LOCUS       NM_030912               2759 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens tripartite motif containing 8 (TRIM8), transcript
            variant 1, mRNA.
ACCESSION   NM_030912
VERSION     NM_030912.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2759)
  AUTHORS   Peng,Y., Qian,H., Xu,W.P., Xiao,M.C., Ding,C.H., Liu,F., Hong,H.Y.,
            Liu,S.Q., Zhang,X. and Xie,W.F.
  TITLE     Tripartite motif 8 promotes the progression of hepatocellular
            carcinoma via mediating ubiquitination of HNF1alpha
  JOURNAL   Cell Death Dis 15 (6), 416 (2024)
   PUBMED   38879600
  REMARK    GeneRIF: Tripartite motif 8 promotes the progression of
            hepatocellular carcinoma via mediating ubiquitination of HNF1alpha.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2759)
  AUTHORS   Wu,F., Xu,J., Jin,X., Zhu,Y., Gao,W., Liu,M., Zhang,Y., Qian,W.,
            Huang,X., Zhao,D., Feng,G., Hou,S. and Xi,X.
  TITLE     TRIM8 promotes ovarian cancer proliferation and migration by
            targeting VDAC2 for ubiquitination and degradation
  JOURNAL   Cancer Med 13 (11), e7396 (2024)
   PUBMED   38881325
  REMARK    GeneRIF: TRIM8 promotes ovarian cancer proliferation and migration
            by targeting VDAC2 for ubiquitination and degradation.
REFERENCE   3  (bases 1 to 2759)
  AUTHORS   Xiao,M.C., Jiang,N., Chen,L.L., Liu,F., Liu,S.Q., Ding,C.H.,
            Wu,S.H., Wang,K.Q., Luo,Y.Y., Peng,Y., Yan,F.Z., Zhang,X., Qian,H.
            and Xie,W.F.
  TITLE     TRIB3-TRIM8 complex drives NAFLD progression by regulating
            HNF4alpha stability
  JOURNAL   J Hepatol 80 (5), 778-791 (2024)
   PUBMED   38237865
  REMARK    GeneRIF: TRIB3-TRIM8 complex drives NAFLD progression by regulating
            HNF4alpha stability.
REFERENCE   4  (bases 1 to 2759)
  AUTHORS   Wang,L., Li,H., Huang,A., Zhao,Y., Xiao,C., Dong,J., Liu,X. and
            Shao,N.
  TITLE     Mutual regulation between TRIM21 and TRIM8 via K48-linked
            ubiquitination
  JOURNAL   Oncogene 42 (50), 3708-3718 (2023)
   PUBMED   37914816
  REMARK    GeneRIF: Mutual regulation between TRIM21 and TRIM8 via K48-linked
            ubiquitination.
REFERENCE   5  (bases 1 to 2759)
  AUTHORS   Hosseinalizadeh,H., Mohamadzadeh,O., Kahrizi,M.S., Razaghi
            Bahabadi,Z., Klionsky,D.J. and Mirzei,H.
  TITLE     TRIM8: a double-edged sword in glioblastoma with the power to heal
            or hurt
  JOURNAL   Cell Mol Biol Lett 28 (1), 6 (2023)
   PUBMED   36690946
  REMARK    GeneRIF: TRIM8: a double-edged sword in glioblastoma with the power
            to heal or hurt.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2759)
  AUTHORS   Sakai,Y., Fukai,R., Matsushita,Y., Miyake,N., Saitsu,H.,
            Akamine,S., Torio,M., Sasazuki,M., Ishizaki,Y., Sanefuji,M.,
            Torisu,H., Shaw,C.A., Matsumoto,N. and Hara,T.
  TITLE     De Novo Truncating Mutation of TRIM8 Causes Early-Onset Epileptic
            Encephalopathy
  JOURNAL   Ann Hum Genet 80 (4), 235-240 (2016)
   PUBMED   27346735
  REMARK    GeneRIF: A pathogenic effect of a heterozygous truncating mutation
            in the tripartite motif containing 8 (TRIM8) gene on the postnatal
            development of the human brain.
REFERENCE   7  (bases 1 to 2759)
  AUTHORS   Toniato,E., Flati,V., Laglia,E., Mincione,G. and Martinotti,S.
  TITLE     Genomic organization and cytokine-mediated inducibility of the
            human TRIM-8/Gerp gene
  JOURNAL   Int J Immunopathol Pharmacol 17 (2 Suppl), 71-76 (2004)
   PUBMED   15345195
  REMARK    GeneRIF: Gerp transcribes interferon-gamma in epithelial and
            lymphoid cells and is expressed almost ubiquitously in tissues.
REFERENCE   8  (bases 1 to 2759)
  AUTHORS   Toniato,E., Chen,X.P., Losman,J., Flati,V., Donahue,L. and
            Rothman,P.
  TITLE     TRIM8/GERP RING finger protein interacts with SOCS-1
  JOURNAL   J Biol Chem 277 (40), 37315-37322 (2002)
   PUBMED   12163497
  REMARK    GeneRIF: interacts with SOCS-1
REFERENCE   9  (bases 1 to 2759)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   10 (bases 1 to 2759)
  AUTHORS   Vincent,S.R., Kwasnicka,D.A. and Fretier,P.
  TITLE     A novel RING finger-B box-coiled-coil protein, GERP
  JOURNAL   Biochem Biophys Res Commun 279 (2), 482-486 (2000)
   PUBMED   11118312
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391121.29, BG746631.1,
            AF220034.1 and AA907931.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 4, 2020 this sequence version replaced NM_030912.2.
            
            Summary: This gene encodes a member of the tripartite motif (TRIM)
            protein family. Based on similarities to other proteins, the
            encoded protein is suspected to be an E3 ubiquitin-protein ligase.
            Regulation of this gene may be altered in some cancers. Mutations
            resulting in a truncated protein product have been observed in
            early-onset epileptic encephalopathy (EOEE). [provided by RefSeq,
            Sep 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF281046.1, BC021925.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000643721.2/ ENSP00000496301.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL391121.29        53829-53844
            17-139              BG746631.1         1-123
            140-2554            AF220034.1         1-2415
            2555-2759           AA907931.1         11-215              c
FEATURES             Location/Qualifiers
     source          1..2759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..2759
                     /gene="TRIM8"
                     /gene_synonym="FSGSNEDS; GERP; RNF27"
                     /note="tripartite motif containing 8"
                     /db_xref="GeneID:81603"
                     /db_xref="HGNC:HGNC:15579"
                     /db_xref="MIM:606125"
     exon            1..709
                     /gene="TRIM8"
                     /gene_synonym="FSGSNEDS; GERP; RNF27"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1795
                     /gene="TRIM8"
                     /gene_synonym="FSGSNEDS; GERP; RNF27"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; ring
                     finger protein 27; tripartite motif protein TRIM8;
                     probable E3 ubiquitin-protein ligase TRIM8;
                     glioblastoma-expressed RING finger protein; RING-type E3
                     ubiquitin transferase TRIM8"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM8 isoform 1"
                     /protein_id="NP_112174.2"
                     /db_xref="CCDS:CCDS31274.1"
                     /db_xref="GeneID:81603"
                     /db_xref="HGNC:HGNC:15579"
                     /db_xref="MIM:606125"
                     /translation="MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWA
                     KDSGLVRCPECNQAYNQKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLP
                     AQKVCLRCEAPCCQSHVQTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQ
                     VAVCQYCCYYSGAHQGHSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDK
                     RLVEEKVNQLKEEVRLQYEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERM
                     QEAKKLLGSLQLLFDKTEDVSFMKNTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFL
                     NEVAKKEKQLRKMLEGPFSTPVPFLQSVPLYPCGVSSSGAEKRKHSTAFPEASFLETS
                     SGPVGGQYGAAGTASGEGQSGQPLGPCSSTQHLVALPGGAQPVHSSPVFPPSQYPNGS
                     AAQQPMLPQYGGRKILVCSVDNCYCSSVANHGGHQPYPRSGHFPWTVPSQEYSHPLPP
                     TPSVPQSLPSLAVRDWLDASQQPGHQDFYRVYGQPSTKHYVTS"
     exon            710..805
                     /gene="TRIM8"
                     /gene_synonym="FSGSNEDS; GERP; RNF27"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1039
                     /gene="TRIM8"
                     /gene_synonym="FSGSNEDS; GERP; RNF27"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1071
                     /gene="TRIM8"
                     /gene_synonym="FSGSNEDS; GERP; RNF27"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1187
                     /gene="TRIM8"
                     /gene_synonym="FSGSNEDS; GERP; RNF27"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..2759
                     /gene="TRIM8"
                     /gene_synonym="FSGSNEDS; GERP; RNF27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2736..2741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM8"
                     /gene_synonym="FSGSNEDS; GERP; RNF27"
                     /note="hexamer: AATAAA"
     polyA_site      2759
                     /gene="TRIM8"
                     /gene_synonym="FSGSNEDS; GERP; RNF27"
                     /note="major polyA site"
ORIGIN      
        1 gaaggcgctg ctgactgagc gaccgtcggg gccggctggg gccggagctc ggggctcggt
       61 gggcctacag cggctccgga cggacccccg gggctgggga gtcggggagg cctgccccgg
      121 ccccctgccc gcggccgcca tggcggagaa ttggaagaac tgcttcgagg aggagctcat
      181 ctgccctatc tgcctgcacg ttttcgtgga gccagtgcag ctgccgtgca aacacaactt
      241 ctgccggggc tgcatcggcg aggcgtgggc caaggacagc ggcctcgtac gctgcccaga
      301 gtgcaaccag gcctacaacc agaagccggg cctggagaag aacctgaagc tcaccaacat
      361 cgtggagaag ttcaatgccc tgcacgtgga gaagccgccg gcggcgctgc actgcgtgtt
      421 ctgccgccgc ggccccccgc tgcccgcgca gaaggtctgc ctgcgctgcg aggcgccctg
      481 ctgccagtcc cacgtgcaga cgcacctgca gcagccctcc accgcccgcg ggcacctcct
      541 ggtggaggcg gacgacgtgc gggcctggag ctgcccgcag cacaacgcct accgcctcta
      601 ccactgcgag gccgagcagg tggccgtgtg ccagtactgc tgctactaca gcggcgcgca
      661 tcagggacac tcggtgtgcg acgtggagat ccgaaggaat gaaatccgga agatgctcat
      721 gaagcagcag gaccggctgg aggagcgaga gcaggacatt gaggaccagc tgtacaaact
      781 cgagtcagac aagcgcctgg tggaggagaa agtgaaccaa ctgaaggagg aagttcggct
      841 gcagtacgag aagctgcacc agctgctgga cgaggacctg cggcagacag tggaggtcct
      901 agacaaggcc caggccaagt tctgcagcga gaacgcagcg caggcgctgc acctcgggga
      961 gcgcatgcag gaggccaaga agctgctggg ctccctgcag ctgctctttg ataagacgga
     1021 ggatgtcagc ttcatgaaga acaccaagtc tgtgaaaatc ctgatggaca ggacccagac
     1081 ctgcacgagc agcagccttt cccccactaa gatcggccac ctgaactcca agctcttcct
     1141 gaacgaagtg gccaagaagg agaagcagct gcggaaaatg ctagaaggcc ccttcagcac
     1201 gccggtgccc ttcctgcaga gtgtccccct gtacccttgc ggcgtgagca gctctggggc
     1261 ggaaaagcgc aagcactcaa cggccttccc agaggccagt ttcctagaga cgtcgtcggg
     1321 ccctgtgggc ggccagtacg gggcggcggg cacagccagc ggtgagggcc agtctgggca
     1381 gcccctgggg ccctgcagct ccacgcagca cttggtggcc ctgccgggcg gcgcccaacc
     1441 agtgcactca agccccgtgt tccccccatc gcagtatccc aatggctccg ccgcccagca
     1501 gcccatgctc ccccagtatg gcggccgcaa gattctcgtc tgttctgtgg acaactgtta
     1561 ctgttcttcc gtggccaacc atggcggcca ccagccctac ccccgctccg gccactttcc
     1621 ctggacagtg ccctcgcagg agtactcaca cccgctcccg cccacaccct ccgtccccca
     1681 gtcccttccc agcctggcgg tcagagactg gcttgacgcc tcccagcagc ccggccacca
     1741 ggatttctac agggtgtatg ggcagccgtc caccaaacac tacgtgacga gctaacgcca
     1801 cgcaggcggc ggggcgctgg ggaatcttcc tccccagccc ccgggctcgg gagttatgca
     1861 tccagagacc tgcccttcta ccttcctcgc ctcccctctt cctcattcca ttgccccagg
     1921 tcttttcctt ttggattttg ttttggtttt ggctttgttt ttgatttttt tttattatga
     1981 atctcctgga cgcagaggtg acagtgggag ctggcctggg ccaggacggc aggtggccct
     2041 ggagatggga aagtgtctgt gtcgaggcgc tgagctctct ctctgtttct ccttttttcc
     2101 tctactcctt ccccttcaca cccccgtggc tggaaggaac ctcggcttcc ctgaaagctt
     2161 gggggtccca cccttcttac cccacccggg aggaacgccc agggccccgg gcttgtttct
     2221 cctcttgttt tccttttggg cagtttgatc actgatcgag taaggaatga cctttagatt
     2281 gtgcgacttt tgtttttgtt tttttaaatt tttttaaacc aagaatgatt tctcctgctt
     2341 ccttctcctc accatcttcc cagacggagt tcaaaggcca cttctcaagc agcttttggc
     2401 accttcagcc tcagagtgga atcttttaaa gacaggaccc ctatgtccag gaaaggggaa
     2461 aaggaacttt gccaatgata gtgaccacag caaaagcaaa taataataat attaataata
     2521 ataaagagaa ataaaataat aaaataaaaa acaatagcac agcccttgtt gaggtcagca
     2581 gggaggaggg gctgcccgga gttgggtcct tgcctggatt ttgacacagc aacttcctgt
     2641 agtgagcact ttgtatgaat cgtggacttc ctgttctcaa ggcgcaggta tttattctgt
     2701 atctgtctag agcacacacc aaaatccaac cttctaataa acatgatggc gcagtccca
//
