LOCUS       NM_001008274            8402 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens tripartite motif containing 72 (TRIM72), mRNA.
ACCESSION   NM_001008274
VERSION     NM_001008274.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8402)
  AUTHORS   Jia,H., Zhou,L.C., Chen,Y.F., Zhang,W., Qi,W., Wang,P., Huang,X.,
            Guo,J.W., Hou,W.F., Zhang,R.R., Zhou,J.J. and Zhang,D.W.
  TITLE     Mitochondria-encoded peptide MOTS-c participates in plasma membrane
            repair by facilitating the translocation of TRIM72 to membrane
  JOURNAL   Theranostics 14 (13), 5001-5021 (2024)
   PUBMED   39267782
  REMARK    GeneRIF: Mitochondria-encoded peptide MOTS-c participates in plasma
            membrane repair by facilitating the translocation of TRIM72 to
            membrane.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8402)
  AUTHORS   Zhu,X.Z., Wang,J.Q. and Wu,Y.H.
  TITLE     MG53 ameliorates nerve injury induced neuropathic pain through the
            regulation of Nrf2/HO-1 signaling in rats
  JOURNAL   Behav Brain Res 449, 114489 (2023)
   PUBMED   37169128
  REMARK    GeneRIF: MG53 ameliorates nerve injury induced neuropathic pain
            through the regulation of Nrf2/HO-1 signaling in rats.
REFERENCE   3  (bases 1 to 8402)
  AUTHORS   Cai,M., Gao,X. and Yu,S.
  TITLE     Tripartite motif 72 inhibits apoptosis and mitochondrial
            dysfunction in neural stem cells induced by anesthetic sevoflurane
            by activating PI3K/AKT pathway
  JOURNAL   Chin J Physiol 66 (1), 36-42 (2023)
   PUBMED   36814155
  REMARK    GeneRIF: Tripartite motif 72 inhibits apoptosis and mitochondrial
            dysfunction in neural stem cells induced by anesthetic sevoflurane
            by activating PI3K/AKT pathway.
REFERENCE   4  (bases 1 to 8402)
  AUTHORS   Niu,Y., Chen,G., Lv,F., Xiao,R.P., Hu,X. and Chen,L.
  TITLE     Cryo-EM structure of human MG53 homodimer
  JOURNAL   Biochem J 479 (17), 1909-1916 (2022)
   PUBMED   36053137
  REMARK    GeneRIF: Cryo-EM structure of human MG53 homodimer.
REFERENCE   5  (bases 1 to 8402)
  AUTHORS   Cui,K.M., Hu,Z.P. and Wang,Y.L.
  TITLE     MG53 represses high glucose-induced inflammation and angiogenesis
            in human retinal endothelial cells by repressing the EGR1/STAT3
            axis
  JOURNAL   Immunopharmacol Immunotoxicol 44 (4), 484-491 (2022)
   PUBMED   35438597
  REMARK    GeneRIF: MG53 represses high glucose-induced inflammation and
            angiogenesis in human retinal endothelial cells by repressing the
            EGR1/STAT3 axis.
REFERENCE   6  (bases 1 to 8402)
  AUTHORS   Zhu,H., Lin,P., De,G., Choi,K.H., Takeshima,H., Weisleder,N. and
            Ma,J.
  TITLE     Polymerase transcriptase release factor (PTRF) anchors MG53 protein
            to cell injury site for initiation of membrane repair
  JOURNAL   J Biol Chem 286 (15), 12820-12824 (2011)
   PUBMED   21343302
  REMARK    GeneRIF: membrane-delimited interaction between MG53 and PTRF
            contributes to initiation of cell membrane repair
REFERENCE   7  (bases 1 to 8402)
  AUTHORS   Jung,S.Y. and Ko,Y.G.
  TITLE     TRIM72, a novel negative feedback regulator of myogenesis, is
            transcriptionally activated by the synergism of MyoD (or myogenin)
            and MEF2
  JOURNAL   Biochem Biophys Res Commun 396 (2), 238-245 (2010)
   PUBMED   20399744
REFERENCE   8  (bases 1 to 8402)
  AUTHORS   Park,E.Y., Kwon,O.B., Jeong,B.C., Yi,J.S., Lee,C.S., Ko,Y.G. and
            Song,H.K.
  TITLE     Crystal structure of PRY-SPRY domain of human TRIM72
  JOURNAL   Proteins 78 (3), 790-795 (2010)
   PUBMED   19967786
  REMARK    GeneRIF: Crystal structure of PRY-SPRY domain of human TRIM72.
REFERENCE   9  (bases 1 to 8402)
  AUTHORS   Han,S., Kim-Howard,X., Deshmukh,H., Kamatani,Y., Viswanathan,P.,
            Guthridge,J.M., Thomas,K., Kaufman,K.M., Ojwang,J.,
            Rojas-Villarraga,A., Baca,V., Orozco,L., Rhodes,B., Choi,C.B.,
            Gregersen,P.K., Merrill,J.T., James,J.A., Gaffney,P.M., Moser,K.L.,
            Jacob,C.O., Kimberly,R.P., Harley,J.B., Bae,S.C., Anaya,J.M.,
            Alarcon-Riquelme,M.E., Matsuda,K., Vyse,T.J. and Nath,S.K.
  TITLE     Evaluation of imputation-based association in and around the
            integrin-alpha-M (ITGAM) gene and replication of robust association
            between a non-synonymous functional variant within ITGAM and
            systemic lupus erythematosus (SLE)
  JOURNAL   Hum Mol Genet 18 (6), 1171-1180 (2009)
   PUBMED   19129174
  REMARK    GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
REFERENCE   10 (bases 1 to 8402)
  AUTHORS   Martin,J., Han,C., Gordon,L.A., Terry,A., Prabhakar,S., She,X.,
            Xie,G., Hellsten,U., Chan,Y.M., Altherr,M., Couronne,O., Aerts,A.,
            Bajorek,E., Black,S., Blumer,H., Branscomb,E., Brown,N.C.,
            Bruno,W.J., Buckingham,J.M., Callen,D.F., Campbell,C.S.,
            Campbell,M.L., Campbell,E.W., Caoile,C., Challacombe,J.F.,
            Chasteen,L.A., Chertkov,O., Chi,H.C., Christensen,M., Clark,L.M.,
            Cohn,J.D., Denys,M., Detter,J.C., Dickson,M.,
            Dimitrijevic-Bussod,M., Escobar,J., Fawcett,J.J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Goodwin,L.A., Grady,D.L., Grigoriev,I., Groza,M., Hammon,N.,
            Hawkins,T., Haydu,L., Hildebrand,C.E., Huang,W., Israni,S.,
            Jett,J., Jewett,P.B., Kadner,K., Kimball,H., Kobayashi,A.,
            Krawczyk,M.C., Leyba,T., Longmire,J.L., Lopez,F., Lou,Y., Lowry,S.,
            Ludeman,T., Manohar,C.F., Mark,G.A., McMurray,K.L., Meincke,L.J.,
            Morgan,J., Moyzis,R.K., Mundt,M.O., Munk,A.C., Nandkeshwar,R.D.,
            Pitluck,S., Pollard,M., Predki,P., Parson-Quintana,B., Ramirez,L.,
            Rash,S., Retterer,J., Ricke,D.O., Robinson,D.L., Rodriguez,A.,
            Salamov,A., Saunders,E.H., Scott,D., Shough,T., Stallings,R.L.,
            Stalvey,M., Sutherland,R.D., Tapia,R., Tesmer,J.G., Thayer,N.,
            Thompson,L.S., Tice,H., Torney,D.C., Tran-Gyamfi,M., Tsai,M.,
            Ulanovsky,L.E., Ustaszewska,A., Vo,N., White,P.S., Williams,A.L.,
            Wills,P.L., Wu,J.R., Wu,K., Yang,J., Dejong,P., Bruce,D.,
            Doggett,N.A., Deaven,L., Schmutz,J., Grimwood,J., Richardson,P.,
            Rokhsar,D.S., Eichler,E.E., Gilna,P., Lucas,S.M., Myers,R.M.,
            Rubin,E.M. and Pennacchio,L.A.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131485.1, AC009088.9 and DA058421.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001008274.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131485.1, DRR138518.499365.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800, SAMEA2162946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322122.8/ ENSP00000312675.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-623               AK131485.1         44-666
            624-624             AC009088.9         102057-102057
            625-760             DA058421.1         168-303
            761-2054            AK131485.1         804-2097
            2055-8402           AC009088.9         108105-114452
FEATURES             Location/Qualifiers
     source          1..8402
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..8402
                     /gene="TRIM72"
                     /gene_synonym="MG53"
                     /note="tripartite motif containing 72"
                     /db_xref="GeneID:493829"
                     /db_xref="HGNC:HGNC:32671"
                     /db_xref="MIM:613288"
     exon            1..179
                     /gene="TRIM72"
                     /gene_synonym="MG53"
                     /inference="alignment:Splign:2.1.0"
     exon            180..576
                     /gene="TRIM72"
                     /gene_synonym="MG53"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1620
                     /gene="TRIM72"
                     /gene_synonym="MG53"
                     /EC_number="2.3.2.27"
                     /note="mitsugumin-53; tripartite motif containing 72, E3
                     ubiquitin protein ligase"
                     /codon_start=1
                     /product="tripartite motif-containing protein 72"
                     /protein_id="NP_001008275.2"
                     /db_xref="CCDS:CCDS32437.1"
                     /db_xref="GeneID:493829"
                     /db_xref="HGNC:HGNC:32671"
                     /db_xref="MIM:613288"
                     /translation="MSAAPGLLHQELSCPLCLQLFDAPVTAECGHSFCRACLGRVAGE
                     PAADGTVLCPCCQAPTRPQALSTNLQLARLVEGLAQVPQGHCEEHLDPLSIYCEQDRA
                     LVCGVCASLGSHRGHRLLPAAEAHARLKTQLPQQKLQLQEACMRKEKSVAVLEHQLVE
                     VEETVRQFRGAVGEQLGKMRVFLAALEGSLDREAERVRGEAGVALRRELGSLNSYLEQ
                     LRQMEKVLEEVADKPQTEFLMKYCLVTSRLQKILAESPPPARLDIQLPIISDDFKFQV
                     WRKMFRALMPALEELTFDPSSAHPSLVVSSSGRRVECSEQKAPPAGEDPRQFDKAVAV
                     VAHQQLSEGEHYWEVDVGDKPRWALGVIAAEAPRRGRLHAVPSQGLWLLGLREGKILE
                     AHVEAKEPRALRSPERRPTRIGLYLSFGDGVLSFYDASDADALVPLFAFHERLPRPVY
                     PFFDVCWHDKGKNAQPLLLVGPEGAEA"
     exon            577..672
                     /gene="TRIM72"
                     /gene_synonym="MG53"
                     /inference="alignment:Splign:2.1.0"
     exon            673..903
                     /gene="TRIM72"
                     /gene_synonym="MG53"
                     /inference="alignment:Splign:2.1.0"
     exon            904..926
                     /gene="TRIM72"
                     /gene_synonym="MG53"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1045
                     /gene="TRIM72"
                     /gene_synonym="MG53"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..8402
                     /gene="TRIM72"
                     /gene_synonym="MG53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3356..3361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM72"
                     /gene_synonym="MG53"
                     /note="hexamer: AATAAA"
     polyA_site      3376
                     /gene="TRIM72"
                     /gene_synonym="MG53"
                     /note="major polyA site"
     regulatory      4005..4010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM72"
                     /gene_synonym="MG53"
                     /note="hexamer: AATAAA"
     polyA_site      4025
                     /gene="TRIM72"
                     /gene_synonym="MG53"
     regulatory      8381..8386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM72"
                     /gene_synonym="MG53"
                     /note="hexamer: ATTAAA"
     polyA_site      8402
                     /gene="TRIM72"
                     /gene_synonym="MG53"
ORIGIN      
        1 actgtgtgcc catcacgcgt ggtgtccact gccagctgcc cctgtgagtc cctgtccttg
       61 cttggagcct gctgcttgtc tcagatcctt ggacccagcc ctgaccccag tccagctaag
      121 ctcaaccctg accggtcctc cttcgagact ctttcagcct aagatctcca accagacctg
      181 cccgccatgt cggctgcgcc cggcctcctg caccaggagc tgtcctgccc gctgtgcctg
      241 cagctgttcg acgcgcccgt gacagccgag tgcggccaca gtttctgccg cgcctgccta
      301 ggccgcgtgg ccggggagcc ggcggcggat ggcaccgttc tctgcccctg ctgccaggcc
      361 cccacgcggc cgcaggcact cagcaccaac ctgcagctgg cgcgcctggt ggaggggctg
      421 gcccaggtgc cgcagggcca ctgcgaggag cacctggacc cgctgagcat ctactgcgag
      481 caggaccgcg cgctggtgtg cggagtgtgc gcctcactcg gctcgcaccg cggtcatcgc
      541 ctcctgcctg ccgccgaggc ccacgcacgc ctcaagacac agctgccaca gcagaaactg
      601 cagctgcagg aggcatgcat gcgcaaggag aagagtgtgg ctgtgctgga gcatcagctg
      661 gtggaggtgg aggagacagt gcgtcagttc cggggggccg tgggggagca gctgggcaag
      721 atgcgggtgt tcctggctgc actggagggc tccttggacc gcgaggcaga gcgtgtacgg
      781 ggtgaggcag gggtcgcctt gcgccgggag ctggggagcc tgaactctta cctggagcag
      841 ctgcggcaga tggagaaggt cctggaggag gtggcggaca agccgcagac tgagttcctc
      901 atgaaatact gcctggtgac cagcaggctg cagaagatcc tggcagagtc tcccccaccc
      961 gcccgtctgg acatccagct gccaattatc tcagatgact tcaaattcca ggtgtggagg
     1021 aagatgttcc gggctctgat gccagcgctg gaggagctga cctttgaccc gagctctgcg
     1081 cacccgagcc tggtggtgtc ttcctctggc cgccgcgtgg agtgctcgga gcagaaggcg
     1141 ccgccggccg gggaggaccc gcgccagttc gacaaggcgg tggcggtggt ggcgcaccag
     1201 cagctctccg agggcgagca ctactgggag gtggatgttg gcgacaagcc gcgctgggcg
     1261 ctgggcgtga tcgcggccga ggccccccgc cgcgggcgcc tgcacgcggt gccctcgcag
     1321 ggcctgtggc tgctggggct gcgcgagggc aagatcctgg aggcacacgt ggaggccaag
     1381 gagccgcgcg ctctgcgcag ccccgagagg cggcccacgc gcattggcct ttacctgagc
     1441 ttcggcgacg gcgtcctctc cttctacgat gccagcgacg ccgacgcgct cgtgccgctt
     1501 tttgccttcc acgagcgcct gcccaggccc gtgtacccct tcttcgacgt gtgctggcac
     1561 gacaagggca agaatgccca gccgctgctg ctcgtgggtc ccgaaggcgc cgaggcctga
     1621 gccgccggac gggtagtgga ggggcgcggg ggcctgggtt gaagcttagg tctccttggt
     1681 cgggtctgac gggagaaggg tggggagcgg gttgccaggg cccagggggc tgggaactgg
     1741 gggatctccc agaatactga caagcgtggg gtaggactgg cttggtggct catgcctgta
     1801 atcccagcac tttgggagac ggaggcgggt ggatcacctg aggtcaggag ttcaagacca
     1861 gcctggccaa catggtgaaa ctcctctcta ctgaaaatac aaaaatgagc tgggcgcggt
     1921 ggcatacgcc tgtaatccca gctagttggg aggctgaggc aggataattg cttgaaccca
     1981 ggaggtggag gttgcagtga gcagacattg cggcactgca ctctagcctg ggtgacaaga
     2041 gtgagactct gtctcaaaaa aaaaaaaaag tgtgggggtt ggcatggcct ggggactgct
     2101 ggtgaggggt tggagtgacg ctggggacaa gacccagtgg ggtagggaga tctggagtca
     2161 ggtcagtggg gaaatcagaa tttgggaacc aggaggcctg agaattccag gaagaaacta
     2221 aggttgagcg agggagggac agggccaggt tgggggattg atgggaggag cttgagaacc
     2281 tgtagataag gggctccttt tgcctcacac tcccctcctc cttaggcctt gggtcccccg
     2341 ctccagattc accttaccca aaagccttct ccttagttct ccaccttagg catgcattaa
     2401 aatcaccttt ttaaagccct tagccatgac ttgttaaagc atagggtgct aagtttctga
     2461 tttagtaggt tggacaggtc aaaaatgctc atttcttttt tttatttctt tttttttttt
     2521 tttttttttt ttttgagaca gagtcttgct ctgtcactca aggctagagt gcagtggtgc
     2581 catctcggct cactgcaacc tctgcctcca gggttcaagc aattctcatg cctcagcctc
     2641 ccaagtagct gggactacag acgcccgcca ccacacctgg ctatttattt ttatttttag
     2701 taggggtttc actatgttgg ccaagctggt ctcgaactcc tgacctcaag tgattcaccc
     2761 gccttggcct cccatagtgc tgggattaca gacatgagcc actgcacctg gctgaaaatg
     2821 ctcatttttt tttttttaat ttagtttttg tagaaatggt gtctcgttac attgcccagg
     2881 ctgatcttga actcttggcc tcaggtgatc ctcctgcctt ggccttccaa gtgctgggat
     2941 tacaggtgtg agccaccacg ccctgccaaa aatgtgcatt tctagcaggt tcccaggtga
     3001 cgctgctggc cacaggggct gacgctgcgg gaagccctga cctagtgcac aacccattgg
     3061 gctcttcact gtcagtgtag aggcataggt ccaaaatatg tttccccagt caaaaacatg
     3121 taaggtttgc accaggagtg gaaggaaaca aacaaacata aaccaaagca aagacactta
     3181 agggctgggt actcatgcct gtaaacccaa cactttggga gtttgaggca ggaggctcat
     3241 ttgaggccag gagtttgaga ccagcctggg gaacatagtg agaccctgtt gcaacaaaaa
     3301 ccagaaaaac aacaaaaaga agacattgga aaatggctgg agctgattct aggtgaataa
     3361 acaaccctcg acttaacttg ctttgcctct gggatatgtt tatcgagcgt cttgaacgtt
     3421 gaggaagcca gccaagagaa agagcctgat gccaaggtca cactggtccc tgctgctcat
     3481 ggggaagaga aggcccccaa ctagatgtcc cagaactggc cgctccccac ttacttgctg
     3541 gttcacacct tctttggttt tagcgcacag ggcatttctt gggctctgga gtaaccactg
     3601 aggccagagt gagagtccct cttccctgga gggagaggcc tttggggatc cagacaggct
     3661 tctctcctga gggaagacgc tggcctgggg tcactcattt tcacggggag ggtgtgctgg
     3721 cgggatgggt ggaagggcct ggggccccgg cagcccattg cggaggtttt ctcgggagat
     3781 ggtgggtatg ggactaaggg tgaaagggaa gttgtgagtt gggtaagaaa ggcctgagga
     3841 tctggcaggg gaaggcggca cacctgggtg tgtctcccag aggaaggcct gtggagccct
     3901 ggcttcagga gacagaagag aggattaacg gtagaagctc tttcatgtta gaaaataaaa
     3961 caatatagct aagggattat ttggttgtaa aatccaacac cattaataaa actgttatat
     4021 tctgactcct tcctcattaa atccacatga aaagacatgt gacctactgc aaggcctcct
     4081 aattgccctc cagcctttaa tcctgacttg gtaatgtttc caaaaatgca aatgtggtca
     4141 cgggactcag ttgctcaaaa ctttcaacaa ctccctcttg cctacaggat aaagccccca
     4201 gtctttggct tagcatttga gctgttctgc catttttttt gttggttggt ttgtttgttt
     4261 tgtttgagac agagtctcgc tctgtcgccc aggctggagt gcagtggtgt gatcaccgta
     4321 acctccgcct cctaggttca agggattctc ctgcctcagc ctcccgagta gctgggatta
     4381 caggtgcccg ccaggctggt ctcgaactcc tgacctcagg tgatccaccc attttggcct
     4441 cccaaagtgc tgggattaca ggctggcctt ccagcttcat ctgtttttag ttaaaaaaca
     4501 attttttttt ttgagacaag gtcttgctct gtcgcacagg ctggagtgca atggtgtgat
     4561 tgtggctcac tgcagccttg acctcctggg ctcacatgat cctcccactc cagcctcctg
     4621 agtagatagg atggcaggca cccatcacca tgcctgacta ttttttattt tttgtatttt
     4681 ggtagagatg aggtctcact atgttgctca tgctggtctc gagctcctgg cctcaagcga
     4741 tcctcccatc ttggcttccc aaagtgttgg gattacaggt gtgagccact gagcccagcc
     4801 cagcttcatc ttttatttta ttattatttt ttgagatgga gtctcaccgt gtcacccagg
     4861 ttagagtgca gtggtgtgat cttggctcac tgcaacctct gcctcccagg ttcaagtgat
     4921 cctcctgcct cagcctcccg agtagctggg actataggca ggtgacacta cgcctagctg
     4981 atttttgtat ttctagtggg gacaggggct tcactatgtt ggccagcctg gtctcgaact
     5041 cctgacctca ggggatcccc caactcggcc tcccaaagta ctaggattac aggcttgaac
     5101 cgccgcgccc agccccagct tcatcttaaa aagaaaagtt ctctgtttta atatctaaca
     5161 gggcaaatat tgaaagataa aaccacataa caaaagctct ttgggatcct agtgttgggg
     5221 aaaggctgct gtccattgac tgtcactgaa ctctctgtca ttgctcaggc taaggactgg
     5281 ccacagtgag ggagggacct gtggtctcct gtgttgctcc tcaccctgta gactgtgggc
     5341 tgtgggctgt gtccagcctc accttggatc accgccctgt gcatgtctac actctggcta
     5401 tgctgaactg aactgctggg gtctctgcac ctcctttttt tttttttttt ttttgagatg
     5461 cagtcttgct ctgtcgccca ggctggagtg caatggtgct atctcagctc actgcaacct
     5521 ctgcctccca ggttcaagtg attctcctgc ctcagcctcc gcagtagcta ggattacagg
     5581 cacccaccac cacgccaggt tagttttttc atttttattt gtatttttag tagaggcggg
     5641 gttttgccat gttggccagg ctgatctcga actcctgacc tcaaatgatc tgcccgcctc
     5701 agcctcccaa agtgctggga ttacaggcat gagctgtcgg gcctggcccc tgcacttctt
     5761 ttttaggaat gtcagttccc tcccacttat ccttcatggc tctcccaaaa caccaccatt
     5821 tcctgtcctc tcttgacctt ctaggcctcc aggaagaatc agttactctc ctctctggat
     5881 cgcccagcag ctcctccacc atgtgtagcc cacggcattg aattgtctac acacaggcca
     5941 tggtgtctgg agggatggtg gtatctgaga cccaaagcct ccttctgagg aaatgggtac
     6001 tctgagaagc agatgccaag ataggattaa atgggcagag attttaggag ggaagatgcc
     6061 catgtgaggg aagatgggga gggccatcag accgtgtcgc aagtctgctg ttcgtgtggg
     6121 agggagggag ggaaggctct tgtggcgtct ccggcagcca gagccaccgt ccaaacactc
     6181 ctgtgccttc cgggacccgg gctggcttta gtctccctgc agagctgagt aatgtatgct
     6241 gccttttgtt ggaattatat caggaaactt tctttcgaag ctgccacagg ttctttctgc
     6301 gtatagttgc cccagcttga gctgcatgca ttgaaggaaa tggcccatgg ctgactgagt
     6361 gaggtgggct ttgtgggaaa agctgcgtaa tccaggtggt ccttgtcggg tggggctgcc
     6421 tgacccaggc agggtctccc tggggatgta ggaaggtgaa atgtgaacag agaaaggagt
     6481 tcctccagca catgtgttct aaagcaccag cgtcccctcc gtgagtccct cctctccacg
     6541 ggaacgctgg aaacccccag aaactggctg ccaagacatt tcctgtgttt cctgacatct
     6601 ttaggtagca taatagcaaa cttgaacctg ccaaggccat gataaaactg caagcaagaa
     6661 catttatcgt ggccaggtgc agtggctcac gcctgtaatc ccagcacttt tggaggttga
     6721 ggcgggtgaa tcacctgagg tcaggagttc gagaccagtc tggtcaacat ggtgaaaccc
     6781 catctttact aaaaatacaa aaattagcca ggcatggtgg tgcatgcctg caatcccagc
     6841 tactcaggag gctgaggcag gagaatcact tgaacctggg aggcagaggt tccgatgagc
     6901 tgagatcggg ccactgcatt ccagtctggg tgagagagtt aaaacaggaa ttaaaagaaa
     6961 ttaaagaatg tgtaagcaaa aactcagttg tatgtaagaa aaccccattc accctgagga
     7021 agagaaagag ctaaagtcct ttaaaaatta actgcctgtt tttctgtgga tagtgagcct
     7081 tatctctctc cctttcccag gcattgtgaa gaccctgttt ctctagctgt gcagctgcaa
     7141 ggtcactagg cagataaact caagtcataa aacatgtttt tccttgaaaa gtaaaaaatg
     7201 atgtaatgca tgtctcaact gaataactgt ctttgtttct tgcttctgta atatgcttcc
     7261 ccctgcacag atctccccct gccccacaaa atgcttaaaa ggtaaccgga gccgggcgtg
     7321 gtggctcacg cctgtaatcc cagcactttg ggaggctgag gcaggcggat catgaggtca
     7381 ggagatcgag accgtcctgg ttaacatgtt gaaaccccgt ctctactaaa aatacaaaaa
     7441 attagccggg cgtggtggca ggcacctgta gtcccagcta cttgggaggc tgaggcagga
     7501 gaatggcctg aacccgggag gcggagcttg cagtgagccg agatggcgcc actacactcc
     7561 agcctgggtg acagagcgag actccgcctc aaaaaaaaaa aaaaaaaaag gtaaccggac
     7621 tctttgttca gggctcagtc tttttggatg ttaatctgac cgggccagtg cacctaacta
     7681 aataataaat aataagtatc ctcctcaacc tcttggtctc tctgattcct aaattatccc
     7741 actgcagaat gagactctgt ctcaaaggaa aaaaaagaaa atttattgag accttattat
     7801 gcgtcaatag ctctctattc agaatctcac tgatcttcgc aaccctggat ctcacaacaa
     7861 cgagagcccc actaggttgc ctcttttgtt ttgttttgtt ttttttttga gatggagtct
     7921 cactgtctcc caggctggag tgcagtggcg tgatctcggc tcactgcaac ctccgccctc
     7981 tgggttcacg ccattctcct gcctcagcct cccaagtagc tgggactaca ggcgcccgcc
     8041 accatgcctg gttaattttt ttgtattttt agtagagacg gggtttcacc atgtttgcca
     8101 ggatggtctc catctcctga cctcgtgatc cgcccgcctc ggcctcccaa agtgctggga
     8161 ttacaggcgt gagccaccgc gtccggctta ggttgcctct tatactgggt tcacgcatcc
     8221 cctgggtgca tgacagtctg accacaaagg accccggtcc acagaagcat gatgcatctt
     8281 ggagtatcga ctttatgcca atattcttct tcttgatact ggtggtggtg agaaagttgg
     8341 gtaatttaac caaaagtaaa aatcaagatg tcacgttccc attaaaacaa acatagagta
     8401 ca
//
