LOCUS       NM_178556               1896 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens tripartite motif family like 1 (TRIML1), mRNA.
ACCESSION   NM_178556
VERSION     NM_178556.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1896)
  AUTHORS   Ji,Y., Schaid,D.J., Desta,Z., Kubo,M., Batzler,A.J., Snyder,K.,
            Mushiroda,T., Kamatani,N., Ogburn,E., Hall-Flavin,D., Flockhart,D.,
            Nakamura,Y., Mrazek,D.A. and Weinshilboum,R.M.
  TITLE     Citalopram and escitalopram plasma drug and metabolite
            concentrations: genome-wide associations
  JOURNAL   Br J Clin Pharmacol 78 (2), 373-383 (2014)
   PUBMED   24528284
REFERENCE   2  (bases 1 to 1896)
  AUTHORS   Tian,L., Wu,X., Lin,Y., Liu,Z., Xiong,F., Han,Z., Zhou,Y., Zeng,Q.,
            Wang,Y., Deng,J. and Chen,H.
  TITLE     Characterization and potential function of a novel pre-implantation
            embryo-specific RING finger protein: TRIML1
  JOURNAL   Mol Reprod Dev 76 (7), 656-664 (2009)
   PUBMED   19156909
  REMARK    GeneRIF: This paper describes the mouse ortholog of the human
            TRIML1 gene.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB058735.1, AK093499.1 and
            BC015684.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_178556.4.
            
            Summary: The protein encoded by this gene is a tripartite motif
            family protein with similarities to E3 ubiquitin-protein ligases.
            While the function of the encoded protein has not been determined,
            the orthologous protein in mouse has been shown to bind
            ubiquitin-specific protease 5 and is involved in the blastocyst
            development stage. [provided by RefSeq, Sep 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK093499.1, BC113860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332517.4/ ENSP00000327738.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DB058735.1         1-3
            4-1648              AK093499.1         1-1645
            1649-1896           BC015684.2         991-1238
FEATURES             Location/Qualifiers
     source          1..1896
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.2"
     gene            1..1896
                     /gene="TRIML1"
                     /gene_synonym="RNF209"
                     /note="tripartite motif family like 1"
                     /db_xref="GeneID:339976"
                     /db_xref="HGNC:HGNC:26698"
                     /db_xref="MIM:620979"
     exon            1..526
                     /gene="TRIML1"
                     /gene_synonym="RNF209"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1525
                     /gene="TRIML1"
                     /gene_synonym="RNF209"
                     /EC_number="2.3.2.27"
                     /note="RING finger protein 209; RING-type E3 ubiquitin
                     transferase TRIML1"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase TRIML1"
                     /protein_id="NP_848651.2"
                     /db_xref="CCDS:CCDS3851.1"
                     /db_xref="GeneID:339976"
                     /db_xref="HGNC:HGNC:26698"
                     /db_xref="MIM:620979"
                     /translation="MSTADLMENLREELTCFICLDYFSSPVTTECGHSFCLVCLLRSW
                     EEHNTPLSCPECWRTLEGPHFQSNERLGRLASIARQLRSQVLQSEDEQGSYGRMPTTA
                     KALSDDEQGGSAFVAQSHGANRVHLSSEAEEHHREKLQEILNLLRVRRKEAQAVLTHE
                     KERVKLCQEETKTCKQVVVSEYMKMHQFLKEEEQLQLQLLEQEEKENMRKLRNNEIKL
                     TQQIRSLSKMIAQIESSSQSSAFESLEEVRGALERSEPLLLQCPEATTTELSLCRITG
                     MKEMLRKFSTEITLDPATANAYLVLSEDLKSVKYGGSRQQLPDNPERFDQSATVLGTQ
                     IFTSGRHYWEVEVGNKTEWEVGICKDSVSRKGNLPKPPGDLFSLIGLKIGDDYSLWVS
                     SPLKGQHVREPVCKVGVFLDYESGHIAFYNGTDESLIYSFPQASFQEALRPIFSPCLP
                     NEGTNTDPLTICSLNSHV"
     exon            527..622
                     /gene="TRIML1"
                     /gene_synonym="RNF209"
                     /inference="alignment:Splign:2.1.0"
     exon            623..853
                     /gene="TRIML1"
                     /gene_synonym="RNF209"
                     /inference="alignment:Splign:2.1.0"
     exon            854..876
                     /gene="TRIML1"
                     /gene_synonym="RNF209"
                     /inference="alignment:Splign:2.1.0"
     exon            877..974
                     /gene="TRIML1"
                     /gene_synonym="RNF209"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1896
                     /gene="TRIML1"
                     /gene_synonym="RNF209"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1751..1756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIML1"
                     /gene_synonym="RNF209"
                     /note="hexamer: AGTAAA"
     polyA_site      1772
                     /gene="TRIML1"
                     /gene_synonym="RNF209"
     regulatory      1849..1854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIML1"
                     /gene_synonym="RNF209"
                     /note="hexamer: AATATA"
     polyA_site      1873
                     /gene="TRIML1"
                     /gene_synonym="RNF209"
                     /note="major polyA site"
ORIGIN      
        1 gtcataacaa cataggaaca ggtcacccgc gtgttactca aaactgtagg acggcagtga
       61 gggctttgct aatcccagaa cagaggtgta acctggctgc atatccagcc tcgagaaaat
      121 gtctacagca gatctgatgg agaacctcag ggaggaactc acctgtttca tctgcttaga
      181 ctatttcagc agcccagtga ccaccgagtg tgggcacagc ttttgtctgg tgtgtctcct
      241 caggagctgg gaggaacata acacaccttt atcttgtcct gagtgctgga ggaccttgga
      301 gggcccgcat ttccagtcaa acgagcgtct ggggaggctg gccagcatcg ccaggcagct
      361 ccggtcccag gtgctgcaga gcgaggatga gcagggcagc tacgggagga tgcccaccac
      421 tgccaaggcg ctctccgatg acgagcaggg tggaagcgcc ttcgtagccc agagccatgg
      481 tgcaaacaga gtgcatctct ccagcgaggc tgaggagcat cacagagaga aactccagga
      541 aatcctgaat cttttgcgtg taaggagaaa ggaagctcag gctgtactaa cccatgagaa
      601 ggagagagtg aaactgtgcc aggaagaaac aaagacttgt aaacaggttg ttgtgtcaga
      661 atacatgaaa atgcaccagt tcctgaagga agaggagcag ctgcaactcc agctactaga
      721 acaggaagag aaagagaaca tgaggaagct gaggaacaat gagatcaaac tgacccagca
      781 aatcagaagc ctaagcaaaa tgatcgcaca gattgagtcc tcaagtcaaa gctcggcttt
      841 cgaatctctt gaggaagtga gaggagccct ggaaaggagc gagccactct tgcttcagtg
      901 tccagaggcc accaccacag agctgagtct gtgccgcatc acgggaatga aggagatgct
      961 aagaaaattc agcacggaga taacgctgga cccagccaca gctaatgcct atctcgtgtt
     1021 gtcggaggat ctgaagagtg tgaaatatgg gggaagcaga cagcagctac ccgacaaccc
     1081 ggaaagattt gaccagtctg cgactgtgct gggtactcag atcttcacca gtgggagaca
     1141 ctactgggag gtggaggtgg gaaacaagac cgagtgggaa gtgggcatct gcaaggactc
     1201 tgtgagcaga aaggggaatc tccccaagcc acctggggac ctgttctcac taataggttt
     1261 aaaaatcgga gatgattaca gcctctgggt ctcgtcacct ttgaaaggtc agcacgtcag
     1321 agagcctgtg tgtaaggttg gtgtcttcct ggactatgaa tctggacata tagcattcta
     1381 caacgggacg gatgaatccc tcatctacag cttcccgcag gcttctttcc aagaggccct
     1441 caggcctatc ttttccccct gcctcccaaa tgaggggaca aacacagacc ctctcaccat
     1501 ctgctcactg aacagccacg tctgaggggc gtgccctgag ccgtcacagc gggcgatgtc
     1561 tgagaccaag acacaactat taagacgatg aaggcatcga cagtattaat gtcaggtgat
     1621 ctgaaataaa ctcccgtaac cccaccccac ccccaagagt ttccattaac ttgatcccat
     1681 tatgaacagc cacattacac aatcaacttc aaccccaata gaagagagct gatcatattc
     1741 tgtgtcttta agtaaatgta ttctctgggc taccccatgt gtgtgctggt cactcaaata
     1801 ttgagcccct attaccatga atcctactgc cataggccag attttataaa tatatgtcac
     1861 tttttcaagt gtatttaatt atttgactct taaaaa
//
