LOCUS       NM_001388022           10695 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens tripartite motif containing 66 (TRIM66), transcript
            variant 2, mRNA.
ACCESSION   NM_001388022 XM_006718397
VERSION     NM_001388022.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10695)
  AUTHORS   Chen,L., Zhou,Y., Cheng,H., Lu,W., Cai,M. and Jiang,K.
  TITLE     Circ-SATB2 (hsa_circ_0008928) and miR-150-5p are regulators of
            TRIM66 in the regulation of NSCLC cell growth and metastasis of
            NSCLC cells via the ceRNA pathway
  JOURNAL   J Biochem Mol Toxicol 38 (1), e23615 (2024)
   PUBMED   38084627
  REMARK    GeneRIF: Circ-SATB2 (hsa_circ_0008928) and miR-150-5p are
            regulators of TRIM66 in the regulation of NSCLC cell growth and
            metastasis of NSCLC cells via the ceRNA pathway.
REFERENCE   2  (bases 1 to 10695)
  AUTHORS   Xu,Y., Yang,Q., Fang,Z., Tan,X., Zhang,M. and Chen,W.
  TITLE     TRIM66 Promotes Malignant Progression of Non-Small-Cell Lung Cancer
            Cells via Targeting MMP9
  JOURNAL   Comput Math Methods Med 2022, 6058720 (2022)
   PUBMED   35912155
  REMARK    GeneRIF: TRIM66 Promotes Malignant Progression of Non-Small-Cell
            Lung Cancer Cells via Targeting MMP9.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10695)
  AUTHORS   Chen,W., Zhang,Y., Fang,Z., Qi,W. and Xu,Y.
  TITLE     TRIM66 hastens the malignant progression of non-small cell lung
            cancer via modulating MMP9-mediated TGF-beta/SMAD pathway
  JOURNAL   Cytokine 153, 155831 (2022)
   PUBMED   35301175
  REMARK    GeneRIF: TRIM66 hastens the malignant progression of non-small cell
            lung cancer via modulating MMP9-mediated TGF-beta/SMAD pathway.
REFERENCE   4  (bases 1 to 10695)
  AUTHORS   Cao,H., Wang,D., Sun,P., Chen,L., Feng,Y. and Gao,R.
  TITLE     Zhoushi Qi Ling decoction represses docetaxel resistance and
            glycolysis of castration-resistant prostate cancer via regulation
            of SNHG10/miR-1271-5p/TRIM66 axis
  JOURNAL   Aging (Albany NY) 13 (19), 23096-23107 (2021)
   PUBMED   34613933
  REMARK    GeneRIF: Zhoushi Qi Ling decoction represses docetaxel resistance
            and glycolysis of castration-resistant prostate cancer via
            regulation of SNHG10/miR-1271-5p/TRIM66 axis.
REFERENCE   5  (bases 1 to 10695)
  AUTHORS   Zhang,H., Zheng,Y. and Zhang,Y.
  TITLE     Knockdown of TRIM66 in MDA-MB-468 triple negative breast cancer
            cell line suppresses proliferation and promotes apoptosis through
            EGFR signaling
  JOURNAL   Pol J Pathol 72 (2), 160-166 (2021)
   PUBMED   34706523
  REMARK    GeneRIF: Knockdown of TRIM66 in MDA-MB-468 triple negative breast
            cancer cell line suppresses proliferation and promotes apoptosis
            through EGFR signaling.
REFERENCE   6  (bases 1 to 10695)
  AUTHORS   Chen,Y., Guo,Y., Yang,H., Shi,G., Xu,G., Shi,J., Yin,N. and Chen,D.
  TITLE     TRIM66 overexpresssion contributes to osteosarcoma carcinogenesis
            and indicates poor survival outcome
  JOURNAL   Oncotarget 6 (27), 23708-23719 (2015)
   PUBMED   26247633
  REMARK    GeneRIF: TRIM66 may act as an oncogene through suppressing
            apoptosis pathway and promoting TGF-beta signaling in osteosarcoma
            carcinogenesis. TRIM66 may be a prognostic factor and potential
            therapeutic target in osteosarcoma.
REFERENCE   7  (bases 1 to 10695)
  AUTHORS   Gong,F., Chiu,L.Y., Cox,B., Aymard,F., Clouaire,T., Leung,J.W.,
            Cammarata,M., Perez,M., Agarwal,P., Brodbelt,J.S., Legube,G. and
            Miller,K.M.
  TITLE     Screen identifies bromodomain protein ZMYND8 in chromatin
            recognition of transcription-associated DNA damage that promotes
            homologous recombination
  JOURNAL   Genes Dev 29 (2), 197-211 (2015)
   PUBMED   25593309
REFERENCE   8  (bases 1 to 10695)
  AUTHORS   Elks,C.E., Perry,J.R., Sulem,P., Chasman,D.I., Franceschini,N.,
            He,C., Lunetta,K.L., Visser,J.A., Byrne,E.M., Cousminer,D.L.,
            Gudbjartsson,D.F., Esko,T., Feenstra,B., Hottenga,J.J.,
            Koller,D.L., Kutalik,Z., Lin,P., Mangino,M., Marongiu,M.,
            McArdle,P.F., Smith,A.V., Stolk,L., van Wingerden,S.H., Zhao,J.H.,
            Albrecht,E., Corre,T., Ingelsson,E., Hayward,C., Magnusson,P.K.,
            Smith,E.N., Ulivi,S., Warrington,N.M., Zgaga,L., Alavere,H.,
            Amin,N., Aspelund,T., Bandinelli,S., Barroso,I., Berenson,G.S.,
            Bergmann,S., Blackburn,H., Boerwinkle,E., Buring,J.E., Busonero,F.,
            Campbell,H., Chanock,S.J., Chen,W., Cornelis,M.C., Couper,D.,
            Coviello,A.D., d'Adamo,P., de Faire,U., de Geus,E.J., Deloukas,P.,
            Doring,A., Smith,G.D., Easton,D.F., Eiriksdottir,G., Emilsson,V.,
            Eriksson,J., Ferrucci,L., Folsom,A.R., Foroud,T., Garcia,M.,
            Gasparini,P., Geller,F., Gieger,C., Gudnason,V., Hall,P.,
            Hankinson,S.E., Ferreli,L., Heath,A.C., Hernandez,D.G., Hofman,A.,
            Hu,F.B., Illig,T., Jarvelin,M.R., Johnson,A.D., Karasik,D.,
            Khaw,K.T., Kiel,D.P., Kilpelainen,T.O., Kolcic,I., Kraft,P.,
            Launer,L.J., Laven,J.S., Li,S., Liu,J., Levy,D., Martin,N.G.,
            McArdle,W.L., Melbye,M., Mooser,V., Murray,J.C., Murray,S.S.,
            Nalls,M.A., Navarro,P., Nelis,M., Ness,A.R., Northstone,K.,
            Oostra,B.A., Peacock,M., Palmer,L.J., Palotie,A., Pare,G.,
            Parker,A.N., Pedersen,N.L., Peltonen,L., Pennell,C.E., Pharoah,P.,
            Polasek,O., Plump,A.S., Pouta,A., Porcu,E., Rafnar,T., Rice,J.P.,
            Ring,S.M., Rivadeneira,F., Rudan,I., Sala,C., Salomaa,V., Sanna,S.,
            Schlessinger,D., Schork,N.J., Scuteri,A., Segre,A.V.,
            Shuldiner,A.R., Soranzo,N., Sovio,U., Srinivasan,S.R.,
            Strachan,D.P., Tammesoo,M.L., Tikkanen,E., Toniolo,D., Tsui,K.,
            Tryggvadottir,L., Tyrer,J., Uda,M., van Dam,R.M., van Meurs,J.B.,
            Vollenweider,P., Waeber,G., Wareham,N.J., Waterworth,D.M.,
            Weedon,M.N., Wichmann,H.E., Willemsen,G., Wilson,J.F., Wright,A.F.,
            Young,L., Zhai,G., Zhuang,W.V., Bierut,L.J., Boomsma,D.I.,
            Boyd,H.A., Crisponi,L., Demerath,E.W., van Duijn,C.M., Econs,M.J.,
            Harris,T.B., Hunter,D.J., Loos,R.J., Metspalu,A., Montgomery,G.W.,
            Ridker,P.M., Spector,T.D., Streeten,E.A., Stefansson,K.,
            Thorsteinsdottir,U., Uitterlinden,A.G., Widen,E., Murabito,J.M.,
            Ong,K.K. and Murray,A.
  CONSRTM   GIANT Consortium
  TITLE     Thirty new loci for age at menarche identified by a meta-analysis
            of genome-wide association studies
  JOURNAL   Nat Genet 42 (12), 1077-1085 (2010)
   PUBMED   21102462
REFERENCE   9  (bases 1 to 10695)
  AUTHORS   Khetchoumian,K., Teletin,M., Mark,M., Lerouge,T., Cervino,M.,
            Oulad-Abdelghani,M., Chambon,P. and Losson,R.
  TITLE     TIF1delta, a novel HP1-interacting member of the transcriptional
            intermediary factor 1 (TIF1) family expressed by elongating
            spermatids
  JOURNAL   J Biol Chem 279 (46), 48329-48341 (2004)
   PUBMED   15322135
  REMARK    GeneRIF: Data suggest a role for transcriptional intermediary
            factor 1 (TIF1) delta in heterochromatin-mediated gene silencing
            during postmeiotic phases of spermatogenesis.
REFERENCE   10 (bases 1 to 10695)
  AUTHORS   Amid,C., Bahr,A., Mujica,A., Sampson,N., Bikar,S.E.,
            Winterpacht,A., Zabel,B., Hankeln,T. and Schmidt,E.R.
  TITLE     Comparative genomic sequencing reveals a strikingly similar
            architecture of a conserved syntenic region on human chromosome
            11p15.3 (including gene ST5) and mouse chromosome 7
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 284-290 (2001)
   PUBMED   11528127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091053.11 and AC104360.8.
            
            On Oct 19, 2020 this sequence version replaced XM_006718397.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000646038.2/ ENSP00000495413.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC091053.11        134909-134973
            66-228              AC091053.11        137511-137673
            229-423             AC091053.11        137760-137954
            424-501             AC091053.11        142691-142768
            502-639             AC091053.11        145189-145326
            640-952             AC091053.11        145476-145788
            953-1056            AC104360.8         95658-95761
            1057-1204           AC104360.8         97674-97821
            1205-1337           AC104360.8         99013-99145
            1338-1454           AC104360.8         99475-99591
            1455-1569           AC104360.8         101000-101114
            1570-1716           AC104360.8         101674-101820
            1717-1834           AC104360.8         104435-104552
            1835-2760           AC104360.8         106409-107334
            2761-2922           AC104360.8         108746-108907
            2923-3438           AC104360.8         122333-122848
            3439-3631           AC104360.8         123010-123202
            3632-3692           AC104360.8         124685-124745
            3693-3867           AC104360.8         125742-125916
            3868-4157           AC104360.8         126240-126529
            4158-4284           AC104360.8         126989-127115
            4285-4359           AC104360.8         127437-127511
            4360-4512           AC104360.8         128026-128178
            4513-4731           AC104360.8         128593-128811
            4732-10695          AC104360.8         129558-135521
FEATURES             Location/Qualifiers
     source          1..10695
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..10695
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /note="tripartite motif containing 66"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
     exon            1..65
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            66..228
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            229..423
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            424..501
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            502..639
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             613..4791
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcriptional intermediary factor 1 delta; tripartite
                     motif-containing protein 66"
                     /codon_start=1
                     /product="tripartite motif-containing protein 66 isoform
                     2"
                     /protein_id="NP_001374951.1"
                     /db_xref="CCDS:CCDS91432.1"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
                     /translation="MARLSFWSQGVELARSTRCFSPEDISGKAPVLGTGMAVDMGMSF
                     MGLPLAGQKHCPKSGQMEAMVMTCSLCHQDLPGMGSHLLSCQHLLRKDCFQGLIQELG
                     QIAKAHETVADELISCPGCERVYLTRDVTEHFFLHCVPTEQPKMARNCSECKEKRAAH
                     ILCTYCNRWLCSSCTEEHRHSPVPGGPFFPRAQKGSPGVNGGPGDFTLYCPLHTQEVL
                     KLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLLEGVTTQVAHKKSSLQTSAK
                     QIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNERKRKLEQQLQ
                     SIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCNTDPGSPWSIR
                     FTWEPNFWTKQLASLGCITTEGGQMSRADAPAYGGLQGSSPFYQSHQSPVAQQEALSH
                     PSHKFQSPAVCSSSVCCSHCSPVSPSLKGQVPPPSIHPAHSFRQPPEMVPQQLGSLQC
                     SALLPREKELACSPHPPKLLQPWLETQPPVEQESTSQRLGQQLTSQPVCIVPPQDVQQ
                     GAHAQPTLQTPSIQVQFGHHQKLKLSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQPH
                     PPLPPSQHLASSQHESPPGPACSQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQT
                     KSPQHLQQTIVGQINYIVRQPAPVQSQSQEETLQATDEPPASQGSKPALPLDKNTAAA
                     LPQASGEETPLSVPPVDSTIQHSSPNVVRKHSTSLSIMGFSNTLEMELSSTRLERPLE
                     PQIQSVSNLTAGAPQAVPSLLSAPPKMVSSLTSVQNQAMPSLTTSHLQTVPSLVHSTF
                     QSMPNLISDSPQAMASLASDHPQAGPSLMSGHTQAVPSLATCPLQSIPPVSDMQPETG
                     SSSSSGRTSGSLCPRDGADPSLENALCKMESEDSTRFTDLLGQGPIVPGLDAPKDLAI
                     PSELEEPINLSVKKPPLAPVVSTSTALQQYQNPKECENFEQGALELDAKENQSIRAFN
                     SEHKIPYVRLERLKICAASSGEMPVFKLKPQKNDQDGSFLLIIECGTESSSMSIKVSQ
                     DRLSEATQAPGLEGRKVTVTSLAGQRPPEVEGTSPEEHRLIPRTPGAKKGPPAPIENE
                     DFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQPEMEYDCEN
                     ACYNQPGMRASPGLSMYDQKKCEKLVLSLCCNNLSLPFHEPVSPLARHYYQIIKRPMD
                     LSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWL
                     KEIYPEKRFAQPRQEDSDSEEVSSESGCSTPQGFPWPPYMQEGIQPKRRRRHMENERA
                     KRMSFRLANSISQV"
     exon            640..952
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1056
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1204
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1337
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1454
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1569
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1716
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1834
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..2760
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2922
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3438
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3631
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..3692
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..3867
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            3868..4157
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4158..4284
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4285..4359
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4360..4512
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4513..4731
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     exon            4732..10695
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10668..10673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /note="hexamer: AATAAA"
     polyA_site      10695
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /note="major polyA site"
ORIGIN      
        1 gcttcctctt tctgagggtg gtgatccccc atcacggagt gtcctggtgg cggtgtacgg
       61 tttcgaacac ttcagtccac aaggataaca accaacattt tcagagcact tggcaattta
      121 caaaatacat ctgcctgaag gtacagcact accagcctca ttttacgtgt gtgaaaactg
      181 aagcacagaa gaattgggtg acttgtcaga cgctgcatag gtggtcagca ttatggtctt
      241 catccctcca tcaaccttaa tcacatactg catgtgacca gcaggaagag gggtcttgag
      301 aataggaggg gagatcaaag aagacatcgt cgtctatttg acatcaaaac tggccagtaa
      361 gtgcacaaga aatgagctgg gttacctgga acctaacctt gggaagatga tctgtcaatg
      421 gagctgtatg tctgtgtgag actggatttt cctcatatac tgtgaacaaa acaacatata
      481 acagattgac tgcagaaaca ggtcaagctt gtctaccaat aaggagaggc acaggtacgg
      541 gacacttttg aagggtttgt tcgccttcag acaaacagca gacacctcca cgctttgttt
      601 tccacggcag agatggctag actctctttt tggtcccagg gagtggagct ggctcgctct
      661 acacgctgct tctcacctga ggatatcagt ggaaaagccc cagtcctggg cacaggcatg
      721 gctgtggaca tgggcatgag ctttatgggg ctgccactag ctggccagaa acactgccct
      781 aagagtggac agatggaggc catggtaatg acctgctcat tgtgccatca ggacctgcca
      841 ggtatgggct ctcatctcct atcctgccag catttgctcc gtaaggactg cttccagggc
      901 ttgatacagg agctagggca gattgccaag gctcatgaga ctgttgcaga tgagctcatc
      961 tcctgtcctg ggtgtgaacg agtatatctt accagggatg taactgaaca tttttttctg
     1021 cattgtgttc ctactgagca acccaagatg gccaggaact gctctgagtg caaggagaag
     1081 agggcagcac atatcctctg cacctactgc aatcgctggc tgtgcagctc ttgcacagag
     1141 gaacaccgac acagccctgt ccccgggggc ccattctttc ctcgggccca gaagggatct
     1201 ccaggagtga atggtggtcc cggagacttc accttgtatt gtcctctaca cacacaggaa
     1261 gtactcaagc tattctgtga gacatgtgat atgctcactt gccatagctg cctagtggtg
     1321 gaacacaaag aacacaggtg cagacatgtt gaagaagttt tgcaaaacca gaggatgctt
     1381 ctggaaggtg tgactacaca ggtggcacat aagaaatcca gtctacagac atctgcaaag
     1441 caaattgagg acaggatttt tgaagtgaag catcagcata ggaaggtgga aaaccagatc
     1501 aaaatggcca agatggttct gatgaatgag ctgaacaaac aggccaatgg gctaatagag
     1561 gaattagagg ggattactaa tgagagaaag cggaagctgg aacagcagtt acagagcatc
     1621 atggttctca accgtcagtt tgagcatgtg cagaatttca tcaactgggc tgtctgcagc
     1681 aaaaccagtg tcccttttct tttcagcaaa gagctgattg tgtttcagat gcagcgattg
     1741 ctggagacaa gttgtaacac agatcctggc tccccttgga gtatcagatt cacctgggag
     1801 cctaacttct ggaccaagca gctagcttct cttggctgca taactactga aggtggacaa
     1861 atgtccaggg cagatgctcc tgcttatgga ggcttacagg ggtcatcacc cttttatcaa
     1921 agccaccagt ctccagtggc tcagcaagag gctcttagcc acccctcaca caagttccag
     1981 tctccagcag tgtgctcctc atctgtgtgc tgctcccact gctccccagt ctcgccttcc
     2041 ctcaaaggcc aggtcccccc acccagcata cacccagccc acagcttcag gcagccccct
     2101 gagatggtgc cccagcagct ggggtctctg cagtgctctg ccctgctgcc cagggagaaa
     2161 gagctggcct gcagccctca tccaccaaag ctgctgcagc cctggctgga aacccagccc
     2221 cccgtggagc aggagagcac atcccagcgg ctggggcagc agctgacttc ccagcccgtg
     2281 tgcattgtcc ccccacagga tgttcagcaa ggagcccatg cccagcccac cttacagaca
     2341 ccctctatcc aagtccagtt tggccaccac cagaagctga agctcagtca ctttcagcag
     2401 cagccacagc agcagctacc acctccacca ccacccctcc cccatccccc acctcccctt
     2461 ccccctcccc cacagcagcc acacccacct cttcctccat cccagcatct ggcttctagt
     2521 cagcacgaga gccctcctgg ccctgcctgt tctcagaaca tggacataat gcatcacaag
     2581 tttgagctgg aggaaatgca gaaggacttg gagcttcttc tccaggctca acagcccagc
     2641 ctgcaactga gtcagaccaa atctcctcag catcttcagc aaaccattgt ggggcagatc
     2701 aactacatcg tgaggcagcc agcacctgtc cagtcccaga gccaggagga gaccctgcag
     2761 gctacagatg agcccccagc atctcagggc tcaaagccgg ctctccctct tgacaagaat
     2821 actgctgctg ccttgcccca ggcgtctggg gaagaaaccc ctctcagtgt ccccccagtg
     2881 gacagcacca tccagcactc ctctccaaat gtggtgagaa agcactccac ctcgctgagc
     2941 atcatgggct tttccaacac tctggagatg gagttgtcat ctaccaggtt ggagaggccc
     3001 ctagagccac agatccagag tgtgagcaac ctgacagctg gtgcccccca ggcagtacca
     3061 agcctgctga gtgctccccc caaaatggtg tccagcctga caagtgttca aaaccaggcc
     3121 atgcccagcc tgacaaccag tcacctacag actgtgccca gccttgtgca tagcacattc
     3181 cagtccatgc ccaacctgat aagtgactcc cctcaggcta tggcaagcct ggcaagtgat
     3241 caccctcagg ctgggcccag cctaatgtct ggtcacaccc aggctgtgcc gagtctggca
     3301 acttgtcctc tgcagagcat ccctccagtt tctgacatgc agccagaaac tgggtccagc
     3361 tccagttctg gccgaacttc agggagcctg tgtcccagag atggggctga tccctccctg
     3421 gagaatgctc tgtgtaagat ggaaagtgag gattccactc gcttcactga cttactggga
     3481 caaggtccca tagtccccgg tctggatgct cccaaggact tggccatccc ctcagaactg
     3541 gaggagccaa ttaacctctc tgtgaagaaa cctccactgg cgccagtggt cagcacgtct
     3601 acagctctgc agcagtacca gaacccaaaa gagtgtgaga attttgaaca aggagcccta
     3661 gagctggatg caaaagagaa ccagagcatc agagccttca atagtgagca taagattccc
     3721 tatgtgcgac tggagcgact caagatctgt gctgcctcct caggagagat gcctgtgttc
     3781 aaactgaagc cacagaagaa tgatcaggat gggagcttcc tgctgatcat cgagtgtggc
     3841 actgagtcct ccagcatgtc cattaaggtc agccaggaca gactgtctga ggccacccag
     3901 gccccaggtc tggagggaag aaaggtcact gtcacttctt tggctgggca gcggccacca
     3961 gaagtggagg gcacatctcc tgaagaacac agactcattc ctcgaacccc aggagccaag
     4021 aagggccccc cagccccaat agagaatgag gacttctgtg ctgtttgcct caatggcgga
     4081 gagttactgt gctgtgaccg ctgccccaaa gtgttccacc tctcctgcca tgtgccagcc
     4141 ttgctcagct tcccaggggg agagtgggtg tgtaccttgt gccgcagcct gacccagccc
     4201 gagatggagt acgactgtga gaatgcctgc tataaccagc ctggaatgcg ggcatctcct
     4261 ggcctaagca tgtatgacca gaagaagtgt gagaagctgg tattgtcctt gtgctgcaat
     4321 aacctcagcc tgcccttcca tgaacctgtc agccccctgg cccggcatta ttaccagatt
     4381 atcaagaggc ccatggacct gtcaatcatc cggaggaagc tgcaaaagaa ggacccagct
     4441 cactatacca ccccagagga ggtggtatca gatgtgcgcc tcatgttctg gaactgtgct
     4501 aagttcaatt atcctgactc cgaggttgca gaggctggcc gctgcctgga agtgttcttt
     4561 gagggctggt tgaaggagat ctacccggag aaacggtttg cccagccaag gcaggaggac
     4621 tcagactccg aggaggtgtc tagtgagagt ggatgttcca ctccccaggg cttcccgtgg
     4681 cctccctaca tgcaggaggg catccaaccc aagaggcggc gacgacatat ggagaatgaa
     4741 agagcaaaaa gaatgtcatt tcgcctggcc aacagcatct ctcaggtgtg agagccaaaa
     4801 ggagactggg cactctggca gctgttgtcc catactgtcg accattcctc cccatcttgc
     4861 agcttatcct cttcagagtg tggatggtag atgagtcttg ttgaactgtg tagtgctctt
     4921 ctttgccatt tgcatctaca gcatttattt gggagccgta gtacatccac tacagagaag
     4981 atttcagtaa taaacaggaa agaggaaggt atttattatt accagagtaa tcagatgtat
     5041 aggctccact tgacaagacc acacctggtt aggctcggga aaacctactt tccttggtga
     5101 atttttttct gcctgggaaa gcagacccgt ctaacctttt agtgtccagg gctcaggagc
     5161 catgtataca tctgaactcc tcctgggctc agaagtgggt aaaagaaggg agagaggttt
     5221 agacatatgg caggactgtg atccctggcc cagcacagcc aaagactgtc actgtttgcc
     5281 tttgcttgtc ctgtctggat agaggcacct gccatgtgca gactagtgga ggcttctaga
     5341 ggccataggt ctcaatttgt gcctatttgg gttctaacgg ttttcagggt atttgttttg
     5401 catagtcact ttcctgatgt tgacataggt ggctgctgtg aaaatgctgt ggatggtgtg
     5461 acattcttga ctgagctggg tggctgtgga gagaccactt aaatcttctg gttcagattt
     5521 cacttacaga cttagtaaga tgtccacttc agagcccgcc ctctgtgcta cttactctgg
     5581 gctaatcaca cttctttagg gtgagaacct gccttcctag aagtgactgt tggtgcttgt
     5641 cagtggccat acccttcatc atcctcattc agaggtatgg atcgtgagtt ctgcttgtga
     5701 atactgtgag acagctgctg tctgcttcag gtccagagtt ccatgggtgg agagagtaac
     5761 ccacaaccag ctcactcctc tgggcctctc ctcctgctta aagattctag ttctcaacct
     5821 ctccaagttc atgagccaaa gatcagaagt gagtcttctg accagcccgc ctccaggctg
     5881 tctacagccc caaaaaagcc aacacttttc tggcagccct ttttgttgga ggttagagaa
     5941 ggcctcaggg accaacaggg gccagatcta gacattcctg ggggaagttt gtctaaggtg
     6001 gacaggggga aaaatcaaga ggcaaaaagc cagtgtcctt tggtgaccat gaagcaacct
     6061 cagagcctta gttctcctag aatgcagaga gaagcattct ggaagccatg ggaacaggag
     6121 ctcgaggctg catcctgaat gcatctgcat ggccctcgca gggtgtttgt gaggatactg
     6181 gaggtcaggc tacctcccaa gcaagggctt ggttgagaag gaacccattg ctcatattgt
     6241 tgggggagct atgaacctga catgtcagtg gccaggactg agacagctct ccctggtcct
     6301 gtcattgcat ggctaatttc aggggagtct gaggtcatgg ctttattttt gctaacagat
     6361 gaagttcaag gatgttcttg tttgtagggc ctttgctaat gagcagtttt ttaattagaa
     6421 aacatttctt ctctctttgt gagttgatgg tattgctcat ttccttctct acccaacctg
     6481 agagatcatc ttcactttaa agcaaaccat gccccttggc ttgccattct ttcagcagca
     6541 catgccacgt tctaagcaga tgggcttccg tgatcccgtt ttctagtttg gggtaactga
     6601 gtcttgaatg ctttactagt ccggcaatct ttggacttag gcttctgccc tttgagactc
     6661 acatgacttt ctggtttggg gtctggtcat ttccctttca atttttgaat ctccttctct
     6721 gttcagttgg cttggcaaag taccctctgt tctcatgtca ctaattcctg ctctaggtca
     6781 tctttccttt gtgcagccca cattcccacc atcctgtgaa ctttgttgta cttggtgttg
     6841 ggcaactggt gagtgttgtg acaggctcag acctgatcct tcctcaggag caattggaga
     6901 ccacaaattt aaagcagaaa tacctgttaa aagcttggct ttccttatat gagtgaggct
     6961 cccagcttgg gtgtggcctc ctgggctcac ggatcagctt gctgggccag agggggtctt
     7021 agtaatgtgc tagagagaca catgctccct tctcatcgta gagagcctgc atgctgagag
     7081 gctcccttta cacacctgcc tctcgctggc ttttccttta gacctagcca ccagtgtttt
     7141 gaatcatggt tttgttttgt ttttgcatgc aaaaaccaga acatgactta gaaattaaaa
     7201 aaaaaaaaat cctactagcc aagtgactgc ctgcagaggc tcttcattaa catttgggct
     7261 gatcctgctt ttgacttatt cccataatgg cccagttttg aagtcagcca agtccttttg
     7321 tccttgacaa catcatgcag tggaaatacg gtgagttcta gattcttatg ggacagcatg
     7381 cagccctaga ggaaaaattg acttcttggg tatgctgaga aataagacag taaaatggct
     7441 tcagttgatg caaggggatt ttagttaaaa attggttcag gatttttaaa ttttatttta
     7501 ttttttggct gggcgcggtg gctcacgcct gtaatcccag cactttggga ggctgaggtg
     7561 ggtggatcac ctaaggacag cagttcgaga ccagcctggc caacatagtg aaaccctgtc
     7621 tctactaaaa atacaaatat cagccaggtg tgatggcaca tgcctgtaat cccagctact
     7681 tgggaggctg aggcaggaga attgcttgaa tccgggaggt ggaggttgca gtgagctgag
     7741 atcatgccat tgcattccag cctgggcaac agaacgagac tccgtctcaa aaaaaaaaaa
     7801 attggttcag gatgaacttg cagagcactc ttccacagaa catggttagg ttagccctgc
     7861 ctgacttcta gcaattgcta actatacacc ttgcctgcct ctaggacccc tacctgagtg
     7921 gcaaccatac cttccatatg ctctgttcca tggcagtccc tgccatcccc caccagcgga
     7981 ctctggctcc ctccctgtac ccatttctag caacagctcc ttgcctggct gctaagacgg
     8041 aggcgcctcc ttgtttgttc ctgggctctg ttctgctccc tctctcactc catggagtca
     8101 cttatagtct tcctttctga acgccagaat tgagcctttg ctccttctgg atcacccctt
     8161 cctgggcttc ttctccatcc ctcagtactg ctaaaattgc cctgctcctt tagtccattt
     8221 ccatgacctc agccctctct ctcctctcct tgtcttttaa ctttctcctg gacttcttcc
     8281 tctccccagc atgaacccag agcctatcac acactgatgt ttttgtcagc atcctgaact
     8341 ttctcatgcc cttcaacttt atttatttat ttatttattt attttttatt ttttgagaga
     8401 gagagtctca ctctgtcatg caggctggag tgcagtggta tgatgtcggc tcattgcaac
     8461 ctctgccttc tgggctcagg tgatcctccc atctcagcct cctgagtagc tgggactaca
     8521 ggtgcatgcc accatgcctg gctaattttt ctactttagg tagagatgga gtttcgccat
     8581 gttgctcaag ctggtatcaa cactcctggg ctcaagcagt ctgcttccct tggcctccca
     8641 aagtgctggg attacaggcg tgagccactg cgccaggcgt atccccttca attttgctga
     8701 aactatcagc cattctccat tttcggcatc atcatatttg ctgcttccac ctcctgggct
     8761 gctatgcatg acagattcac agttggcagc ctcagttgag ctctcagtgt tgactggaaa
     8821 ttctttaact tgttgtgatc cctttttttt tccccaccca tgcctccatc tttgtcctcc
     8881 acaaatgact gagctcactg tctacttcac agaagacagc ccctaaagca agagcttcct
     8941 tgcctgctgt tcctctctcc cctctcattc atctgtgtct gtaactctcc ccaacccctc
     9001 cattcttgct cctatttaat tctctatatc ttgaatcctg ttgtatgtcc tccaagactg
     9061 ctccctcgct tactccactg ctcccactcc ctggagtctc cagcctctgt ctccactggt
     9121 tacctccaca cagcctgcaa acaagttctc cacaagatta aaacagcatt tctcagagtc
     9181 tgttacccct tacacatttt ccttgttaac caagttactt ttaaaaagat cctttttaaa
     9241 ctgattcttc ctcagctgtt cttcagccct ctatactttt tcataaaagt caccagtgac
     9301 tgcccagttg ccaaatagaa tgaatacctt tcagtgctca gctgtcttga cctctccgca
     9361 gcatttcaca ccacccacca accctcagtg aaacaacctc ctcccttagc ttttatgaca
     9421 ccacaagtct ctggattctc agagaatcca gaaaaacaag tctctggatt ctctcctctt
     9481 acctctcagc ccacacaggc tgagctgtcc ttgaaaccta gatgggggaa atgtctgtgg
     9541 ctgtctgtgg tctcttcttt tcaggagttg ggtagggagg aagaatcaca gctgctcctg
     9601 cttcctctgt ctgtctctct atttcctgag tcccttcctt ttcctgaact cagttctcct
     9661 catgccaacc atgtttatga gctcctgctg ggaggacagc atctgtgagt ccttccctct
     9721 gtctctccca gacaacacag aggttttagc ctgtttgcta agagacccca tctaagtcag
     9781 cccaagggtg tggattaggt tttacagcat ccaggccgca gtctggctaa actggattac
     9841 caggctggtg ggcagctcct caccatgatc ctgcaccagt tagagcctgc tgtagttggg
     9901 aaggagcctg ggattgtggt aagatgtgtt tccgtgcatg tcagtgctgc taaccaggag
     9961 gagaacctgg cagggtgggt gcctgctgct gataacattc ggatggaggg agactaggga
    10021 gcgcggtggc tgctcccttg ctggggctca gctggagtca gcatgactcc ttatatcagg
    10081 gcctttccca cctgtgctga tcaccaccac ctgcttgctc cagttgtttc tggagttgga
    10141 ggcagctatt ggttgctttc ttggaggtaa ggaggtatat actagaaaga tatctgattt
    10201 gagagtctga acaccaaaat ttttggctct ttccattatg agctgtgtaa ccttggatac
    10261 agtttcctca tctataaagt tgtggtggga gaatggctga gaacagtgat ctctcagctc
    10321 tccagctgta aagatgttaa ttatgatttt aactctcaag atcaggccac ataaggaaca
    10381 ggggaattcc aggggtggga cacagctggg ggagtccaga ccagggcagg gaaaggagac
    10441 tcacaagcca aacagagctg ctttggggaa agttcttatc agctggtgct gcttcctgag
    10501 ccatatgccc attcctcaag ctgtacccct ttcttggcta tgtaggatga gttcctccta
    10561 ggcccttgtt aggagtggct attggattct aagcggttgg ggcatgaggg aggatatttt
    10621 aaagggaagt atagctgatt ttaaaagaac ctatacattc aagaacaaat aaaaaacagc
    10681 acttttcttt accaa
//
