga
      181 tctcctccag ggaaatgaag gcaaaaaagg tcaattcata gaagaactta taaccaaatg
      241 gcaaaagaat gatcaggagt tgatttcgga tcctttgcag cagtgcttca aaaaagatga
      301 aattttagat gggcagaaat caggcgacca tctaaagcgg ggtaggaaga aagggagaaa
      361 cagacaggaa gttcctgcat ttactgaacc tgacacgact gcagaggtta aaacaccttt
      421 tgatttggcc aaggcacaag agaacagcaa ctccgtaaag aagaagacaa agtttgtcaa
      481 tttatacaca agagagggac aggacaggct tgcagtcctg ctccctggtc gtcacccttg
      541 tgattgcctg ggccagaagc acaagctcat caataactgt ctgatctgtg ggcgcattgt
      601 ctgtgaacaa gaaggctcag gcccttgctt attctgtggc actctggtgt gtactcatga
      661 ggaacaagat attttacagc gtgactcaaa caagagccag aaactgctaa agaaactcat
      721 gtcaggagtg gagaattctg gaaaggtgga catctctacc aaggaccttc ttcctcatca
      781 agaattgcga attaagtctg gtctggagaa ggctatcaag cataaagaca aactgttaga
      841 gtttgacaga actagtattc gaaggaccca agtcattgat gatgagtcag attactttgc
      901 cagtgattct aaccaatggt tgtccaaact tgagcgggaa accttgcaga agcgagagga
      961 ggagctgaga gaacttcgac acgcctctcg actttctaag aaggtcacca ttgactttgc
     1021 aggaaggaag atcctggaag aagaaaattc actagcagag tatcatagca gactagatga
     1081 gacaatacag gccattgcca atggaacctt gaaccagcca ctgaccaaat tggatagatc
     1141 ttctgaagag cctttgggag ttctggtaaa tcccaacatg taccagtccc ctccccagtg
     1201 ggttgaccac acaggtgcag cctcacagaa gaaggctttc cgttcttcag gatttggact
     1261 agagttcaac tcatttcagc accagttgcg aatccaggat caagaatttc aggaaggctt
     1321 tgatggtggc tggtgcctct ctgtacatca gccctgggct tctctgcttg tcagagggat
     1381 taaaagggtg gagggcagat cctggtacac cccccacaga ggacgacttt ggatagcagc
     1441 cacagctaaa aaaccctccc ctcaagaagt ctcagaactc caggctacat atcgtcttct
     1501 tcgtgggaaa gatgtggaat ttcctaatga ctatccgtca ggttgtcttc tgggctgtgt
     1561 ggacctaatt gactgcttgt cccagaagca atttaaggag cagtttccag acatcagtca
     1621 agagtctgat tctccatttg ttttcatctg caaaaatcct caggaaatgg ttgtgaagtt
     1681 tcctattaaa ggaaatccaa aaatctggaa attggattcc aagatccatc aaggagcaaa
     1741 gaaggggtta atgaagcaga ataaagctgt ctgacccagg agaaaaggaa ctatacagca
     1801 tagtggagtt ttgtgtacta aaattgctat ctactggtcc tttggaattg aagtagtaga
     1861 aacctaaagg cttggcgtca ggcttgaata tctcagaact taaactctta ccaaaatctg
     1921 tatatttttc ttaaggagtg ggattcctac tttatgtaat ggggtcgaaa tctttgaaca
     1981 cattatttat aaaaacctgt ttaaaaattc taa
//
