LOCUS       NM_001003819            3479 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens TRIM6-TRIM34 readthrough (TRIM6-TRIM34), mRNA.
ACCESSION   NM_001003819
VERSION     NM_001003819.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3479)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   2  (bases 1 to 3479)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3479)
  AUTHORS   Li,X., Li,Y., Stremlau,M., Yuan,W., Song,B., Perron,M. and
            Sodroski,J.
  TITLE     Functional replacement of the RING, B-box 2, and coiled-coil
            domains of tripartite motif 5alpha (TRIM5alpha) by heterologous
            TRIM domains
  JOURNAL   J Virol 80 (13), 6198-6206 (2006)
   PUBMED   16775307
  REMARK    GeneRIF: heterologous RING, B-box 2, and CC domains from related
            TRIM proteins can functionally substitute for TRIM5alpha(rh)
            domains.
REFERENCE   4  (bases 1 to 3479)
  AUTHORS   Orimo,A., Tominaga,N., Yoshimura,K., Yamauchi,Y., Nomura,M.,
            Sato,M., Nogi,Y., Suzuki,M., Suzuki,H., Ikeda,K., Inoue,S. and
            Muramatsu,M.
  TITLE     Molecular cloning of ring finger protein 21
            (RNF21)/interferon-responsive finger protein (ifp1), which
            possesses two RING-B box-coiled coil domains in tandem
  JOURNAL   Genomics 69 (1), 143-149 (2000)
   PUBMED   11013086
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015691.6, BC140722.1 and AB039903.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001003819.3.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
            and a coiled-coil region. This gene represents a readthrough
            transcript from genes TRIM6 and TRIM34, and it was described as a
            splice variant of TRIM34. This gene is mapped to chromosome 11p15,
            where it resides within a TRIM gene cluster. [provided by RefSeq,
            Nov 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB039903.1, BC140722.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 53840, 117854
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC015691.6         69234-69312         c
            80-2824             BC140722.1         1-2745
            2825-2825           AC015691.6         22205-22205         c
            2826-3075           BC140722.1         2747-2996
            3076-3076           AC015691.6         21954-21954         c
            3077-3104           BC140722.1         2998-3025
            3105-3479           AB039903.1         3015-3389
FEATURES             Location/Qualifiers
     source          1..3479
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..3479
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /note="TRIM6-TRIM34 readthrough"
                     /db_xref="GeneID:445372"
                     /db_xref="HGNC:HGNC:33440"
     exon            1..278
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..2790
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /note="interferon-responsive finger protein 1 long form;
                     Tripartite motif-containing protein 34; RING finger
                     protein 21; Tripartite motif-containing protein 6; RING
                     finger protein 89; RING-type E3 ubiquitin transferase
                     TRIM6"
                     /codon_start=1
                     /product="tripartite motif-containing 6 and tripartite
                     motif-containing 34"
                     /protein_id="NP_001003819.1"
                     /db_xref="GeneID:445372"
                     /db_xref="HGNC:HGNC:33440"
                     /translation="MCGSERILQAGNILEIRVGQAGARRVATMTSPVLVDIREEVTCP
                     ICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQPGNLRPNRHL
                     ANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERSQEHRGHHTFL
                     VEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQTEFNQL
                     RNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQGSTMEL
                     LQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWAIQGSL
                     TRRERRASGVRTRRSQGSSAMASKILLNVQEEVTCPICLELLTEPLSLDCGHSLCRAC
                     ITVSNKEAVTSMGGKSSCPVCGISYSFEHLQANQHLANIVERLKEVKLSPDNGKKRDL
                     CDHHGEKLLLFCKEDRKVICWLCERSQEHRGHHTVLTEEVFKECQEKLQAVLKRLKKE
                     EEEAEKLEADIREEKTSWKYQVQTERQRIQTEFDQLRSILNNEEQRELQRLEEEEKKT
                     LDKFAEAEDELVQQKQLVRELISDVECRSQWSTMELLQDMSGIMKWSEIWRLKKPKMV
                     SKKLKTVFHAPDLSRMLQMFRELTAVRCYWVDVTLNSVNLNLNLVLSEDQRQVISVPI
                     WPFQCYNYGVLGSQYFSSGKHYWEVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQN
                     LYTKYRPLFGYWVIGLQNKCKYGVFEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIV
                     SFFNVTSHGSLIYKFSKCCFSQPVYPYFNPWNCPAPMTLCPPSS"
     exon            279..768
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /inference="alignment:Splign:2.1.0"
     exon            769..864
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1095
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1118
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1219
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1246
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1746
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1842
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2073
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2096
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2197
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2224
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..3479
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3449..3454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /note="hexamer: AATAAA"
     polyA_site      3479
                     /gene="TRIM6-TRIM34"
                     /gene_synonym="IFP1; RNF21; RNF89; TRIM34; TRIM6"
                     /note="major polyA site"
ORIGIN      
        1 agaaggagtt gggagatgag ccttccgcaa actcctgacc tgtgggtccg tccgttcaac
       61 ggccaaaggc tggcggagga gggatcccct gcctttctcg gaacggaacg gagcagagtc
      121 gtgcgtggtt gagtttagat aaaagccgag tgagcgcgct ctgttcctta agattagttt
      181 aaggtgcctt ggattgctct gaagagcttt gaccacctga tattgcttac atctggaact
      241 tcttggcttc tcattcccca gatgtgcggg tcagagagga ttctacaggc aggaaacatc
      301 ttagaaatca gggttgggca ggcaggagcc aggagagtag ctacaatgac ttcaccagta
      361 ctggtggaca tacgagaaga ggtgacctgc cctatctgcc tggagctcct aacagaaccc
      421 ctgagcatag actgtggcca cagcttctgc caagcctgca tcacaccaaa tggcagggaa
      481 tcagtgattg gtcaagaagg ggaaagaagc tgccctgtgt gccagaccag ctaccagcca
      541 gggaacctgc ggcctaatcg gcatctggcc aacatagtga ggcggctcag agaggtagtg
      601 ttgggccctg ggaagcagct gaaagcagtt ctttgtgcag accatggaga aaaactgcag
      661 ctcttctgtc aggaggatgg gaaggtcatt tgctggcttt gtgagcggtc tcaggagcac
      721 cgtggtcacc acacgttcct cgtggaggag gttgcccagg agtaccagga gaagtttcag
      781 gagtctctaa agaagctgaa gaacgaggag caggaagctg agaagctaac agcttttatc
      841 agagagaaga aaacatcctg gaagaatcag atggagcctg agagatgcag gatccagaca
      901 gagtttaatc agctgcgaaa tatcctagac agagtggagc aacgggagct gaaaaagctg
      961 gaacaggaag agaagaaggg gctacgaatt atagaagagg ctgagaatga tctggtccac
     1021 cagacccagt cgctgcgaga gctcatctcg gatctggagc gtcgatgtca ggggtcaaca
     1081 atggagctgc tgcaggatgt gagtgatgtc acagaaagga gtgagttctg gaccctgagg
     1141 aagccagaag ctctccctac aaagctgaga agtatgttcc gagccccaga tctgaaaagg
     1201 atgctgcgag tgtgtagaga gctgacagat gtccaaagct actgggccat ccaggggtct
     1261 ttaaccagaa gagagaggag agcctcagga gttaggacca gaagaagcca gggaagcagt
     1321 gcaatggctt caaaaatctt gcttaacgta caagaggagg tgacctgtcc catctgcctg
     1381 gagctgttga cagaaccctt gagtctagac tgtggccaca gcctctgccg agcctgcatc
     1441 actgtgagca acaaggaggc agtgaccagc atgggaggaa aaagcagctg tcctgtgtgt
     1501 ggtatcagtt actcatttga acatctacag gctaatcagc atctggccaa catagtggag
     1561 agactcaagg aggtcaagtt gagcccagac aatgggaaga agagagatct ctgtgatcat
     1621 catggagaga aactcctact cttctgtaag gaggatagga aagtcatttg ctggctttgt
     1681 gagcggtctc aggagcaccg tggtcaccac acagtcctca cggaggaagt attcaaggaa
     1741 tgtcaggaga aactccaggc agtcctcaag aggctgaaga aggaagagga ggaagctgag
     1801 aagctggaag ctgacatcag agaagagaaa acttcctgga agtatcaggt acaaactgag
     1861 agacaaagga tacaaacaga atttgatcag cttagaagca tcctaaataa tgaggagcag
     1921 agagagctgc aaagattgga agaagaagaa aagaagacgc tggataagtt tgcagaggct
     1981 gaggatgagc tagttcagca gaagcagttg gtgagagagc tcatctcaga tgtggagtgt
     2041 cggagtcagt ggtcaacaat ggagctgctg caggacatga gtggaatcat gaaatggagt
     2101 gagatctgga ggctgaaaaa gccaaaaatg gtttccaaga aactgaagac tgtattccat
     2161 gctccagatc tgagtaggat gctgcaaatg tttagagaac tgacagctgt ccggtgctac
     2221 tgggtggatg tcacactgaa ttcagtcaac ctaaatttga atcttgtcct ttcagaagat
     2281 cagagacaag tgatatctgt gccaatttgg ccttttcagt gttataatta tggtgtcttg
     2341 ggatcccaat atttctcctc tgggaaacat tactgggaag tggacgtgtc caagaaaact
     2401 gcctggatcc tgggggtata ctgtagaaca tattcccgcc atatgaagta tgttgttaga
     2461 agatgtgcaa atcgtcaaaa tctttacacc aaatacagac ctctatttgg ctactgggtt
     2521 atagggttac agaataaatg taagtatggt gtctttgaag agtctttgtc ctctgatccc
     2581 gaggttttga ctctctccat ggctgtgcct ccctgccgtg ttggggtttt cctcgactat
     2641 gaagcaggca ttgtctcatt tttcaatgtc acaagccatg gctccctcat ttacaagttc
     2701 tctaaatgtt gcttttctca gcctgtttat ccatatttca atccttggaa ctgtccagct
     2761 cccatgactc tatgcccacc aagctcttga attttctcat ttcttcacct acaacccttt
     2821 gtcttgactt atctcctgca actgactcat ctgcaacatt cacaccattg cttccttgtg
     2881 gtttcccttc tttagaactt ttactcatcc ttgagatgta tggtgtattt ggcttgagtt
     2941 atgagagatg cttatttatt catttactct ttttcatatt ttcagagaaa gttacctaat
     3001 ccctcctaaa gacacagcag tatgggtata acatccttgc cttcccattt atccatgttt
     3061 cactttatca ctgatatgaa gaggcccaaa gcctgttagc caccatccat gctacctagg
     3121 tagtccatag gaaccacccc catgaccacc accaacatca actaaaggtt cttggagggt
     3181 atgtcagtgt gttgctcagg ataccccagg tacatcaagg aatcaaggag aggaaaatat
     3241 gagcaatatg tgtattcaga gtgaagattt tatgtccaga gtatttgagc tcaaaccttg
     3301 cctgttgttt tctaatcatg atgaatactt tctcagtttc tttttcctga aatataaatt
     3361 gggatttaag actgtaccta actattaaga tcactgtgta aaactaagtg tctctaaatg
     3421 taatgcatcg atttagtgtc tggaacataa taaatatttg ctctcatgat tgctaaaaa
//
