LOCUS       NM_001387360            4579 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens tripartite motif containing 9 (TRIM9), transcript
            variant 3, mRNA.
ACCESSION   NM_001387360
VERSION     NM_001387360.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4579)
  AUTHORS   Hendrix,S. and Zelcer,N.
  TITLE     A new SPRING in lipid metabolism
  JOURNAL   Curr Opin Lipidol 34 (5), 201-207 (2023)
   PUBMED   37548386
  REMARK    GeneRIF: A new SPRING in lipid metabolism.
            Review article
REFERENCE   2  (bases 1 to 4579)
  AUTHORS   Lin,Z., Huang,J., Zhu,L., Lin,X., Huang,Y., Chen,C. and Pan,X.
  TITLE     TRIM9 Interacts with ZEB1 to Suppress Esophageal Cancer by
            Promoting ZEB1 Protein Degradation via the UPP Pathway
  JOURNAL   Biomed Res Int 2023, 2942402 (2023)
   PUBMED   37124931
  REMARK    GeneRIF: TRIM9 Interacts with ZEB1 to Suppress Esophageal Cancer by
            Promoting ZEB1 Protein Degradation via the UPP Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4579)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 4579)
  AUTHORS   Wang,Z., Wang,B. and Wang,K.
  TITLE     Targeting TRIM9 by miR-218-5p Restricts Cell Proliferation and
            Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer
  JOURNAL   Ann Clin Lab Sci 53 (1), 106-115 (2023)
   PUBMED   36889762
  REMARK    GeneRIF: Targeting TRIM9 by miR-218-5p Restricts Cell Proliferation
            and Epithelial-Mesenchymal Transition in Non-Small Cell Lung
            Cancer.
REFERENCE   5  (bases 1 to 4579)
  AUTHORS   Zhao,W. and Wang,Q.
  TITLE     Knockdown of TRIM9 attenuates irinotecan-induced intestinal
            mucositis in IEC-6 cells by regulating DUSP6 expression via the P38
            pathway
  JOURNAL   Mol Med Rep 24 (6) (2021)
   PUBMED   34676875
  REMARK    GeneRIF: Knockdown of TRIM9 attenuates irinotecaninduced intestinal
            mucositis in IEC6 cells by regulating DUSP6 expression via the P38
            pathway.
REFERENCE   6  (bases 1 to 4579)
  AUTHORS   Tanji,K., Kamitani,T., Mori,F., Kakita,A., Takahashi,H. and
            Wakabayashi,K.
  TITLE     TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in
            the brain of Parkinson's disease and dementia with Lewy bodies
  JOURNAL   Neurobiol Dis 38 (2), 210-218 (2010)
   PUBMED   20085810
  REMARK    GeneRIF: These results suggest that TRIM9 plays an important role
            in the regulation of neuronal functions and participates in
            pathological process of Lewy body disease through its ligase
            activity.
REFERENCE   7  (bases 1 to 4579)
  AUTHORS   Li,Y., Chin,L.S., Weigel,C. and Li,L.
  TITLE     Spring, a novel RING finger protein that regulates synaptic vesicle
            exocytosis
  JOURNAL   J Biol Chem 276 (44), 40824-40833 (2001)
   PUBMED   11524423
REFERENCE   8  (bases 1 to 4579)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   9  (bases 1 to 4579)
  AUTHORS   Ohara,O., Nagase,T., Ishikawa,K., Nakajima,D., Ohira,M., Seki,N.
            and Nomura,N.
  TITLE     Construction and characterization of human brain cDNA libraries
            suitable for analysis of cDNA clones encoding relatively large
            proteins
  JOURNAL   DNA Res 4 (1), 53-59 (1997)
   PUBMED   9179496
REFERENCE   10 (bases 1 to 4579)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591770.3 and AL358334.3.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. The protein localizes to cytoplasmic
            bodies. Its function has not been identified. Alternate splicing of
            this gene generates two transcript variants encoding different
            isoforms. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.243623.1,
                                           SRR1660809.25231.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684578.1/ ENSP00000507131.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-988               AL591770.3         71364-72351         c
            989-1084            AL358334.3         4521-4616
            1085-1207           AL358334.3         6924-7046
            1208-1318           AL358334.3         19387-19497
            1319-1472           AL358334.3         20648-20801
            1473-1630           AL358334.3         29041-29198
            1631-1769           AL358334.3         31693-31831
            1770-1958           AL358334.3         43737-43925
            1959-2000           AL358334.3         46460-46501
            2001-2024           AL358334.3         46916-46939
            2025-2328           AL358334.3         47778-48081
            2329-2491           AL358334.3         50332-50494
            2492-4579           AL358334.3         52528-54615
FEATURES             Location/Qualifiers
     source          1..4579
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..4579
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /note="tripartite motif containing 9"
                     /db_xref="GeneID:114088"
                     /db_xref="HGNC:HGNC:16288"
                     /db_xref="MIM:606555"
     exon            1..988
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..2554
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 3;
                     homolog of rat RING finger Spring; tripartite
                     motif-containing protein 9; E3 ubiquitin-protein ligase
                     TRIM9; RING finger protein 91; RING-type E3 ubiquitin
                     transferase TRIM9; SNAP-25-interacting RING finger
                     protein"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM9 isoform 3"
                     /protein_id="NP_001374289.1"
                     /db_xref="CCDS:CCDS91879.1"
                     /db_xref="GeneID:114088"
                     /db_xref="HGNC:HGNC:16288"
                     /db_xref="MIM:606555"
                     /translation="MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPES
                     ESPQSHRAAGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVF
                     PPAMPPPATHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQ
                     SKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVS
                     RRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQ
                     LSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQL
                     LARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRR
                     VHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEE
                     CCTHNNSATLSWKQPPLSTVPADGYILELDDGNGGQFREVYVGKETMCTVDGLHFNST
                     YNARVKAFNKTGVSPYSKTLVLQTSEDTDSEEQTLPFPVPSERLPLRRMSPFSSTLNL
                     QPSFPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSAPYSQLVDIKKLLAVAWFA
                     FDPGSAHSDIILSNDNLTVTCSSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFG
                     VARMDVMKDVMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNR
                     KNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA"
     exon            989..1084
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1207
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1318
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1472
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1630
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1769
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1958
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2000
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2024
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2328
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2491
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..4579
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4557..4562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /note="hexamer: AATAAA"
     polyA_site      4579
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /note="major polyA site"
ORIGIN      
        1 acagagctag cgcctctctg ggtgtccgtg ccagtgctgc gcgggaaggc accaccacca
       61 cagccgccgc cgctggccag ggtgctggac aagacgggcc cgtcggccac ctcgccagct
      121 caggcacccg ctgcagccgt cgctgtctcc tcccagaccg gtccccatgg aggagatgga
      181 agaggagttg aaatgccccg tgtgcggctc cttctatcgg gagcccatca tcctgccctg
      241 ctctcacaat ttgtgtcagg cgtgcgcccg caacatcctg gtgcagaccc cagagtctga
      301 atccccccag agccatcggg ccgcgggctc cggggtctcc gactatgact atctggacct
      361 ggacaagatg agcctataca gcgaggcgga cagcggctat ggctcctacg gggggttcgc
      421 cagcgccccc actaccccgt gccagaagtc ccccaacggc gtccgcgtgt ttcccccggc
      481 tatgccgcca ccggccaccc acttgtcacc ggccctggcc ccggtgcccc gcaactcctg
      541 tatcacctgc ccccagtgtc accgcagcct catcctggat gaccgggggc tccgcggctt
      601 ccccaagaat cgcgtactgg aaggggtaat tgaccgctac cagcagagca aagccgcggc
      661 cctcaagtgc cagctctgcg agaaggcgcc caaggaagcc accgtcatgt gcgaacagtg
      721 cgatgtcttc tactgcgatc cgtgccgcct gcgctgccac ccgccccggg ggcccctagc
      781 caagcaccgc ctggtgcccc cggcccaggg tcgtgtgagc cggaggctga gcccacgcaa
      841 ggtctccacc tgcacagacc acgagctgga gaaccacagc atgtactgcg tgcaatgcaa
      901 gatgcccgtg tgctaccagt gcttggagga gggcaaacac tccagccacg aagtcaaggc
      961 tctgggggcc atgtggaaac tacataagag ccagctctcc caggcgctga acggactgtc
     1021 agacagggcc aaagaagcca aggagtttct ggtacagctg cgcaacatgg tccagcagat
     1081 ccaggagaac agtgtggagt ttgaagcctg tctggtggcc caatgtgatg ccctcatcga
     1141 tgccctcaac agaagaaaag cccagctgct ggcccgcgtc aacaaggagc atgagcacaa
     1201 gctgaaggtg gttcgagatc agatctctca ctgcacagtg aaattgcgcc agaccacagg
     1261 tctcatggag tactgcttgg aggtgattaa ggaaaatgat cctagtggtt ttttgcagat
     1321 ttctgacgcc ctcataagaa gagtgcacct gactgaggat cagtggggta aaggcacact
     1381 cactccaagg atgaccacgg actttgactt gagtctggac aacagccctc tgctgcaatc
     1441 catccaccag ctggatttcg tgcaagtgaa agcttcctct ccagtcccag caacccctat
     1501 cctacagctg gaggaatgtt gtacccacaa caacagcgct acgttgtcct ggaaacagcc
     1561 acctctgtcc acggtgcccg ccgatggata cattctggag ctggatgatg gcaacggtgg
     1621 tcaattccgg gaggtgtatg tggggaagga gacaatgtgc actgtggatg gtcttcactt
     1681 caacagcaca tacaacgctc gggtcaaggc cttcaacaaa acaggagtca gcccgtacag
     1741 caagaccctg gtcctccaaa cgtctgagga cacagattca gaagaacaga ccctcccttt
     1801 tccagtgcct tcggaaagat tgccgctccg tagaatgagt cctttctcct ccacccttaa
     1861 tctacaaccc agcttccccg ggagatccta ctttgatttc cgatcctcac cccaccagct
     1921 gagcttgcat tcctctttac agtctctcaa tgcaccggga tgcaattttg agacacaatc
     1981 tgcaccttac tctcaattag ttgacattaa aaagctgttg gcagtggcct ggtttgcttt
     2041 cgaccctggc tcggcgcact cggacatcat cctctccaat gacaacctga cagtgacctg
     2101 tagtagctat gatgaccggg tggtgctagg gaagactggc ttctccaagg gcatccacta
     2161 ctgggagctc acggtagatc gctatgacaa ccaccctgat cctgcctttg gtgtggctcg
     2221 catggacgtg atgaaggatg tgatgttagg aaaagacgac aaagcttggg caatgtatgt
     2281 ggacaataac cggagctggt tcatgcacaa caactcgcac accaacagaa ctgagggagg
     2341 gatcacaaaa ggggccacaa ttggggtcct cctcgactta aatagaaaaa acttgacatt
     2401 ttttatcaac gatgaacaac aaggtcccat agcatttgat aacgtggagg gcctcttctt
     2461 ccctgcggtc agcctgaaca ggaacgtgca ggtcacgctg cacaccgggc tcccagtccc
     2521 cgacttctac tccagcagag catcaatagc ctaaggatgt gccgtggagg cgccagctgc
     2581 ctgttcttac ctccgcctgc gagagccaca gcaaggagct cagccagccg tggtggggtg
     2641 cagagttggc aggagtggga gaaggaggag agaaaagctg gtcctctgca gtctttacac
     2701 ccacagctct gcccttttcc ctttcaacct ctcctccgct gtcatgcctg cttccgcttc
     2761 catgtccaac aattctaacc aacaaaggac ctagacagcc caccaagtca cttggttccc
     2821 actcccagat tttgctttta tttaacttaa ttttttatgt aggtgagtta tattttcttt
     2881 cttttctgat caggttattg gtgacttact ggactggcac cgccaggaga aaattctcct
     2941 gctaactttt tttcttaagc tttctgtcaa acaatgaggt tgtaggggga ggtagggaag
     3001 aatgagctga atttgtagca tacagcttac ctgctagaat gttcttaccc tcttacctct
     3061 cctgtagcgt tagctctgca gagctaagct ttgggagaat gaatctatca ctgagaagtt
     3121 ttactactca ttgaagcaca aaaatatccg ctacacaggt tcacatcagg gtaggatcgt
     3181 taggatggct ctataattag gataggccag aaccctggcc actgtataaa attggaaagt
     3241 ctctaagaca caggcaaacc aggggactta atgatttggt tcgtttattt aataaaagct
     3301 tttaattgag aacctactat tgaccaggca ctgttcaaga cactagaaca ttatgttcta
     3361 gacactgtgg ggacacagtg gtgaacagac aggcatggtc tctgcccttc ggagcttata
     3421 ttccagtagg agaaaaagca aaaataaaat aattataaat ggtcatatgt actagaaagg
     3481 aaatgggcaa gggtcaaaga gactcatggg caagatcttt caggcttcct agaatgatgc
     3541 taaaaatcca cacattctgg ccatagcacc agaaatgtac caactcaatg ccttttcagc
     3601 tgcactattt aattatggta cctgctgcca ctcatcacag agcccttctt ggtagaaatg
     3661 atgtcagcat tcttatttgc tgatgctgct atgataccac gccttaaaaa ttgacagttg
     3721 aaaaaaaaaa gagtgaccag agggcaaagg acccattctc agtaatggga gatcttgagt
     3781 tgcagtccac agcattcaca ttctcaggat aaacatgctt gtctccatat atactatctg
     3841 tgcctgttat gaatgaaaaa tccatccact ctgctgccat tcacagccta attttctgga
     3901 gtagtccaaa caatgtttgg aaaaacatgg gactgtatgt cattactatg actgatagca
     3961 gaataataat gcatcttact tctatataga gatagactta cataggttac ccttgaaatt
     4021 cattagtttg tcataaagtt ttaggaaagg taggacccgg aaagaagttc taattagttg
     4081 tctaaatatt tttcagtgag ccaagaaatt caccatgaaa aaacaagaat aacaaataga
     4141 agggaagaga taggatggga aagctaacaa attaaagttt tggcaaaaag gaatatatgt
     4201 aaatagctaa ttatttactt ttgtgcttac tttatttaga ttatttctat cagttacaat
     4261 ctttttctag ttaagtgtac ctaatttatg gaatgggtgc tatcctgttt atgtgtgtct
     4321 tggtttttct tggctacaga aaaactgttg cagggcaaca ctagtttgat atttgattta
     4381 ctctccaatg agactcaatg gctgggccgt ggtagactca tagttcctct tgttctttat
     4441 taaattcatc ctgctaatta gatttctagt gacttgtaac atgtagttta cactgaattg
     4501 caattacaga tgcatacaac tactatacta gaaaaaattg tcatttctga tgtgccaata
     4561 aatgattttt atgagagaa
//
