LOCUS       NM_138632               1743 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens TRIO and F-actin binding protein (TRIOBP), transcript
            variant 2, mRNA.
ACCESSION   NM_138632
VERSION     NM_138632.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1743)
  AUTHORS   Wang,L., Zhao,W., Xia,C., Ma,S., Li,Z., Wang,N., Ding,L., Wang,Y.,
            Cheng,L., Liu,H., Yang,J., Li,Y., Rosas,I. and Yu,G.
  TITLE     TRIOBP modulates beta-catenin signaling by regulation of miR-29b in
            idiopathic pulmonary fibrosis
  JOURNAL   Cell Mol Life Sci 81 (1), 13 (2023)
   PUBMED   38157020
  REMARK    GeneRIF: TRIOBP modulates beta-catenin signaling by regulation of
            miR-29b in idiopathic pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1743)
  AUTHORS   Pavesic Radonja,A., Blazevic Zelic,S., Rubesa,G. and Bradshaw,N.J.
  TITLE     SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3, DYSBINDIN-1
            AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A PANSS-BASED
            FOLLOW UP STUDY
  JOURNAL   Psychiatr Danub 35 (2), 180-186 (2023)
   PUBMED   37480305
  REMARK    GeneRIF: SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3,
            DYSBINDIN-1 AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A
            PANSS-BASED FOLLOW UP STUDY.
REFERENCE   3  (bases 1 to 1743)
  AUTHORS   Kabahuma,R.I., Schubert,W.D., Labuschagne,C., Yan,D., Pepper,M.S.
            and Liu,X.Z.
  TITLE     Elucidation of repeat motifs R1- and R2-related TRIOBP variants in
            autosomal recessive nonsyndromic hearing loss DFNB28 among
            indigenous South African individuals
  JOURNAL   Mol Genet Genomic Med 10 (10), e2015 (2022)
   PUBMED   36029164
  REMARK    GeneRIF: Elucidation of repeat motifs R1- and R2-related TRIOBP
            variants in autosomal recessive nonsyndromic hearing loss DFNB28
            among indigenous South African individuals.
REFERENCE   4  (bases 1 to 1743)
  AUTHORS   Zaharija,B., Odorcic,M., Hart,A., Samardzija,B., Marreiros,R.,
            Prikulis,I., Jukovic,M., Hyde,T.M., Kleinman,J.E., Korth,C. and
            Bradshaw,N.J.
  TITLE     TRIOBP-1 Protein Aggregation Exists in Both Major Depressive
            Disorder and Schizophrenia, and Can Occur through Two Distinct
            Regions of the Protein
  JOURNAL   Int J Mol Sci 23 (19), 11048 (2022)
   PUBMED   36232351
  REMARK    GeneRIF: TRIOBP-1 Protein Aggregation Exists in Both Major
            Depressive Disorder and Schizophrenia, and Can Occur through Two
            Distinct Regions of the Protein.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1743)
  AUTHORS   Park,S., Lee,H., Kim,M., Park,J., Kim,S.H. and Park,J.
  TITLE     Emerging roles of TRIO and F-actin-binding protein in human
            diseases
  JOURNAL   Cell Commun Signal 16 (1), 29 (2018)
   PUBMED   29890989
  REMARK    GeneRIF: roles of TRIO and F-actin-binding protein in human
            diseases
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1743)
  AUTHORS   Seipel,K., O'Brien,S.P., Iannotti,E., Medley,Q.G. and Streuli,M.
  TITLE     Tara, a novel F-actin binding protein, associates with the Trio
            guanine nucleotide exchange factor and regulates actin cytoskeletal
            organization
  JOURNAL   J Cell Sci 114 (Pt 2), 389-399 (2001)
   PUBMED   11148140
REFERENCE   7  (bases 1 to 1743)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   8  (bases 1 to 1743)
  AUTHORS   Ueki,N., Oda,T., Kondo,M., Yano,K., Noguchi,T. and Muramatsu,M.
  TITLE     Selection system for genes encoding nuclear-targeted proteins
  JOURNAL   Nat Biotechnol 16 (13), 1338-1342 (1998)
   PUBMED   9853615
REFERENCE   9  (bases 1 to 1743)
  AUTHORS   Mayer,B.J., Ren,R., Clark,K.L. and Baltimore,D.
  TITLE     A putative modular domain present in diverse signaling proteins
  JOURNAL   Cell 73 (4), 629-630 (1993)
   PUBMED   8500161
REFERENCE   10 (bases 1 to 1743)
  AUTHORS   Shearer,A.E., Hildebrand,M.S., Odell,A.M. and Smith,R.J.H.
  TITLE     Genetic Hearing Loss Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301607
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ880866.1, BC003618.2,
            BC022200.1 and BU621193.1.
            
            On Oct 27, 2005 this sequence version replaced NM_138632.1.
            
            Summary: This gene encodes a protein with an N-terminal pleckstrin
            homology domain and a C-terminal coiled-coil region. The protein
            interacts with trio, which is involved with neural tissue
            development and controlling actin cytoskeleton organization, cell
            motility and cell growth. The protein also associates with F-actin
            and stabilizes F-actin structures. Mutations in this gene have been
            associated with a form of autosomal recessive nonsyndromic
            deafness. Multiple alternatively spliced transcript variants that
            would encode different isoforms have been found for this gene,
            however some transcripts may be subject to nonsense-mediated decay
            (NMD). [provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR,
            and coding region (compared to variant 6), resulting in a protein
            that has shorter and distinct N- and C-termini when it is compared
            to isoform 6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022200.1, SRR1163658.140280.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               BQ880866.1         1-133
            134-1189            BC003618.2         56-1111
            1190-1720           BC022200.1         1184-1714
            1721-1743           BU621193.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1743
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..1743
                     /gene="TRIOBP"
                     /gene_synonym="DFNB28; dJ37E16.4; HRIHFB2122; TAP68; TARA"
                     /note="TRIO and F-actin binding protein"
                     /db_xref="GeneID:11078"
                     /db_xref="HGNC:HGNC:17009"
                     /db_xref="MIM:609761"
     exon            1..187
                     /gene="TRIOBP"
                     /gene_synonym="DFNB28; dJ37E16.4; HRIHFB2122; TAP68; TARA"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..1300
                     /gene="TRIOBP"
                     /gene_synonym="DFNB28; dJ37E16.4; HRIHFB2122; TAP68; TARA"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tara-like protein; trio-associated repeat on actin;
                     protein Tara; TRF1-associated protein of 68 kDa"
                     /codon_start=1
                     /product="TRIO and F-actin-binding protein isoform 2"
                     /protein_id="NP_619538.2"
                     /db_xref="CCDS:CCDS33644.1"
                     /db_xref="GeneID:11078"
                     /db_xref="HGNC:HGNC:17009"
                     /db_xref="MIM:609761"
                     /translation="MGGWKGPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAREP
                     RPRSCLLLPPPWGAAMTPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLT
                     DSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSG
                     IRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRG
                     GPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKW
                     FEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLT
                     ALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGY
                     ISQLVGVITVPVLQTRPLSSERLCDLPKVTPPAGLKGGI"
     exon            188..244
                     /gene="TRIOBP"
                     /gene_synonym="DFNB28; dJ37E16.4; HRIHFB2122; TAP68; TARA"
                     /inference="alignment:Splign:2.1.0"
     exon            245..352
                     /gene="TRIOBP"
                     /gene_synonym="DFNB28; dJ37E16.4; HRIHFB2122; TAP68; TARA"
                     /inference="alignment:Splign:2.1.0"
     exon            353..442
                     /gene="TRIOBP"
                     /gene_synonym="DFNB28; dJ37E16.4; HRIHFB2122; TAP68; TARA"
                     /inference="alignment:Splign:2.1.0"
     exon            443..552
                     /gene="TRIOBP"
                     /gene_synonym="DFNB28; dJ37E16.4; HRIHFB2122; TAP68; TARA"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1078
                     /gene="TRIOBP"
                     /gene_synonym="DFNB28; dJ37E16.4; HRIHFB2122; TAP68; TARA"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1189
                     /gene="TRIOBP"
                     /gene_synonym="DFNB28; dJ37E16.4; HRIHFB2122; TAP68; TARA"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1727
                     /gene="TRIOBP"
                     /gene_synonym="DFNB28; dJ37E16.4; HRIHFB2122; TAP68; TARA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1707..1712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIOBP"
                     /gene_synonym="DFNB28; dJ37E16.4; HRIHFB2122; TAP68; TARA"
                     /note="hexamer: AATATA"
     polyA_site      1727
                     /gene="TRIOBP"
                     /gene_synonym="DFNB28; dJ37E16.4; HRIHFB2122; TAP68; TARA"
                     /note="major polyA site"
ORIGIN      
        1 ttttatgggc ggatggaagg ggccggggca gcgtcgggga aaggaagggc cggaggcgcg
       61 gcggcgggcg gccgagaggg gcggcggcgg cggcggcggc ggggttcccg cgccgcggag
      121 cccggcccga gagccgcgtc cacgttcctg cctcctgctc ccgccgccct ggggcgccgc
      181 catgacgccc gatctgctca acttcaagaa gggatggatg tcgatcttgg acgagcctgg
      241 agagcctccc tccccctcgc tcaccaccac ctctacttcg cagtggaaga aacattggtt
      301 tgtgctgaca gattcaagtc tcaaatatta cagagactcc actgctgagg aggcagatga
      361 gctggatggt gagatcgacc tgcgttcctg cacggatgtc actgagtacg cggtgcagcg
      421 caactatggc ttccagatcc acaccaagga tgctgtctat accttgtcgg ccatgacctc
      481 aggcatccgg cggaactgga tcgaggctct gagaaagacc gtacgtccaa cttcagcccc
      541 agatgtcacc aagctctcgg actctaacaa ggagaacgcg ctgcacagct acagcaccca
      601 gaagggcccc ctgaaggcag gggagcagcg ggcgggctct gaggtcatca gccggggtgg
      661 ccctcggaag gcggacgggc agcgtcaggc cttggactac gtggagctct cgccgctgac
      721 ccaggcttcc ccgcagcggg cccgcacccc agcccgcact cctgaccgcc tggccaagca
      781 ggaggagctg gagcgggacc tggcccagcg ctccgaggag cggcgcaagt ggtttgaggc
      841 cacagacagc aggaccccag aggtgcctgc tggtgagggg ccgcgccggg gcctgggtgc
      901 ccccctgact gaggaccagc aaaaccggct tagtgaggag atcgagaaga agtggcagga
      961 gctggagaag ctgcccctgc gggagaataa gcgggtgccc ctcactgccc tgctcaacca
     1021 aagccgcgga gagcgccgag ggcccccaag tgacggccac gaggcactgg agaaggaggt
     1081 tcaggctctt cgggcccagc tggaggcgtg gcgtctccaa ggggaggctc ctcagagtgc
     1141 actgagatcc caggaggatg gccacatccc cccgggctac atctcacagc tggtgggcgt
     1201 gatcactgtg cccgttttac agacaaggcc actgagctct gagaggttat gtgacttgcc
     1261 caaggtcacc ccgcctgcag gtctcaaagg tgggatttga gcgagggtcc ggctgactgc
     1321 agagcctgtg tgtgagtccc cgtgtgacac tctgcacttg gacccttgcc ccggggaagt
     1381 ggggggctag tggccccgag agtcactccc tgaacacagg gaaatcctgc cgaggcccac
     1441 tgggccaagg ccccacacaa ggaggtctgc aggacagggg agcctccagt agccctcaga
     1501 gaatgcaccg tccgcctagg acagcggttc tcaacggggt ccattttgtc ccccttgggg
     1561 acatttggct gtgtctggga atacttctgg ttgtcacaac taggacaaac taactctcta
     1621 gaaaaaacgt gtgtgtgtac acatatataa gtttattata aattttacca ataaaaacaa
     1681 tgcttagtac acaatttaca aataaaaata tataatttta ttgtgaaaaa aaaaaaaaaa
     1741 aaa
//
