LOCUS       NM_018073               3324 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens tripartite motif containing 68 (TRIM68), transcript
            variant 1, mRNA.
ACCESSION   NM_018073
VERSION     NM_018073.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3324)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 3324)
  AUTHORS   Xu,X., Yang,M., Liu,X., Gong,A., Guo,Q., Xu,W. and Qian,H.
  TITLE     Tripartite motif-containing 68-stabilized modulator of apoptosis-1
            retards the proliferation and metastasis of lung cancer
  JOURNAL   Biochem Biophys Res Commun 648, 11-20 (2023)
   PUBMED   36724555
  REMARK    GeneRIF: Tripartite motif-containing 68-stabilized modulator of
            apoptosis-1 retards the proliferation and metastasis of lung
            cancer.
REFERENCE   3  (bases 1 to 3324)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3324)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3324)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3324)
  AUTHORS   Hatakeyama,S.
  TITLE     TRIM proteins and cancer
  JOURNAL   Nat Rev Cancer 11 (11), 792-804 (2011)
   PUBMED   21979307
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3324)
  AUTHORS   Baek Sorensen,R., Faurschou,M., Troelsen,L., Schrama,D.,
            Jacobsen,S., Becker,J.C., Thor Straten,P. and Andersen,M.H.
  TITLE     Melanoma inhibitor of apoptosis protein (ML-IAP) specific cytotoxic
            T lymphocytes cross-react with an epitope from the auto-antigen
            SS56
  JOURNAL   J Invest Dermatol 129 (8), 1992-1999 (2009)
   PUBMED   19212346
REFERENCE   8  (bases 1 to 3324)
  AUTHORS   Miyajima,N., Maruyama,S., Bohgaki,M., Kano,S., Shigemura,M.,
            Shinohara,N., Nonomura,K. and Hatakeyama,S.
  TITLE     TRIM68 regulates ligand-dependent transcription of androgen
            receptor in prostate cancer cells
  JOURNAL   Cancer Res 68 (9), 3486-3494 (2008)
   PUBMED   18451177
  REMARK    GeneRIF: TRIM68 functions as a cofactor for AR-mediated
            transcription and is likely to be a novel diagnostic tool and a
            potentially therapeutic target for prostate cancer.
REFERENCE   9  (bases 1 to 3324)
  AUTHORS   Chang,G.T., Steenbeek,M., Schippers,E., Blok,L.J., van
            Weerden,W.M., van Alewijk,D.C., Eussen,B.H., van Steenbrugge,G.J.
            and Brinkmann,A.O.
  TITLE     A novel gene on human chromosome 2p24 is differentially expressed
            between androgen-dependent and androgen-independent prostate cancer
            cells
  JOURNAL   Eur J Cancer 37 (16), 2129-2134 (2001)
   PUBMED   11597395
REFERENCE   10 (bases 1 to 3324)
  AUTHORS   Billaut-Mulot,O., Cocude,C., Kolesnitchenko,V., Truong,M.J.,
            Chan,E.K., Hachula,E., de la Tribonniere,X., Capron,A. and
            Bahr,G.M.
  TITLE     SS-56, a novel cellular target of autoantibody responses in Sjogren
            syndrome and systemic lupus erythematosus
  JOURNAL   J Clin Invest 108 (6), 861-869 (2001)
   PUBMED   11560955
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090719.8.
            
            On Nov 23, 2018 this sequence version replaced NM_018073.7.
            
            Summary: This gene encodes a member of the tripartite
            motif-containing protein family, whose members are characterized by
            a 'really interesting new gene' (RING) finger domain, a
            zinc-binding B-box motif, and a coiled-coil region. Members of this
            family function as E3 ubiquitin ligases and are involved in a broad
            range of biological processes. This gene regulates the activation
            of nuclear receptors, such as androgen receptor, and has been
            implicated in development of prostate cancer cells, where its
            expression increases in response to a downregulation of microRNAs.
            In addition, this gene participates in viral defense regulation as
            a negative regulator of interferon-beta. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jan
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.118822.1,
                                           SRR1803616.248038.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300747.10/ ENSP00000300747.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC090719.8         100605-100809
            206-688             AC090719.8         103275-103757
            689-784             AC090719.8         105496-105591
            785-1045            AC090719.8         106424-106684
            1046-1068           AC090719.8         107150-107172
            1069-1169           AC090719.8         107709-107809
            1170-3324           AC090719.8         108010-110164
FEATURES             Location/Qualifiers
     source          1..3324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..3324
                     /gene="TRIM68"
                     /gene_synonym="GC109; RNF137; SS-56; SS56"
                     /note="tripartite motif containing 68"
                     /db_xref="GeneID:55128"
                     /db_xref="HGNC:HGNC:21161"
                     /db_xref="MIM:613184"
     exon            1..205
                     /gene="TRIM68"
                     /gene_synonym="GC109; RNF137; SS-56; SS56"
                     /inference="alignment:Splign:2.1.0"
     exon            206..688
                     /gene="TRIM68"
                     /gene_synonym="GC109; RNF137; SS-56; SS56"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1720
                     /gene="TRIM68"
                     /gene_synonym="GC109; RNF137; SS-56; SS56"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; SSA
                     protein SS-56; ring finger protein 137; Ro/SSA1 related
                     protein; E3 ubiquitin-protein ligase TRIM68; tripartite
                     motif-containing protein 68; RING-type E3 ubiquitin
                     transferase TRIM68"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM68 isoform 1"
                     /protein_id="NP_060543.5"
                     /db_xref="CCDS:CCDS31356.1"
                     /db_xref="GeneID:55128"
                     /db_xref="HGNC:HGNC:21161"
                     /db_xref="MIM:613184"
                     /translation="MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLW
                     EIPGESQNWGYTCPLCRAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHG
                     EKLKMFCKEDVLIMCEACSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAW
                     KLEVGERKRTATWKIQVETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQR
                     EAAETMQKLELNHSELIQQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQ
                     QPEPISLELKTDCRVLGLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKL
                     PDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYG
                     FWVIRLRKGNEYRAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFP
                     RYPFPGRLLPYFSPCYSIGTNNTAPLAICSLDGED"
     exon            689..784
                     /gene="TRIM68"
                     /gene_synonym="GC109; RNF137; SS-56; SS56"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1045
                     /gene="TRIM68"
                     /gene_synonym="GC109; RNF137; SS-56; SS56"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1068
                     /gene="TRIM68"
                     /gene_synonym="GC109; RNF137; SS-56; SS56"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1169
                     /gene="TRIM68"
                     /gene_synonym="GC109; RNF137; SS-56; SS56"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..3324
                     /gene="TRIM68"
                     /gene_synonym="GC109; RNF137; SS-56; SS56"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3301..3306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM68"
                     /gene_synonym="GC109; RNF137; SS-56; SS56"
                     /note="hexamer: AATAAA"
     polyA_site      3324
                     /gene="TRIM68"
                     /gene_synonym="GC109; RNF137; SS-56; SS56"
                     /note="major polyA site"
ORIGIN      
        1 agagccgggt gtagtattct gggagctgcg ggctactggg cctgcgctgc cgggctttgg
       61 gttctgggcc tctgccgctc tctggcccta agtgctgagc tgccgggaac ggcagcttct
      121 gacgctgggc cattggacgc tgcggaacca ggcttcttca ctttgagttt ccgccgcgaa
      181 gcgccagtcc gggccgagga gggagccttt actacttctc cctggtttca ttcatgttct
      241 gaggagggtg tgagaaggaa ccatggatcc cacagccttg gtggaagcca ttgtggaaga
      301 agtggcctgt cccatctgta tgaccttcct gagggagccc atgagcattg actgtggcca
      361 cagcttctgc cacagctgtc tctctggact ctgggagatc ccaggagaat cccagaactg
      421 gggttacacc tgtcccctct gtcgagctcc tgtccagcca aggaacctgc ggcctaattg
      481 gcagctggcc aatgttgtag aaaaagtccg tctgctaagg ctacatccag gaatggggct
      541 gaagggtgac ctgtgtgagc gccatgggga aaagctgaag atgttctgca aagaggatgt
      601 cttgataatg tgtgaggcct gcagccagtc cccagagcat gaggcccaca gtgttgtgcc
      661 aatggaggat gttgcctggg agtacaagtg ggaacttcat gaggccctcg aacatctgaa
      721 gaaagagcaa gaagaggcct ggaagcttga agttggtgaa aggaaacgaa ctgccacctg
      781 gaagatacag gtggaaaccc gaaaacagag tattgtatgg gagtttgaaa aataccagcg
      841 attactagag aaaaagcagc caccacatcg gcagctgggg gcagaggtag cagcagctct
      901 ggccagccta cagcgggagg cagcggagac catgcagaaa ctggagttga accatagcga
      961 gctcatccag cagagccagg tcctgtggag gatgattgca gagttgaaag agaggtcgca
     1021 gaggcctgtc cgctggatgt tgcaggatat tcaggaagtg ttaaacagga gcaaatcttg
     1081 gagcttgcag cagccagaac caatctccct ggagttgaag acagattgcc gtgtgctggg
     1141 gctaagagag atcctgaaga cttatgcagc tgatgtgcgc ttggatccag atactgctta
     1201 ctcccgtctc atcgtgtctg aggacagaaa acgtgtgcac tatggagaca ccaaccagaa
     1261 actgccagac aatcctgaga gattttaccg ctataatatc gtcctgggaa gccagtgcat
     1321 ctcctcaggc cggcactact gggaggtgga ggtgggagac aggtctgagt ggggcctggg
     1381 agtatgtaag caaaatgtag accggaagga ggtggtctac ttatcccccc actatggatt
     1441 ctgggtgata aggctgagga agggaaatga gtaccgagca ggcaccgatg agtacccaat
     1501 cctgtccttg ccggtccctc ctcgccgggt gggaatcttc gtggattatg aggcccatga
     1561 catttctttc tacaatgtga ctgactgtgg ctcccacatc ttcactttcc cccgctatcc
     1621 cttccctggg cgcctcctgc cctattttag tccttgctac agcattggaa ccaacaacac
     1681 tgctcctctg gccatctgct ccctggatgg ggaggactaa gaaagctacc accctaacca
     1741 gagaggcttg gaattgggcc tggcccccat ggggcttgga ggaccgagcc actgacaggt
     1801 atcccctgaa actgagctga gcccagtatc caaggattcc tctgtctgat cctttggtct
     1861 ttgctaccag gctgaagtct gtcatgaaac cacttatttt aaaaagcaga ggcccagtca
     1921 aatgagcatt gcatcccatg agggaagcac gacagggctg atggtgagga tcagagcagt
     1981 tctaaggtga ctcgttgggg taaggatcag gactttgtcc atgtagtagc caaccaccct
     2041 cttccctgat tcccgtccgg tgtcacagtt cagtcagtga ggatgatgaa gtagatacag
     2101 tcttcaggac accattagat gggctttccc aataggccaa aaaaatgctg cgcataccca
     2161 gagctggttg ttgtgctgag gccagtcaga ggatgcttcc cctgaggttt gctataacta
     2221 agcaaccttt atgtgactct caccttctga cctcctggca agagaaattc agtgcagcag
     2281 ggggacacag acctgcccaa gccaccccac tgccgttccc tctctgagca caagctgggc
     2341 aaatcactgt cccttggact ccaggagacc agtgtcctag tcttgccttt tttctctaag
     2401 tggcaggatc agaaaacctg cgagctttag tttgtatttt cactttatga atgaggaaac
     2461 tgaaatggcc ttaagggagc aagttatttc tttttttttg acacggagtc tcactctgtt
     2521 gcccaggctg gagtgcagtg gcacgatctc ggctcactgc aggctctgcc tcctgggttc
     2581 acgccattct cctgcctcag cttcccgagt agctgggact acaggcgccc accacgacgc
     2641 ctggctcatt tttttgtatt tttagtagag acggagtttc accatgttag ctaggatggt
     2701 ctcgatctcc tgacctcatg atccgccctc ctcagcctcc cacagtgctg ggattagagg
     2761 catgagccac tgcgcccggc ccctggagca agttatttct tacaaagctg ctgaaggtaa
     2821 gattatcaaa attataaagc atttttcaca ctcaagtgaa acaaggttga caaactcact
     2881 tcgcaggtca catgcctata catcacttat tatatttggg tctgaaactt ctcacatgtt
     2941 tgggaggttt tatgtgtcct cattgggaaa atgggtgtaa ttcagcataa aacctcatat
     3001 gattgtcctg cctcatggag ctgttgtata gatcccagat ccatcccatg atttgttcct
     3061 gtctgaggca tagaggcagg caagccgtgg attttgcaca tggtgacttt cccactgtgc
     3121 catgatacag tctgcatctt atagcagtgc ctttgtctca gggcctctgc tggcagtcta
     3181 gaccttttgg gcagaaagga gcttcaaatg gctgtgataa ggaatattaa aaattgtgtt
     3241 tctactttaa ttgtattggc tgttcatgta tgtaggagtt aaaataggcc aaactggaga
     3301 aataaacgca ttctgtccac catg
//
