LOCUS       NM_018207               3817 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tripartite motif containing 62 (TRIM62), transcript
            variant 1, mRNA.
ACCESSION   NM_018207
VERSION     NM_018207.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3817)
  AUTHORS   Zhang,K., Li,Y.J., Peng,L.J., Gao,H.F., Liu,L.M. and Chen,H.
  TITLE     M2 macrophage-derived exosomal miR-193b-3p promotes progression and
            glutamine uptake of pancreatic cancer by targeting TRIM62
  JOURNAL   Biol Direct 18 (1), 1 (2023)
   PUBMED   36631876
  REMARK    GeneRIF: M2 macrophage-derived exosomal miR-193b-3p promotes
            progression and glutamine uptake of pancreatic cancer by targeting
            TRIM62.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3817)
  AUTHORS   Fan,W., Liu,X. and Ren,D.
  TITLE     TRIM62 silencing represses the proliferation and invasion and
            increases the chemosensitivity of hepatocellular carcinoma cells by
            affecting the NF-kappaB pathway
  JOURNAL   Toxicol Appl Pharmacol 445, 116035 (2022)
   PUBMED   35469851
  REMARK    GeneRIF: TRIM62 silencing represses the proliferation and invasion
            and increases the chemosensitivity of hepatocellular carcinoma
            cells by affecting the NF-kappaB pathway.
REFERENCE   3  (bases 1 to 3817)
  AUTHORS   Xu,W., Rush,J.S., Graham,D.B., Cao,Z. and Xavier,R.J.
  TITLE     USP15 Deubiquitinates CARD9 to Downregulate C-Type Lectin
            Receptor-Mediated Signaling
  JOURNAL   Immunohorizons 4 (10), 670-678 (2020)
   PUBMED   33093067
  REMARK    GeneRIF: USP15 Deubiquitinates CARD9 to Downregulate C-Type Lectin
            Receptor-Mediated Signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3817)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3817)
  AUTHORS   Liu,T.Y., Chen,J., Shang,C.L., Shen,H.W., Huang,J.M., Liang,Y.C.,
            Wang,W., Zhao,Y.H., Liu,D., Shu,M., Guo,L.Y., Hu,Z. and Yao,S.Z.
  TITLE     Tripartite motif containing 62 is a novel prognostic marker and
            suppresses tumor metastasis via c-Jun/Slug signaling-mediated
            epithelial-mesenchymal transition in cervical cancer
  JOURNAL   J Exp Clin Cancer Res 35 (1), 170 (2016)
   PUBMED   27793172
  REMARK    GeneRIF: Results found that TRIM62 was frequently down-regulated in
            both human cervical cancer (CC) cells and tissues. Low expression
            of TRIM62 in CC tissues was associated with aggressive
            clinicopathological features of CC patients. Its overexpression
            inhibits proliferation, migration and invasion of cervical cancer
            cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3817)
  AUTHORS   Uchil,P.D., Hinz,A., Siegel,S., Coenen-Stass,A., Pertel,T.,
            Luban,J. and Mothes,W.
  TITLE     TRIM protein-mediated regulation of inflammatory and innate immune
            signaling and its association with antiretroviral activity
  JOURNAL   J Virol 87 (1), 257-272 (2013)
   PUBMED   23077300
REFERENCE   7  (bases 1 to 3817)
  AUTHORS   Lott,S.T., Chen,N., Chandler,D.S., Yang,Q., Wang,L., Rodriguez,M.,
            Xie,H., Balasenthil,S., Buchholz,T.A., Sahin,A.A., Chaung,K.,
            Zhang,B., Olufemi,S.E., Chen,J., Adams,H., Band,V., El-Naggar,A.K.,
            Frazier,M.L., Keyomarsi,K., Hunt,K.K., Sen,S., Haffty,B.,
            Hewitt,S.M., Krahe,R. and Killary,A.M.
  TITLE     DEAR1 is a dominant regulator of acinar morphogenesis and an
            independent predictor of local recurrence-free survival in
            early-onset breast cancer
  JOURNAL   PLoS Med 6 (5), e1000068 (2009)
   PUBMED   19536326
  REMARK    GeneRIF: The evidence for the genetic alteration and loss of
            expression of DEAR1 in breast cancer and for the functional role of
            DEAR1 in the dominant regulation of acinar morphogenesis in 3D
            culture
REFERENCE   8  (bases 1 to 3817)
  AUTHORS   Muthuswamy,S.K.
  TITLE     A new tumor suppressor that regulates tissue architecture
  JOURNAL   PLoS Med 6 (5), e1000073 (2009)
   PUBMED   19536324
  REMARK    GeneRIF: DEAR1 is a predictive biomarker for early onset breast
            cancer.
REFERENCE   9  (bases 1 to 3817)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   10 (bases 1 to 3817)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA338982.1, BM722392.1, BC007999.1, AK001621.1, CX872720.1 and
            AL662907.11.
            
            On Nov 22, 2018 this sequence version replaced NM_018207.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001621.1, BC011689.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291416.10/ ENSP00000291416.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-531               DA338982.1         38-568
            532-982             BM722392.1         214-664
            983-2436            BC007999.1         405-1858
            2437-2926           AK001621.1         2060-2549
            2927-3278           CX872720.1         358-709
            3279-3814           BC007999.1         2700-3235
            3815-3817           AL662907.11        5922-5924           c
FEATURES             Location/Qualifiers
     source          1..3817
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..3817
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /note="tripartite motif containing 62"
                     /db_xref="GeneID:55223"
                     /db_xref="HGNC:HGNC:25574"
                     /db_xref="MIM:616755"
     exon            1..1019
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             612..2039
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ductal epithelium-associated RING Chromosome 1; tripartite
                     motif-containing protein 62; E3 ubiquitin-protein ligase
                     TRIM62; RING-type E3 ubiquitin transferase TRIM62"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM62 isoform 1"
                     /protein_id="NP_060677.2"
                     /db_xref="CCDS:CCDS376.1"
                     /db_xref="GeneID:55223"
                     /db_xref="HGNC:HGNC:25574"
                     /db_xref="MIM:616755"
                     /translation="MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEA
                     QGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQAHDKVKLF
                     CLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLL
                     KRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRY
                     SQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTG
                     PLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRF
                     DVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMH
                     DGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLC
                     SYFSPGQSHANGKNVQPLRINTVRI"
     exon            1020..1115
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1372
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1488
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..3817
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3796..3801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /note="hexamer: ATTAAA"
     polyA_site      3817
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /note="major polyA site"
ORIGIN      
        1 gggttgagag gctgcgctgg accgaagcgg tggctgctaa gctcgcgggg gtaaggggtc
       61 gcgctgggcc agggtttggg gccgggatcc ggcagctgag cgggccggca cccctcctct
      121 tctctgccgg tcacagccaa tgtacggctc ggcctggctg ccccctcccc caggattccc
      181 catccccagc ttctcgccct ccccgcaccg cccccacccc gggatttcga cccccttaag
      241 ggctccaccc cgctccggga tccccttctc ccagctccta tcccttagga ctgccccgcc
      301 ccctagaacc tccccgtcag gatctccgtc cctcagccgc tcacagcctc ctcccagcgc
      361 ccatcgcctt gagctgccca ctacctctag actgccctcc cgggctggcg tcccacggag
      421 tctcagccgc gcaccccttc ctcgcgttac cctccttccg gacagcaccc cctcccttct
      481 ccggtagctc ctacccctgc ctgtgcgggc ctcgtccccg cgcccagccc tcggtgctgc
      541 ctccgacagc gccgcgctct ctcagccgcc cccctgcccc tcgggccccc ctctctgctg
      601 cccctggcgc catggcgtgc agcctcaagg acgagctgct gtgctccatc tgcctgagca
      661 tctaccagga cccggtgagc ctgggctgcg agcattactt ctgccgccgc tgcatcacgg
      721 agcactgggt gcggcaggag gcgcagggcg cccgcgactg ccccgagtgc cggcgcacgt
      781 tcgccgagcc cgcgctggcg cccagcctca agctggccaa catcgtggag cgctacagct
      841 ccttcccgct ggacgccatc ctcaacgcgc gccgcgccgc gcgaccctgc caggcgcacg
      901 acaaggtcaa gctcttctgc ctcacggacc gcgcgcttct ctgcttcttc tgcgacgagc
      961 ctgcactgca cgagcagcat caggtcaccg gcatcgacga cgccttcgac gagctgcaga
     1021 gggagctgaa ggaccaactt caggcccttc aagacagcga gcgggaacac accgaagcgc
     1081 tgcagctgct caagcgacaa ctggcggaga ccaagtcttc caccaagagc ctgcggacca
     1141 ctatcggcga ggccttcgag cggctgcacc ggctgctgcg tgaacgccag aaggccatgc
     1201 tagaggagct ggaggcggac acggcccgca cgctgaccga catcgagcag aaagtccagc
     1261 gctacagcca gcagctgcgc aaggtccagg agggagccca gatcctgcag gagcggctgg
     1321 ctgaaaccga ccggcacacc ttcctggctg gggtggcctc actgtccgag cggctcaagg
     1381 gaaaaatcca tgagaccaac ctcacatatg aagacttccc gacctccaag tacacaggcc
     1441 ccctgcagta caccatctgg aagtccctgt tccaggacat ccacccagtg ccagccgccc
     1501 taaccctgga cccgggcaca gcccaccagc gcctgatcct gtcggacgac tgcaccattg
     1561 tggcttacgg caacttgcac ccacagccac tgcaggactc gccaaagcgc ttcgatgtgg
     1621 aggtgtcggt gctgggttct gaagccttca gtagtggcgt ccactactgg gaggtggtgg
     1681 tggcggagaa gacccagtgg gtgatcgggc tggcacacga agccgcaagc cgcaagggca
     1741 gcatccagat ccagcccagc cgcggcttct actgcatcgt gatgcacgat ggcaaccagt
     1801 acagcgcctg cacggagccc tggacgcggc ttaacgtccg ggacaagctt gacaaggtgg
     1861 gtgtcttcct ggactatgac caaggcttgc tcatcttcta caatgctgat gacatgtcct
     1921 ggctctacac cttccgcgag aagttccctg gcaagctctg ctcttacttc agccctggcc
     1981 agagccacgc caatggcaag aacgttcagc cgctgcggat caacaccgtc cgcatctagt
     2041 ccaggcagaa ggagaccaca acctcctggg accactgcca cctgcaagag ccctgcccag
     2101 gagatagaag acctggactc cagcccaccg tggccactgg agacctcagg ccagttgttt
     2161 accctccagc ctccagtctg taaaatggag gttgcattcc ctacttccta aactctcttc
     2221 cagcatcgat gttctgtagc tctgaccttg atagggatac agctttgatc caaggatgtg
     2281 acatggcttc tcctcagggc aacccctgcc caaccctcat ccccatcttc tcaggggcag
     2341 gggactacct tccagtgtct ccctccagcc cagccctgac ctcaggaagt gtcagagcat
     2401 ggccagtagt tggcagcccg aaagacacac agcaccctct tatgtcccat ggcctaagac
     2461 ttacccctga ccaagctagt gatgggccat ttacccttga ccccagtcca cagtggtcac
     2521 aggtagtacc tggtcctagg gttgcctgag agccaacctc tcctgccacc cccacaccaa
     2581 gaactatatg gttcctactt ctcccactga tctgctggtc agtgatgatg ctgtggcctg
     2641 tggaaggcac ctggtagttg agtccacaca ttatagtcat gtgccaccac cttcctgccc
     2701 acaggccgag ggacagggtg agggtatacc caaagctgat gcagagccca ttagcctaaa
     2761 agcaactgca ggacaagcct ccctggatga tcgaggtccc cagtagctct gaacaagagt
     2821 ccagccaacc ctcttcagcc aggcctctgt gacctgctag ggtgcaggag gcttccagaa
     2881 gcagttgttg taattaggac ccaagcactg ggaggggctg ttggctggac cccttgtcag
     2941 acttggcatc tatctcagtt aggatcctgc tgcagaaaac aagagccact tgtagctggt
     3001 ttaattagac aaggatttac tacctggccc ctggtggctt gcaaaattgt tggaagagct
     3061 ggagaagcag actctgctga atttccagga actcccagcg ccagattcat catgtctgtt
     3121 gtgaccagga aagctgcccc catctgcagg aagccactat gccagaaagc tgctgactgc
     3181 agaactaggc tccctctgcc acggtccgtg ccagccaata gatgtcctga ggcctgcccc
     3241 tctcccactt cactcagttc ccaaatctaa atttttacaa gagattctgt ttgggggaac
     3301 ttaagtcaga tccagaacct tggctgcaag ggagtctggg aaatgtcatt tccctagaag
     3361 gaagttaggg tgggtggagc aagccccacc tgcgtttttc tgccacagca tccaatcgtg
     3421 aagaactcgg gagagggtgg agtccacatc tagggttgtc ctgccccttg gctctatccc
     3481 tgcccagagg tgggaactgg aggagtgggc tgcaagactg agcctaaatg tctccccggc
     3541 cttgactttt ctttctagtc ctggggccta gattctgcac ttggggtctc tgacacaaca
     3601 caccatccca aagtagccgg aagagctaaa cacagggggt tcttaaaatg gctgcccccg
     3661 ccacccgggc ctcccttggg caaaaggaat tgtcagccct accccaaccc ttcaactacc
     3721 agaatctggg ccaccccagc agtattttta tttaaaatgt tgcccatttt atgagttatg
     3781 atcaatttgt attaaattaa agttacagat gtcagta
//
