LOCUS       NM_032588               1770 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens tripartite motif containing 63 (TRIM63), mRNA.
ACCESSION   NM_032588
VERSION     NM_032588.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1770)
  AUTHORS   Taylor,A.S., Mannan,R., Pantanowitz,L., Chinnaiyan,A.M.,
            Dhanasekaran,S.M., Hrycaj,S., Cao,X., Chan,M.P., Lucas,D.,
            Wang,X.M. and Mehra,R.
  TITLE     Evaluation of TRIM63 RNA in situ hybridization (RNA-ISH) as a
            potential biomarker for alveolar soft-part sarcoma (ASPS)
  JOURNAL   Med Oncol 41 (3), 76 (2024)
   PUBMED   38393424
  REMARK    GeneRIF: Evaluation of TRIM63 RNA in situ hybridization (RNA-ISH)
            as a potential biomarker for alveolar soft-part sarcoma (ASPS).
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1770)
  AUTHORS   Ham,S.J., Lee,D., Xu,W.J., Cho,E., Choi,S., Min,S., Park,S. and
            Chung,J.
  TITLE     Loss of UCHL1 rescues the defects related to Parkinson's disease by
            suppressing glycolysis
  JOURNAL   Sci Adv 7 (28) (2021)
   PUBMED   34244144
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1770)
  AUTHORS   Salazar-Mendiguchia,J., Ochoa,J.P., Palomino-Doza,J., Dominguez,F.,
            Diez-Lopez,C., Akhtar,M., Ramiro-Leon,S., Clemente,M.M.,
            Perez-Cejas,A., Robledo,M., Gomez-Diaz,I., Pena-Pena,M.L.,
            Climent,V., Salmeron-Martinez,F., Hernandez,C., Garcia-Granja,P.E.,
            Mogollon,M.V., Cardenas-Reyes,I., Cicerchia,M.,
            Garcia-Giustiniani,D., Lamounier,A. Jr., Gil-Fournier,B.,
            Diaz-Flores,F., Salguero,R., Santome,L., Syrris,P., Olive,M.,
            Garcia-Pavia,P., Ortiz-Genga,M., Elliott,P.M. and Monserrat,L.
  CONSRTM   GENESCOPIC Research Group
  TITLE     Mutations in TRIM63 cause an autosomal-recessive form of
            hypertrophic cardiomyopathy
  JOURNAL   Heart 106 (17), 1342-1348 (2020)
   PUBMED   32451364
  REMARK    GeneRIF: Mutations in TRIM63 cause an autosomal-recessive form of
            hypertrophic cardiomyopathy.
REFERENCE   4  (bases 1 to 1770)
  AUTHORS   Liu,Z., Liu,H., He,J., Lin,P., Tong,Q. and Yang,J.
  TITLE     Myeloma cells shift osteoblastogenesis to adipogenesis by
            inhibiting the ubiquitin ligase MURF1 in mesenchymal stem cells
  JOURNAL   Sci Signal 13 (633) (2020)
   PUBMED   32457115
  REMARK    GeneRIF: Myeloma cells shift osteoblastogenesis to adipogenesis by
            inhibiting the ubiquitin ligase MURF1 in mesenchymal stem cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1770)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1770)
  AUTHORS   McElhinny,A.S., Kakinuma,K., Sorimachi,H., Labeit,S. and
            Gregorio,C.C.
  TITLE     Muscle-specific RING finger-1 interacts with titin to regulate
            sarcomeric M-line and thick filament structure and may have nuclear
            functions via its interaction with glucocorticoid modulatory
            element binding protein-1
  JOURNAL   J Cell Biol 157 (1), 125-136 (2002)
   PUBMED   11927605
  REMARK    GeneRIF: interacts with titin to regulate sarcomeric M-line and
            thick filament structure and may have nuclear functions via its
            interaction with glucocorticoid modulatory element binding
            protein-1.
REFERENCE   7  (bases 1 to 1770)
  AUTHORS   Bodine,S.C., Latres,E., Baumhueter,S., Lai,V.K., Nunez,L.,
            Clarke,B.A., Poueymirou,W.T., Panaro,F.J., Na,E., Dharmarajan,K.,
            Pan,Z.Q., Valenzuela,D.M., DeChiara,T.M., Stitt,T.N.,
            Yancopoulos,G.D. and Glass,D.J.
  TITLE     Identification of ubiquitin ligases required for skeletal muscle
            atrophy
  JOURNAL   Science 294 (5547), 1704-1708 (2001)
   PUBMED   11679633
REFERENCE   8  (bases 1 to 1770)
  AUTHORS   Dai,K.S. and Liew,C.C.
  TITLE     A novel human striated muscle RING zinc finger protein, SMRZ,
            interacts with SMT3b via its RING domain
  JOURNAL   J Biol Chem 276 (26), 23992-23999 (2001)
   PUBMED   11283016
REFERENCE   9  (bases 1 to 1770)
  AUTHORS   Centner,T., Yano,J., Kimura,E., McElhinny,A.S., Pelin,K.,
            Witt,C.C., Bang,M.L., Trombitas,K., Granzier,H., Gregorio,C.C.,
            Sorimachi,H. and Labeit,S.
  TITLE     Identification of muscle specific ring finger proteins as potential
            regulators of the titin kinase domain
  JOURNAL   J Mol Biol 306 (4), 717-726 (2001)
   PUBMED   11243782
REFERENCE   10 (bases 1 to 1770)
  AUTHORS   Cirino,A.L. and Ho,C.
  TITLE     Hypertrophic Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301725
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA900348.1, BC080529.1,
            AI351421.1 and AL391650.18.
            
            On Feb 27, 2020 this sequence version replaced NM_032588.3.
            
            Summary: This gene encodes a member of the RING zinc finger protein
            family found in striated muscle and iris. The product of this gene
            is an E3 ubiquitin ligase that localizes to the Z-line and M-line
            lattices of myofibrils. This protein plays an important role in the
            atrophy of skeletal and cardiac muscle and is required for the
            degradation of myosin heavy chain proteins, myosin light chain,
            myosin binding protein, and for muscle-type creatine kinase.
            [provided by RefSeq, Feb 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056942.1, SRR14038195.2832200.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267764 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374272.4/ ENSP00000363390.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DA900348.1         5-22
            19-1559             BC080529.1         1-1541
            1560-1767           AI351421.1         2-209               c
            1768-1770           AL391650.18        36802-36804         c
FEATURES             Location/Qualifiers
     source          1..1770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..1770
                     /gene="TRIM63"
                     /gene_synonym="IRF; MURF1; MURF2; RNF28; SMRZ"
                     /note="tripartite motif containing 63"
                     /db_xref="GeneID:84676"
                     /db_xref="HGNC:HGNC:16007"
                     /db_xref="MIM:606131"
     exon            1..295
                     /gene="TRIM63"
                     /gene_synonym="IRF; MURF1; MURF2; RNF28; SMRZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1198
                     /gene="TRIM63"
                     /gene_synonym="IRF; MURF1; MURF2; RNF28; SMRZ"
                     /EC_number="2.3.2.27"
                     /note="striated muscle RING zinc finger protein; ring
                     finger protein 28; muscle specific ring finger protein 2;
                     iris ring finger protein; muscle-specific RING finger
                     protein 1; tripartite motif-containing protein 63;
                     tripartite motif containing 63, E3 ubiquitin protein
                     ligase; RING-type E3 ubiquitin transferase TRIM63"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM63"
                     /protein_id="NP_115977.2"
                     /db_xref="CCDS:CCDS273.1"
                     /db_xref="GeneID:84676"
                     /db_xref="HGNC:HGNC:16007"
                     /db_xref="MIM:606131"
                     /translation="MDYKSSLIQDGNPMENLEKQLICPICLEMFTKPVVILPCQHNLC
                     RKCANDIFQAANPYWTSRGSSVSMSGGRFRCPTCRHEVIMDRHGVYGLQRNLLVENII
                     DIYKQECSSRPLQKGSHPMCKEHEDEKINIYCLTCEVPTCSMCKVFGIHKACEVAPLQ
                     SVFQGQKTELNNCISMLVAGNDRVQTIITQLEDSRRVTKENSHQVKEELSQKFDTLYA
                     ILDEKKSELLQRITQEQEKKLSFIEALIQQYQEQLDKSTKLVETAIQSLDEPGGATFL
                     LTAKQLIKSIVEASKGCQLGKTEQGFENMDFFTLDLEHIADALRAIDFGTDEEEEEFI
                     EEEDQEEEESTEGKEEGHQ"
     exon            296..468
                     /gene="TRIM63"
                     /gene_synonym="IRF; MURF1; MURF2; RNF28; SMRZ"
                     /inference="alignment:Splign:2.1.0"
     exon            469..637
                     /gene="TRIM63"
                     /gene_synonym="IRF; MURF1; MURF2; RNF28; SMRZ"
                     /inference="alignment:Splign:2.1.0"
     exon            638..733
                     /gene="TRIM63"
                     /gene_synonym="IRF; MURF1; MURF2; RNF28; SMRZ"
                     /inference="alignment:Splign:2.1.0"
     exon            734..967
                     /gene="TRIM63"
                     /gene_synonym="IRF; MURF1; MURF2; RNF28; SMRZ"
                     /inference="alignment:Splign:2.1.0"
     exon            968..990
                     /gene="TRIM63"
                     /gene_synonym="IRF; MURF1; MURF2; RNF28; SMRZ"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1115
                     /gene="TRIM63"
                     /gene_synonym="IRF; MURF1; MURF2; RNF28; SMRZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1187
                     /gene="TRIM63"
                     /gene_synonym="IRF; MURF1; MURF2; RNF28; SMRZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1770
                     /gene="TRIM63"
                     /gene_synonym="IRF; MURF1; MURF2; RNF28; SMRZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1733..1738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM63"
                     /gene_synonym="IRF; MURF1; MURF2; RNF28; SMRZ"
                     /note="hexamer: AATAAA"
     polyA_site      1770
                     /gene="TRIM63"
                     /gene_synonym="IRF; MURF1; MURF2; RNF28; SMRZ"
                     /note="major polyA site"
ORIGIN      
        1 agaattcggg caccaggaga aggaagccaa caggatccga cccggtgttt tgtgacaaag
       61 gcaagacccc caggtctact tagagcaaag ttagtagagg aggcagctag gcgtggctct
      121 cattccttcc cacagaatgg attataagtc gagcctgatc caggatggga atcccatgga
      181 gaacttggag aagcagctga tctgccctat ctgcctggag atgtttacca agccagtggt
      241 catcttgccg tgccagcaca acctgtgccg gaagtgtgcc aatgacatct tccaggctgc
      301 aaatccctac tggaccagcc ggggcagctc agtgtccatg tctggaggcc gtttccgctg
      361 ccccacctgc cgccacgagg tgatcatgga tcgtcacgga gtgtacggcc tgcagaggaa
      421 cctgctggtg gagaacatca tcgacatcta caaacaggag tgctccagtc ggccgctgca
      481 gaagggcagt caccccatgt gcaaggagca cgaagatgag aaaatcaaca tctactgtct
      541 cacgtgtgag gtgcccacct gctccatgtg caaggtgttt gggatccaca aggcctgcga
      601 ggtggcccca ttgcagagtg tcttccaggg acaaaagact gaactgaata actgtatctc
      661 catgctggtg gcggggaatg accgtgtgca gaccatcatc actcagctgg aggattcccg
      721 tcgagtgacc aaggagaaca gtcaccaggt aaaggaagag ctgagccaga agtttgacac
      781 gttgtatgcc atcctggatg agaagaaaag tgagttgctg cagcggatca cgcaggagca
      841 ggagaaaaag cttagcttca tcgaggccct catccagcag taccaggagc agctggacaa
      901 gtccacaaag ctggtggaaa ctgccatcca gtccctggac gagcctgggg gagccacctt
      961 cctcttgact gccaagcaac tcatcaaaag cattgtggaa gcttccaagg gctgccagct
     1021 ggggaagaca gagcagggct ttgagaacat ggacttcttt actttggatt tagagcacat
     1081 agcagacgcc ctgagagcca ttgactttgg gacagatgag gaagaggaag aattcattga
     1141 agaagaagat caggaagagg aagagtccac agaagggaag gaagaaggac accagtaagg
     1201 agctggatga atgagaggcc cccagatgca gagagactgg agagggtggg gaggggccca
     1261 gcggccttgg tgacaggccc agggtgggag gggtcggggc ccctggaggg gcaatgggga
     1321 ggtgatgtct tctctctgct cagagagcag ggactagggt aggaccctca ccgctgcgtc
     1381 cagcagacac tgaaccagaa ttggaaacgt gcttgaaaca atcacacagg acacttttct
     1441 acattggtgc aaaatggaat attttgtaca tttttaaaat gtgatttttg tatatacttg
     1501 tatatgtatg ccaatttggt gctttttgta aaggaacttt tgtataataa tgcctggtcg
     1561 ttgggtgacc tgcgattgtc agaaagaggg gaaggaagcc aggttgatac agctgcccac
     1621 ttcctttcct gagcaggagg atggggtagc actcacaggg acgatgtgct gtatttcagt
     1681 gcctatccca gacatacggg gtggtaactg agtttgtgtt atatgttgtt ttaataaatg
     1741 cacaatgctc tcttcctgtt cttcaaagga
//
