LOCUS       NM_203293               2864 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tripartite motif containing 7 (TRIM7), transcript
            variant 1, mRNA.
ACCESSION   NM_203293
VERSION     NM_203293.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2864)
  AUTHORS   Chen,Q., Zhang,T., Zeng,R., Zhang,K., Li,B., Zhu,Z., Ma,X.,
            Zhang,Y., Li,L., Zhu,J. and Zhang,G.
  TITLE     The E3 ligase TRIM7 suppresses the tumorigenesis of gastric cancer
            by targeting SLC7A11
  JOURNAL   Sci Rep 14 (1), 6655 (2024)
   PUBMED   38509147
  REMARK    GeneRIF: The E3 ligase TRIM7 suppresses the tumorigenesis of
            gastric cancer by targeting SLC7A11.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2864)
  AUTHORS   Li,M., Yan,J., Zhu,H., Guo,C., Jiang,X., Gao,Y., Liu,X., Jiang,P.
            and Bai,J.
  TITLE     TRIM7 inhibits encephalomyocarditis virus replication by activating
            interferon-beta signaling pathway
  JOURNAL   Vet Microbiol 281, 109729 (2023)
   PUBMED   37023504
  REMARK    GeneRIF: TRIM7 inhibits encephalomyocarditis virus replication by
            activating interferon-beta signaling pathway.
REFERENCE   3  (bases 1 to 2864)
  AUTHORS   Lu,M., Ma,A., Liu,J., Zhou,W., Cao,P., Chu,T. and Fan,L.
  TITLE     Study on the expression of TRIM7 in peripheral blood mononuclear
            cells of patients with sepsis and its early diagnostic value
  JOURNAL   BMC Infect Dis 22 (1), 865 (2022)
   PUBMED   36402943
  REMARK    GeneRIF: Study on the expression of TRIM7 in peripheral blood
            mononuclear cells of patients with sepsis and its early diagnostic
            value.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2864)
  AUTHORS   Li,K., Chen,B., Xu,A., Shen,J., Li,K., Hao,K., Hao,R., Yang,W.,
            Jiang,W., Zheng,Y., Ge,F. and Wang,Z.
  TITLE     TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in
            glioblastoma cells
  JOURNAL   Redox Biol 56, 102451 (2022)
   PUBMED   36067704
  REMARK    GeneRIF: TRIM7 modulates NCOA4-mediated ferritinophagy and
            ferroptosis in glioblastoma cells.
REFERENCE   5  (bases 1 to 2864)
  AUTHORS   Zhou,F., Liu,Y., Ai,W., Wang,Y., Gan,M., Jiang,Q., Han,T. and
            Wang,J.B.
  TITLE     GNIP1 functions both as a scaffold protein and an E3 ubiquitin
            ligase to regulate autophagy in lung cancer
  JOURNAL   Cell Commun Signal 20 (1), 133 (2022)
   PUBMED   36042481
  REMARK    GeneRIF: GNIP1 functions both as a scaffold protein and an E3
            ubiquitin ligase to regulate autophagy in lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2864)
  AUTHORS   Liang,Q., Deng,H., Li,X., Wu,X., Tang,Q., Chang,T.H., Peng,H.,
            Rauscher,F.J. 3rd, Ozato,K. and Zhu,F.
  TITLE     Tripartite motif-containing protein 28 is a small ubiquitin-related
            modifier E3 ligase and negative regulator of IFN regulatory factor
            7
  JOURNAL   J Immunol 187 (9), 4754-4763 (2011)
   PUBMED   21940674
  REMARK    GeneRIF: TRIM28 is a specific SUMO E3 ligase of interferon
            regulatory factor (IRF)7 and negatively regulates its activity and
            interferon (IFN)-based antiviral responses, in support of the
            expanding roles of TRIM proteins which regulate innate immunity.
REFERENCE   7  (bases 1 to 2864)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 2864)
  AUTHORS   Zhai,L., Dietrich,A., Skurat,A.V. and Roach,P.J.
  TITLE     Structure-function analysis of GNIP, the glycogenin-interacting
            protein
  JOURNAL   Arch Biochem Biophys 421 (2), 236-242 (2004)
   PUBMED   14984203
REFERENCE   9  (bases 1 to 2864)
  AUTHORS   Skurat,A.V., Dietrich,A.D., Zhai,L. and Roach,P.J.
  TITLE     GNIP, a novel protein that binds and activates glycogenin, the
            self-glucosylating initiator of glycogen biosynthesis
  JOURNAL   J Biol Chem 277 (22), 19331-19338 (2002)
   PUBMED   11916970
  REMARK    GeneRIF: GNIP, a novel protein that binds and activates glycogenin,
            the self-glucosylating initiator of glycogen biosynthesis
REFERENCE   10 (bases 1 to 2864)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF220032.1, BC132863.1,
            BM825056.1 and BQ000256.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_203293.2.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1, a B-box type 2, and a
            coiled-coil region. The protein localizes to both the nucleus and
            the cytoplasm, and may represent a participant in the initiation of
            glycogen synthesis. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1, also known as GNIP1) encodes
            the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132867.1, AF396651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274773.12/ ENSP00000274773.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AF220032.1         98-121
            25-2219             BC132863.1         1-2195
            2220-2318           BM825056.1         464-562
            2319-2864           BQ000256.1         18-563              c
FEATURES             Location/Qualifiers
     source          1..2864
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..2864
                     /gene="TRIM7"
                     /gene_synonym="GNIP; RNF90"
                     /note="tripartite motif containing 7"
                     /db_xref="GeneID:81786"
                     /db_xref="HGNC:HGNC:16278"
                     /db_xref="MIM:609315"
     exon            1..608
                     /gene="TRIM7"
                     /gene_synonym="GNIP; RNF90"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1622
                     /gene="TRIM7"
                     /gene_synonym="GNIP; RNF90"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glycogenin-interacting protein; tripartite motif protein
                     TRIM7; RING finger protein 90; E3 ubiquitin-protein ligase
                     TRIM7"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM7 isoform 1"
                     /protein_id="NP_976038.1"
                     /db_xref="CCDS:CCDS4462.1"
                     /db_xref="GeneID:81786"
                     /db_xref="HGNC:HGNC:16278"
                     /db_xref="MIM:609315"
                     /translation="MAAVGPRTGPGTGAEALALAAELQGEATCSICLELFREPVSVEC
                     GHSFCRACIGRCWERPGAGSVGAATRAPPFPLPCPQCREPARPSQLRPNRQLAAVATL
                     LRRFSLPAAAPGEHGSQAAAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAREHRE
                     HAVLPLDEAVQEAKELLESRLRVLKKELEDCEVFRSTEKKESKELLKQMAAEQEKVGA
                     EFQALRAFLVEQEGRLLGRLEELSREVAQKQNENLAQLGVEITQLSKLSSQIQETAQK
                     PDLDFLQEFKSTLSRCSNVPGPKPTTVSSEMKNKVWNVSLKTFVLKGMLKKFKEDLRG
                     ELEKEEKVELTLDPDTANPRLILSLDLKGVRLGERAQDLPNHPCRFDTNTRVLASCGF
                     SSGRHHWEVEVGSKDGWAFGVARESVRRKGLTPFTPEEGVWALQLNGGQYWAVTSPER
                     SPLSCGHLSRVRVALDLEVGAVSFYAVEDMRHLYTFRVNFQERVFPLFSVCSTGTYLR
                     IWP"
     exon            609..704
                     /gene="TRIM7"
                     /gene_synonym="GNIP; RNF90"
                     /inference="alignment:Splign:2.1.0"
     exon            705..935
                     /gene="TRIM7"
                     /gene_synonym="GNIP; RNF90"
                     /inference="alignment:Splign:2.1.0"
     exon            936..958
                     /gene="TRIM7"
                     /gene_synonym="GNIP; RNF90"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1074
                     /gene="TRIM7"
                     /gene_synonym="GNIP; RNF90"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1110
                     /gene="TRIM7"
                     /gene_synonym="GNIP; RNF90"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..2864
                     /gene="TRIM7"
                     /gene_synonym="GNIP; RNF90"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2840..2845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM7"
                     /gene_synonym="GNIP; RNF90"
                     /note="hexamer: AATGAA"
     polyA_site      2864
                     /gene="TRIM7"
                     /gene_synonym="GNIP; RNF90"
                     /note="major polyA site"
ORIGIN      
        1 agtgggccct cggcgcccag ctccgcgtcc tgtgaggtcc agtggccgcc caggcgcgac
       61 cagatctggg tgcgcggaga gcgcgcatgg cggctgtggg accgcggacc ggccccggaa
      121 ccggcgccga ggctctagcg ctggcggcag agctgcaggg cgaggcgacg tgctccatct
      181 gcctagagct ctttcgtgag ccggtgtccg tcgagtgcgg ccacagcttc tgccgcgcct
      241 gcatagggcg ctgctgggag cgcccgggcg cggggtctgt tggggccgcc acccgcgcgc
      301 cccccttccc actgccctgt ccgcagtgcc gcgagcccgc gcgccccagt cagctgcggc
      361 ccaaccggca gctggcggca gtggccacgc tcctgcggcg cttcagcctg cccgcggctg
      421 ccccgggaga gcacgggtct caggcggccg cggcccgggc agcggctgcc cgctgcgggc
      481 agcatggcga acccttcaag ctctactgcc aggacgacgg acgcgccatc tgcgtggtgt
      541 gcgaccgcgc ccgcgagcac cgcgagcacg ccgtgctgcc gctggacgag gcggtgcagg
      601 aggccaagga gctcttggag tccaggctga gggtcttgaa gaaggaactg gaggactgtg
      661 aggtgttccg gtccacggaa aagaaggaga gcaaggagct gctgaaacag atggcagcgg
      721 agcaggagaa ggtgggggca gagttccagg cactgagggc tttcctggtg gagcaggagg
      781 gtcggctgct aggccgcctg gaggaactgt cccgggaggt ggcacagaag cagaatgaga
      841 acctggccca gctcggggtt gagatcaccc agctgtccaa gctcagcagc cagatccagg
      901 agacagctca aaagcctgac cttgactttc tccaggaatt caaaagcacg ctgagcaggt
      961 gtagcaatgt gcctggcccc aagccaacca cagtctcttc tgagatgaag aataaagtct
     1021 ggaatgtttc tctcaagacc tttgtcttaa aagggatgct gaagaagttc aaagaggacc
     1081 ttcggggaga gctggagaaa gaggagaaag tggagctcac cttggatccc gacacggcca
     1141 acccgcgcct catcctctct ctggatctta agggcgtgcg cctcggcgag cgggcccagg
     1201 acctgcccaa ccacccctgc cgcttcgaca ccaacacccg cgtcctggcg tcctgcggct
     1261 tctcctcggg ccggcatcac tgggaggtgg aggtgggctc taaggacggc tgggcctttg
     1321 gcgtggcccg cgagagcgtg cgccgaaagg gcctgacgcc cttcactccc gaggagggcg
     1381 tctgggccct gcagctcaac ggcggccagt actgggccgt gaccagcccc gagcggtcgc
     1441 ccctcagctg cgggcacctg tcgcgcgtgc gggtggccct ggacctggag gtgggagccg
     1501 tgtccttcta cgctgtggag gacatgcgcc acctctacac cttccgcgtc aacttccagg
     1561 agcgcgtgtt cccgcttttc tctgtttgct ccacgggcac ctacttgcga atctggcctt
     1621 gaggggcact gctggggagc tcctgtctct gggctgccgg tgggagggga tgtcgcctcc
     1681 ccagagatgc ctggtccgtc ttgggtctgc cctccgtgct cctgacccct gctgcccaag
     1741 agagcctgct acagacacaa ccccgaggca ggagagtgac tgtggccaac cgagcagggg
     1801 aacaggggct ttggactcct gagggtgttc ccttcctgag gtcacatgtg gatttggcca
     1861 gagccttcag gaggtggagg ccggtgaggt caggagccca gctctccagg gggcttctgc
     1921 cctgactggg aagggtgcct ggctccctaa aacaatgtca aagccagtcc tgctgttctc
     1981 tgttgccagg gggcaggtct gggcctgggc caaccacgtt tgttatcatg gctgctgcct
     2041 tctggacagc tgccagctct gccttgagag gttgtgggac ctctggatcc agctgacctg
     2101 acaggtcatc tactcaggga ggagccctgt gctcccagct cagaggacag tctgggccag
     2161 aactggaagg agacatctgt cccgtctttg agtgacaagc ccgggacaac agccagtggg
     2221 catcacggct ctccagcact ccttagccgg aggatacaga gtgatgggtg catcctgacc
     2281 aatgcgacaa ccaacacgtg ctctcacaaa cccctgactc ccgcactttc cagtgccaaa
     2341 gtacaaacgc tgcttggata aggagagcaa agcttctgga actttattta ctctttcttt
     2401 ttaattttct tttaagagac tgggtcttgc tatgttgccc aggctggtct tgaactcctg
     2461 gcctcaagtg atcctccagt ttccatctcc ctaagagctg ggattacagg tgtgagccgc
     2521 tgtacccgaa ctttttttgt ttttgcttct ggaactttga aacacaaaac acaagttggc
     2581 acttacaatt ttaaagatgc agccagctct aaacaacaca cagagcacaa atatgctcct
     2641 gacggactca ggaaaatgcc aacagcagag caccctggtg ccaaggcctt ctcagcccat
     2701 gccctggagg gcattcccct ggccagcctc agccccttgt ctacttgttc tccagcttct
     2761 gggtagctgg gcttctggaa gggtggcagt gggctactcc ctgctcagcg ctcccctggg
     2821 aagggggtga ggagatgaaa atgaaactat gagctgtctt tgga
//
