LOCUS       NM_173553               1998 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens tripartite motif family like 2 (TRIML2), transcript
            variant 2, mRNA.
ACCESSION   NM_173553 XM_017007882
VERSION     NM_173553.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1998)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1998)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1998)
  AUTHORS   Zhang,X., Pavlicev,M., Jones,H.N. and Muglia,L.J.
  TITLE     Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the
            Evolution of Placentation
  JOURNAL   Mol Biol Evol 37 (2), 507-523 (2020)
   PUBMED   31633784
  REMARK    GeneRIF: Eutherian-Specific Gene TRIML2 Attenuates Inflammation in
            the Evolution of Placentation.
REFERENCE   4  (bases 1 to 1998)
  AUTHORS   Gu,F., Wang,C., Wei,F., Wang,Y., Zhu,Q., Ding,L., Xu,W., Zhu,C.,
            Cai,C., Qian,Z., Yuan,Z., Robertson,E. and Cai,Q.
  TITLE     STAT6 degradation and ubiquitylated TRIML2 are essential for
            activation of human oncogenic herpesvirus
  JOURNAL   PLoS Pathog 14 (12), e1007416 (2018)
   PUBMED   30532138
  REMARK    GeneRIF: the degradation of STAT6 is induced and required for the
            lytic activation of human herpesviruses and is association with the
            increased ubiquitylated form of TRIML2
            Erratum:[PLoS Pathog. 2022 Jun 1;18(6):e1010579. doi:
            10.1371/journal.ppat.1010579.. PMID: 35648772]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1998)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 1998)
  AUTHORS   Kang,W.S., Park,J.K., Kim,Y.J., Cho,A.R., Park,H.J., Kim,S.K.,
            Paik,J.W., Lee,K.J., Na,H.R., Kim,Y.Y., Lim,H.K., Jeong,H.G. and
            Kim,J.W.
  TITLE     Association of tripartite motif family-like 2 (TRIML2)
            polymorphisms with late-onset Alzheimer's disease risk in a Korean
            population
  JOURNAL   Neurosci Lett 630, 127-131 (2016)
   PUBMED   27471163
  REMARK    GeneRIF: Findings indicate that the C allele of two single
            nucleotide polymorphisms in the tripartite motif family-like 2
            (TRIML2) gene was associated with an increased risk of Alzheimer
            disease (AD). These results suggest that TRIML2 may contribute to
            AD susceptibility.
REFERENCE   7  (bases 1 to 1998)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   8  (bases 1 to 1998)
  AUTHORS   Kung,C.P., Khaku,S., Jennis,M., Zhou,Y. and Murphy,M.E.
  TITLE     Identification of TRIML2, a novel p53 target, that enhances p53
            SUMOylation and regulates the transactivation of proapoptotic genes
  JOURNAL   Mol Cancer Res 13 (2), 250-262 (2015)
   PUBMED   25256710
  REMARK    GeneRIF: Data indicate that TRIML2 is part of a feed-forward loop
            that activates p53 in cells expressing the R72 variant,
            particularly after prolonged stress.
REFERENCE   9  (bases 1 to 1998)
  AUTHORS   Ouyang,J., Shi,Y., Valin,A., Xuan,Y. and Gill,G.
  TITLE     Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific
            repression by the LSD1/CoREST1/HDAC complex
  JOURNAL   Mol Cell 34 (2), 145-154 (2009)
   PUBMED   19394292
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108073.3, DC382432.1,
            DA666390.1, AK300428.1, AK098667.1 and BC111959.1.
            
            On Jun 2, 2019 this sequence version replaced NM_173553.3.
            
            Summary: This gene encodes a member of the tri-partite motif (TRIM)
            family of proteins. This protein may be regulated by the tumor
            suppressor p53 and may regulate p53 through the enhancement of p53
            SUMOylation. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an alternate in-frame exon in the 5' coding region compared
            to variant 1. This results in isoform 2, which is shorter than
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2296743.1,
                                           SRR14038194.839387.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2149398
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682553.1/ ENSP00000507413.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               AC108073.3         215858-216192       c
            336-404             DC382432.1         1-69
            405-433             DA666390.1         403-431
            434-697             AK300428.1         99-362
            698-1218            AK098667.1         1-521
            1219-1219           BC111959.1         516-516
            1220-1695           AK098667.1         523-998
            1696-1696           AC108073.3         198163-198163       c
            1697-1997           AK098667.1         1000-1300
            1998-1998           AC108073.3         197861-197861       c
FEATURES             Location/Qualifiers
     source          1..1998
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.2"
     gene            1..1998
                     /gene="TRIML2"
                     /gene_synonym="SPRYD6"
                     /note="tripartite motif family like 2"
                     /db_xref="GeneID:205860"
                     /db_xref="HGNC:HGNC:26378"
                     /db_xref="MIM:620480"
     exon            1..361
                     /gene="TRIML2"
                     /gene_synonym="SPRYD6"
                     /inference="alignment:Splign:2.1.0"
     exon            362..772
                     /gene="TRIML2"
                     /gene_synonym="SPRYD6"
                     /inference="alignment:Splign:2.1.0"
     CDS             584..1897
                     /gene="TRIML2"
                     /gene_synonym="SPRYD6"
                     /EC_number="2.3.2.27"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tripartite motif family-like protein 2; probable E3
                     ubiquitin-protein ligase TRIML2; SPRY domain-containing
                     protein 6; RING-type E3 ubiquitin transferase TRIML2"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase TRIML2
                     isoform 2"
                     /protein_id="NP_775824.2"
                     /db_xref="CCDS:CCDS3850.2"
                     /db_xref="GeneID:205860"
                     /db_xref="HGNC:HGNC:26378"
                     /db_xref="MIM:620480"
                     /translation="MSKRLSPQLQHNITEDAYCETHLEPTRLFCDVDQITLCSKCFQS
                     QEHKHHMVCGIQEAAENYRKLFQEILNTSREKLEAAKSILTDEQERMAMIQEEEQNFK
                     KMIESEYSMRLRLLNEECEQNLQRQQECISDLNLRETLLNQAIKLATELEEMFQEMLQ
                     RLGRVGRENMEKLKESEARASEQVRSLLKLIVELEKKCGEGTLALLKNAKYSLERSKS
                     LLLEHLEPAHITDLSLCHIRGLSSMFRVLQRHLTLDPETAHPCLALSEDLRTMRLRHG
                     QQDGAGNPERLDFSAMVLAAESFTSGRHYWEVDVEKATRWQVGIYHGSADAKGSTARA
                     SGEKVLLTGSVMGTEWTLWVFPPLKRLFLEKKLDTVGVFLDCEHGQISFYNVTEMSLI
                     YNFSHCAFQGALRPVFSLCIPNGDTSPDSLTILQHGPSCDATVSP"
     exon            773..868
                     /gene="TRIML2"
                     /gene_synonym="SPRYD6"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1063
                     /gene="TRIML2"
                     /gene_synonym="SPRYD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1204
                     /gene="TRIML2"
                     /gene_synonym="SPRYD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1227
                     /gene="TRIML2"
                     /gene_synonym="SPRYD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1328
                     /gene="TRIML2"
                     /gene_synonym="SPRYD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1998
                     /gene="TRIML2"
                     /gene_synonym="SPRYD6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1980..1985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIML2"
                     /gene_synonym="SPRYD6"
                     /note="hexamer: AATAAA"
     polyA_site      1998
                     /gene="TRIML2"
                     /gene_synonym="SPRYD6"
                     /note="major polyA site"
ORIGIN      
        1 agctttttcc ctaaaggaaa taccttggtt cggtgtggtg actcattcct gtaatcccag
       61 tactttggga ggctgaagca ggcagattgc ttgagcccag gagttcaaga ccagcctggg
      121 aaaaatactg aaaccccgtc tctacaaaaa atacaaaaat tagccgggtg tggtcgtgca
      181 gcgcctgtaa tcccagctac tcaggaggtc aaggtgggag aatcacttga gcctgggagc
      241 tcgaggctgt agtgagccga gattgcgcca ctgcattcca gcctgggtga cagagcaaga
      301 ccctgtctca aaaaaaaaaa aaaaaaaaaa aaaggaaata cccaggattg ctacaaagaa
      361 acaggcagct gccagaaatt tgttggattt gaggagtcca gagcgccgac ccgctctgtc
      421 tgcgtggact tatttccttg gatcttcgtg gactctgaag ttgccaagtg tgtgtgcctg
      481 ctccagaaaa caaaggaagc caccattttt tctcattcac agtgcaggga gatacctcag
      541 tagaagcata cagtccagtc ttcaactagg gacccctacc aggatgtcca aaaggctcag
      601 ccctcagtta cagcacaaca tcacagaaga tgcctattgt gaaacacacc tggaaccaac
      661 acggctgttc tgtgatgttg accaaatcac actctgcagc aaatgcttcc agtcccagga
      721 gcacaaacat cacatggtgt gtgggataca agaggctgct gagaattaca ggaagttatt
      781 ccaggaaata ttgaacacat cgagggagaa acttgaagca gctaaaagca tattgactga
      841 tgagcaagaa agaatggcga tgattcagga agaggaacaa aattttaaaa agatgattga
      901 gtctgagtat agtatgagac tccggttgtt gaatgaagag tgtgagcaga atctccagag
      961 acagcaggaa tgcatatctg acttgaacct gagagaaacc cttctgaatc aagcgatcaa
     1021 gcttgccacc gagctagagg agatgttcca ggaaatgcta cagagactgg gccgtgtggg
     1081 gagagagaac atggagaaac tgaaggagag tgaagccagg gcttctgaac aggtccgcag
     1141 cctcctaaag ctcatcgtgg agcttgagaa aaagtgtggg gaaggcacct tggcattgct
     1201 caagaatgca aaatactctt tagaaaggag caagtcactg ctgcttgagc atctggagcc
     1261 cgctcatatc acagacctga gtttatgcca cataagagga ctcagcagca tgttcagagt
     1321 actccagaga catttaacat tggatcctga aacagctcat ccctgcctgg cactatctga
     1381 ggacctgaga actatgagat tgagacatgg gcagcaggat ggggctggca acccagaaag
     1441 attggatttc agtgccatgg tgctggctgc ggagagcttc acctcaggga ggcactactg
     1501 ggaggtggac gtggaaaagg caaccaggtg gcaagtgggc atataccacg gctctgcaga
     1561 cgcgaagggc agcacggcca gagcttccgg agagaaagtc ttgctcacgg ggtcggtgat
     1621 ggggaccgag tggactctct gggtcttccc ccctctgaaa aggctcttcc tggaaaagaa
     1681 gttggacaca gttggcgttt tccttgactg cgaacacggg cagatatcat tctacaatgt
     1741 gaccgagatg tccctcattt acaatttctc ccattgcgcc ttccaaggag ctctcaggcc
     1801 tgtgttttcc ctctgtatcc caaatggaga cacaagtcca gactccctca ccatcttaca
     1861 acatggtcct tcttgtgatg ctactgttag cccttaatct tctgtgtgta aaatccaaga
     1921 ccacgagaca ccagaaagtt ggagaacaag actttgaaag aatttgtgta aactaaccca
     1981 ataaaaagcg ttccagga
//
