LOCUS       NM_001414904            2324 bp    mRNA    linear   PRI 14-JUN-2024
DEFINITION  Homo sapiens tripartite motif containing 61 (TRIM61), transcript
            variant 1, mRNA.
ACCESSION   NM_001414904
VERSION     NM_001414904.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2324)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   2  (bases 1 to 2324)
  AUTHORS   Huang,C.J., Chang,J.G., Wu,S.C. and Choo,K.B.
  TITLE     Negative transcriptional modulation and silencing of the bi-exonic
            Rnf35 gene in the preimplantation embryo. Binding of the
            CCAAT-displacement protein/Cux to the untranslated exon 1 sequence
  JOURNAL   J Biol Chem 280 (35), 30681-30688 (2005)
   PUBMED   15994318
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC106872.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.1652809.1,
                                           SRR14372079.1301056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000710271.1/ ENSP00000518164.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC106872.5         96868-96994         c
            128-265             AC106872.5         96025-96162         c
            266-2324            AC106872.5         87618-89676         c
FEATURES             Location/Qualifiers
     source          1..2324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.3"
     gene            1..2324
                     /gene="TRIM61"
                     /gene_synonym="RNF35"
                     /note="tripartite motif containing 61"
                     /db_xref="GeneID:391712"
                     /db_xref="HGNC:HGNC:24339"
                     /db_xref="MIM:619417"
     exon            1..127
                     /gene="TRIM61"
                     /gene_synonym="RNF35"
                     /inference="alignment:Splign:2.1.0"
     exon            128..265
                     /gene="TRIM61"
                     /gene_synonym="RNF35"
                     /inference="alignment:Splign:2.1.0"
     exon            266..2324
                     /gene="TRIM61"
                     /gene_synonym="RNF35"
                     /inference="alignment:Splign:2.1.0"
     CDS             603..2018
                     /gene="TRIM61"
                     /gene_synonym="RNF35"
                     /note="isoform 1 is encoded by transcript variant 1; ring
                     finger protein 35; putative tripartite motif-containing
                     protein 61"
                     /codon_start=1
                     /product="putative tripartite motif-containing protein 61
                     isoform 1"
                     /protein_id="NP_001401833.1"
                     /db_xref="GeneID:391712"
                     /db_xref="HGNC:HGNC:24339"
                     /db_xref="MIM:619417"
                     /translation="MEFVTALADLRAEASCPICLDYLKDPVTISCGHNFCLSCIIMSW
                     KDLHDSFPCPFCHFCCPERKFISNPQLGSLTEIAKQLQIRSKKRKRQEEKHVCKKHNQ
                     VLTFFCQKDLELLCPRCSLSTDHQHHCVWPIKKAASYHRKKLEEYNAPWKERVELIEK
                     VITMQTRKSLELKKKVKHRAEEVKSEFEQLRLFLQNEQETVLRQLQDEEMDILAQLNE
                     SLTKFSDYTSSLKYLLKEIESIYVKSELELLANVKDIYHRYENLKFPELFLFKLKKYG
                     YHLPPQYSGLDKIIKRFQVDVILDPETAHRKLIVSEDRKTVRYGNTTQNVPHNPRRFY
                     LLPAVLGSKGYSCGRQYWEVEVKDKPEWILGVCNDCLPRRRKSQPILVQDGLWGIWRS
                     SQNNYIVLGHREIILLPQVIPSKIGIFLDYEMNEVSFYNLNDRSLLYTFNDNFTGALW
                     PYFYTGTDSKPLKISTVTDSE"
     regulatory      2297..2302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM61"
                     /gene_synonym="RNF35"
                     /note="hexamer: AATAAA"
     polyA_site      2324
                     /gene="TRIM61"
                     /gene_synonym="RNF35"
                     /note="major polyA site"
ORIGIN      
        1 accgcgcagg ctgagcccca ggcaggaagc agcccacttg gtggggttgg ggtatgagtc
       61 cttcctcgcg ggggctcggt gggtcctgag tattctttgg ccggatttgc tgatccgtct
      121 gctccagcat aggttcacaa agtacagtcc gcaggccagc agcatcatct gggaacttag
      181 gaaaaaacca gccctactga gtcagaaact ggggatgtgg cccaggcaat cttttaccaa
      241 gacctccagg tgattataat gcaaggaagg attccctatc ttggacctga ggctgctttc
      301 ttgaagaaaa cttgacttta tttcatttag tgggaagagc agcagcccag ctattaagtt
      361 ctaatatgca ataggctgca ggctgtgaag tgttcgtggc agtagactct gaagctaagg
      421 agctgagggc ttaacaagtt tctagaagct gccatcaaca tgccaagtca gtaaaactga
      481 tagttgatca gatttcaagg tctggggagt atatccactg tgtactgggt cttgagctct
      541 agagagctag gccttgctaa aataaaagaa ttaccttacc taccatcttt gttcaagtct
      601 caatggaatt tgttacggcc ctggctgacc tccgagcaga ggctagctgt cccatctgtc
      661 tggactactt gaaagaccca gtgaccatca gctgtgggca taacttctgt ctctcctgca
      721 tcattatgtc ctggaaggat ctacatgata gtttcccctg ccccttttgc cacttttgct
      781 gtccagaaag gaaatttata agcaatcccc agctgggtag tttgactgaa attgctaagc
      841 aactccagat aagaagcaag aagaggaaga ggcaggaaga gaagcatgtg tgtaagaagc
      901 ataatcaggt tttgactttc ttctgtcaga aagacctaga gcttttatgt ccaaggtgca
      961 gtttgtccac tgatcaccag catcactgtg tttggcccat aaagaaggct gcctcctatc
     1021 ataggaaaaa actggaggaa tacaatgcac cgtggaagga gagagtggaa ctaattgaaa
     1081 aagtcataac tatgcaaacc aggaaatcac tggaactgaa gaaaaaggta aaacataggg
     1141 cagaagaagt caagtctgaa tttgagcaac ttaggttatt tctccaaaat gagcaagaga
     1201 ctgttcttag gcaattacaa gatgaagaga tggatatttt agcacaacta aatgaaagcc
     1261 taacaaaatt ttcagattat acctcctcat taaaatatct actaaaggag atagagagca
     1321 tatatgtgaa gtcagaactg gaattactgg caaatgttaa ggatatctat cacagatatg
     1381 agaatttaaa attccctgag ctgtttttat tcaaattaaa aaaatatggt taccatctgc
     1441 ctccacaata ttctggccta gacaaaatta tcaagcgatt tcaagtagat gtaattctag
     1501 atcctgaaac agcacatcgt aaacttatag tctcagaaga tagaaaaact gtgcgctatg
     1561 gaaatacaac acaaaatgta cctcataacc caagaagatt ttatctcctc ccagctgttc
     1621 tgggttctaa gggatatagt tgtggcaggc agtactggga agtagaagtg aaagacaagc
     1681 ctgaatggat tcttggtgtc tgtaatgact gtcttcccag aaggaggaag agtcaaccaa
     1741 ttttagtaca ggatggatta tggggaattt ggcgatctag tcagaataat tatattgtat
     1801 tgggccacag ggaaattatt ctgctgccac aagtaattcc tagtaagatt ggcatttttt
     1861 tagactatga aatgaatgaa gtttcctttt ataatttgaa tgatagatct cttctctata
     1921 cttttaatga taattttaca ggagcacttt ggccttattt ttatactgga actgactcaa
     1981 aacctcttaa aatttctaca gtaacagatt ctgaatgaat tattagaaga ctcagtttct
     2041 ttcacctagt agacataact gagccagtga atctagtttt ggctattctg tattttgtcc
     2101 agtttttccc ataagaaagc aatatttttt tatctcagtt tcagcaactt ccaaaaaatg
     2161 tgattatggg acctacttta tattaaatta tggggtcagt gacaaggtac tttagaaatt
     2221 ctacagtaaa atacttgaaa catatattac tgaagaaatg tattatgtaa gaaaatctat
     2281 tacttttgta attgccaata aaagcccagt aatttttttc tgta
//
