LOCUS       NM_152620               1847 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens tripartite motif containing 60 (TRIM60), transcript
            variant 2, mRNA.
ACCESSION   NM_152620
VERSION     NM_152620.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1847)
  AUTHORS   Gu,Z., Chen,X., Yang,W., Qi,Y., Yu,H., Wang,X., Gong,Y., Chen,Q.,
            Zhong,B., Dai,L., Qi,S., Zhang,Z., Zhang,H. and Hu,H.
  TITLE     The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-kappaB
            activation and the innate immune response
  JOURNAL   Cell Mol Immunol 18 (8), 1981-1994 (2021)
   PUBMED   33184450
REFERENCE   2  (bases 1 to 1847)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1847)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1847)
  AUTHORS   Saurin,A.J., Borden,K.L., Boddy,M.N. and Freemont,P.S.
  TITLE     Does this have a familiar RING?
  JOURNAL   Trends Biochem Sci 21 (6), 208-214 (1996)
   PUBMED   8744354
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK093201.1 and AC106872.5.
            
            On Nov 22, 2018 this sequence version replaced NM_152620.2.
            
            Summary: The protein encoded by this gene contains a RING finger
            domain, a motif present in a variety of functionally distinct
            proteins and known to be involved in protein-protein and
            protein-DNA interactions. Pseudogenes of this gene are located on
            more than six chromosomes including chromosome 4. Multiple
            alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK093201.1, HY008149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000512596.6/ ENSP00000421142.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-880               AK093201.1         2-881
            881-1668            AC106872.5         160120-160907
            1669-1842           AK093201.1         1670-1843
            1843-1847           AC106872.5         161082-161086
FEATURES             Location/Qualifiers
     source          1..1847
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.3"
     gene            1..1847
                     /gene="TRIM60"
                     /gene_synonym="RNF129; RNF33"
                     /note="tripartite motif containing 60"
                     /db_xref="GeneID:166655"
                     /db_xref="HGNC:HGNC:21162"
                     /db_xref="MIM:619416"
     exon            1..114
                     /gene="TRIM60"
                     /gene_synonym="RNF129; RNF33"
                     /inference="alignment:Splign:2.1.0"
     exon            115..166
                     /gene="TRIM60"
                     /gene_synonym="RNF129; RNF33"
                     /inference="alignment:Splign:2.1.0"
     exon            167..1847
                     /gene="TRIM60"
                     /gene_synonym="RNF129; RNF33"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1586
                     /gene="TRIM60"
                     /gene_synonym="RNF129; RNF33"
                     /note="ring finger protein 33; ring finger protein 129"
                     /codon_start=1
                     /product="tripartite motif-containing protein 60"
                     /protein_id="NP_689833.1"
                     /db_xref="CCDS:CCDS3808.1"
                     /db_xref="GeneID:166655"
                     /db_xref="HGNC:HGNC:21162"
                     /db_xref="MIM:619416"
                     /translation="MEFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSW
                     KDLDDTFPCPVCRFCFPYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQ
                     FLTLFCVKDLEILCTQCSFSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEK
                     VIILQGSKSVELKKKVEYKREEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNE
                     NLVELSDYVSTLKHLLREVEGKSVQSNLELLTQAKSMHHKYQNLKCPELFSFRLTKYG
                     FSLPPQYSGLDRIIKPFQVDVILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFY
                     VCPAVLGSQRFSSGRHYWEVEVGNKPKWILGVCQDCLLRNWQDQPSVLGGFWAIGRYM
                     KSGYVASGPKTTQLLPVVKPSKIGIFLDYELGDLSFYNMNDRSILYTFNDCFTEAVWP
                     YFYTGTDSEPLKICSVSDSER"
     regulatory      1821..1826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM60"
                     /gene_synonym="RNF129; RNF33"
                     /note="hexamer: AATAAA"
     polyA_site      1847
                     /gene="TRIM60"
                     /gene_synonym="RNF129; RNF33"
                     /note="major polyA site"
ORIGIN      
        1 aaaactcgaa aaccaaggcg cccagggttg tgtgagggtt tccgctctgc gccccgcggg
       61 gttccatggg tcctgcacag catcaggcct gagccgccgg tccaactgct ccaggtcatc
      121 agtttgcccc atcattggtt aaggtggtat tctctacatt ataaagctcg atggagtttg
      181 tgacagccct ggtgaacctc caagaggagt ctagctgtcc catctgtctg gagtacttga
      241 aagacccagt gaccatcaac tgtgggcaca acttctgtcg ctcctgcctc agtgtatcct
      301 ggaaggatct agatgatacc tttccctgtc ctgtctgccg tttttgcttt ccatacaaga
      361 gcttcaggag gaacccccag ctccgtaatt tgactgaaat tgctaaacaa ctccagatta
      421 ggaggagcaa gagaaagagg cagaaagaga atgccatgtg tgaaaaacac aaccagtttc
      481 tgaccctctt ctgtgttaaa gatctagaga tcttatgtac acagtgcagt ttctccacta
      541 aacaccagaa gcactacatt tgccctatta agaaagctgc ctcttatcac agagaaattc
      601 tagaaggtag ccttgagccc ttgaggaata atatagaacg agttgaaaaa gtgataattc
      661 tgcaaggcag caaatcagtg gagctgaaaa agaaggtaga atataagagg gaagaaataa
      721 attctgagtt tgagcaaata agattgtttt tacagaatga acaagagatg attcttaggc
      781 agatacaaga tgaagagatg aacattttag caaaactaaa tgaaaacctt gtagaacttt
      841 cagattatgt ttccacatta aaacatctac tgagggaggt agagggcaag tctgtgcagt
      901 caaacctgga attactgaca caagctaaga gtatgcacca caagtatcaa aacctaaaat
      961 gccctgaact cttttcattt agattaacaa aatatggttt cagtcttcct cctcaatatt
     1021 ctggcttgga cagaattatc aagccatttc aagtagatgt gattctagat ctcaacacag
     1081 cacatcctca acttcttgtc tctgaggata gaaaagctgt gcgatatgaa agaaaaaaac
     1141 gaaacatttg ttatgaccca aggagatttt atgtctgccc tgctgtccta ggctctcaga
     1201 gatttagttc tggccgacat tactgggaag tagaagtggg aaacaaacct aaatggatat
     1261 tgggtgtgtg tcaagactgt cttcttagga actggcagga tcagccatca gttctgggcg
     1321 gattctgggc aattgggcga tacatgaaga gtggttatgt tgcgtcaggt cctaagacaa
     1381 cccagcttct gccagtagta aaacccagta aaattggtat ttttctggac tatgaattgg
     1441 gtgatctttc cttttataat atgaatgata ggtctattct ctatactttt aacgattgtt
     1501 tcacagaagc cgtttggcct tatttctata ctggaacaga ttccgaacct cttaaaatct
     1561 gctcagtatc agattctgaa agataaggaa ctggtaaatg ggtctgtttc agtttttgta
     1621 ggtaacttag ccagtaaatt taatctcatt tctggactct ttaagtttta ccactgaaaa
     1681 ccagagtcga tttttctcct aaatttttgg caactataag atgttcataa tgccactttc
     1741 atatattcta tgaatatcaa ttgtcaggtg ctttgatttc taagataaaa tattttagaa
     1801 ttatgttact taacatgtcc aataaaatgt tttcaaattg cctataa
//
