LOCUS       NM_004239               9996 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens thyroid hormone receptor interactor 11 (TRIP11),
            transcript variant 1, mRNA.
ACCESSION   NM_004239
VERSION     NM_004239.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9996)
  AUTHORS   Upadhyai,P., Radhakrishnan,P., Guleria,V.S., Kausthubham,N.,
            Nayak,S.S., Superti-Furga,A. and Girisha,K.M.
  TITLE     Biallelic deep intronic variant c.5457+81T>A in TRIP11 causes loss
            of function and results in achondrogenesis 1A
  JOURNAL   Hum Mutat 42 (8), 1005-1014 (2021)
   PUBMED   34057271
  REMARK    GeneRIF: Biallelic deep intronic variant c.5457+81T>A in TRIP11
            causes loss of function and results in achondrogenesis 1A.
REFERENCE   2  (bases 1 to 9996)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 9996)
  AUTHORS   Del Pino,M., Sanchez-Soler,M.J., Parron-Pajares,M., Aza-Carmona,M.,
            Heath,K.E. and Fano,V.
  TITLE     Description of four patients with TRIP11 variants expand the
            clinical spectrum of odontochondroplasia (ODCD) and demonstrate the
            existence of common variants
  JOURNAL   Eur J Med Genet 64 (5), 104198 (2021)
   PUBMED   33746040
  REMARK    GeneRIF: Description of four patients with TRIP11 variants expand
            the clinical spectrum of odontochondroplasia (ODCD) and demonstrate
            the existence of common variants.
REFERENCE   4  (bases 1 to 9996)
  AUTHORS   Medina,C.T.N., Sandoval,R., Oliveira,G., da Costa Silveira,K.,
            Cavalcanti,D.P. and Pogue,R.
  TITLE     Pathogenic variants in the TRIP11 gene cause a skeletal dysplasia
            spectrum from odontochondrodysplasia to achondrogenesis 1A
  JOURNAL   Am J Med Genet A 182 (4), 681-688 (2020)
   PUBMED   31903676
  REMARK    GeneRIF: Pathogenic variants in the TRIP11 gene cause a skeletal
            dysplasia spectrum from odontochondrodysplasia to achondrogenesis
            1A.
REFERENCE   5  (bases 1 to 9996)
  AUTHORS   Wehrle,A., Witkos,T.M., Unger,S., Schneider,J., Follit,J.A.,
            Hermann,J., Welting,T., Fano,V., Hietala,M., Vatanavicharn,N.,
            Schoner,K., Spranger,J., Schmidts,M., Zabel,B., Pazour,G.J.,
            Bloch-Zupan,A., Nishimura,G., Superti-Furga,A., Lowe,M. and
            Lausch,E.
  TITLE     Hypomorphic mutations of TRIP11 cause odontochondrodysplasia
  JOURNAL   JCI Insight 4 (3), e124701 (2019)
   PUBMED   30728324
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9996)
  AUTHORS   Ramos-Morales,F., Vime,C., Bornens,M., Fedriani,C. and Rios,R.M.
  TITLE     Two splice variants of Golgi-microtubule-associated protein of 210
            kDa (GMAP-210) differ in their binding to the cis-Golgi network
  JOURNAL   Biochem J 357 (Pt 3), 699-708 (2001)
   PUBMED   11463340
REFERENCE   7  (bases 1 to 9996)
  AUTHORS   Infante,C., Ramos-Morales,F., Fedriani,C., Bornens,M. and Rios,R.M.
  TITLE     GMAP-210, A cis-Golgi network-associated protein, is a minus end
            microtubule-binding protein
  JOURNAL   J Cell Biol 145 (1), 83-98 (1999)
   PUBMED   10189370
  REMARK    Erratum:[J Cell Biol 2002 Aug 5;158(3):593]
REFERENCE   8  (bases 1 to 9996)
  AUTHORS   Abe,A., Emi,N., Tanimoto,M., Terasaki,H., Marunouchi,T. and
            Saito,H.
  TITLE     Fusion of the platelet-derived growth factor receptor beta to a
            novel gene CEV14 in acute myelogenous leukemia after clonal
            evolution
  JOURNAL   Blood 90 (11), 4271-4277 (1997)
   PUBMED   9373237
REFERENCE   9  (bases 1 to 9996)
  AUTHORS   Chang,K.H., Chen,Y., Chen,T.T., Chou,W.H., Chen,P.L., Ma,Y.Y.,
            Yang-Feng,T.L., Leng,X., Tsai,M.J., O'Malley,B.W. and Lee,W.H.
  TITLE     A thyroid hormone receptor coactivator negatively regulated by the
            retinoblastoma protein
  JOURNAL   Proc Natl Acad Sci U S A 94 (17), 9040-9045 (1997)
   PUBMED   9256431
REFERENCE   10 (bases 1 to 9996)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049872.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 31, 2016 this sequence version replaced NM_004239.3.
            
            Summary: This gene was identified based on the interaction of its
            protein product with thyroid hormone receptor beta. This protein is
            associated with the Golgi apparatus. The N-terminal region of the
            protein binds Golgi membranes and the C-terminal region binds the
            minus ends of microtubules; thus, the protein is thought to play a
            role in assembly and maintenance of the Golgi ribbon structure
            around the centrosome. Mutations in this gene cause achondrogenesis
            type IA.[provided by RefSeq, Mar 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1667731.1, BC146845.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267622.8/ ENSP00000267622.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AL049872.3         117139-117651       c
            514-575             AL049872.3         110784-110845       c
            576-686             AL049872.3         102902-103012       c
            687-962             AL049872.3         99148-99423         c
            963-1031            AL049872.3         95274-95342         c
            1032-1197           AL049872.3         93288-93453         c
            1198-1560           AL049872.3         91807-92169         c
            1561-1601           AL049872.3         89347-89387         c
            1602-1688           AL049872.3         88578-88664         c
            1689-1901           AL049872.3         85232-85444         c
            1902-4931           AL049872.3         81011-84040         c
            4932-5072           AL049872.3         77560-77700         c
            5073-5266           AL049872.3         76832-77025         c
            5267-5430           AL049872.3         72944-73107         c
            5431-5534           AL049872.3         71401-71504         c
            5535-5634           AL049872.3         65876-65975         c
            5635-5716           AL049872.3         53700-53781         c
            5717-5831           AL049872.3         52764-52878         c
            5832-5948           AL049872.3         52219-52335         c
            5949-6093           AL049872.3         50309-50453         c
            6094-9996           AL049872.3         43583-47485         c
FEATURES             Location/Qualifiers
     source          1..9996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..9996
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /note="thyroid hormone receptor interactor 11"
                     /db_xref="GeneID:9321"
                     /db_xref="HGNC:HGNC:12305"
                     /db_xref="MIM:604505"
     exon            1..513
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..6314
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Golgi-microtubule-associated protein of 210 kDa; clonal
                     evolution-related gene on chromosome 14 protein;
                     TR-interacting protein 11; golgi-associated
                     microtubule-binding protein 210"
                     /codon_start=1
                     /product="thyroid receptor-interacting protein 11 isoform
                     1"
                     /protein_id="NP_004230.2"
                     /db_xref="CCDS:CCDS9899.1"
                     /db_xref="GeneID:9321"
                     /db_xref="HGNC:HGNC:12305"
                     /db_xref="MIM:604505"
                     /translation="MSSWLGGLGSGLGQSLGQVGGSLASLTGQISNFTKDMLMEGTEE
                     VEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQ
                     KEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDD
                     DMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNII
                     KELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGG
                     SGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR
                     EQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQ
                     ALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNN
                     EYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEAT
                     KHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQ
                     SEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIR
                     NELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKL
                     VLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYE
                     KTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSS
                     SLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLG
                     SMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKH
                     HQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTI
                     EQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL
                     EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQ
                     QQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTR
                     FESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQF
                     EELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSK
                     LQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSAS
                     LLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIA
                     ATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNE
                     NELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLR
                     EKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLA
                     LKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLR
                     KKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQ
                     YALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEA
                     NAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLM
                     RNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHDDQGGVTRWMTGWLGGGSKS
                     VPNTPLRPNQQSVVNSSFSELFVKFLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTN
                     APESFKDTAESRSGRRTDVNPFLAPRSAAVPLINPAGLGPGGPGHLLLKPISDVLPTF
                     TPLPALPDNSAGVVLKDLLKQ"
     exon            514..575
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            576..686
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            687..962
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1031
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1197
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1560
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1601
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1688
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1901
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..4931
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4932..5072
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5073..5266
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5267..5430
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5431..5534
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5535..5634
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5635..5716
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5717..5831
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5832..5948
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5949..6093
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     exon            6094..9996
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6445..6450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /note="hexamer: AATAAA"
     polyA_site      6473
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /note="major polyA site"
     polyA_site      8088
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
     regulatory      9973..9978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /note="hexamer: AATAAA"
     polyA_site      9996
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /note="major polyA site"
ORIGIN      
        1 gatccgctgc cgctttccga gcgagtgtca tggcggccgg cgtcgagttg gcaggagtaa
       61 cccacggaac tgaggaaagt cattagagct gagaaagaag tggcccaatc tggacggtgg
      121 gaattcgtgg gaatgagcag aaggccctcc gtaggtgact gtgtcactag aggcgggccc
      181 ctggtaaaat tccaggccag gcctctgcgt ttctaggcag aacctggagt cggccttgcc
      241 tgagaaccca gctttgtgtt atcgtatcct gtctcgcgaa ggcaggcgtt caaggatatt
      301 tggtcggatc gcccggcggc gctaaacgtt ttcttttttc cgagcggacc gggtcgttct
      361 ctaaactcgc cgcgatgtcg tcctggcttg ggggcctcgg ctccggattg ggccagtctc
      421 tgggtcaagt cgggggcagc ctggcttccc tcactggcca gatatcaaac tttacaaagg
      481 atatgctgat ggagggcacg gaggaagtgg aagcagaatt acctgattct aggacaaagg
      541 aaattgaagc cattcatgca atcttgagat cagagaatga aaggcttaag aaactttgta
      601 ctgatctaga agagaaacat gaagcatcag agattcaaat aaagcagcaa tctacaagtt
      661 accgaaatca acttcaacaa aaagaggtag aaatcagcca tcttaaagcc agacagattg
      721 cactccagga tcagttgctg aaactgcagt cagctgctca gtcagtacct tcaggagctg
      781 gtgtaccagc aaccactgca tcatcttcat tcgcttatgg gattagtcat catccttcag
      841 ctttccatga cgatgacatg gactttggtg atataatttc atcccaacaa gaaataaacc
      901 gactctcaaa tgaagtttca agacttgagt ctgaagttgg ccattggagg catattgctc
      961 agacttccaa agcacaagga acagataact ctgatcaaag tgaaatatgt aaactacaaa
     1021 atatcattaa ggaactaaaa cagaaccgaa gtcaggaaat tgatgaccat caacatgaaa
     1081 tgtcagtact gcagaatgca caccaacaga aattgacaga aataagtcga cgacatcgag
     1141 aagaattaag tgactatgaa gaacgaattg aagaacttga aaatctgtta caacaaggtg
     1201 gctctggagt tatagaaact gatctctcta aaatctatga gatgcaaaaa actattcaag
     1261 ttctacaaat agaaaaagtg gagtctacca aaaaaatgga acaacttgag gataaaataa
     1321 aagatataaa taaaaaatta tcttctgcag aaaatgacag agatattttg aggagagaac
     1381 aagaacagct aaatgtggaa aagagacaaa taatggaaga atgtgaaaac ttgaaattgg
     1441 aatgtagtaa attgcagcct tctgctgtga agcaaagtga tactatgaca gaaaaggaaa
     1501 gaattcttgc ccagagtgca tcagtggaag aagtgttcag actacaacaa gcactgtctg
     1561 atgccgaaaa tgaaataatg agattgagta gtttaaacca ggataacagt cttgctgaag
     1621 acaatctgaa acttaaaatg cgtatcgaag ttttagaaaa agagaagtca ttactgagtc
     1681 aagaaaagga agaacttcag atgtcacttt taaaattgaa caatgaatat gaagtaatta
     1741 aaagtacagc tacaagagac ataagtttgg attcagaatt acatgactta agacttaatt
     1801 tggaggcaaa ggaacaagaa ctcaatcaga gtattagtga aaaggaaaca ctgatagctg
     1861 agatagaaga attggacaga cagaatcaag aagctacaaa gcacatgatt ttgataaaag
     1921 atcagctatc aaaacaacaa aatgaaggag atagcatcat cagtaaactg aaacaagatc
     1981 taaatgatga aaaaaagaga gttcatcaac ttgaagatga taaaatggac attactaaag
     2041 agttagatgt acagaaagaa aagctaattc aaagtgaagt ggccctaaat gatttacatt
     2101 taaccaagca gaaacttgag gacaaagtag aaaatttagt agatcagcta aataaatcac
     2161 aagaaagtaa tgtaagcatc cagaaggaga atttagaact taaggagcat attagacaaa
     2221 atgaggagga gctttctaga ataaggaatg agttaatgca gtctctaaat caagactcta
     2281 atagtaattt taaggatacc ttacttaaag aaagagaagc tgaagttaga aacttaaagc
     2341 aaaatctttc agaattagaa cagctcaatg aaaatttaaa gaaagttgct tttgatgtca
     2401 aaatggaaaa tgaaaagtta gttttagcat gtgaagatgt gaggcatcag ttagaagaat
     2461 gtcttgctgg taacaatcag ctttctctgg aaaaaaacac tattgtggag actctaaaaa
     2521 tggaaaaagg agagatagag gcagaattgt gttgggctaa aaagaggctg ttggaagaag
     2581 caaacaagta tgagaaaacc attgaagaac tgtcaaatgc acgtaatttg aatacctctg
     2641 ccttacagct ggaacatgag catttaatta aactcaatca aaagaaagac atggaaatag
     2701 cagaactcaa aaagaatatt gaacaaatgg atactgacca taaagaaact aaggacgttt
     2761 tgtcatctag tttagaagag cagaagcagt tgacacaact tataaacaag aaagaaattt
     2821 ttattgaaaa gcttaaagaa agaagttcaa agctgcagga ggaattggat aaatattctc
     2881 aggccttaag aaaaaatgaa attttaagac agaccataga ggaaaaagac cgaagtcttg
     2941 gatccatgaa agaggaaaat aatcatctgc aagaagaatt ggaacgactc agggaagagc
     3001 agagtcgaac cgcacctgtg gctgacccta aaacccttga tagtgttact gaactagcat
     3061 ctgaggtatc tcaactgaac acgatcaagg aacatcttga agaggaaatt aaacatcatc
     3121 aaaagataat tgaagatcaa aaccagagta agatgcaact acttcagtct ttacaagagc
     3181 aaaagaagga aatggatgag tttagatacc agcatgagca aatgaacgcc acacacaccc
     3241 agctcttttt agagaaggat gaggaaatta agagtttgca aaaaacaatt gaacaaatca
     3301 aaacccagtt gcatgaagaa agacaggaca ttcaaacaga taactctgat atttttcaag
     3361 aaacaaaagt tcagagcctt aatatagaaa atggaagtga aaagcatgat ttatctaaag
     3421 ctgaaacgga aagattagtg aaaggaataa aagagcgaga actggagatt aaacttctaa
     3481 atgaaaagaa tatatcttta actaaacaga ttgatcagtt gtccaaagat gaagttggta
     3541 aactaactca gattattcag cagaaagatt tggagataca agctcttcat gctagaattt
     3601 cttcaacttc ccatactcaa gatgttgttt accttcaaca gcaactgcag gcttatgcta
     3661 tggaaagaga aaaggtattt gctgttttga atgagaagac tagggaaaat agccatctaa
     3721 aaacagaata tcacaaaatg atggatattg ttgctgccaa ggaagcagct cttatcaaac
     3781 tgcaagatga aaataaaaaa ttgtccacta gatttgaaag tagtggccaa gatatgttta
     3841 gagaaactat tcagaattta tcacgtatca ttcgagaaaa agacatcgaa atagatgcac
     3901 taagtcagaa atgtcagact ttattggcag ttttacaaac atccagcact ggtaatgagg
     3961 ctggaggtgt taatagtaat caatttgagg agcttctaca ggaacgtgac aagttaaaac
     4021 agcaagtaaa gaaaatggaa gagtggaagc agcaggtgat gaccacagta caaaatatgc
     4081 aacacgagtc agcccagctt caggaagagc ttcaccaact tcaagcacag gttttggttg
     4141 acagtgataa taattctaaa ttacaagtgg actatactgg cctgatccaa agttatgagc
     4201 agaatgaaac caaactcaaa aattttgggc aggaattagc acaagttcag cacagcattg
     4261 ggcagctttg caataccaag gatcttcttt taggaaaact tgatattatt tcaccccagc
     4321 tgtcttctgc atcattgctt actccccagt ctgcagagtg tcttagagca agtaagtctg
     4381 aagtattgag tgaatcttct gaattgcttc agcaagagtt agaagagcta agaaaatcac
     4441 tacaggaaaa agatgcaaca attagaactc tccaggaaaa taaccacaga ttgtctgatt
     4501 cgattgctgc cacctcagag ctagaaagaa aagaacacga acaaaccgat tcagaaatca
     4561 agcagctaaa ggagaaacaa gatgttttgc aaaagttact taaggaaaaa gacctcttaa
     4621 tcaaagccaa aagtgatcaa ctactttctt ccaatgaaaa tttcactaac aaagtaaatg
     4681 aaaacgaact tttgaggcag gcagtaacaa acctgaagga gagaatatta attctagaga
     4741 tggacattgg caaactaaaa ggagaaaatg aaaaaatagt ggaaacatac aggggaaagg
     4801 aaacagaata tcaagcgtta caagagacta acatgaagtt ttctatgatg ctgcgagaaa
     4861 aagagtttga gtgccactca atgaaggaga aggctcttgc ttttgaacag ctattgaaag
     4921 agaaagaaca gggcaagact ggagagttaa atcagctttt aaatgcagtt aaatcaatgc
     4981 aggagaagac agttgtgttt caacaggaga gagaccaagt catgttggcc ctgaaacaaa
     5041 aacaaatgga aaatactgcc ctacagaatg aggttcaacg tttacgtgac aaagaatttc
     5101 gttcaaacca agagctagag agattgcgta atcatctttt agaatcagaa gattcttata
     5161 cccgtgaagc tttggctgca gaagatagag aggctaaact aagaaagaaa gtcacagtat
     5221 tggaggaaaa gctagtttca tcctctaatg caatggaaaa tgcaagccat caagccagtg
     5281 tgcaggtaga gtcattgcaa gaacagttga atgtagtttc caagcaaagg gatgaaactg
     5341 cgctgcagct ttctgtctct caggaacaag taaagcagta tgctctgtca ctggccaacc
     5401 tgcagatggt actagagcat ttccaacaag aggaaaaagc tatgtattct gctgaactcg
     5461 aaaagcaaaa acagcttata gctgaatgga agaaaaacgc agaaaatctg gaaggaaaag
     5521 tgatatcatt acaggaatgt ttggatgaag caaatgctgc attggattca gcatcaagac
     5581 ttacagaaca gttagatgta aaagaagaac aaattgaaga acttaaaaga caaaatgagc
     5641 tccgacaaga aatgctggat gatgtacaaa agaaattgat gagcttagca aacagctcag
     5701 aaggaaaagt agacaaagtc ctaatgagaa acctcttcat tggtcatttc cacacaccga
     5761 aaaatcagcg tcatgaagtg ttacggttaa tggggagcat cctgggcgtc agaagggagg
     5821 agatggagca gttgtttcat gacgatcagg gcggtgttac caggtggatg actgggtggc
     5881 ttggaggagg atcaaaaagt gttcccaaca cacctttgag accaaatcag caatctgtgg
     5941 ttaatagttc tttttcagaa ctttttgtta aatttctaga aacagaatct catccatcca
     6001 ttccaccacc aaagctttct gttcatgata tgaaacctct ggattcacca ggaagaagaa
     6061 aaagagatac aaatgcacca gaaagtttta aagatacagc agaatccagg tctggtagaa
     6121 gaacagatgt aaatccgttt ttggctcctc gctcggcagc tgtacctctt attaacccag
     6181 ctggacttgg acctggtggg cccgggcatc ttcttctgaa acccatctca gatgttttgc
     6241 ccacatttac acctttgcca gcgttacctg acaacagtgc tggggttgtg ctgaaagacc
     6301 ttttaaagca atagatgatt ctcaagccag agacaatcta gcactttaaa gaaaccatga
     6361 acactatatg tatgtacttt atcacaaagt ggcctttggg gagaaagtca tgtatttgtt
     6421 cgcaattatg ctttctctga atttaataaa aatattccta atgcttttag aaactgcagg
     6481 tgtcaggagc aagtgtttgc tatataatct gctttattcc ttctgatttg acctaattta
     6541 agctaggaac atttaattta tcttttacct taatttacaa aaatacagac agacaaaaat
     6601 actagtagct atatggcagc tttttatttc cttttgtgat ttccaagctc atttaagcta
     6661 gagattgtgg tttatcaaga gagtgttttt tttttttaaa cgaagaataa aaaaatacta
     6721 gtagtggctt ctctgcatag tgcagaaagt tgatttgaag catatattga tcatctttag
     6781 aggactttgt ggagacaggc caacaagatt gttgctggaa ggtcataggt tccctgaggt
     6841 gaagtatgta tttggtcctg tgcaatatta tcatgtgtgt agattctttt tttgtttgtt
     6901 ttaaatagag atggggtctc actatgttgc caggctggcc tcaaactcct gggctcaagt
     6961 gatcctccca cctcagcctc ccaaagtgct gggattaagg catgagccac tgcgcctggc
     7021 cctgtgtgta aattcatgtg actaccacca caggcaagac acggaagact tccattacaa
     7081 gcatccccct gtgttgccct ctcataatca ttgccacctc tctccctggc cctctcctta
     7141 atccctgaca accacttact gttctccatc tcagtcattt tgttattttg agaatgttat
     7201 ataaatggaa tcaatatata ccctcttgag actggctttt tttcactcag cataattccc
     7261 ttgagatcca tccaaggctt tggatgtatc actagtttgt tcctttttat tgttgagcat
     7321 atagtgcaga tatatcactt agttttaaca gctaaggtat ctatttaaag ataccatctt
     7381 aaaactaaat gttacacaaa ttcatgcaac tttcatataa gcattaaacc atacagctgc
     7441 atctacgtaa gtataattag caaaatcact gaacatgcca cttcctgcct ccgtctgcgg
     7501 tgttgacata tgaggtacag caatccgaga gtcaactgtt atcacggtgg ccactgaggg
     7561 cagtgaaatc actttgatag caccagtacc cagatgtttg aaacttaaga aagtatttct
     7621 ttaatttttc ataaacccat cataaaaaaa aaatcccgac ttgaaactta actgtatctg
     7681 gatgttcata tttttattag ttgttgaagt tgtacattta aaaagatatt tcttgcaaat
     7741 tttgtaaatt tctatatgct tttaaaatag aaacatttgt ataacaagga aggatgaaaa
     7801 taaaacaaat tcaaatatgt gaatagtcct ggctgaggcc agaactaaat ttggttattt
     7861 gcaagtttta ctgtgattaa ctgtactttc taatgtattt ggaagactgg aagtcttaat
     7921 tccatgttga tgggtgaaac ttgtttttct gaaaaatgaa gtaactgaaa atgctgcttc
     7981 agaatgtctt gtatctcctt agataactaa tttatattgc cattctttat ttactatact
     8041 ttaaaggaag ttgtcatgca agttctatat tagaactgtc aaactgcctc ttggtttttg
     8101 cctattatta tttctctgtg agttgttact ccttggtttt tatatgctcc taacaaagat
     8161 actttcactg actatcctac attatttgct gcttgccatt gaaatttcat ttcagtgtgg
     8221 agaaatgaaa tactagtttc taagttaaaa aagacacatg gtcctttatt tttaagaaat
     8281 agaatatgta aaaagttttc tcttttaatt tgaaaaagag atgcatggtt ggtatttaag
     8341 tagtatgtca tcatatttga aatgcctttt gtgacatttt tgagtatttc cttctctgac
     8401 caaaacaact tgtccgcctc tcatcccatg gtttaacgta agtttaaaag ctgttgtggg
     8461 tggattgcat agctaaacat cacagagcat gatattaaat ggctgctatt taaataaata
     8521 tgtgaccttg tcctaaagct ataatactgg ccgggcacag tggctcacgc ctgtaatccc
     8581 agaactttgg gagggtgagg tgggtggatc acctgaggtc aggagttcaa gaccagcctg
     8641 gccaacatgg tgaaacccca tctctactaa aaatacaaaa attagctggg catggtggca
     8701 ggcgcctata atcccagcta ctcaggaggc tgaggcagga gaattgcttg accccgggaa
     8761 gtggaggttg cagttagcaa ccactccact gcactccagc ctgagcgaca gagcgagact
     8821 ctgtctcaaa aaaaaaaaaa aaaaaaaaaa agctatagta cctaatgttt tcattgtgtc
     8881 attgaaacta tagctgactg gtatgtatac taagtgttcg ttgatctaaa ccagatataa
     8941 gtcattgact tttctgaaac ttagttgtgt cagagatgaa ccacctgctc actgaaccgt
     9001 cttagtaacc agtgatgaag catataattc taatgttggc aataggacat tgctaacagt
     9061 gcgtttaact gcaatatttt aactacagta atttttctgt ttatttctct atccactcag
     9121 tagaatttgt ggttgaattc caccttcgct gccatagttt tttaccacat tcctaatggt
     9181 tttcaacctc tatactgtag tagaaaattc atctaactac tgaatttaat tttagcataa
     9241 tactggatca aattgtttga attttcattc ctgtcatttt tgatttttaa aaaatgaaac
     9301 aaaactaaac aacaaaaccc taggaaaaga atggcttctt tccaactagt caattaaaac
     9361 gtccagtatc tccccaaata aagccttagg tttcttttaa cctcttaatg gttaattgaa
     9421 aagagtacag aaactatcaa aatacttatc caatcaatgg ggggaaaagc tatgtcttca
     9481 gggacagtag agtgatgaga attttttaga aaacactatt atccatcaaa cttaaaagca
     9541 tttggacctg atatttaaag ataatgaagt tttccacata ttgaagtatt caagacatct
     9601 tccatccaca aaaatttatc tttaagtttt gtaaatatca agtaagtata gatgatattt
     9661 attttatata ttcctatgga aaaaatgcta ctttaatgtt ctgacatttg tgattatttg
     9721 ccagtcttta ctttttaact tattaaaaag ttaaatactt attaaggttt ctctatgtaa
     9781 aacaatttaa attgtctttt gatttttagg gaaatatcta aacgtgggaa atttccaacg
     9841 caaccttaat attaggttgt gttatttata gagctaaagt taatgcattt ttgaatttct
     9901 caggagcact gcaaggcaaa aaaatactcc aaataaaaat gatatatgta agttggcaat
     9961 gtcttcagtc acaataaaaa aaatttttag caaaca
//
