LOCUS       NM_001288962            2207 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens thyroid hormone receptor interactor 10 (TRIP10),
            transcript variant 1, mRNA.
ACCESSION   NM_001288962 XM_005259681
VERSION     NM_001288962.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2207)
  AUTHORS   Fang,L., Shi,L., Wang,W., Wu,X., Hu,T., Huang,Y. and Rao,X.
  TITLE     Low expression of CIP4 in predicting worse overall survival: A
            potential biomarker for laryngeal cancer
  JOURNAL   PLoS One 16 (9), e0253545 (2021)
   PUBMED   34570775
  REMARK    GeneRIF: Low expression of CIP4 in predicting worse overall
            survival: A potential biomarker for laryngeal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2207)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2207)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2207)
  AUTHORS   Tonucci,F.M., Almada,E., Borini-Etichetti,C., Pariani,A.,
            Hidalgo,F., Rico,M.J., Girardini,J., Favre,C., Goldenring,J.R.,
            Menacho-Marquez,M. and Larocca,M.C.
  TITLE     Identification of a CIP4 PKA phosphorylation site involved in the
            regulation of cancer cell invasiveness and metastasis
  JOURNAL   Cancer Lett 461, 65-77 (2019)
   PUBMED   31319138
  REMARK    GeneRIF: CIP4 PKA phosphorylation is associated with cancer cell
            invasiveness and metastasis.
            Erratum:[Cancer Lett. 2020 Mar 31;473:200-201. doi:
            10.1016/j.canlet.2019.12.033.. PMID: 31932121]
REFERENCE   5  (bases 1 to 2207)
  AUTHORS   Chan Wah Hak,L., Khan,S., Di Meglio,I., Law,A.L., Lucken-Ardjomande
            Hasler,S., Quintaneiro,L.M., Ferreira,A.P.A., Krause,M.,
            McMahon,H.T. and Boucrot,E.
  TITLE     FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma
            membrane for fast endophilin-mediated endocytosis
  JOURNAL   Nat Cell Biol 20 (9), 1023-1031 (2018)
   PUBMED   30061681
  REMARK    GeneRIF: FBP17 and CIP4 prime the membrane of resting cells for
            fast endophilin-mediated endocytosis by recruiting the 5'-lipid
            phosphatase SHIP2 and lamellipodin to mediate the local production
            of phosphatidylinositol-3,4-bisphosphate and endophilin
            pre-enrichment.
            Erratum:[Nat Cell Biol. 2018 Oct;20(10):1229. doi:
            10.1038/s41556-018-0191-3.. PMID: 30127497]
REFERENCE   6  (bases 1 to 2207)
  AUTHORS   Linder,S., Hufner,K., Wintergerst,U. and Aepfelbacher,M.
  TITLE     Microtubule-dependent formation of podosomal adhesion structures in
            primary human macrophages
  JOURNAL   J Cell Sci 113 Pt 23, 4165-4176 (2000)
   PUBMED   11069762
REFERENCE   7  (bases 1 to 2207)
  AUTHORS   Tian,L., Nelson,D.L. and Stewart,D.M.
  TITLE     Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich
            syndrome protein to microtubules
  JOURNAL   J Biol Chem 275 (11), 7854-7861 (2000)
   PUBMED   10713100
REFERENCE   8  (bases 1 to 2207)
  AUTHORS   Tsuji,E. and Tsuji,Y.
  TITLE     Molecular cloning and chromosomal localization of human
            salt-tolerant protein
  JOURNAL   Genetica 108 (3), 259-262 (2000)
   PUBMED   11294612
REFERENCE   9  (bases 1 to 2207)
  AUTHORS   Aspenstrom,P.
  TITLE     A Cdc42 target protein with homology to the non-kinase domain of
            FER has a potential role in regulating the actin cytoskeleton
  JOURNAL   Curr Biol 7 (7), 479-487 (1997)
   PUBMED   9210375
REFERENCE   10 (bases 1 to 2207)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008760.7, DB198268.1, CB997985.1, AF502289.1 and AY081141.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001288962.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1047939.1, AF502289.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313244.14/ ENSP00000320117.7
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC008760.7         175366-175367
            3-16                DB198268.1         3-16
            17-47               CB997985.1         28-58
            48-2123             AF502289.1         5-2080
            2124-2203           AY081141.1         1988-2067
            2204-2207           AC008760.7         187213-187216
FEATURES             Location/Qualifiers
     source          1..2207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2207
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /note="thyroid hormone receptor interactor 10"
                     /db_xref="GeneID:9322"
                     /db_xref="HGNC:HGNC:12304"
                     /db_xref="MIM:604504"
     exon            1..106
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1888
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CDC42-interacting protein 4; salt tolerator; protein
                     Felic; salt tolerant protein; TR-interacting protein 10;
                     thyroid receptor-interacting protein 10"
                     /codon_start=1
                     /product="cdc42-interacting protein 4 isoform 1"
                     /protein_id="NP_001275891.1"
                     /db_xref="CCDS:CCDS74271.1"
                     /db_xref="GeneID:9322"
                     /db_xref="HGNC:HGNC:12304"
                     /db_xref="MIM:604504"
                     /translation="MDWGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAK
                     QLRSLVKKYLPKRPAKDDPESKFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCLEL
                     TKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQ
                     DINATKADVEKAKQQAHLRSHMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQD
                     MDERRATRLGAGYGLLSEAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGF
                     ARPGDVEFEDFSQPMNRAPSDSSLGTPSDGRPELRGPGRSRTKRWPFGKKNKPRPPPL
                     SPLGGPVPSALPNGPPSPRSGRDPLAILSEISKSVKPRLASFRSLRGSRGTVVTEDFS
                     HLPPEQQRKRLQQQLEERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAET
                     LSNIERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSASQD
                     TKESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEGSSEGTISMAEGED
                     LSLMEEDKGDGWTRVRRKEGGEGYVPTSYLRVTLN"
     exon            107..222
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            223..279
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            280..427
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            428..490
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            491..595
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            596..724
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            725..871
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1066
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1234
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1344
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1477
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1617
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1739
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..2207
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2157
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /note="major polyA site"
     regulatory      2181..2186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
                     /note="hexamer: TATAAA"
     polyA_site      2207
                     /gene="TRIP10"
                     /gene_synonym="CIP4; HSTP; STOT; STP; TRIP-10"
ORIGIN      
        1 gagtctcccc ggggagggcg gcgggcggcg ggcggcgggg accgggtgcg gtggtggctg
       61 cggcggcggc ggcgggagca gcatggattg gggcactgag ctgtgggatc agttcgaggt
      121 gctcgagcgc cacacgcagt gggggctgga cctgttggac agatatgtaa agttcgtgaa
      181 agaacgcacc gaagtggaac aggcttacgc caaacaactg cggagcctgg tgaaaaaata
      241 tctgcccaag agacctgcca aggatgatcc tgagtccaaa ttcagccagc aacagtcctt
      301 cgtacagatt ctccaggagg tgaatgactt tgcaggccag cgggagctgg tggctgagaa
      361 cctcagtgtc cgtgtatgtc ttgagctgac caagtactca caagagatga aacaggagag
      421 gaagatgcac ttccaagaag ggcggcgggc ccagcagcag ctggaaaatg gctttaaaca
      481 gctggagaat agtaagcgta aatttgagcg ggactgccgg gaggcagaga aggcagccca
      541 gactgctgaa cggctagacc aggatatcaa cgccaccaag gctgatgtgg agaaggccaa
      601 gcagcaagcc caccttcgga gtcacatggc cgaagaaagc aaaaacgaat atgcggctca
      661 actgcagcgc ttcaaccgag accaagccca cttctatttt tcacagatgc cccagatatt
      721 cgataagctc caagacatgg atgaacgcag ggccacccgc ctgggtgccg ggtatgggct
      781 cctgtcggag gccgagctgg aggtggtgcc cataatagcc aagtgcttgg agggcatgaa
      841 ggtggctgca aatgctgtgg atcccaagaa cgactcccac gtccttatag agctgcacaa
      901 gtcaggtttt gcccgcccgg gcgacgtgga attcgaggac ttcagccagc ccatgaaccg
      961 tgcaccctcc gacagcagtc tgggcacccc ctcggatgga cggcctgaac tccgaggccc
     1021 gggtcgcagc cgcaccaagc gctggccttt tggcaagaag aacaagcctc gccccccacc
     1081 cctctccccc ctggggggcc ccgtaccctc ggcattgcct aacggacccc cgtccccccg
     1141 ctccggccgt gaccccttgg ccatactgag cgagatcagt aagtcggtca aaccgaggct
     1201 agcatccttc cgcagccttc gaggcagccg tgggacagtg gtgaccgagg attttagcca
     1261 cttgccccca gagcagcagc gaaaacggct tcaacagcag ttggaagaac gcagtcgtga
     1321 acttcagaag gaggttgacc agagggaagc cctaaagaaa atgaaggatg tctatgagaa
     1381 gacacctcag atgggggacc ccgccagctt ggagccccag atcgctgaaa ccctgagcaa
     1441 cattgaacgg ctgaaattgg aagtgcagaa gtatgaggcg tggctggcag aagctgaaag
     1501 tcgagtcctt agcaaccggg gagacagcct gagccggcac gcccggcctc ccgacccccc
     1561 cgctagcgcc ccgccagaca gcagcagcaa cagcgcatca caggacacca aggagagctc
     1621 tgaagagcct ccctcagaag agagccagga cacccccatt tacacggagt ttgatgagga
     1681 tttcgaggag gaacccacat cccccatagg tcactgtgtg gccatctacc actttgaagg
     1741 gtccagcgag ggcactatct ctatggccga gggtgaagac ctcagtctta tggaagaaga
     1801 caaaggggac ggctggaccc gggtcaggcg gaaagaggga ggcgagggct acgtgcccac
     1861 ctcctacctc cgagtcacgc tcaattgaac cctgccagag acgggaagag gggggctgtc
     1921 ggctgctgct tctgggccac ggggagcccc aggacctatg cactttattt ctgaccccgt
     1981 ggcttcggct gagacctgtg taacctgctg ccccctccac ccccaaccca gtcctacctg
     2041 tcacaccgga cggacccgct gtgccttcta ccatcgttcc accattgatg tacatactca
     2101 tgttttacat cttttctttc tgccgctcgg ctccggccat tttgttttat acaaaaatgg
     2161 gaaaaaaaaa aaagaaatta tataaagttc ctagagtcgg tgtctta
//
