LOCUS       NM_007118              11460 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens trio Rho guanine nucleotide exchange factor (TRIO),
            transcript variant 1, mRNA.
ACCESSION   NM_007118 XM_001720067 XM_001721583 XM_001723929
VERSION     NM_007118.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11460)
  AUTHORS   Rao,S., Sadybekov,A., DeWitt,D.C., Lipka,J., Katritch,V. and
            Herring,B.E.
  TITLE     Detection of autism spectrum disorder-related pathogenic trio
            variants by a novel structure-based approach
  JOURNAL   Mol Autism 15 (1), 12 (2024)
   PUBMED   38566250
  REMARK    GeneRIF: Detection of autism spectrum disorder-related pathogenic
            trio variants by a novel structure-based approach.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11460)
  AUTHORS   Bonnet,M., Roche,F., Fagotto-Kaufmann,C., Gazdagh,G., Truong,I.,
            Comunale,F., Barbosa,S., Bonhomme,M., Nafati,N., Hunt,D.,
            Rodriguez,M.P., Chaudhry,A., Shears,D., Madruga,M., Vansenne,F.,
            Curie,A., Kajava,A.V., Baralle,D., Fassier,C., Debant,A. and
            Schmidt,S.
  TITLE     Pathogenic TRIO variants associated with neurodevelopmental
            disorders perturb the molecular regulation of TRIO and axon
            pathfinding in vivo
  JOURNAL   Mol Psychiatry 28 (4), 1527-1544 (2023)
   PUBMED   36717740
  REMARK    GeneRIF: Pathogenic TRIO variants associated with
            neurodevelopmental disorders perturb the molecular regulation of
            TRIO and axon pathfinding in vivo.
REFERENCE   3  (bases 1 to 11460)
  AUTHORS   Bircher,J.E., Corcoran,E.E., Lam,T.T., Trnka,M.J. and Koleske,A.J.
  TITLE     Autoinhibition of the GEF activity of cytoskeletal regulatory
            protein Trio is disrupted in neurodevelopmental disorder-related
            genetic variants
  JOURNAL   J Biol Chem 298 (9), 102361 (2022)
   PUBMED   35963430
  REMARK    GeneRIF: Autoinhibition of the GEF activity of cytoskeletal
            regulatory protein Trio is disrupted in neurodevelopmental
            disorder-related genetic variants.
REFERENCE   4  (bases 1 to 11460)
  AUTHORS   Bandekar,S.J., Chen,C.L., Ravala,S.K., Cash,J.N., Avramova,L.V.,
            Zhalnina,M.V., Gutkind,J.S., Li,S. and Tesmer,J.J.G.
  TITLE     Structural/functional studies of Trio provide insights into its
            configuration and show that conserved linker elements enhance its
            activity for Rac1
  JOURNAL   J Biol Chem 298 (8), 102209 (2022)
   PUBMED   35779635
  REMARK    GeneRIF: Structural/functional studies of Trio provide insights
            into its configuration and show that conserved linker elements
            enhance its activity for Rac1.
REFERENCE   5  (bases 1 to 11460)
  AUTHORS   Wang,J., Yuan,L., Xu,X., Zhang,Z., Ma,Y., Hong,L. and Ma,J.
  TITLE     Rho-GEF Trio regulates osteosarcoma progression and osteogenic
            differentiation through Rac1 and RhoA
  JOURNAL   Cell Death Dis 12 (12), 1148 (2021)
   PUBMED   34893584
  REMARK    GeneRIF: Rho-GEF Trio regulates osteosarcoma progression and
            osteogenic differentiation through Rac1 and RhoA.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11460)
  AUTHORS   Seipel,K., Medley,Q.G., Kedersha,N.L., Zhang,X.A., O'Brien,S.P.,
            Serra-Pages,C., Hemler,M.E. and Streuli,M.
  TITLE     Trio amino-terminal guanine nucleotide exchange factor domain
            expression promotes actin cytoskeleton reorganization, cell
            migration and anchorage-independent cell growth
  JOURNAL   J Cell Sci 112 (Pt 12), 1825-1834 (1999)
   PUBMED   10341202
REFERENCE   7  (bases 1 to 11460)
  AUTHORS   Liu,X., Wang,H., Eberstadt,M., Schnuchel,A., Olejniczak,E.T.,
            Meadows,R.P., Schkeryantz,J.M., Janowick,D.A., Harlan,J.E.,
            Harris,E.A., Staunton,D.E. and Fesik,S.W.
  TITLE     NMR structure and mutagenesis of the N-terminal Dbl homology domain
            of the nucleotide exchange factor Trio
  JOURNAL   Cell 95 (2), 269-277 (1998)
   PUBMED   9790533
REFERENCE   8  (bases 1 to 11460)
  AUTHORS   Taviaux,S., Diriong,S., Bellanger,J.M., Streuli,M. and Debant,A.
  TITLE     Assignment of TRIO, the Trio gene (PTPRF interacting) to human
            chromosome bands 5p 15.1-->p 14 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 76 (1-2), 107-108 (1997)
   PUBMED   9154137
REFERENCE   9  (bases 1 to 11460)
  AUTHORS   Debant,A., Serra-Pages,C., Seipel,K., O'Brien,S., Tang,M.,
            Park,S.H. and Streuli,M.
  TITLE     The multidomain protein Trio binds the LAR transmembrane tyrosine
            phosphatase, contains a protein kinase domain, and has separate
            rac-specific and rho-specific guanine nucleotide exchange factor
            domains
  JOURNAL   Proc Natl Acad Sci U S A 93 (11), 5466-5471 (1996)
   PUBMED   8643598
REFERENCE   10 (bases 1 to 11460)
  AUTHORS   Varvagiannis,K., Vissers,L.E.L.M., Baralle,D., de Vries,B.B.A. and
            Gazdagh,G.
  TITLE     TRIO-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   28796471
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010419.6, BF058117.1,
            BC035585.1, U42390.1, AI478154.1, BQ691537.1, AF091395.1,
            BC017268.2, AK131423.1 and BQ184284.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007118.3.
            
            Summary: This gene encodes a large protein that functions as a GDP
            to GTP exchange factor. This protein promotes the reorganization of
            the actin cytoskeleton, thereby playing a role in cell migration
            and growth. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF091395.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344204.9/ ENSP00000339299.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               AC010419.6         87601-87960         c
            361-613             BF058117.1         1-253
            614-1358            BC035585.1         179-923
            1359-2033           U42390.1           864-1538
            2034-4781           BC035585.1         1599-4346
            4782-4807           AI478154.1         525-550             c
            4808-5463           U42390.1           4313-4968
            5464-5513           BQ691537.1         514-563
            5514-7271           U42390.1           5019-6776
            7272-8693           AF091395.1         6777-8198
            8694-10066          BC017268.2         170-1542
            10067-10505         AK131423.1         2673-3111
            10506-11459         AK131423.1         3113-4066
            11460-11460         BQ184284.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..11460
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.2"
     gene            1..11460
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /note="trio Rho guanine nucleotide exchange factor"
                     /db_xref="GeneID:7204"
                     /db_xref="HGNC:HGNC:12303"
                     /db_xref="MIM:601893"
     exon            1..541
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..9678
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /EC_number="2.7.11.1"
                     /note="PTPRF-interacting protein; triple functional domain
                     (PTPRF interacting)"
                     /codon_start=1
                     /product="triple functional domain protein"
                     /protein_id="NP_009049.2"
                     /db_xref="CCDS:CCDS3883.1"
                     /db_xref="GeneID:7204"
                     /db_xref="HGNC:HGNC:12303"
                     /db_xref="MIM:601893"
                     /translation="MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLA
                     DIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQE
                     DLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIK
                     PDNFWQKQRTNFGSSKFEFETNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRV
                     AFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLD
                     LEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKL
                     KLDQCFQLRLFEQDAEKMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCM
                     NVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
                     HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSL
                     LDKLQRPLTPGSSDSLTASANYSKAVHHVLDVIHEVLHHQRQLENIWQHRKVRLHQRL
                     QLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNA
                     DKLLEAAEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKE
                     LWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTTLQVTVNVIKEGEDLIQQLRD
                     SAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDI
                     ISDLESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYV
                     NEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQA
                     EVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAE
                     AMLQANHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESL
                     EQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYL
                     HRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERS
                     AKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHEEFQITAKQTKERVKLLIQLAD
                     GFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQLD
                     IIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLW
                     EMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWAD
                     KFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLL
                     KELLTCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQV
                     WDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDP
                     CKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKT
                     APATRQKGRRDGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFT
                     ACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGLVPCGSLCIAHSRSSME
                     MEGIFNHKDSLSVSSNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRL
                     SSGKADGHVKKLAHKHKKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSG
                     TLSKSSSSGMQSCGEEEGEEGADAVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTS
                     SETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDE
                     MEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVF
                     GNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSE
                     YIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAV
                     EVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLVTDQDAGLLPRCRERRIFL
                     FEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVET
                     FILHSSSPSVRQTWIHEINQILENQRNFLNALTSPIEYQRNHSGGGGGGGSGGSGGGG
                     GSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSRIPQPVRHHPPVLVSSAASSQAEAD
                     KMSGTSTPGPSLPPPGAAPEAGPSAPSRRPPGADAEGSEREAEPIPKMKVLESPRKGA
                     ANASGSSPDAPAKDARASLGTLPLGKPRAGAASPLNSPLSSAVPSLGKEPFPPSSPLQ
                     KGGSFWSSIPASPASRPGSFTFPGDSDSLQRQTPRHAAPGKDTDRMSTCSSASEQSVQ
                     STQSNGSESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQILASNQQNMFLVFRAAT
                     DQCPAAEGWIPGFVLGHTSAVIVENPDGTLKKSTSWHTALRLRKKSEKKDKDGKREGK
                     LENGYRKSREGLSNKVSVKLLNPNYIYDVPPEFVIPLSEVTCETGETVVLRCRVCGRP
                     KASITWKGPEHNTLNNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCIAVNDMGSASS
                     SASLRVLGPGMDGIMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTKRAVATKFVN
                     KKLMKRDQVTHELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDCVVRWGS
                     LTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDAVQLN
                     TTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCL
                     NICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGV
                     LDTSRLTSFIERRKHQNDVRPIRSIKNFLQSRLLPRV"
     exon            542..616
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            617..731
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            732..924
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1437
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1560
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1752
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1884
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2115
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2238
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2430
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2600
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2775
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2971
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3138
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3258
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3450
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            3451..3600
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            3601..3715
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3831
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            3832..3954
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            3955..4149
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            4150..4265
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            4266..4332
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            4333..4442
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            4443..4512
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            4513..4602
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            4603..4695
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            4696..4807
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            4808..4998
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            4999..5100
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            5101..5243
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            5244..5343
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            5344..5587
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            5588..5880
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            5881..6051
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            6052..6147
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            6148..6296
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            6297..6363
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            6364..6467
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            6468..6537
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            6538..6627
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            6628..6720
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            6721..6771
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            6772..6849
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            6850..7041
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            7042..7219
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            7220..8016
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            8017..8264
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            8265..8403
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            8404..8431
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            8432..8594
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            8595..8716
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            8717..8795
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            8796..8996
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            8997..9135
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     exon            9136..11460
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10585..10590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /note="hexamer: AATAAA"
     polyA_site      10605
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
     regulatory      11442..11447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /note="hexamer: ATTAAA"
     polyA_site      11460
                     /gene="TRIO"
                     /gene_synonym="ARHGEF23; MEBAS; MRD44; MRD63; tgat"
                     /note="major polyA site"
ORIGIN      
        1 attgaaatca agatggaggc tcgcggcagc cgccggcgcc cgtgatcccg gaggtctcgc
       61 cggccacggg cccccgccct cgcgactgcg cgtccgggag gcgcgtgctg ctgcccgcgc
      121 tccggccggc gcccgggagg ccgtggctcc gcgcctccgc ccctcggcca gctcgcggct
      181 accgggcgga gtcctcgtct atgtgggcgc gctccttggg ccgagccgcc gccgccgccc
      241 cccgccgccc cggggctctg cgtccgcgcg ccgggcgcgg gcagctgggt gctcggcgcc
      301 gccaggcccg gcgcggagcg ggcggcacgc ggcgctaggg gcgcggggcc cgaggcgggc
      361 gcggccgcgg gcgccgccgc agccatgagc ggcagcagcg gcggagccgc cgcccccgcc
      421 gcgtcctccg gccccgccgc ggcggccagc gcggctggct cgggctgcgg gggcggtgcc
      481 ggcgaggggg cagaggaggc ggccaaggac ctggccgaca tcgcggcctt cttccgatcc
      541 gggtttcgaa aaaacgatga aatgaaagct atggatgttt taccaatttt gaaggaaaaa
      601 gttgcatacc tttcaggtgg gagagataaa cgtggaggtc ccattttaac gtttccggcc
      661 cgcagcaatc atgacagaat acgacaggag gatctcagga gactcatttc ctatctagcc
      721 tgtattccca gcgaggaggt ctgcaagcgt ggcttcacgg tgatcgtgga catgcgtggg
      781 tccaagtggg actccatcaa gccccttctg aagatcctgc aggagtcctt cccctgctgc
      841 atccatgtgg ccctgatcat caagccagac aacttctggc agaaacagag gactaatttt
      901 ggcagttcta aatttgaatt tgagacaaat atggtctctt tagaaggcct taccaaagta
      961 gttgatcctt ctcagctaac tcctgagttt gatggctgcc tggaatacaa ccacgaagaa
     1021 tggattgaaa tcagagttgc ttttgaagac tacattagca atgccaccca catgctgtct
     1081 cggctggagg aacttcagga catcctagct aagaaggagc tgcctcagga tttagagggg
     1141 gctcggaata tgatcgagga acattctcag ctgaagaaga aggtgattaa ggcccccatc
     1201 gaggacctgg atttggaggg acagaagctg cttcagagga tacagagcag tgaaagcttt
     1261 cccaaaaaga actcaggctc aggcaatgcg gacctgcaga acctcttgcc caaggtgtcc
     1321 accatgctgg accggctgca ctcgacacgg cagcatctgc accagatgtg gcatgtgagg
     1381 aagctgaagc tggaccagtg cttccagctg aggctgtttg aacaggatgc tgagaagatg
     1441 tttgactgga tcacacacaa caaaggcctg tttctaaaca gctacacaga gattgggacc
     1501 agccaccctc atgccatgga gcttcagacg cagcacaatc actttgccat gaactgtatg
     1561 aacgtgtatg taaatataaa ccgcatcatg tcggtggcca atcgtctggt ggagtctggc
     1621 cactatgcct cgcagcagat caggcagatc gcgagtcagc tggagcagga gtggaaggcg
     1681 tttgcggcag ccctggatga gcggagcacc ttgctggaca tgtcctccat tttccaccag
     1741 aaggccgaaa agtatatgag caacgtggat tcatggtgta aagcttgcgg tgaggtagac
     1801 cttccctcag agctgcagga cctagaagat gccattcatc accaccaggg aatatatgaa
     1861 catatcactc ttgcttattc tgaggtcagc caagatggga agtcgctcct tgacaagctc
     1921 cagcggccct tgactcccgg cagctccgat tccctgacag cctctgccaa ctactccaag
     1981 gccgtgcacc atgtcctgga tgtcatccac gaggtgctgc accaccagcg gcagctggag
     2041 aacatctggc aacaccgcaa ggtccggctg catcagaggc tgcagctgtg tgttttccag
     2101 caggacgttc agcaggtgct agactggatc gagaaccacg gagaagcatt tctgagcaaa
     2161 catacaggtg tggggaaatc tcttcatcgg gccagagcat tgcagaaacg tcatgaagat
     2221 tttgaagaag tggcacagaa cacatacacc aatgcggata aattactgga agcagcagaa
     2281 cagctggctc agactgggga atgtgacccc gaagagattt atcaggctgc ccatcagctg
     2341 gaagaccgga ttcaagattt cgttcggcgt gttgagcagc gaaagatcct actggacatg
     2401 tcagtgtcct ttcacaccca tgtgaaagag ctgtggacgt ggctggagga gctgcagaag
     2461 gagctgctgg acgacgtgta tgccgagtcg gtggaggccg tgcaggacct catcaagcgc
     2521 tttggccagc agcagcagac caccctgcag gtgactgtca acgtgatcaa ggaaggggag
     2581 gacctcatcc agcagctcag ggactctgcc atctccagta acaagacccc ccacaacagc
     2641 tccatcaacc acattgagac ggtgctgcag cagctggacg aggcgcagtc gcagatggag
     2701 gagctcttcc aggagcgcaa gatcaagctg gagctcttcc tgcagctgcg catcttcgag
     2761 agggacgcca tcgacattat ctcagacctc gagtcttgga atgatgagct ttctcagcaa
     2821 atgaatgact tcgacacaga agatctcacg attgcagagc agcgcctcca gcaccatgca
     2881 gacaaagcct tgaccatgaa caacttgact tttgacgtca tccaccaagg gcaagatctt
     2941 ctgcagtatg tcaatgaggt ccaggcctct ggtgtggagc tgctgtgtga tagagatgta
     3001 gacatggcaa ctcgggtcca ggacctgctg gagtttcttc atgaaaaaca gcaggaattg
     3061 gatttagccg cagagcagca tcggaaacac ctggagcagt gcgtgcagct gcgccacctg
     3121 caggcagaag tgaaacaggt gctgggttgg atccgcaacg gagagtccat gttaaatgcc
     3181 ggacttatca cagccagctc gttacaagag gcagagcagc tccagcgaga gcacgagcag
     3241 ttccagcatg ccattgagaa aacacatcag agcgcgctgc aggtgcagca gaaggcagaa
     3301 gccatgctac aggccaacca ctacgacatg gacatgatcc gggactgcgc cgagaaggtg
     3361 gcgtctcact ggcaacagct catgctcaag atggaagatc gcctcaagct cgtcaacgcc
     3421 tctgtcgctt tctacaaaac ctcagagcag gtctgcagcg tcctcgagag cctggaacag
     3481 gagtacaaga gagaagaaga ctggtgtggc ggggcggata agctgggccc aaactctgag
     3541 acggaccacg tgacgcccat gatcagcaag cacctggagc agaaggaggc attcctgaag
     3601 gcttgcaccc ttgctcggag gaatgcagac gtcttcctga aatacctgca caggaacagc
     3661 gtgaacatgc caggaatggt gacgcacatc aaagctcctg aacagcaagt gaaaaatatc
     3721 ttgaatgaac tcttccaacg ggagaacagg gtattgcatt actggaccat gaggaagaga
     3781 cggctggacc agtgtcagca gtacgtggtc tttgagagga gtgccaagca ggctttggaa
     3841 tggatccatg acaatggcga gttctacctt tccacacaca cctccacggg ctccagtata
     3901 cagcacaccc aggagctcct gaaagagcac gaggagttcc agataactgc aaagcaaacc
     3961 aaagagagag tgaagctatt gatacagctg gctgatggct tttgtgaaaa agggcatgcc
     4021 catgcggcag agataaaaaa atgtgttact gctgtggata agaggtacag agatttctct
     4081 ctgcggatgg agaagtacag gacctctttg gaaaaagccc tggggatttc ttcagattcc
     4141 aacaaatcga gtaaaagtct ccagctagat atcattccag ccagtatccc tggctcagag
     4201 gtgaaacttc gagatgctgc tcatgaactt aatgaagaga agcggaaatc tgcccgcagg
     4261 aaagagttca taatggctga gctcattcaa actgaaaagg cttatgtaag agacctccgg
     4321 gaatgtatgg atacgtacct gtgggaaatg accagtggcg tggaagagat tccacctggc
     4381 attgtaaaca aagaactcat catcttcgga aacatgcaag aaatctacga atttcataat
     4441 aacatattcc taaaggagct ggaaaaatat gaacagttgc cagaggatgt tggacattgt
     4501 tttgttactt gggcagacaa gtttcagatg tatgtcacat attgcaaaaa taagcctgat
     4561 tctactcagc tgatattgga acatgcaggg tcctattttg acgagataca gcagcgacat
     4621 ggattagcca attccatttc ttcctacctt attaaaccag ttcagcgaat aacgaagtat
     4681 cagctccttt taaaagagct gctgacgtgc tgtgaggaag gaaagggaga gattaaagat
     4741 ggcctggagg tgatgctcag cgtgccgaag cgagccaatg atgccatgca cctcagcatg
     4801 ctggaagggt ttgatgaaaa cattgagtct cagggagaac tcatcctaca ggaatccttc
     4861 caagtgtggg acccaaaaac cttaattcga aagggtcgag aacggcatct cttccttttt
     4921 gaaatgtcct tagtatttag taaagaagtg aaagattcca gtgggagaag caagtacctt
     4981 tataaaagca aattgtttac ctcagagttg ggtgtcacag aacatgttga aggagaccct
     5041 tgcaaatttg cactgtgggt ggggagaaca ccaacttcag ataataaaat tgtccttaag
     5101 gcttccagca tagagaacaa gcaggactgg ataaagcata tccgcgaagt catccaggag
     5161 cggacgatcc acctgaaggg agccctgaag gagcccattc acatccctaa gaccgctccc
     5221 gccacaagac agaagggaag gagggatgga gaggatctgg acagccaagg agacggcagc
     5281 agccagcctg atacgatttc catcgcctca cggacgtctc agaacacgct ggacagcgat
     5341 aagctctctg gtggctgtga gctgacagtg gtgatccatg acttcaccgc ttgcaacagc
     5401 aacgagctga ccatccgacg gggccagacc gtggaagttc tggagcggcc gcatgacaag
     5461 cctgactggt gtctggtgcg gacaactgac cgctccccag cggcagaagg cctggtcccc
     5521 tgtggttcac tgtgcatcgc ccactccaga agtagcatgg aaatggaggg catcttcaac
     5581 cacaaagact cgctctccgt ctccagcaat gacgccagtc cacccgcatc cgtggcttcc
     5641 ctccagcccc acatgatcgg ggcccagagc tcgccgggcc ccaagcggcc gggcaacacc
     5701 ctgcgcaagt ggctcaccag ccccgtgcgg cggctcagca gcggcaaggc cgacgggcac
     5761 gtgaagaagc tggcgcacaa gcacaagaag agccgcgagg tccgcaagag cgccgacgcc
     5821 ggctcgcaga aggactccga cgacagtgcg gccaccccgc aggacgagac ggtcgaggag
     5881 agaggccgga acgagggcct gagcagcggt actctctcca aatcctcctc ctcggggatg
     5941 cagagctgtg gagaagagga aggcgaggag ggggccgacg ccgtgcccct gccgccaccc
     6001 atggccatcc agcagcacag cctcctccag ccagactcac aggatgacaa ggcctcttct
     6061 cggttattag tccgccccac cagctccgaa acaccgagtg cagccgagct cgtcagtgca
     6121 attgaggaac tcgtgaaaag caagatggca ctggaggatc gccccagctc actccttgtt
     6181 gaccagggag atagtagcag cccttccttc aacccttcgg ataattccct tctctcttcc
     6241 tcctcgccca ttgatgagat ggaagaaagg aaatccagct ctttaaagag aagacactac
     6301 gttttgcaag aactagtgga gacagagcgt gactatgtgc gggaccttgg ctatgtggtt
     6361 gagggctaca tggcacttat gaaagaagat ggtgttcctg atgacatgaa aggaaaagac
     6421 aaaattgtgt tcggcaacat ccatcagatt tacgactggc acagagactt ttttttagga
     6481 gagttagaga agtgccttga agatccagaa aaactaggat ccctttttgt taaacacgag
     6541 agaaggttgc acatgtacat agcttattgt caaaataaac caaagtctga gcacattgtc
     6601 tcagaataca ttgatacctt ttttgaggac ttaaagcagc gtcttggcca caggttacag
     6661 ctcacagatc tgttgatcaa accagtgcag agaatcatga agtatcagct gttactgaag
     6721 gacttcctca agtattccaa aaaggccagc ctggatacat cagaattaga gagagctgtg
     6781 gaagtcatgt gcatagtacc caggcggtgc aacgacatga tgaacgtggg gcggctgcaa
     6841 ggattcgacg ggaaaatcgt tgcccagggt aaactgctct tgcaggacac attcttggtc
     6901 acagaccaag atgcaggact tctgcctcgc tgcagagaga ggcgcatctt cctctttgag
     6961 cagatcgtca tattcagcga accacttgat aaaaagaagg gcttctccat gccgggattc
     7021 ctgtttaaga acagtatcaa ggtgagttgc ctttgcctgg aggaaaatgt ggaaaatgat
     7081 ccctgtaaat ttgctctgac atcgaggacg ggtgacgtgg tagagacctt cattttgcat
     7141 tcatctagtc caagtgtccg gcaaacttgg atccatgaaa tcaaccaaat tttagaaaac
     7201 cagcgcaatt ttttaaatgc cttgacatcg ccaatcgagt accagaggaa ccacagcggg
     7261 ggcggcggcg gcggcggcag cgggggcagc ggcgggggtg ggggcagcgg cggcggcggg
     7321 gcccccagtg gcggcagcgg ccacagtggc ggccccagca gctgcggcgg cgcccccagc
     7381 acgagcagga gccggccctc ccggatcccc cagcctgtcc gacaccaccc ccccgtgctg
     7441 gtctcctctg cagcctcgag ccaggcagag gcagacaaga tgtcaggtac gtccaccccc
     7501 gggccctccc tgcctccccc tggcgcggcc cccgaggccg gccccagcgc gcccagcagg
     7561 cggccccccg gcgcggacgc cgaggggtcc gagcgagaag cggagccgat ccccaagatg
     7621 aaggtgctgg agagccccag gaaaggcgcc gcgaacgcct cggggtcgag cccagacgcc
     7681 cccgccaagg acgcgcgcgc tagcctgggc accctgccgc ttgggaagcc ccgggccggg
     7741 gccgcttcgc cgctgaactc gccgctctcc agcgcggtcc cttctctcgg caaggagccc
     7801 ttccccccca gcagccccct gcagaagggg ggctccttct ggagctccat ccccgcctcc
     7861 cccgccagcc gacccggctc cttcaccttc ccgggggaca gcgactccct ccagcggcag
     7921 acaccccgcc acgcggcccc tggcaaggat actgaccgca tgagcacgtg ctcctcggcc
     7981 agcgagcagt ccgtgcagtc cacccagagc aacgggagtg aaagcagcag cagtagcaac
     8041 atctccacca tgttggtgac acacgattac acggcagtga aggaggatga gatcaacgtc
     8101 taccaaggag aggtcgttca aattctggcc agcaaccagc agaacatgtt tctggtgttc
     8161 cgagccgcca ctgaccagtg ccccgcagct gagggctgga ttccaggctt tgtcctgggc
     8221 cacaccagtg cagtcatcgt ggagaacccg gacgggactc tcaagaagtc aacatcttgg
     8281 cacacagcac tccgtttaag gaaaaaatct gagaaaaaag ataaagacgg caaaagggaa
     8341 ggcaagttag agaacggtta tcggaagtca cgggaaggac tcagcaacaa ggtatctgtg
     8401 aagcttctca atcccaacta catttatgac gttcccccag aattcgtcat tccattgagt
     8461 gaggtcacgt gtgagacagg ggagaccgtt gttcttagat gtcgagtctg tggccgcccc
     8521 aaagcctcaa ttacctggaa gggccctgaa cacaacacct tgaacaacga tggtcactac
     8581 agcatctcct acagtgacct gggagaggcc acgctgaaga ttgtgggcgt gaccacggaa
     8641 gatgacggca tctacacgtg catcgctgtc aatgacatgg gttcagcctc atcgtcggcc
     8701 agcctgaggg tcctaggtcc agggatggat gggatcatgg tgacctggaa agacaacttt
     8761 gactccttct acagtgaagt ggctgagctt ggcaggggca gattctctgt cgttaagaaa
     8821 tgtgatcaga aaggaaccaa gcgagcagtg gccactaagt ttgtgaacaa gaagttgatg
     8881 aagcgcgacc aggtcaccca tgagcttggc atcctgcaga gcctccagca ccccctgctt
     8941 gtcggcctcc tcgacacctt tgagaccccc accagctaca tcctggtctt agaaatggct
     9001 gaccagggtc gcctcctgga ctgcgtggtg cgatggggaa gcctcactga agggaagatc
     9061 agggcgcacc tgggggaggt tctggaagct gtccggtacc tgcacaactg caggatagca
     9121 cacctggacc taaagcctga gaatatcctg gtggatgaga gtttagccaa gccaaccatc
     9181 aaactggctg actttggaga tgctgttcag ctcaacacga cctactacat ccaccagtta
     9241 ctggggaacc ctgaattcgc agcccctgaa atcatcctcg ggaaccctgt ctccctgacc
     9301 tcggatacgt ggagtgttgg agtgctcaca tacgtacttc ttagtggcgt gtcccccttc
     9361 ctggatgaca gtgtggaaga gacctgcctg aacatttgcc gcttagactt tagcttccca
     9421 gatgactact ttaaaggagt gagccagaag gccaaggagt tcgtgtgctt cctcctgcag
     9481 gaggaccccg ccaagcgtcc ctcggctgcg ctggccctcc aggagcagtg gctgcaggcc
     9541 ggcaacggca gaagcacggg cgtcctcgac acgtccagac tgacttcctt cattgagcgg
     9601 cgcaaacacc agaatgatgt tcgacctatc cgtagcatta aaaactttct gcagagcagg
     9661 cttctgccta gagtttgacc tatccagaag ttctttctca ttctctttca cctgccaatc
     9721 agctgttaat ctgaattttc aagagaaaac aagcaaacat aactgatcag ctgccggtat
     9781 gttcatcgtg tgaaattgca ttccaagtga gctgtgctca gcagtgcttg gacacagagc
     9841 tgcaagctgc gctggggtgg aggaccgtca cttacactct gcccaaggca gaggtcgcat
     9901 tgctgtatca cagtatttta ttcaggtttc tgcaaaaaaa taaaaagata acttttttaa
     9961 acaaacatga atagaatttt gcaaatttaa cgttttcaag atttattcaa ggaaacaaaa
    10021 tgcctatgtt caaccactgg tgttaatgaa caaagatact gtgcgtctct ggggaagacg
    10081 cacctaggtg gcggccactc ccatggcctt gtctaggact cagagaccac tcggctctga
    10141 gcttccaggc gcctcgtctg tgtgcatctc acgcccgacg tggcttctga aacgtgcatt
    10201 caacctcaaa cttttgcata aaatagaatg aatcgttttg ctctgatgaa atgtaggcct
    10261 tacttgtata taagactgtt cctgccttcg gtctgtcatt ttcccacctg cctcccctac
    10321 ccacccccca cccaccacct ggggcttcct ctgggggtcc gagggtcttc ccatcacatg
    10381 aagacatcag gttgggtcct gccccactgc ccctccccct gttcctgccc caagccgtca
    10441 atcagattgt ggagcagtac acagtcagat gaaaatactg taaatgcact cattgggggt
    10501 tttttggttt tacttcatat catgtgcaat gttgtggctt taacatttta tgcaactatt
    10561 tatgaagacc tctgttgtac ctgtaataaa tatatagaaa aagcacatac ttcgtatggt
    10621 gagctttatg gttttgtgtg tgtgttgggg ttggcgggtg ggtgggtagg gtcgtagccc
    10681 tgtgccatcg gttcaaagag acttttcgtg aaatttgttg gttttgagga ctgtaaaagt
    10741 gatttcatac tctgaatata aaactggata atagggtaat gttttaaaat ttattatgct
    10801 attattcaga atgccaaagt attatttttt ttcccaaaat cagtctggac atttactact
    10861 ttttagactt tttgacgttg aactttctgt ataaaaattg gctgggtttt gagcttttgg
    10921 taagaaataa aagccgatta agcactggcc gccccgcggc tggtacccaa tgcccgagtc
    10981 actgtggcag cattcgcact ggtgtgggga gtcctttcaa ctcaaggagg ctgggtttct
    11041 gggcaccctc gaagttttct ggatgtcttt ttatctttct cgtgtgaact gcactacaaa
    11101 agagaccagc ccgcttccca agccagccag acacctgggt cttgagccat aaactggcgt
    11161 agttaagctt tgcagcttcc agtgtatttt atttattctt ttgttgggtt tttgtttgtt
    11221 tcttcttgta aaattgtaca gaaacttttt aaaagaaatt ggattcgaaa ctggatgtgt
    11281 attcgtaacc tcataatttt tatttgtgta ttgtttcttt tattatttca gttaaatttt
    11341 tacattattt tgcatgtata tttctttgta cagagacctt acatgtttac acagtatgat
    11401 gtgatgtaaa tattttattt tgccatcagt tattttaaaa aattaaacat atttgcctga
//
