LOCUS       NM_001348323           10100 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens thyroid hormone receptor interactor 12 (TRIP12),
            transcript variant 13, mRNA.
ACCESSION   NM_001348323 XM_005246956
VERSION     NM_001348323.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10100)
  AUTHORS   Brunet,M., Vargas,C., Fanjul,M., Varry,D., Hanoun,N., Larrieu,D.,
            Pieruccioni,L., Labrousse,G., Lulka,H., Capilla,F., Ricard,A.,
            Selves,J., Couvelard,A., Gigoux,V., Cordelier,P.,
            Guillermet-Guibert,J., Dufresne,M. and Torrisani,J.
  TITLE     The E3 ubiquitin ligase TRIP12 is required for pancreatic acinar
            cell plasticity and pancreatic carcinogenesis
  JOURNAL   J Pathol 263 (4-5), 466-481 (2024)
   PUBMED   38924548
  REMARK    GeneRIF: The E3 ubiquitin ligase TRIP12 is required for pancreatic
            acinar cell plasticity and pancreatic carcinogenesis.
REFERENCE   2  (bases 1 to 10100)
  AUTHORS   Abbasi,S., Bayat,L. and Schild-Poulter,C.
  TITLE     Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome
            Identifies Ku Association with TRIP12 in Response to DNA Damage
  JOURNAL   Int J Mol Sci 24 (8), 7041 (2023)
   PUBMED   37108203
  REMARK    GeneRIF: Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome
            Identifies Ku Association with TRIP12 in Response to DNA Damage.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10100)
  AUTHORS   Aerden,M., Denomme-Pichon,A.S., Bonneau,D., Bruel,A.L., Delanne,J.,
            Gerard,B., Mazel,B., Philippe,C., Pinson,L., Prouteau,C.,
            Putoux,A., Tran Mau-Them,F., Viora-Dupont,E., Vitobello,A.,
            Ziegler,A., Piton,A., Isidor,B., Francannet,C., Maillard,P.Y.,
            Julia,S., Philippe,A., Schaefer,E., Koene,S., Ruivenkamp,C.,
            Hoffer,M., Legius,E., Theunis,M., Keren,B., Buratti,J., Charles,P.,
            Courtin,T., Misra-Isrie,M., van Haelst,M., Waisfisz,Q.,
            Wieczorek,D., Schmetz,A., Herget,T., Kortum,F., Lisfeld,J.,
            Debray,F.G., Bramswig,N.C., Atallah,I., Fodstad,H., Jouret,G.,
            Almoguera,B., Tahsin-Swafiri,S., Santos-Simarro,F.,
            Palomares-Bralo,M., Lopez-Gonzalez,V., Kibaek,M., Torring,P.M.,
            Renieri,A., Bruno,L.P., Ounap,K., Wojcik,M., Hsieh,T.C., Krawitz,P.
            and Van Esch,H.
  TITLE     The neurodevelopmental and facial phenotype in individuals with a
            TRIP12 variant
  JOURNAL   Eur J Hum Genet 31 (4), 461-468 (2023)
   PUBMED   36747006
  REMARK    GeneRIF: The neurodevelopmental and facial phenotype in individuals
            with a TRIP12 variant.
REFERENCE   4  (bases 1 to 10100)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10100)
  AUTHORS   Xiong,Y., Wang,L., Xu,S., Fu,B., Che,Y., Zaky,M.Y., Tian,R.,
            Yao,R., Guo,D., Sha,Z., Lin,F., Lin,X. and Wu,H.
  TITLE     Small molecule Z363 co-regulates TAF10 and MYC via the E3 ligase
            TRIP12 to suppress tumour growth
  JOURNAL   Clin Transl Med 13 (1), e1153 (2023)
   PUBMED   36639831
  REMARK    GeneRIF: Small molecule Z363 co-regulates TAF10 and MYC via the E3
            ligase TRIP12 to suppress tumour growth.
REFERENCE   6  (bases 1 to 10100)
  AUTHORS   Chen,D., Shan,J., Zhu,W.G., Qin,J. and Gu,W.
  TITLE     Transcription-independent ARF regulation in oncogenic
            stress-mediated p53 responses
  JOURNAL   Nature 464 (7288), 624-627 (2010)
   PUBMED   20208519
REFERENCE   7  (bases 1 to 10100)
  AUTHORS   Sowa,M.E., Bennett,E.J., Gygi,S.P. and Harper,J.W.
  TITLE     Defining the human deubiquitinating enzyme interaction landscape
  JOURNAL   Cell 138 (2), 389-403 (2009)
   PUBMED   19615732
REFERENCE   8  (bases 1 to 10100)
  AUTHORS   Park,Y., Yoon,S.K. and Yoon,J.B.
  TITLE     The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin
            fusion degradation pathway
  JOURNAL   J Biol Chem 284 (3), 1540-1549 (2009)
   PUBMED   19028681
  REMARK    GeneRIF: The HECT domain of TRIP12 ubiquitinates substrates of the
            ubiquitin fusion degradation pathway.
REFERENCE   9  (bases 1 to 10100)
  AUTHORS   Park,Y., Yoon,S.K. and Yoon,J.B.
  TITLE     TRIP12 functions as an E3 ubiquitin ligase of APP-BP1
  JOURNAL   Biochem Biophys Res Commun 374 (2), 294-298 (2008)
   PUBMED   18627766
  REMARK    GeneRIF: TRIP12 promotes degradation of APP-BP1 by catalyzing its
            ubiquitination, which in turn modulates the neddylation pathway.
REFERENCE   10 (bases 1 to 10100)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009973.10, AC105380.5 and
            AC093384.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 20, 2020 this sequence version replaced NM_001348323.2.
            
            Summary: The protein encoded by this gene is an E3
            ubiquitin-protein ligase involved in the degradation of the
            p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded
            protein also plays a role in the DNA damage response by regulating
            the stability of USP7, which regulates tumor suppressor p53.
            [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (13), as well as variants 12 and
            14-17, encodes isoform h.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.4422082.1,
                                           SRR14038196.2384583.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000675903.1/ ENSP00000502713.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC009973.10        107885-108014       c
            131-277             AC009973.10        65987-66133         c
            278-403             AC009973.10        46411-46536         c
            404-1206            AC009973.10        44777-45579         c
            1207-1312           AC009973.10        26827-26932         c
            1313-1449           AC009973.10        22853-22989         c
            1450-1533           AC009973.10        16761-16844         c
            1534-1629           AC009973.10        15198-15293         c
            1630-1778           AC009973.10        4369-4517           c
            1779-1814           AC009973.10        1278-1313           c
            1815-1910           AC009973.10        1104-1199           c
            1911-2003           AC009973.10        238-330             c
            2004-2039           AC009973.10        1-36                c
            2040-2165           AC105380.5         5280-5405           c
            2166-2234           AC105380.5         2546-2614           c
            2235-2400           AC105380.5         2290-2455           c
            2401-2518           AC093384.4         100703-100820       c
            2519-2675           AC093384.4         100159-100315       c
            2676-2829           AC093384.4         98181-98334         c
            2830-3058           AC093384.4         96450-96678         c
            3059-3177           AC093384.4         96022-96140         c
            3178-3385           AC093384.4         94703-94910         c
            3386-3486           AC093384.4         91734-91834         c
            3487-3661           AC093384.4         91326-91500         c
            3662-3803           AC093384.4         90141-90282         c
            3804-3995           AC093384.4         89042-89233         c
            3996-4147           AC093384.4         87630-87781         c
            4148-4320           AC093384.4         85424-85596         c
            4321-4394           AC093384.4         84604-84677         c
            4395-4594           AC093384.4         84317-84516         c
            4595-4722           AC093384.4         83575-83702         c
            4723-4874           AC093384.4         82062-82213         c
            4875-5017           AC093384.4         81249-81391         c
            5018-5174           AC093384.4         79956-80112         c
            5175-5273           AC093384.4         78208-78306         c
            5274-5388           AC093384.4         71327-71441         c
            5389-5543           AC093384.4         70884-71038         c
            5544-5708           AC093384.4         69766-69930         c
            5709-5873           AC093384.4         66548-66712         c
            5874-5987           AC093384.4         63970-64083         c
            5988-6082           AC093384.4         61682-61776         c
            6083-6186           AC093384.4         61067-61170         c
            6187-10100          AC093384.4         56288-60201         c
FEATURES             Location/Qualifiers
     source          1..10100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.3"
     gene            1..10100
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /note="thyroid hormone receptor interactor 12"
                     /db_xref="GeneID:9320"
                     /db_xref="HGNC:HGNC:12306"
                     /db_xref="MIM:604506"
     exon            1..130
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            131..277
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..6383
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /EC_number="2.3.2.26"
                     /note="isoform h is encoded by transcript variant 13;
                     thyroid receptor interacting protein 12; probable E3
                     ubiquitin-protein ligase TRIP12; TR-interacting protein
                     12; E3 ubiquitin-protein ligase for Arf; HECT-type E3
                     ubiquitin transferase TRIP12"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIP12 isoform h"
                     /protein_id="NP_001335252.1"
                     /db_xref="CCDS:CCDS92966.1"
                     /db_xref="GeneID:9320"
                     /db_xref="HGNC:HGNC:12306"
                     /db_xref="MIM:604506"
                     /translation="MSNRPNNNPGGSLRRSQRNTAGAQPQDDSIGGRSHLGQAKHKGY
                     SPPESRKSNSKAPKVQSNTTSELSRGHLSKRSCSSSSAVIVPQPEDPDRANTSERQKT
                     GQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPKALQHTESPSETNKPHSKSKKRHLDQ
                     EQQLKSAQSPSTSKAHTRKSGATGGSRSQKRKRTESSCVKSGSGSESTGAEERSAKPT
                     KLASKSATSAKAGCSTITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQNKARRS
                     RSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSKPGP
                     SGLQAKLASLRKSTKKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAAEA
                     RRQEKMADPESNQEAVNSSAARTDEAPQGAAASSSVAGAVGMTTSGESESDDSEMGRL
                     QALLEARGLPPHLFGPLGPRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIE
                     MCQLLVMGNEETLGGFPVKSVVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAV
                     VVDAIPVFLEKLQVIQCIDVAEQALTALEMLSRRHSKAILQAGGLADCLLYLEFFSIN
                     AQRNALAIAANCCQSITPDEFHFVADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQ
                     HEENLLQQVASKDLLTNVQQLLVVTPPILSSGMFIMVVRMFSLMCSNCPTLAVQLMKQ
                     NIAETLHFLLCGASNGSCQEQIDLVPRSPQELYELTSLICELMPCLPKEGIFAVDTML
                     KKGNAQNTDGAIWQWRDDRGLWHPYNRIDSRIIEAAHQVGEDEISLSTLGRVYTIDFN
                     SMQQINEDTGTARAIQRKPNPLANSNTSGYSESKKDDARAQLMKEDPELAKSFIKTLF
                     GVLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLK
                     IVVGALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAESESLLTSPPKACTNGSGSMG
                     STTSVSSGTATAATHAAADLGSPSLQHSRDDSLDLSPQGRLSDVLKRKRLPKRGPRRP
                     KYSPPRDDDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLSTQSNSNNIEPARTAGGS
                     GLARAASKDTISNNREKIKGWIKEQAHKFVERYFSSENMDGSNPALNVLQRLCAATEQ
                     LNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIRLK
                     RFLHVFFSSPLPGEEPIGRVEPVGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGT
                     GGSFSLNRGSQALKFFNTHQLKCQLQRHPDCANVKQWKGGPVKIDPLALVQAIERYLV
                     VRGYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQ
                     AVRQFSIQAEDERESTDDESNPLGRAGIWTKTHTIWYKPVREDEESNKDCVGGKRGRA
                     QTAPTKTSPRNAKKHDELWHDGVCPSVSNPLEVYLIPTPPENITFEDPSLDVILLLRV
                     LHAISRYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELG
                     KTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTV
                     NREELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQRADLGLWR
                     GEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIM
                     DFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKS
                     QTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLV
                     IFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKTLMECC
                     RPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRK
                     TFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGQQSFHLS"
     exon            278..403
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            404..1206
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1312
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1449
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1533
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1629
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1778
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1814
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1910
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2003
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2165
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2234
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2400
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2518
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2675
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2829
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..3058
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3177
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3385
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3486
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3661
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            3662..3803
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            3804..3995
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            3996..4147
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            4148..4320
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            4321..4394
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            4395..4594
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            4595..4722
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            4723..4874
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            4875..5017
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            5018..5174
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            5175..5273
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            5274..5388
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            5389..5543
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            5544..5708
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            5709..5873
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            5874..5987
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            5988..6082
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            6083..6186
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     exon            6187..10100
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6702..6707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /note="hexamer: AATAAA"
     polyA_site      6725
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /note="major polyA site"
     regulatory      10082..10087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
                     /note="hexamer: AATAAA"
     polyA_site      10100
                     /gene="TRIP12"
                     /gene_synonym="MRD49; TRIP-12; TRIPC; ULF"
ORIGIN      
        1 gctgcggctc agctgataat tgaaggaacc cggagccgcc gccgccgcgc cgctgggggg
       61 ggtgggggga gctagtggaa gttactgccg cgccaccgag tccggaccgg agactttggg
      121 gcctaactag tgaatggtag tgtctagaaa gggtatgtcc cttcaagaga gaggtgccaa
      181 tgtccaaccg gcctaataac aatccagggg ggtcactgcg acgttcacag aggaacactg
      241 ccggggccca accacaagac gactcaatag gaggaaggtc acatttaggg caggcaaaac
      301 ataagggata tagccctcct gagagtagaa aatctaattc taaggcaccc aaagtgcagt
      361 ctaatactac ttctgaactg tcaaggggac acctttctaa aagaagctgc agttcatcat
      421 ctgctgtgat agttccacaa ccagaggatc cagacagagc caatacttca gaaagacaaa
      481 aaacggggca ggtgcctaag aaagacaatt ctcgaggagt gaagcgcagt gctagtccag
      541 actacaacag gaccaattct cctagctctg caaaaaaacc aaaagcactt cagcatactg
      601 aatctccctc agaaacaaat aagccacata gtaagtcaaa gaagagacat ttagaccagg
      661 agcaacaact gaaatctgca caatcaccat caacaagcaa ggctcatacc aggaagagtg
      721 gggccactgg cggttcacgg agtcagaaaa gaaaaaggac agagagttct tgtgtaaaga
      781 gtggctccgg gtctgaatca actggtgcag aagagagatc tgcgaaacct accaagctgg
      841 cttcaaaatc agccacctca gccaaagctg ggtgtagcac catcactgat tcttcttctg
      901 ctgcctctac ttcctcctcg tcttctgctg tagcctcggc ctcctccact gtaccaccag
      961 gtgccagagt gaaacaagga aaagatcaga acaaggccag gcgttcccgt tcagcgtcca
     1021 gtcccagccc cagaagaagt agcagggaaa aggaacagag taaaactggt ggctcttcaa
     1081 aatttgattg ggctgctcgt ttcagcccta aagttagcct tcctaaaaca aaactgtctc
     1141 ttccagggtc ttctaagtca gagacatcaa aacctggacc ttctggatta caggccaaat
     1201 tagcaagttt aagaaaatct acgaagaaac gcagtgagtc tccacctgct gagctcccca
     1261 gtttgaggcg gagcacacgc caaaagacca cgggctcctg tgctagtacc agtcggcgag
     1321 gctctggcct gggcaaaaga ggagcagctg aagctcgtcg acaggagaaa atggcagacc
     1381 ctgaaagcaa ccaggaggca gtaaattctt cagctgctcg gacagatgaa gctccccaag
     1441 gagctgcagc ctctagttct gttgcagggg ctgttggcat gaccacctct ggggagagtg
     1501 aatcagatga ttccgagatg ggacgtttgc aagctttgtt agaggcaagg ggtcttcccc
     1561 ctcacctatt tggtcctctt ggtcctcgga tgtcacagct tttccataga acaattggaa
     1621 gtggagctag ttctaaggcc cagcagctac tacaaggatt gcaagccagt gatgaaagtc
     1681 aacagcttca ggcagttatt gagatgtgtc agttactggt catgggaaat gaggagacac
     1741 tgggagggtt tcctgtcaag agtgttgttc cagctttgat tacgttactt cagatggagc
     1801 acaattttga tattatgaac catgcttgtc gagccttaac atacatgatg gaagcacttc
     1861 ctcgatcttc tgctgttgta gtagatgcta ttcctgtctt tttagaaaag ctgcaagtta
     1921 ttcagtgtat tgatgtggca gagcaggcct tgactgcctt ggagatgttg tcacggagac
     1981 atagtaaagc cattctacag gcgggtggtt tggcagactg cttgctgtac ctagaattct
     2041 tcagcataaa tgcccaaaga aatgcattag caattgcagc taattgctgc cagagtatca
     2101 cgccagatga atttcatttt gtggcagatt cactcccatt gctaacccaa aggctaacac
     2161 atcaggataa aaagtcagta gaaagcactt gcctttgttt tgcacgccta gtggacaact
     2221 tccagcatga ggagaattta ctccagcagg ttgcttccaa agatctgctt acaaatgttc
     2281 aacagctgtt ggtagtgact ccacccattt taagttctgg gatgtttata atggtggttc
     2341 gcatgttttc tctgatgtgt tccaactgtc caactttagc tgttcaactt atgaaacaaa
     2401 acattgcaga aacgcttcac tttctcctgt gtggtgcctc caatggaagt tgtcaggaac
     2461 agattgatct tgttccacga agccctcaag agttgtatga actgacatct ctgatttgtg
     2521 aacttatgcc atgtttacca aaagaaggca tttttgcagt tgataccatg ttgaagaagg
     2581 gaaatgcaca gaacacagat ggtgcgatat ggcagtggcg tgatgatcgg ggcctctggc
     2641 atccatataa caggattgac agccggatca ttgaggcagc ccatcaggtc ggtgaggatg
     2701 agataagctt gtccactctg ggacgagttt atactattga ttttaattct atgcagcaaa
     2761 tcaatgagga cacgggaaca gcacgtgcca ttcagagaaa acctaacccg ttagccaata
     2821 gtaacactag tggatattca gagtcaaaga aggatgatgc tcgagcacag cttatgaaag
     2881 aggatccgga actggctaag tcttttatta agacattatt tggtgttctt tatgaagtgt
     2941 atagttcctc agcaggacct gcggtcagac ataagtgcct tagagcaatt cttaggataa
     3001 tttattttgc ggatgctgaa cttctgaagg atgttctgaa aaatcatgct gtttcaagtc
     3061 acattgcttc catgctgtca agccaagacc tgaagatagt agtgggagca cttcagatgg
     3121 cagaaatttt aatgcagaag ttacctgata tttttagtgt ttacttcaga agagaaggtg
     3181 taatgcatca agtaaaacac ttagcagaat cagagtcttt gttgacaagt ccaccaaagg
     3241 catgtacgaa tggatcggga tccatgggat ccacaacttc agtcagcagt gggacagcca
     3301 cagctgccac tcatgctgca gctgacttgg gatcacccag cttgcagcac agcagggatg
     3361 attctttaga tctcagccct caaggtcgat taagtgatgt tctaaagaga aaacgactgc
     3421 caaaacgagg gccaagaagg ccaaagtact cacctccaag agatgatgac aaagtagaca
     3481 atcaagctaa aagccccacc actactcagt cacctaaatc ttctttcctg gcaagcttga
     3541 atccaaaaac atggggaagg ttaagtacac agtccaacag caacaacatt gagccagcac
     3601 ggactgcggg aggtagtggc cttgccaggg ctgcctcaaa ggataccatc tccaataata
     3661 gagaaaaaat taaaggttgg attaaggagc aggcacataa atttgtagaa cgttatttca
     3721 gttctgagaa tatggatgga agcaaccctg cattgaatgt ccttcagaga ctttgtgctg
     3781 caaccgaaca actcaacctc caggtggatg gtggagctga gtgccttgta gaaatccgta
     3841 gcatagtctc agagtcagat gtttcatcat ttgaaatcca acatagtgga tttgtgaagc
     3901 agctgttgct ttatttgaca tctaaaagtg aaaaggatgc tgtgagcaga gagatcagat
     3961 taaagcgatt tcttcatgta tttttttctt ctccacttcc tggagaagag cccattggaa
     4021 gagtggaacc agtgggtaat gcacctttgt tggcattagt tcacaagatg aacaactgcc
     4081 tcagccagat ggaacaattt ccagtcaaag tacatgattt ccctagtgga aatgggacag
     4141 gaggcagctt ttctctcaac agaggatcac aggctttaaa atttttcaac acacatcaat
     4201 taaaatgcca gttacaaagg catccagact gtgcaaatgt gaagcagtgg aagggtggac
     4261 ctgtcaagat tgaccctctg gctttggtac aagccatcga gagatacctt gtagttagag
     4321 ggtatggaag agtaagagaa gatgatgaag acagcgatga cgatggatca gatgaggaaa
     4381 tagatgagtc tctggctgct cagttcctaa attcaggaaa tgtaagacac aggctgcagt
     4441 tttatattgg agaacatttg ctgccgtata acatgactgt gtatcaggca gtacggcagt
     4501 ttagtataca ggctgaagat gaaagagaat ccacagatga tgagagcaat cctctaggca
     4561 gagctggtat ttggacaaag actcatacaa tatggtataa acctgtgaga gaggatgaag
     4621 aaagtaataa agattgtgtt ggtggtaaaa gaggaagagc ccaaacagct ccaacgaaaa
     4681 cttcccctag aaatgcaaaa aagcatgatg agttatggca cgatggagtg tgcccatcag
     4741 tatcaaatcc tttagaagtt tacctcattc ccacaccacc tgaaaatata acatttgaag
     4801 acccgtcatt agatgtgatc cttcttttaa gagttttaca tgctatcagt cgatactggt
     4861 attacttgta tgataatgca atgtgcaagg aaattattcc aactagtgaa tttattaaca
     4921 gtaagttaac agcaaaagca aataggcaac ttcaagatcc tttagtaatc atgacaggaa
     4981 acatcccaac atggcttact gagctaggaa aaacctgccc atttttcttt ccttttgata
     5041 cccggcaaat gcttttttat gtaactgcat ttgatcggga ccgagcaatg caaagattac
     5101 ttgataccaa cccagaaatc aaccagtctg attctcaaga tagcagagtt gcacctagat
     5161 tggatagaaa aaaacgtact gtgaaccgag aggagctgct gaaacaggcg gagtctgtga
     5221 tgcaggacct cggcagctca cgggccatgt tagaaatcca gtatgaaaat gaggttggta
     5281 caggtcttgg gcctacactg gagttttatg cgcttgtatc tcaggaacta cagagagctg
     5341 acttgggtct ttggagaggt gaagaagtaa ctcttagcaa tccaaaaggg agccaagaag
     5401 ggaccaagta tattcaaaac ctccagggcc tgtttgcgct tccctttggt aggacagcaa
     5461 agccagctca tatcgcaaag gttaagatga agtttcgctt cttaggaaaa ttaatggcca
     5521 aggctatcat ggatttcaga ttggtggacc ttccccttgg cttacccttt tataaatgga
     5581 tgctacggca agaaacttca ctgacatcac acgatttgtt tgacatcgac ccagttgtag
     5641 ccagatcagt ttatcaccta gaagacattg tcagacagaa gaaaagactt gaacaagata
     5701 aatcccagac caaagagagt ctacagtatg cattagaaac cttgactatg aatggctgct
     5761 cagttgaaga tctaggactg gatttcactc tgccagggtt tcccaatatc gaactgaaga
     5821 aaggagggaa ggatatacca gtcactatcc acaatttaga ggagtatcta agactggtta
     5881 tattctgggc actaaatgaa ggcgtttcta ggcaatttga ttcgttcaga gatggatttg
     5941 aatcagtctt cccactcagt catcttcagt acttctaccc ggaggaactg gatcagctcc
     6001 tttgtggcag taaagcagac acttgggatg caaagacact gatggaatgc tgtaggcctg
     6061 atcatggtta tactcatgac agtcgggctg tgaagttttt gtttgagatt ctcagtagtt
     6121 ttgataatga gcagcagagg ttatttctcc agtttgtgac tggtagccca agattgcctg
     6181 ttggaggatt ccggagtttg aatccacctt tgacaattgt ccgaaagacg tttgaatcaa
     6241 cagaaaaccc agatgacttc ttgccctctg taatgacttg tgtgaactat cttaagttgc
     6301 cggactattc aagcattgag ataatgcgtg aaaaactgtt gatagcagca agagaagggc
     6361 agcagtcgtt ccatctttcc tgatcatagc aagaaatgca gtgtctgcct gttacagcaa
     6421 aagaaacaaa tcatgatttc ttttctaatg ttatcacctg agtcaaggaa acatgttacg
     6481 ccttcttgtt gtaggaaaaa cggcttgcag attataaaga gacatttggt tgatattcat
     6541 taatggcccc atggacttaa agtgatcagg ccctaaaacg ttgttgtgat gaggtttctt
     6601 tagcaagttc ttgtttaaat tatcatttat ttgatgagtg aagtttttaa catgctttgc
     6661 tgtgtgaaat ttaaaaaagg gatgtttttc caggctggaa caataaatgt ggctgtgcag
     6721 tttaattctg ggctgtgtgt atccatctag ctaagtctgc agttttcttt cctccaaaga
     6781 caactcttgt acataagtac agaaatttaa gctcacatgt atttgacaaa tatagtttag
     6841 tagactagct ctatgtgctt ttcactttcc tctgattttc tctccctgat tcattattat
     6901 ctgtgcagct cacagttttt tttttgtata caactcacag ttctcaaatt ttcgttaccc
     6961 atgggcttct gttgtcccat gttctctcca gttaagatct aatttaaaat tcattggatt
     7021 gaaatttatt gaatataatt cagcttttgt aactaggtag acttttctta tagtttagtt
     7081 ttaatatagt ttagggtatt actggctttt tcccaggtga cacactaagg actgtttaca
     7141 tggcaattcc agcagcaaca gcctctggaa tgagacaagg aaagctcatt tgtttctttt
     7201 atgaaggtta agaagtctac agcttgggct ggccggtatt tattattctg tggccagagg
     7261 attttaaatt aatgtaaatt ttttaaacaa aataagcagt tttccttccc tgttggagta
     7321 aaaaaatttt tttccctttg ttgttttacg tttttgttca tagtcttctt tattccacgc
     7381 tcctcttccc cttctcccag tgctgacttg ggacaaaaca gttcagcctt tgtctcgacg
     7441 cagataaaag cacctgtaag caatgctgtc cagtcatttt atgtgctgat ttctcaaatc
     7501 tgcaataatc catcaggtta atgtttttac ctgaaaataa agaaagtttg cttcaccttt
     7561 ttgtttatag ttttgtgctg tatgcataac tttcaattgt atagatgtat ttcaatgcaa
     7621 ggaaatccac atatctccat gattcgggtc atggctgatt ttgctattca aacaatttat
     7681 aatagcaact tgaagaaact aaaatgtgaa gagaaaatgg gaggagattc cttcctaagg
     7741 tccaaaacta ggcctgtggc ataaatttga aggaattttc cataattcat ctccttgaaa
     7801 ataagagatg agctagtttt tttttttaat tgaactttga gaaatcaatt tttttgactg
     7861 ttctgtaagt tttaattaat tgacacaaaa gcccttttcc ctatcccacc acccaaaaga
     7921 aactcagtgg cttgtttgac atagattgct gtgtcaattt acacttaaat ggccttatat
     7981 ggaaatgtcc cctcctgaga gttcacttgg gcagtgaccc cattaagtgg aagggaactg
     8041 tcagaggagt tgggggcaga gaattctctc cctgtctctg cagagactga caagtgaatg
     8101 gcttttccct gaaatccaag aagggaattg tgtttctgca gttttcacca ctaacagcac
     8161 agttgctgag cagcttcatc aagtgaagtt aaagactgaa acaatttgtt ttcaactgtt
     8221 ctgatatctt cctgcaaatt aagcacaagg atttttgtgt gaacatagca ttttgttcct
     8281 gatttttaaa gggttctgtt aaaatttaga catgtataaa caaaataatg tttcatctgt
     8341 acttgacatt ttatccatgt tgcagccctg gcaaatttgg cctcattgat tccagcatct
     8401 aataagtata tatgatgatt ttgactcaaa ctctaaagtc ttgagtgttt caaagtcagt
     8461 cgttacctgt ttaaaagcct cagcctttag cttattcctc cttcaataca cgggaccttt
     8521 ggttaatttg gggcaggaaa actcttaaag taatctctct tggcagaggc cttattgcac
     8581 cagagggaaa aagtatatac ttcatttgct gttactccag ttatgcctta aattcatttg
     8641 cttggtaatc ctatcaacga gcactaactt cttagtatac tttaaacact tagttgggta
     8701 acaactgaga ttttgttgtc ctttattttt tgctgagatg gagtcagtca gatgttagtc
     8761 atagctaaca ccgaatttgt gttgtcattt agacagttac tgattcgatc tgctttatat
     8821 atgagaacgt atttttaact attccaagaa ggaagaggta gctaaatgta atcccctctt
     8881 cctatccccc cagaaaactg aactgtaagt tctaggtaga ctaattggga gcagacacgg
     8941 agttttagat gccttagcca aacccagcag aaacctttca cacagccact catcgtaaga
     9001 aacgcagatt tttctcttct catgcttgtc tctggttccc tgcatttgta gtgacagaac
     9061 tttcactagc aggatataaa gaaagtaatt atgcttggag tccctcttta ctgggtttga
     9121 gttaggtgca taacatggaa aggagtggtg ccttcaaatg aatgtgacca ctccgtattg
     9181 tggagtgact tccctagggc atcctataca tcctaccaca gaaggccaag ggacagagca
     9241 ccaacttcag tatccaagaa attagatcca caactcttga ttttccacac tgaggactgt
     9301 cgcgagtaag ttgtaagttt gccgtcttcc ttctggctta gcaggtgctg cagctgtact
     9361 ctcgactcct gtctgtgagc gtgagctcag gaaatgagag tggagtctat tccaaaaaaa
     9421 aaatgtgatg aagtttttca taaaagtgca ttcatatgcc aaatcctttt tggaggattc
     9481 tggatgctat tgttcatttc tctactagta aaatgatcaa gccttcattt attttaggct
     9541 ttgttttttg atccattttg ttttccctgc tgtaatgaga ataattgttt ggaaatgtca
     9601 tattctgtat ttatgattct ctgagaaatg cttttgtata agtcttaggt ttgacattgc
     9661 agtagttgac atacacggta aaggataacc tagtgacaaa tcactgaaga tgcttccttt
     9721 gttacctcaa aaaaaaaaat ccagacaaaa tagcatttat aaatatagaa aacaggattg
     9781 gctgttttcc aagaacttca agttaacaat tcttatgcaa ggaaaagttc ttaatgctaa
     9841 agacttgttc tgcatgaagg agacattctt taataatgga agaggtggtt ttatttttac
     9901 tacaagccga ctcatatttc caaacctata accaattgct gatctcctgt gtaaagcatt
     9961 tttttccttt tatctgaaac agtgatttat atgaactgtt ggaataatgg aacctcaaac
    10021 tacagatgtg tatgtaaaat tgcataaatg cactgacttc cttctccctg actatatttt
    10081 taataaacag cattatccta
//
