LOCUS       NM_182985               1735 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens tripartite motif containing 69 (TRIM69), transcript
            variant a, mRNA.
ACCESSION   NM_182985 XM_378511
VERSION     NM_182985.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1735)
  AUTHORS   Sun,L., Chen,Y., Xia,L., Wang,J., Zhu,J., Li,J., Wang,K., Shen,K.,
            Zhang,D., Zhang,G., Shi,T. and Chen,W.
  TITLE     TRIM69 suppressed the anoikis resistance and metastasis of gastric
            cancer through ubiquitin-proteasome-mediated degradation of PRKCD
  JOURNAL   Oncogene 42 (49), 3619-3632 (2023)
   PUBMED   37864033
  REMARK    GeneRIF: TRIM69 suppressed the anoikis resistance and metastasis of
            gastric cancer through ubiquitin-proteasome-mediated degradation of
            PRKCD.
REFERENCE   2  (bases 1 to 1735)
  AUTHORS   Wang,Y., Risteski,P., Yang,Y., Chen,H., Droby,G., Walens,A.,
            Jayaprakash,D., Troester,M., Herring,L., Chernoff,J., Tolic,I.M.,
            Bowser,J. and Vaziri,C.
  TITLE     The TRIM69-MST2 signaling axis regulates centrosome dynamics and
            chromosome segregation
  JOURNAL   Nucleic Acids Res 51 (19), 10568-10589 (2023)
   PUBMED   37739411
  REMARK    GeneRIF: The TRIM69-MST2 signaling axis regulates centrosome
            dynamics and chromosome segregation.
REFERENCE   3  (bases 1 to 1735)
  AUTHORS   Yuan,J., Lv,T., Yang,J., Wu,Z., Yan,L., Yang,J. and Shi,Y.
  TITLE     HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by
            diminishing Trim69-dependent FSP1 degradation in hepatocellular
            carcinoma
  JOURNAL   Redox Biol 58, 102546 (2022)
   PUBMED   36423520
  REMARK    GeneRIF: HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability
            by diminishing Trim69-dependent FSP1 degradation in hepatocellular
            carcinoma.
REFERENCE   4  (bases 1 to 1735)
  AUTHORS   Song,Y., Nguyen,X.N., Kumar,A., da Silva,C., Picard,L., Etienne,L.
            and Cimarelli,A.
  TITLE     Trim69 is a microtubule regulator that acts as a pantropic viral
            inhibitor
  JOURNAL   Proc Natl Acad Sci U S A 119 (43), e2211467119 (2022)
   PUBMED   36251989
  REMARK    GeneRIF: Trim69 is a microtubule regulator that acts as a pantropic
            viral inhibitor.
REFERENCE   5  (bases 1 to 1735)
  AUTHORS   Bagga,T., Tulsian,N.K., Mok,Y.K., Kini,R.M. and Sivaraman,J.
  TITLE     Mapping of molecular interactions between human E3 ligase TRIM69
            and Dengue virus NS3 protease using hydrogen-deuterium exchange
            mass spectrometry
  JOURNAL   Cell Mol Life Sci 79 (5), 233 (2022)
   PUBMED   35397701
  REMARK    GeneRIF: Mapping of molecular interactions between human E3 ligase
            TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium
            exchange mass spectrometry.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1735)
  AUTHORS   Han,Y., Li,R., Gao,J., Miao,S. and Wang,L.
  TITLE     Characterisation of human RING finger protein TRIM69, a novel
            testis E3 ubiquitin ligase and its subcellular localisation
  JOURNAL   Biochem Biophys Res Commun 429 (1-2), 6-11 (2012)
   PUBMED   23131556
  REMARK    GeneRIF: hTRIM69 is a novel E3 ubiquitin ligase identified from
            human testis and may function to ubiquitinate its particular
            substrates during spermatogenesis.
REFERENCE   7  (bases 1 to 1735)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   8  (bases 1 to 1735)
  AUTHORS   Shyu,H.W., Hsu,S.H., Hsieh-Li,H.M. and Li,H.
  TITLE     Forced expression of RNF36 induces cell apoptosis
  JOURNAL   Exp Cell Res 287 (2), 301-313 (2003)
   PUBMED   12837286
REFERENCE   9  (bases 1 to 1735)
  AUTHORS   Shyu,H.W., Hsu,S.H., Hsieh-Li,H.M. and Li,H.
  TITLE     A novel member of the RBCC family, Trif, expressed specifically in
            the spermatids of mouse testis
  JOURNAL   Mech Dev 108 (1-2), 213-216 (2001)
   PUBMED   11578878
  REMARK    GeneRIF: Gene and protein analysis of the mouse counterpart.
REFERENCE   10 (bases 1 to 1735)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI827618.1, AY305385.1,
            AC122108.2, AF302088.1 and DB524904.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_182985.4.
            
            Summary: This gene encodes a member of the RING-B-box-coiled-coil
            (RBCC) family and encodes a protein with an N-terminal RING finger
            motif, a PRY domain and a C-terminal SPRY domain. The mouse
            ortholog of this gene is specifically expressed in germ cells at
            the round spermatid stages during spermatogenesis and, when
            overexpressed, induces apoptosis. Alternatively spliced transcript
            variants encoding distinct isoforms have been described. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (a) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047945.1, AK292252.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329464.9/ ENSP00000332284.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               BI827618.1         166-301
            137-658             AY305385.1         1-522
            659-659             AC122108.2         48272-48272
            660-1581            AY305385.1         524-1445
            1582-1582           AC122108.2         60571-60571
            1583-1723           AF302088.1         1128-1268
            1724-1724           AC122108.2         60713-60713
            1725-1735           DB524904.1         456-466
FEATURES             Location/Qualifiers
     source          1..1735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..1735
                     /gene="TRIM69"
                     /gene_synonym="HSD-34; HSD34; RNF36; Trif"
                     /note="tripartite motif containing 69"
                     /db_xref="GeneID:140691"
                     /db_xref="HGNC:HGNC:17857"
                     /db_xref="MIM:616017"
     exon            1..183
                     /gene="TRIM69"
                     /gene_synonym="HSD-34; HSD34; RNF36; Trif"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1680
                     /gene="TRIM69"
                     /gene_synonym="HSD-34; HSD34; RNF36; Trif"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant a; ring
                     finger protein 36; RFP-like domain-containing protein
                     trimless; E3 ubiquitin-protein ligase TRIM69; RING-type E3
                     ubiquitin transferase TRIM69"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM69 isoform a"
                     /protein_id="NP_892030.3"
                     /db_xref="CCDS:CCDS32220.1"
                     /db_xref="GeneID:140691"
                     /db_xref="HGNC:HGNC:17857"
                     /db_xref="MIM:616017"
                     /translation="MEVSTNPSSNIDPGDYVEMNDSITHLPSKVVIQDITMELHCPLC
                     NDWFRDPLMLSCGHNFCEACIQDFWRLQAKETFCPECKMLCQYNNCTFNPVLDKLVEK
                     IKKLPLLKGHPQCPEHGENLKLFSKPDGKLICFQCKDARLSVGQSKEFLQISDAVHFF
                     TEELAIQQGQLETTLKELQTLRNMQKEAIAAHKENKLHLQQHVSMEFLKLHQFLHSKE
                     KDILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKDITTL
                     LHSLEQGMKVLATRELISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHP
                     NLVLSKSQTSVWHGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTV
                     GVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLDYE
                     GGQLSFYNAKTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHILHPQ"
     exon            184..660
                     /gene="TRIM69"
                     /gene_synonym="HSD-34; HSD34; RNF36; Trif"
                     /inference="alignment:Splign:2.1.0"
     exon            661..756
                     /gene="TRIM69"
                     /gene_synonym="HSD-34; HSD34; RNF36; Trif"
                     /inference="alignment:Splign:2.1.0"
     exon            757..990
                     /gene="TRIM69"
                     /gene_synonym="HSD-34; HSD34; RNF36; Trif"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1013
                     /gene="TRIM69"
                     /gene_synonym="HSD-34; HSD34; RNF36; Trif"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1138
                     /gene="TRIM69"
                     /gene_synonym="HSD-34; HSD34; RNF36; Trif"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1735
                     /gene="TRIM69"
                     /gene_synonym="HSD-34; HSD34; RNF36; Trif"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1713..1718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM69"
                     /gene_synonym="HSD-34; HSD34; RNF36; Trif"
                     /note="hexamer: ATTAAA"
     polyA_site      1735
                     /gene="TRIM69"
                     /gene_synonym="HSD-34; HSD34; RNF36; Trif"
                     /note="major polyA site"
ORIGIN      
        1 agacctcact ctggccttgc tgcttctctc cagctcctga acttttcttt cttccatcat
       61 gctctgagcc cattccttga aaactaaaag gtccctgact cccagtctgc agccatcctg
      121 ggcctgctga gctctgattc aagtgcctgc ctctgcccct tggtgggctg aagcttcatg
      181 gaggtatcca ccaacccctc ctccaacatc gatccaggcg actatgttga aatgaatgat
      241 tcaatcaccc acctaccctc taaagtggtg atacaagata ttactatgga gctacactgc
      301 cctctgtgca atgattggtt ccgagaccca ctgatgctaa gctgtggcca caacttctgt
      361 gaagcctgta tccaagactt ttggaggctg caagcaaagg aaacattctg tcctgagtgt
      421 aagatgctat gtcagtataa caactgtaca ttcaaccctg tactggacaa gttggtagag
      481 aagattaaga agttaccctt actcaagggc catccacagt gcccagagca tggagagaac
      541 ctgaaactgt tcagtaaacc agatgggaaa ctgatctgct ttcaatgcaa ggatgctcgg
      601 ttgtctgtgg ggcagtctaa ggagttcctg caaatctctg atgctgtcca tttcttcacg
      661 gaggagcttg ccatccaaca gggtcaactg gagacaactc tgaaggagct tcagaccctg
      721 aggaacatgc agaaggaagc tattgctgct cacaaggaaa acaagctaca tctgcagcaa
      781 catgtgtcca tggagtttct aaagctgcat cagttcctgc acagcaaaga aaaggacatt
      841 ttaactgagc tccgggaaga ggggaaagcc ttgaatgagg agatggagtt gaatctgagc
      901 cagcttcagg agcaatgtct cttagccaag gatatgttgg tgagcattca ggcaaagacg
      961 gaacaacaga actccttcga ctttctcaaa gacatcacaa ctctcttaca tagcttggag
     1021 caaggaatga aggtgctggc aaccagagag cttatttcca gaaagctgaa cctgggccag
     1081 tacaaaggtc ctatccagta catggtatgg agggaaatgc aggacactct ctgcccaggc
     1141 ctgtctccac taactctgga ccctaaaaca gctcacccaa atctggtgct ctccaaaagc
     1201 caaaccagcg tctggcatgg tgacattaag aagataatgc ctgatgatcc tgagaggttt
     1261 gactcaagtg tggctgtact gggctcaaga ggcttcacct ctggaaagtg gtactgggaa
     1321 gtagaagtag caaagaagac aaaatggaca gttggagttg tcagagaatc catcattcgg
     1381 aagggcagct gtcctctaac tcctgagcaa ggattctggc ttttaagact aaggaaccaa
     1441 actgatctaa aggctctgga tttgccttct ttcagtctga cactgactaa caacctcgac
     1501 aaggtgggca tatacctgga ttatgaagga ggacagttgt ccttctacaa tgctaaaacc
     1561 atgactcaca tttacacctt cagtaacact ttcatggaga aactttatcc ctacttctgc
     1621 ccctgcctta atgatggtgg agagaataaa gaaccattgc acatcttaca tccacagtaa
     1681 tgagtcataa tattatacaa attcagagtg ttattaaaga ggtattgaaa tattt
//
