LOCUS       NM_198853               1350 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens tripartite motif containing 74 (TRIM74), transcript
            variant 1, mRNA.
ACCESSION   NM_198853 XM_353614
VERSION     NM_198853.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1350)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1350)
  AUTHORS   Kim,Y.J., Ahn,K., Gim,J.A., Oh,M.H., Han,K. and Kim,H.S.
  TITLE     Gene structure variation in segmental duplication block C of human
            chromosome 7q 11.23 during primate evolution
  JOURNAL   Gene 573 (2), 285-295 (2015)
   PUBMED   26196062
REFERENCE   4  (bases 1 to 1350)
  AUTHORS   Arking,D.E., Pulit,S.L., Crotti,L., van der Harst,P., Munroe,P.B.,
            Koopmann,T.T., Sotoodehnia,N., Rossin,E.J., Morley,M., Wang,X.,
            Johnson,A.D., Lundby,A., Gudbjartsson,D.F., Noseworthy,P.A.,
            Eijgelsheim,M., Bradford,Y., Tarasov,K.V., Dorr,M.,
            Muller-Nurasyid,M., Lahtinen,A.M., Nolte,I.M., Smith,A.V.,
            Bis,J.C., Isaacs,A., Newhouse,S.J., Evans,D.S., Post,W.S.,
            Waggott,D., Lyytikainen,L.P., Hicks,A.A., Eisele,L., Ellinghaus,D.,
            Hayward,C., Navarro,P., Ulivi,S., Tanaka,T., Tester,D.J.,
            Chatel,S., Gustafsson,S., Kumari,M., Morris,R.W., Naluai,A.T.,
            Padmanabhan,S., Kluttig,A., Strohmer,B., Panayiotou,A.G.,
            Torres,M., Knoflach,M., Hubacek,J.A., Slowikowski,K.,
            Raychaudhuri,S., Kumar,R.D., Harris,T.B., Launer,L.J.,
            Shuldiner,A.R., Alonso,A., Bader,J.S., Ehret,G., Huang,H.,
            Kao,W.H., Strait,J.B., Macfarlane,P.W., Brown,M., Caulfield,M.J.,
            Samani,N.J., Kronenberg,F., Willeit,J., Smith,J.G., Greiser,K.H.,
            Meyer Zu Schwabedissen,H., Werdan,K., Carella,M., Zelante,L.,
            Heckbert,S.R., Psaty,B.M., Rotter,J.I., Kolcic,I., Polasek,O.,
            Wright,A.F., Griffin,M., Daly,M.J., Arnar,D.O., Holm,H.,
            Thorsteinsdottir,U., Denny,J.C., Roden,D.M., Zuvich,R.L.,
            Emilsson,V., Plump,A.S., Larson,M.G., O'Donnell,C.J., Yin,X.,
            Bobbo,M., D'Adamo,A.P., Iorio,A., Sinagra,G., Carracedo,A.,
            Cummings,S.R., Nalls,M.A., Jula,A., Kontula,K.K., Marjamaa,A.,
            Oikarinen,L., Perola,M., Porthan,K., Erbel,R., Hoffmann,P.,
            Jockel,K.H., Kalsch,H., Nothen,M.M., den Hoed,M., Loos,R.J.,
            Thelle,D.S., Gieger,C., Meitinger,T., Perz,S., Peters,A.,
            Prucha,H., Sinner,M.F., Waldenberger,M., de Boer,R.A., Franke,L.,
            van der Vleuten,P.A., Beckmann,B.M., Martens,E., Bardai,A.,
            Hofman,N., Wilde,A.A., Behr,E.R., Dalageorgou,C., Giudicessi,J.R.,
            Medeiros-Domingo,A., Barc,J., Kyndt,F., Probst,V., Ghidoni,A.,
            Insolia,R., Hamilton,R.M., Scherer,S.W., Brandimarto,J.,
            Margulies,K., Moravec,C.E., del Greco,M. F, Fuchsberger,C.,
            O'Connell,J.R., Lee,W.K., Watt,G.C., Campbell,H., Wild,S.H., El
            Mokhtari,N.E., Frey,N., Asselbergs,F.W., Mateo Leach,I., Navis,G.,
            van den Berg,M.P., van Veldhuisen,D.J., Kellis,M., Krijthe,B.P.,
            Franco,O.H., Hofman,A., Kors,J.A., Uitterlinden,A.G.,
            Witteman,J.C., Kedenko,L., Lamina,C., Oostra,B.A., Abecasis,G.R.,
            Lakatta,E.G., Mulas,A., Orru,M., Schlessinger,D., Uda,M.,
            Markus,M.R., Volker,U., Snieder,H., Spector,T.D., Arnlov,J.,
            Lind,L., Sundstrom,J., Syvanen,A.C., Kivimaki,M., Kahonen,M.,
            Mononen,N., Raitakari,O.T., Viikari,J.S., Adamkova,V., Kiechl,S.,
            Brion,M., Nicolaides,A.N., Paulweber,B., Haerting,J.,
            Dominiczak,A.F., Nyberg,F., Whincup,P.H., Hingorani,A.D.,
            Schott,J.J., Bezzina,C.R., Ingelsson,E., Ferrucci,L., Gasparini,P.,
            Wilson,J.F., Rudan,I., Franke,A., Muhleisen,T.W., Pramstaller,P.P.,
            Lehtimaki,T.J., Paterson,A.D., Parsa,A., Liu,Y., van Duijn,C.M.,
            Siscovick,D.S., Gudnason,V., Jamshidi,Y., Salomaa,V., Felix,S.B.,
            Sanna,S., Ritchie,M.D., Stricker,B.H., Stefansson,K., Boyer,L.A.,
            Cappola,T.P., Olsen,J.V., Lage,K., Schwartz,P.J., Kaab,S.,
            Chakravarti,A., Ackerman,M.J., Pfeufer,A., de Bakker,P.I. and
            Newton-Cheh,C.
  CONSRTM   CARe Consortium; COGENT Consortium; DCCT/EDIC; eMERGE Consortium;
            HRGEN Consortium
  TITLE     Genetic association study of QT interval highlights role for
            calcium signaling pathways in myocardial repolarization
  JOURNAL   Nat Genet 46 (8), 826-836 (2014)
   PUBMED   24952745
REFERENCE   5  (bases 1 to 1350)
  AUTHORS   Micale,L., Fusco,C., Augello,B., Napolitano,L.M., Dermitzakis,E.T.,
            Meroni,G., Merla,G. and Reymond,A.
  TITLE     Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase
  JOURNAL   Eur J Hum Genet 16 (9), 1038-1049 (2008)
   PUBMED   18398435
  REMARK    GeneRIF: Maps within the critical region of Williams-Beuren
            syndrome.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF498999.1 and BC033871.1.
            
            On May 17, 2019 this sequence version replaced NM_198853.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF498999.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285805.3/ ENSP00000285805.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1349              AF498999.1         1-1349
            1350-1350           BC033871.1         1285-1285
FEATURES             Location/Qualifiers
     source          1..1350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..1350
                     /gene="TRIM74"
                     /gene_synonym="TRIM50C"
                     /note="tripartite motif containing 74"
                     /db_xref="GeneID:378108"
                     /db_xref="HGNC:HGNC:17453"
                     /db_xref="MIM:612550"
     exon            1..182
                     /gene="TRIM74"
                     /gene_synonym="TRIM50C"
                     /inference="alignment:Splign:2.1.0"
     exon            183..599
                     /gene="TRIM74"
                     /gene_synonym="TRIM50C"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..953
                     /gene="TRIM74"
                     /gene_synonym="TRIM50C"
                     /note="tripartite motif-containing 50C; tripartite
                     motif-containing protein 50C"
                     /codon_start=1
                     /product="tripartite motif-containing protein 74"
                     /protein_id="NP_942150.1"
                     /db_xref="CCDS:CCDS5545.1"
                     /db_xref="GeneID:378108"
                     /db_xref="HGNC:HGNC:17453"
                     /db_xref="MIM:612550"
                     /translation="MAWQVSLLELEDWLQCPICLEVFKESLMLQCGHSYCKGCLVSLS
                     YHLDTKVRCPMCWQVVDGSSSLPNVSLAWVIEALRLPGDPEPKVCVHHRNPLSLFCEK
                     DQELICGLCGLLGSHQHHPVTPVSTVCSRMKEELAALFSELKQEQKKVDELIAKLVKN
                     RTRIVNESDVFSWVIRREFQELRHPVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGT
                     RERLAQAECVLEQFGNEDHHEFIWKFHSMASR"
     exon            600..695
                     /gene="TRIM74"
                     /gene_synonym="TRIM50C"
                     /inference="alignment:Splign:2.1.0"
     exon            696..926
                     /gene="TRIM74"
                     /gene_synonym="TRIM50C"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1350
                     /gene="TRIM74"
                     /gene_synonym="TRIM50C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1332..1337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM74"
                     /gene_synonym="TRIM50C"
                     /note="hexamer: AATAAA"
     polyA_site      1350
                     /gene="TRIM74"
                     /gene_synonym="TRIM50C"
                     /note="major polyA site"
ORIGIN      
        1 gagcatgatg gggcatgtgc gggagcgcca ggcggggcat gtaaccagag cgtgcggggc
       61 atgatggggc acggacatgg ggggttaggt ggggcacgta attggagctc gcggggcagg
      121 atggggcatc taactggagc gacagagagc acgatggggc acttacaggg gccggaggct
      181 ggcccgggca gtgagtgtgg atggcttggc aggtgagcct gctggagctg gaggactggc
      241 ttcagtgtcc catctgcctg gaggtcttca aggagtccct aatgctacag tgcggccact
      301 cctactgcaa gggctgcctg gtttccctgt cctaccacct ggacaccaag gtgcgctgcc
      361 ccatgtgctg gcaggtggtg gacggcagca gctccttgcc caacgtctcc ctggcctggg
      421 tgatcgaagc cctgaggctc cctggggacc cggagcccaa ggtctgcgtg caccaccgga
      481 acccgctcag ccttttctgc gagaaggacc aggagctcat ctgtggcctc tgcggtctgc
      541 tgggctccca ccaacaccac ccggtcacgc ccgtctccac cgtctgcagc cgcatgaagg
      601 aggagctcgc agccctcttc tctgagctga agcaggagca gaagaaggtg gatgagctca
      661 tcgccaaact ggtgaaaaac cggacccgaa tcgtcaatga gtcggatgtc ttcagctggg
      721 tgatccgccg cgagttccag gagctgcgcc acccggtgga cgaggagaag gcccgctgcc
      781 tggaggggat agggggtcac acccgtggcc tggtggcctc cctggacatg cagctggagc
      841 aggcccaggg aacccgggag cggctggccc aagccgagtg tgtgctggaa cagttcggaa
      901 atgaggacca ccatgagttc atctggaagt tccactccat ggcctccagg taataacctt
      961 ggagagagct cagccagggt ctggtggctg cgggcacggg catctcagct ccactggttc
     1021 ctccattcag cttaaccagc gcctcccaag cagctgccta tagctggctc tataactgag
     1081 cctggggaag atagaggaaa gtcacgtccc tgccttcaag ggtctcgcag acaggtgggg
     1141 aggcagatgg tgaactgtgg gtacctagaa cagcagaagt tcactcaagc tacagaaata
     1201 ctagaggagg gtagctcatg cctgcaatcc cagtactttg ggaggccaag gcaggagtat
     1261 tgctggaggc cgggagttcg agaccagcct ggccaatgta gtaacacccc cgtctctaca
     1321 aaaaatacaa aaataaaaaa attagttggg
//
