LOCUS       NM_004237               2431 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens thyroid hormone receptor interactor 13 (TRIP13),
            transcript variant 1, mRNA.
ACCESSION   NM_004237
VERSION     NM_004237.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2431)
  AUTHORS   Chen,C., Li,P., Fan,G., Yang,E., Jing,S., Shi,Y., Gong,Y., Zhang,L.
            and Wang,Z.
  TITLE     Role of TRIP13 in human cancer development
  JOURNAL   Mol Biol Rep 51 (1), 1088 (2024)
   PUBMED   39436503
  REMARK    GeneRIF: Role of TRIP13 in human cancer development.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2431)
  AUTHORS   Zhang,G., Yang,R., Wang,B., Yan,Q., Zhao,P., Zhang,J., Su,W.,
            Yang,L. and Cui,H.
  TITLE     TRIP13 regulates progression of gastric cancer through stabilising
            the expression of DDX21
  JOURNAL   Cell Death Dis 15 (8), 622 (2024)
   PUBMED   39187490
  REMARK    GeneRIF: TRIP13 regulates progression of gastric cancer through
            stabilising the expression of DDX21.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2431)
  AUTHORS   Wu,L., Xue,Q. and Xia,X.
  TITLE     High expression of TRIP13 is associated with tumor progression in
            H. pylori infection induced gastric cancer
  JOURNAL   Mutat Res 828, 111854 (2024)
   PUBMED   38492425
  REMARK    GeneRIF: High expression of TRIP13 is associated with tumor
            progression in H. pylori infection induced gastric cancer.
REFERENCE   4  (bases 1 to 2431)
  AUTHORS   Afaq,F., Agarwal,S., Bajpai,P., Diffalha,S.A., Kim,H.G., Peter,S.,
            Khushman,M., Chauhan,S.C., Mukherjee,P., Varambally,S. and Manne,U.
  TITLE     Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of
            pancreatic ductal adenocarcinoma
  JOURNAL   Neoplasia 47, 100951 (2024)
   PUBMED   38039923
  REMARK    GeneRIF: Targeting of oncogenic AAA-ATPase TRIP13 reduces
            progression of pancreatic ductal adenocarcinoma.
REFERENCE   5  (bases 1 to 2431)
  AUTHORS   Liu,G., Wang,H., Ran,R., Wang,Y. and Li,Y.
  TITLE     TRIP13 Activates Glycolysis to Promote Cell Stemness and Strengthen
            Doxorubicin Resistance of Colorectal Cancer Cells
  JOURNAL   Curr Med Chem 31 (22), 3397-3411 (2024)
   PUBMED   38347785
  REMARK    GeneRIF: TRIP13 Activates Glycolysis to Promote Cell Stemness and
            Strengthen Doxorubicin Resistance of Colorectal Cancer Cells.
REFERENCE   6  (bases 1 to 2431)
  AUTHORS   Kim,H.J., Chong,K.H., Kang,S.W., Lee,J.R., Kim,J.Y., Hahn,M.J. and
            Kim,T.J.
  TITLE     Identification of cyclophilin A as a CD99-binding protein by yeast
            two-hybrid screening
  JOURNAL   Immunol Lett 95 (2), 155-159 (2004)
   PUBMED   15388255
REFERENCE   7  (bases 1 to 2431)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   8  (bases 1 to 2431)
  AUTHORS   Yasugi,T., Vidal,M., Sakai,H., Howley,P.M. and Benson,J.D.
  TITLE     Two classes of human papillomavirus type 16 E1 mutants suggest
            pleiotropic conformational constraints affecting E1
            multimerization, E2 interaction, and interaction with cellular
            proteins
  JOURNAL   J Virol 71 (8), 5942-5951 (1997)
   PUBMED   9223484
REFERENCE   9  (bases 1 to 2431)
  AUTHORS   Schepens,J., Cuppen,E., Wieringa,B. and Hendriks,W.
  TITLE     The neuronal nitric oxide synthase PDZ motif binds to -G(D,E)XV*
            carboxyterminal sequences
  JOURNAL   FEBS Lett 409 (1), 53-56 (1997)
   PUBMED   9199503
REFERENCE   10 (bases 1 to 2431)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB443523.1, BC019294.1,
            BM999741.1 and AC122719.2.
            
            On Nov 22, 2018 this sequence version replaced NM_004237.3.
            
            Summary: This gene encodes a protein that interacts with thyroid
            hormone receptors, also known as hormone-dependent transcription
            factors. The gene product interacts specifically with the ligand
            binding domain. This gene is one of several that may play a role in
            early-stage non-small cell lung cancer. [provided by RefSeq, Oct
            2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1133594.1, BC000404.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000166345.8/ ENSP00000166345.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DB443523.1         30-34
            6-2356              BC019294.1         1-2351
            2357-2360           BM999741.1         19-22               c
            2361-2431           AC122719.2         101355-101425
FEATURES             Location/Qualifiers
     source          1..2431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.33"
     gene            1..2431
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /note="thyroid hormone receptor interactor 13"
                     /db_xref="GeneID:9319"
                     /db_xref="HGNC:HGNC:12307"
                     /db_xref="MIM:604507"
     exon            1..207
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1414
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /note="isoform 1 is encoded by transcript variant 1; human
                     papillomavirus type 16 E1 protein-binding protein; HPV16
                     E1 protein binding protein; pachytene checkpoint protein 2
                     homolog; thyroid receptor-interacting protein 13; 16E1-BP;
                     TRIP-13; TR-interacting protein 13; SH3TC1/TRIP13 fusion"
                     /codon_start=1
                     /product="pachytene checkpoint protein 2 homolog isoform
                     1"
                     /protein_id="NP_004228.1"
                     /db_xref="CCDS:CCDS3858.1"
                     /db_xref="GeneID:9319"
                     /db_xref="HGNC:HGNC:12307"
                     /db_xref="MIM:604507"
                     /translation="MDEAVGDLKQALPCVAESPTVHVEVHQRGSSTAKKEDINLSVRK
                     LLNRHNIVFGDYTWTEFDEPFLTRNVQSVSIIDTELKVKDSQPIDLSACTVALHIFQL
                     NEDGPSSENLEEETENIIAANHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFS
                     DKNVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLF
                     SKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDEVESLTAARNACRAGTEPSDAIRV
                     VNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSC
                     LEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLNDISRKSEGLSGRVLRKLP
                     FLAHALYVQAPTVTIEGFLQALSLAVDKQFEERKKLAAYI"
     exon            208..373
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /inference="alignment:Splign:2.1.0"
     exon            374..503
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /inference="alignment:Splign:2.1.0"
     exon            504..559
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /inference="alignment:Splign:2.1.0"
     exon            560..650
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /inference="alignment:Splign:2.1.0"
     exon            651..723
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /inference="alignment:Splign:2.1.0"
     exon            724..787
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /inference="alignment:Splign:2.1.0"
     exon            788..874
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /inference="alignment:Splign:2.1.0"
     exon            875..981
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1135
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1248
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1318
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..2431
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2190..2195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /note="hexamer: AATAAA"
     polyA_site      2224
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /note="major polyA site"
     regulatory      2338..2343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /note="hexamer: ATTAAA"
     polyA_site      2356
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /note="major polyA site"
     regulatory      2404..2409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
                     /note="hexamer: ACTAAA"
     polyA_site      2431
                     /gene="TRIP13"
                     /gene_synonym="16E1BP; MVA3; OOMD9; OZEMA9"
ORIGIN      
        1 agattcgaag ctagggcggg gcccgcgggc tgaggcagcg gctgtggcgg cgacgctggg
       61 cgtgaggtgg cggcggccgc gccctggttg ggtccccact gctctcgggg gcgccatgga
      121 cgaggccgtg ggcgacctga agcaggcgct tccctgtgtg gccgagtcgc caacggtcca
      181 cgtggaggtg catcagcgcg gcagcagcac tgcaaagaaa gaagacataa acctgagtgt
      241 tagaaagcta ctcaacagac ataatattgt gtttggtgat tacacatgga ctgagtttga
      301 tgaacctttt ttgaccagaa atgtgcagtc tgtgtctatt attgacacag aattaaaggt
      361 taaagactca cagcccatcg atttgagtgc atgcactgtt gcacttcaca ttttccagct
      421 gaatgaagat ggccccagca gtgaaaatct ggaggaagag acagaaaaca taattgcagc
      481 aaatcactgg gttctacctg cagctgaatt ccatgggctt tgggacagct tggtatacga
      541 tgtggaagtc aaatcccatc tcctcgatta tgtgatgaca actttactgt tttcagacaa
      601 gaacgtcaac agcaacctca tcacctggaa ccgggtggtg ctgctccacg gtcctcctgg
      661 cactggaaaa acatccctgt gtaaagcgtt agcccagaaa ttgacaatta gactttcaag
      721 caggtaccga tatggccaat taattgaaat aaacagccac agcctctttt ctaagtggtt
      781 ttcggaaagt ggcaagctgg taaccaagat gtttcagaag attcaggatt tgattgatga
      841 taaagacgcc ctggtgttcg tgctgattga tgaggtggag agtctcacag ccgcccgaaa
      901 tgcctgcagg gcgggcaccg agccatcaga tgccatccgc gtggtcaatg ctgtcttgac
      961 ccaaattgat cagattaaaa ggcattccaa tgttgtgatt ctgaccactt ctaacatcac
     1021 cgagaagatc gacgtggcct tcgtggacag ggctgacatc aagcagtaca ttgggccacc
     1081 ctctgcagca gccatcttca aaatctacct ctcttgtttg gaagaactga tgaagtgtca
     1141 gatcatatac cctcgccagc agctgctgac cctccgagag ctagagatga ttggcttcat
     1201 tgaaaacaac gtgtcaaaat tgagccttct tttgaatgac atttcaagga agagcgaggg
     1261 cctcagcggc cgggtcctga gaaaactccc ctttctggct catgcgctgt atgtccaggc
     1321 ccccaccgtc accatagagg ggttcctcca ggccctgtct ctggcagtgg acaagcagtt
     1381 tgaagagaga aagaagcttg cagcttacat ctgatcctgg gcttccccat ctggtgcttt
     1441 tcccatggag aacacacaac cagtaagtga ggttgcccca cacagccgtc tcccagggaa
     1501 tcccttctgc aaaccaaacg ttacttagac tgcaagctag aaagccacca aggccaggct
     1561 ttgttaaaag aagtgtattc tatttatgtt gttttaaaat gcatactgag agacaaacat
     1621 cttgtcattt tcactgtttg taaaagataa ttcagattgt ttgtctcctt gtgaagaacc
     1681 atcgaaacct gtttgttccc agcccacccc cagtggatgg gatgcataat gccagcaagt
     1741 tttgtttaac agcaaaaaag gaagattaat gcaggtgtta tagaagccag aagagaaact
     1801 gtgtcaccct aaagaagcat ataatcatag cattaaaaat gcacacatta ctccaggtgg
     1861 aaggtggcaa ttgctttctg atatcagctc gtttgattta gtgcaaaaat gttttcaaga
     1921 ctatttaatg gatgtaaaaa agcctatttc tacattatac caactgagaa aaaaatggtc
     1981 ggtaaagtgt tctttcataa taaataatca gacatggtcc catttgcagg aaaagtgcag
     2041 actctgagtg ttccagggaa acacatgctg gacatccctt gtaacccggt atgggcgccc
     2101 ctgcattgct gggatgtttc tgcccacggt tttgtttgtg caataacgtt atcacatttc
     2161 taatgaggat tcacattaat ataatataaa ataaataggt cagttactgg tctctttctc
     2221 cgaatgttat gttttgcttt tatctcacag taaaataaat ataattaatg gtttgcatgt
     2281 gaaattcact tttgaaagaa catgttacct taccttttgt tttagaagtt ttcaagtatt
     2341 aaaatatttt ttagaatttt cttgttttga ttctaagtat ctcttccaag tgcttttaat
     2401 tttactaaaa attactcaca tgattactta a
//
