LOCUS       NM_001003818            3422 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens tripartite motif containing 6 (TRIM6), transcript
            variant 1, mRNA.
ACCESSION   NM_001003818
VERSION     NM_001003818.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3422)
  AUTHORS   Zhou,J., Zhou,Y., Wei,X.F., Fan,L., Gao,X., Li,Y., Wu,Y., Feng,W.,
            Shen,X., Liu,L., Xu,G. and Zhang,Z.
  TITLE     TRIM6 facilitates SARS-CoV-2 proliferation by catalyzing the
            K29-typed ubiquitination of NP to enhance the ability to bind viral
            genomes
  JOURNAL   J Med Virol 96 (3), e29531 (2024)
   PUBMED   38515377
  REMARK    GeneRIF: TRIM6 facilitates SARS-CoV-2 proliferation by catalyzing
            the K29-typed ubiquitination of NP to enhance the ability to bind
            viral genomes.
REFERENCE   2  (bases 1 to 3422)
  AUTHORS   Liao,L., Tao,P., Xu,Q., Chen,W., Chen,J., Liu,W., Liu,W., Hu,J. and
            Lu,J.
  TITLE     TRIM6 Promotes ROS-Mediated Inflammasome Activation and Pyroptosis
            in Renal Tubular Epithelial Cells via Ubiquitination and
            Degradation of GPX3 Protein
  JOURNAL   Front Biosci (Landmark Ed) 29 (2), 58 (2024)
   PUBMED   38420829
  REMARK    GeneRIF: TRIM6 Promotes ROS-Mediated Inflammasome Activation and
            Pyroptosis in Renal Tubular Epithelial Cells via Ubiquitination and
            Degradation of GPX3 Protein.
REFERENCE   3  (bases 1 to 3422)
  AUTHORS   Liu,X., Zhao,J., Dong,P., Du,X., Lu,W., Feng,Y. and Wang,L.
  TITLE     TRIM6 silencing for inhibiting growth and angiogenesis of gliomas
            by regulating VEGFA
  JOURNAL   J Chem Neuroanat 132, 102291 (2023)
   PUBMED   37236551
  REMARK    GeneRIF: TRIM6 silencing for inhibiting growth and angiogenesis of
            gliomas by regulating VEGFA.
REFERENCE   4  (bases 1 to 3422)
  AUTHORS   Guo,J., Feng,S., Liu,H., Chen,Z., Ding,C., Jin,Y., Chen,X.,
            Ling,Y., Zeng,Y., Long,H. and Qiu,H.
  TITLE     TRIM6: An Upregulated Biomarker with Prognostic Significance and
            Immune Correlations in Gliomas
  JOURNAL   Biomolecules 13 (9), 1298 (2023)
   PUBMED   37759698
  REMARK    GeneRIF: TRIM6: An Upregulated Biomarker with Prognostic
            Significance and Immune Correlations in Gliomas.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3422)
  AUTHORS   Zhang,Y., Yuan,L., Cui,S. and Wu,S.
  TITLE     Tripartite motif protein 6 promotes hepatocellular carcinoma
            progression via multiple pathways
  JOURNAL   Turk J Med Sci 53 (5), 1032-1044 (2023)
   PUBMED   38813007
  REMARK    GeneRIF: Tripartite motif protein 6 promotes hepatocellular
            carcinoma progression via multiple pathways.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3422)
  AUTHORS   Li,X., Gold,B., O'hUigin,C., Diaz-Griffero,F., Song,B., Si,Z.,
            Li,Y., Yuan,W., Stremlau,M., Mische,C., Javanbakht,H., Scally,M.,
            Winkler,C., Dean,M. and Sodroski,J.
  TITLE     Unique features of TRIM5alpha among closely related human TRIM
            family members
  JOURNAL   Virology 360 (2), 419-433 (2007)
   PUBMED   17156811
REFERENCE   7  (bases 1 to 3422)
  AUTHORS   Li,X., Li,Y., Stremlau,M., Yuan,W., Song,B., Perron,M. and
            Sodroski,J.
  TITLE     Functional replacement of the RING, B-box 2, and coiled-coil
            domains of tripartite motif 5alpha (TRIM5alpha) by heterologous
            TRIM domains
  JOURNAL   J Virol 80 (13), 6198-6206 (2006)
   PUBMED   16775307
  REMARK    GeneRIF: heterologous RING, B-box 2, and CC domains from related
            TRIM proteins can functionally substitute for TRIM5alpha(rh)
            domains.
REFERENCE   8  (bases 1 to 3422)
  AUTHORS   Woo,J.S., Imm,J.H., Min,C.K., Kim,K.J., Cha,S.S. and Oh,B.H.
  TITLE     Structural and functional insights into the B30.2/SPRY domain
  JOURNAL   EMBO J 25 (6), 1353-1363 (2006)
   PUBMED   16498413
REFERENCE   9  (bases 1 to 3422)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   10 (bases 1 to 3422)
  AUTHORS   Orimo,A., Tominaga,N., Yoshimura,K., Yamauchi,Y., Nomura,M.,
            Sato,M., Nogi,Y., Suzuki,M., Suzuki,H., Ikeda,K., Inoue,S. and
            Muramatsu,M.
  TITLE     Molecular cloning of ring finger protein 21
            (RNF21)/interferon-responsive finger protein (ifp1), which
            possesses two RING-B box-coiled coil domains in tandem
  JOURNAL   Genomics 69 (1), 143-149 (2000)
   PUBMED   11013086
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK290172.1, BC047564.1,
            AK316178.1 and AF220030.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001003818.2.
            
            Summary: The protein encoded by this gene is a member of the
            tripartite motif (TRIM) family. The TRIM motif includes three
            zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain,
            and a coiled-coil region. The protein localizes to the nucleus, but
            its specific function has not been identified. This gene is mapped
            to chromosome 11p15, where it resides within a TRIM gene cluster.
            Alternative splicing results in multiple transcript variants. A
            read-through transcript from this gene into the downstream TRIM34
            gene has also been observed, which results in a fusion product from
            these neighboring family members. [provided by RefSeq, Oct 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047564.1, SRR1803611.47676.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380097.8/ ENSP00000369440.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AK290172.1         3-31
            30-49               BC047564.1         11-30
            50-851              AK290172.1         52-853
            852-1451            AK316178.1         321-920
            1452-1841           AK290172.1         1454-1843
            1842-3422           AF220030.1         1633-3213
FEATURES             Location/Qualifiers
     source          1..3422
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..3422
                     /gene="TRIM6"
                     /gene_synonym="RNF89"
                     /note="tripartite motif containing 6"
                     /db_xref="GeneID:117854"
                     /db_xref="HGNC:HGNC:16277"
                     /db_xref="MIM:607564"
     exon            1..278
                     /gene="TRIM6"
                     /gene_synonym="RNF89"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1812
                     /gene="TRIM6"
                     /gene_synonym="RNF89"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; RING
                     finger protein 89; RING-type E3 ubiquitin transferase
                     TRIM6"
                     /codon_start=1
                     /product="tripartite motif-containing protein 6 isoform 1"
                     /protein_id="NP_001003818.1"
                     /db_xref="CCDS:CCDS31389.1"
                     /db_xref="GeneID:117854"
                     /db_xref="HGNC:HGNC:16277"
                     /db_xref="MIM:607564"
                     /translation="MCGSERILQAGNILEIRVGQAGARRVATMTSPVLVDIREEVTCP
                     ICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQPGNLRPNRHL
                     ANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLCERSQEHRGHHTFL
                     VEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQTEFNQL
                     RNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLERRCQGSTMEL
                     LQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWVDVTLN
                     PHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCSVLGSQHFSSGKHYWEVDVAKK
                     TAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYEDSSPSL
                     LLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNCVIP
                     MTLRRPSS"
     exon            279..768
                     /gene="TRIM6"
                     /gene_synonym="RNF89"
                     /inference="alignment:Splign:2.1.0"
     exon            769..864
                     /gene="TRIM6"
                     /gene_synonym="RNF89"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1095
                     /gene="TRIM6"
                     /gene_synonym="RNF89"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1118
                     /gene="TRIM6"
                     /gene_synonym="RNF89"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1219
                     /gene="TRIM6"
                     /gene_synonym="RNF89"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1246
                     /gene="TRIM6"
                     /gene_synonym="RNF89"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..3422
                     /gene="TRIM6"
                     /gene_synonym="RNF89"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3400..3405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM6"
                     /gene_synonym="RNF89"
                     /note="hexamer: AATAAA"
     polyA_site      3422
                     /gene="TRIM6"
                     /gene_synonym="RNF89"
                     /note="major polyA site"
ORIGIN      
        1 agaaggagtt gggagatgag ccttccgcaa actcctgacc tgtgggtccg tccgttcaac
       61 ggccaaaggc tggcggagga gggatcccct gcctttctcg gaacggaacg gagcagagtc
      121 gtgcgtggtt gagtttagat aaaagccgag tgagcgcgct ctgttcctta agattagttt
      181 aaggtgcctt ggattgctct gaagagcttt gaccacctga tattgcttac atctggaact
      241 tcttggcttc tcattcccca gatgtgcggg tcagagagga ttctacaggc aggaaacatc
      301 ttagaaatca gggttgggca ggcaggagcc aggagagtag ctacaatgac ttcaccagta
      361 ctggtggaca tacgagaaga ggtgacctgc cctatctgcc tggagctcct aacagaaccc
      421 ctgagcatag actgtggcca cagcttctgc caagcctgca tcacaccaaa tggcagggaa
      481 tcagtgattg gtcaagaagg ggaaagaagc tgccctgtgt gccagaccag ctaccagcca
      541 gggaacctgc ggcctaatcg gcatctggcc aacatagtga ggcggctcag agaggtagtg
      601 ttgggccctg ggaagcagct gaaagcagtt ctttgtgcag accatggaga aaaactgcag
      661 ctcttctgtc aggaggatgg gaaggtcatt tgctggcttt gtgagcggtc tcaggagcac
      721 cgtggtcacc acacgttcct cgtggaggag gttgcccagg agtaccagga gaagtttcag
      781 gagtctctaa agaagctgaa gaacgaggag caggaagctg agaagctaac agcttttatc
      841 agagagaaga aaacatcctg gaagaatcag atggagcctg agagatgcag gatccagaca
      901 gagtttaatc agctgcgaaa tatcctagac agagtggagc aacgggagct gaaaaagctg
      961 gaacaggaag agaagaaggg gctacgaatt atagaagagg ctgagaatga tctggtccac
     1021 cagacccagt cgctgcgaga gctcatctcg gatctggagc gtcgatgtca ggggtcaaca
     1081 atggagctgc tgcaggatgt gagtgatgtc acagaaagga gtgagttctg gaccctgagg
     1141 aagccagaag ctctccctac aaagctgaga agtatgttcc gagccccaga tctgaaaagg
     1201 atgctgcgag tgtgtagaga gctgacagat gtccaaagct actgggttga cgtgaccctg
     1261 aatccacaca cagctaattt aaatcttgtc ctggctaaaa accggagaca agtgaggttt
     1321 gtgggagcta aagtatctgg accttcctgt ctggaaaagc attatgactg tagtgtcctg
     1381 ggctcccagc acttctcctc tggtaagcat tactgggagg tagatgtggc caagaagact
     1441 gcctggatcc tgggggtatg cagcaattca ctgggaccta cattctcttt caaccatttt
     1501 gctcaaaatc acagtgctta ctccaggtat cagcctcaga gtggatactg ggtgattggg
     1561 ttacagcata accatgaata tagggcctat gaggattctt ccccttccct gcttctctcc
     1621 atgacagtgc cccctcgccg tgttggggtt ttcttagatt atgaggctgg tactgtctcc
     1681 ttttataatg tcacaaacca tggcttcccc atctacactt tctctaaata ttactttccc
     1741 actactcttt gtccatattt taatccttgc aactgtgtaa ttcctatgac cctgcgtcgt
     1801 ccaagctctt gaatattctt ctgttcccac ccacttctga taagtaccct gaggcttatc
     1861 agcatgtgat tctcccttct gatcttctgt ttttctgtgt tctcaattct tttgttgttt
     1921 tttggttttt gaatcttttt tgagatggaa tctcgctctg tcgcccaggc tggagtgcac
     1981 tggcgcaatc tcggctcact gcaacctctg cctcctgggt tcaagcgaac ctcctgcctc
     2041 agcatcccaa gtagctggga ttacaggcac ccaccaccat gcccaactaa tttttgtatt
     2101 tttatagaga tagggtttca ccgtgttggc caggctgatc tcgaactcct gaccgcaagt
     2161 gatccacccg cctcggtctc ccaaagtgct gggattacag atgtgagccg ccgcgcccag
     2221 acagttcttt cgttttaaac agttactcag tactaggatg cacccagtgg tgagagtaag
     2281 catctttgac tgatgacagg tcttgaggtg gatagggggc gctttcagta ttttgccatt
     2341 aagcatagta tttgatgcag gttttttttg attgatgcag gggatcaaat ttaggaagtt
     2401 ctgatctgtt aatttactac aagtttttgt ataaaatgaa aactcgtatt ctacctatgt
     2461 cttttctgta aattattgag acaattgtgt atcatttttg ttctgttaat gtggcttagt
     2521 acattgattt acttcaattt gttaccacaa cttgctgaaa tacaccatta ttatttgttg
     2581 tatgcaatac tggatttatt ttgataacgt attgtttaga ttttgttctc atctatgtta
     2641 atgaaagaaa ttggcctgta tttttacatt cttgtaatat ctttgccagg ttctataaaa
     2701 tgcaataata agcaaataaa ttactttgtt tttgtataag tatgtatagg attgagctct
     2761 aaaaccaaac cattataatg ataatttggg tagcttcaaa ctcaaattga agagagtctt
     2821 cactacaatc ttcactacaa cctttggcct tcctctctac atttaagagt agcaatagaa
     2881 caataaaaaa aaatacgtct ttcaaattaa ttgcagtaaa aacaaaagag tagtggggag
     2941 agaaaaacaa tccaatacat atttttctct cagaatagaa agaaaacaca aagagaaaat
     3001 atgaacaata taaagcactt aaaggaagag gatgatttct tccagctttt ccacactctc
     3061 tttatgcgca ggaacaaaca gctgttgagt gagctgctat gactttggta gagaggtgca
     3121 atatgttttt tgaaccagct ataaaagaaa ttaagaggta catgtgaggg tagaaacaaa
     3181 tatcaaggat gagaatggca ctggctgtcc catatggtat ccaggagcca ccaatgtctg
     3241 ttgagtactt catacatgcc tagtctgaat tgagatgtgc tcaatgtata aaatatatac
     3301 cagatttcaa atacctactt caaaaaataa tgtaaaatat ctcactaata acttttcctt
     3361 tgtgtattgc aatgataata tgttggctct attggattaa ataaagtatg ttattcattt
     3421 ta
//
