LOCUS       NM_198924               1350 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens tripartite motif containing 73 (TRIM73), mRNA.
ACCESSION   NM_198924 XM_942151
VERSION     NM_198924.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Kim,Y.J., Ahn,K., Gim,J.A., Oh,M.H., Han,K. and Kim,H.S.
  TITLE     Gene structure variation in segmental duplication block C of human
            chromosome 7q 11.23 during primate evolution
  JOURNAL   Gene 573 (2), 285-295 (2015)
   PUBMED   26196062
REFERENCE   2  (bases 1 to 1350)
  AUTHORS   Micale,L., Fusco,C., Augello,B., Napolitano,L.M., Dermitzakis,E.T.,
            Meroni,G., Merla,G. and Reymond,A.
  TITLE     Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase
  JOURNAL   Eur J Hum Genet 16 (9), 1038-1049 (2008)
   PUBMED   18398435
  REMARK    GeneRIF: Maps within the critical region of Williams-Beuren
            syndrome.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF498998.1, DA452220.1, AK126632.1 and AC211429.4.
            
            On Aug 14, 2020 this sequence version replaced NM_198924.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF498998.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323819.8/ ENSP00000318615.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AF498998.1         1-127
            128-720             DA452220.1         1-593
            721-1105            AF498998.1         721-1105
            1106-1252           AK126632.1         3631-3777
            1253-1350           AC211429.4         20256-20353
FEATURES             Location/Qualifiers
     source          1..1350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..1350
                     /gene="TRIM73"
                     /gene_synonym="TRIM50B"
                     /note="tripartite motif containing 73"
                     /db_xref="GeneID:375593"
                     /db_xref="HGNC:HGNC:18162"
                     /db_xref="MIM:612549"
     exon            1..182
                     /gene="TRIM73"
                     /gene_synonym="TRIM50B"
                     /inference="alignment:Splign:2.1.0"
     exon            183..599
                     /gene="TRIM73"
                     /gene_synonym="TRIM50B"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..953
                     /gene="TRIM73"
                     /gene_synonym="TRIM50B"
                     /note="tripartite motif-containing protein 50B"
                     /codon_start=1
                     /product="tripartite motif-containing protein 73"
                     /protein_id="NP_944606.2"
                     /db_xref="CCDS:CCDS34665.1"
                     /db_xref="GeneID:375593"
                     /db_xref="HGNC:HGNC:18162"
                     /db_xref="MIM:612549"
                     /translation="MAWQVSLLELEDRLQCPICLEVFKESLMLQCGHSYCKGCLVSLS
                     YHLDTKVRCPMCWQVVDGSSSLPNVSLAWVIEALRLPGDPEPKVCVHHRNPLSLFCEK
                     DQELICGLCGLLGSHQHHPVTPVSTVCSRMKEELAALFSELKQEQKKVDELIAKLVKN
                     RTRIVNESDVFSWVIRREFQELRHPVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGT
                     RERLAQAECVLEQFGNEDHHEFIWKFHSMASR"
     exon            600..695
                     /gene="TRIM73"
                     /gene_synonym="TRIM50B"
                     /inference="alignment:Splign:2.1.0"
     exon            696..926
                     /gene="TRIM73"
                     /gene_synonym="TRIM50B"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1350
                     /gene="TRIM73"
                     /gene_synonym="TRIM50B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1332..1337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM73"
                     /gene_synonym="TRIM50B"
                     /note="hexamer: AATAAA"
     polyA_site      1350
                     /gene="TRIM73"
                     /gene_synonym="TRIM50B"
                     /note="major polyA site"
ORIGIN      
        1 gagcatgatg gggcatgtgc gggagcgcca ggcggggcat gtaaccagag cgtgcggggc
       61 atgatggggc acggacatgg ggggttaggt ggggcacgta attggagctc gcggggcagg
      121 atggggcatc taactggagc gacagagagc acgatggggc acttacaggg gccggaggct
      181 ggcccgggca gtgagtgtgg atggcttggc aggtgagcct gctggagctg gaggaccggc
      241 ttcagtgtcc catctgcctg gaggtcttca aggagtccct aatgctacag tgcggccact
      301 cctactgcaa gggctgcctg gtttccctgt cctaccacct ggacaccaag gtgcgctgcc
      361 ccatgtgctg gcaggtggtg gacggcagca gctccttgcc caacgtctcc ctggcctggg
      421 tgatcgaagc cctgaggctc cctggggacc cggagcccaa ggtctgcgtg caccaccgga
      481 acccgctcag ccttttctgc gagaaggacc aggagctcat ctgtggcctc tgcggtctgc
      541 tgggctccca ccaacaccac ccggtcacgc ccgtctccac cgtctgcagc cgcatgaagg
      601 aggagctcgc agccctcttc tctgagctga agcaggagca gaagaaggtg gatgagctca
      661 tcgccaaact ggtgaaaaac cggacccgaa tcgtcaatga gtcggatgtc ttcagctggg
      721 tgatccgccg cgagttccag gagctgcgcc acccggtgga cgaggagaag gcccgctgcc
      781 tggaggggat agggggtcac acccgtggcc tggtggcctc cctggacatg cagctggagc
      841 aggcccaggg aacccgggag cggctggccc aagccgagtg tgtgctggaa cagttcggca
      901 atgaggacca ccatgagttc atctggaagt tccactccat ggcctccagg taataacctt
      961 ggagagagct cagccagggt ctggtggctg cgggcacggg catctcagct ccactggttc
     1021 ctccattcag cttaaccagc gcctcccaag cagctgccta tagctggctc tataactgag
     1081 cctggggaag atagaggaaa gtcacgtccc tgccttcaag ggtctcgcag acaggtgggg
     1141 aggcagatgg tgaactgtgg gtacctagaa cagcagaagt tcactcaagc tacagaaata
     1201 ctagaggagg gtagctcatg cctgcaatcc cagtactttg ggaggccaag gcaggagtat
     1261 tgctggaggc cgggagttcg agaccagcct ggccaatgta gtaacacccc cgtctctaca
     1321 aaaaatacaa aaataaaaaa attagttggg
//
