LOCUS       NM_173084               3824 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens tripartite motif containing 59 (TRIM59), mRNA.
ACCESSION   NM_173084
VERSION     NM_173084.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3824)
  AUTHORS   Cheng,P., Wang,Y., Wu,Q., Zhang,H., Fang,W. and Feng,F.
  TITLE     Role of TRIM59 in regulating PPM1A in the pathogenesis of silicosis
            and the intervention effect of tanshinone IIA
  JOURNAL   Biomed Pharmacother 177, 117014 (2024)
   PUBMED   38908195
  REMARK    GeneRIF: Role of TRIM59 in regulating PPM1A in the pathogenesis of
            silicosis and the intervention effect of tanshinone IIA.
REFERENCE   2  (bases 1 to 3824)
  AUTHORS   Zhang,L., Li,G. and Li,Y.
  TITLE     TRIM59 suppresses the brain ischaemia/reperfusion injury and
            pyroptosis of microglial through mediating the ubiquitination of
            NLRP3
  JOURNAL   Sci Rep 14 (1), 2511 (2024)
   PUBMED   38291200
  REMARK    GeneRIF: TRIM59 suppresses the brain ischaemia/reperfusion injury
            and pyroptosis of microglial through mediating the ubiquitination
            of NLRP3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3824)
  AUTHORS   Liu,Y., Zhu,L., Ming,Y., Wu,Z., Zhang,L., Chen,Q. and Qi,Y.
  TITLE     A role of TRIM59 in pulmonary hypertension: modulating the protein
            ubiquitylation modification
  JOURNAL   J Transl Med 21 (1), 821 (2023)
   PUBMED   37978515
  REMARK    GeneRIF: A role of TRIM59 in pulmonary hypertension: modulating the
            protein ubiquitylation modification.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3824)
  AUTHORS   Che,B., Du,Y., Yuan,R., Xiao,H., Zhang,W., Shao,J., Lu,H., Yu,Y.,
            Xiang,M., Hao,L., Zhang,S., Du,X., Liu,X., Zhou,W., Wang,K. and
            Chen,L.
  TITLE     SLC35F2-SYVN1-TRIM59 axis critically regulates ferroptosis of
            pancreatic cancer cells by inhibiting endogenous p53
  JOURNAL   Oncogene 42 (44), 3260-3273 (2023)
   PUBMED   37740007
  REMARK    GeneRIF: SLC35F2-SYVN1-TRIM59 axis critically regulates ferroptosis
            of pancreatic cancer cells by inhibiting endogenous p53.
REFERENCE   5  (bases 1 to 3824)
  AUTHORS   Fan,L., Gong,Y., He,Y., Gao,W.Q., Dong,X., Dong,B., Zhu,H.H. and
            Xue,W.
  TITLE     TRIM59 is suppressed by androgen receptor and acts to promote
            lineage plasticity and treatment-induced neuroendocrine
            differentiation in prostate cancer
  JOURNAL   Oncogene 42 (8), 559-571 (2023)
   PUBMED   36544044
  REMARK    GeneRIF: TRIM59 is suppressed by androgen receptor and acts to
            promote lineage plasticity and treatment-induced neuroendocrine
            differentiation in prostate cancer.
REFERENCE   6  (bases 1 to 3824)
  AUTHORS   Zhan,W., Han,T., Zhang,C., Xie,C., Gan,M., Deng,K., Fu,M. and
            Wang,J.B.
  TITLE     TRIM59 Promotes the Proliferation and Migration of Non-Small Cell
            Lung Cancer Cells by Upregulating Cell Cycle Related Proteins
  JOURNAL   PLoS One 10 (11), e0142596 (2015)
   PUBMED   26599082
  REMARK    GeneRIF: we knocked down TRIM59 and found that p53 protein
            expression levels did not upregulate, so we proposed that TRIM59
            may promote NSCLC cell growth through other pathways but not the
            p53 signaling pathway
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3824)
  AUTHORS   Zhou,Z., Ji,Z., Wang,Y., Li,J., Cao,H., Zhu,H.H. and Gao,W.Q.
  TITLE     TRIM59 is up-regulated in gastric tumors, promoting ubiquitination
            and degradation of p53
  JOURNAL   Gastroenterology 147 (5), 1043-1054 (2014)
   PUBMED   25046164
  REMARK    GeneRIF: TRIM59 interacts with P53, promoting its ubiquitination
            and degradation, and TRIM59 might promote gastric carcinogenesis
            via this mechanism.
REFERENCE   8  (bases 1 to 3824)
  AUTHORS   Kondo,T., Watanabe,M. and Hatakeyama,S.
  TITLE     TRIM59 interacts with ECSIT and negatively regulates NF-kappaB and
            IRF-3/7-mediated signal pathways
  JOURNAL   Biochem Biophys Res Commun 422 (3), 501-507 (2012)
   PUBMED   22588174
  REMARK    GeneRIF: These findings indicate that TRIM59 may serve as a
            multifunctional regulator for innate immune signaling pathways.
REFERENCE   9  (bases 1 to 3824)
  AUTHORS   Georgescu,S.P., Li,J.H., Lu,Q., Karas,R.H., Brown,M. and
            Mendelsohn,M.E.
  TITLE     Modulator recognition factor 1, an AT-rich interaction domain
            family member, is a novel corepressor for estrogen receptor alpha
  JOURNAL   Mol Endocrinol 19 (10), 2491-2501 (2005)
   PUBMED   15941852
REFERENCE   10 (bases 1 to 3824)
  AUTHORS   Chang,R., Xu,X. and Li,M.D.
  TITLE     Molecular cloning, mapping and characterization of a novel mouse
            RING finger gene, Mrf1
  JOURNAL   Gene 291 (1-2), 241-249 (2002)
   PUBMED   12095697
  REMARK    GeneRIF: PMID:12095697 pertains to mouse Mrf1 gene which appears to
            be the homolog of human TSBF1.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY159379.1, BC109260.1, AC024221.23 and AI215011.1.
            
            On Nov 23, 2018 this sequence version replaced NM_173084.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB155321.1, SRR1803614.102419.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309784.9/ ENSP00000311219.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1608              AY159379.1         53-1660
            1609-1888           BC109260.1         1648-1927
            1889-3592           AC024221.23        80517-82220         c
            3593-3824           AI215011.1         11-242              c
FEATURES             Location/Qualifiers
     source          1..3824
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.33"
     gene            1..3824
                     /gene="TRIM59"
                     /gene_synonym="IFT80L; MRF1; RNF104; TRIM57; TSBF1"
                     /note="tripartite motif containing 59"
                     /db_xref="GeneID:286827"
                     /db_xref="HGNC:HGNC:30834"
                     /db_xref="MIM:616148"
     exon            1..70
                     /gene="TRIM59"
                     /gene_synonym="IFT80L; MRF1; RNF104; TRIM57; TSBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            71..140
                     /gene="TRIM59"
                     /gene_synonym="IFT80L; MRF1; RNF104; TRIM57; TSBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            141..3824
                     /gene="TRIM59"
                     /gene_synonym="IFT80L; MRF1; RNF104; TRIM57; TSBF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1355
                     /gene="TRIM59"
                     /gene_synonym="IFT80L; MRF1; RNF104; TRIM57; TSBF1"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif-containing 57; tumor suppressor
                     TSBF1; RING finger protein 104; tumor suppressor TSBF-1"
                     /codon_start=1
                     /product="tripartite motif-containing protein 59"
                     /protein_id="NP_775107.1"
                     /db_xref="CCDS:CCDS3190.1"
                     /db_xref="GeneID:286827"
                     /db_xref="HGNC:HGNC:30834"
                     /db_xref="MIM:616148"
                     /translation="MHNFEEELTCPICYSIFEDPRVLPCSHTFCRNCLENILQASGNF
                     YIWRPLRIPLKCPNCRSITEIAPTGIESLPVNFALRAIIEKYQQEDHPDIVTCPEHYR
                     QPLNVYCLLDKKLVCGHCLTIGQHHGHPIDDLQSAYLKEKDTPQKLLEQLTDTHWTDL
                     THLIEKLKEQKSHSEKMIQGDKEAVLQYFKELNDTLEQKKKSFLTALCDVGNLINQEY
                     TPQIERMKEIREQQLELMALTISLQEESPLKFLEKVDDVRQHVQILKQRPLPEVQPVE
                     IYPRVSKILKEEWSRTEIGQIKNVLIPKMKISPKRMSCSWPGKDEKEVEFLKILNIVV
                     VTLISVILMSILFFNQHIITFLSEITLIWFSEASLSVYQSLSNSLHKVKNILCHIFYL
                     LKEFVWKIVSH"
     regulatory      3802..3807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM59"
                     /gene_synonym="IFT80L; MRF1; RNF104; TRIM57; TSBF1"
                     /note="hexamer: AATAAA"
     polyA_site      3824
                     /gene="TRIM59"
                     /gene_synonym="IFT80L; MRF1; RNF104; TRIM57; TSBF1"
                     /note="major polyA site"
ORIGIN      
        1 agcatccgcc tggagctcgt ggcgctgtgt ttccgtgctg tggagttgcc tggtccgctt
       61 cctccccgcg aataagaata aaagattctg gaggagttgg agaagagtgt attcagcccc
      121 caaaccacga gatcaacaaa gaaatgcaca attttgagga agagttaact tgtcccatat
      181 gttatagtat ttttgaagat cctcgtgtac tgccatgctc tcatacattt tgtagaaatt
      241 gtttggaaaa cattcttcag gcatctggta acttttatat atggagacct ttacgaattc
      301 cactcaagtg ccctaattgc agaagtatta ctgaaattgc tccaactggc attgaatctt
      361 tacctgttaa ttttgcacta agggctatta ttgaaaagta ccagcaagaa gaccatccag
      421 atattgtcac ctgccctgaa cattacaggc aaccattaaa tgtttactgt ctattagata
      481 aaaaattagt ttgtggtcat tgccttacca taggtcaaca tcatggtcat cctatagatg
      541 accttcaaag tgcctatttg aaagaaaagg acactcctca aaaactgctt gaacagttga
      601 ctgacacaca ctggacagat cttacccatc ttattgaaaa gctgaaagaa caaaaatctc
      661 attctgagaa aatgatccaa ggcgataagg aagctgttct ccagtatttt aaggagctta
      721 atgatacatt agaacagaaa aaaaaaagtt tcctaacggc tctctgtgat gttggcaatc
      781 taattaatca agaatatact ccacaaattg aaagaatgaa ggaaatacga gagcagcagc
      841 ttgaattaat ggcactgaca atatctttac aagaagagtc tccacttaaa tttcttgaaa
      901 aagttgatga tgtacgccag catgtacaga tcttgaaaca aagaccactt cctgaggttc
      961 aacccgttga aatttatcct cgagtaagca aaatattgaa agaagaatgg agcagaacag
     1021 aaattggaca aattaagaac gttctcattc ccaaaatgaa aatttctcca aaaaggatgt
     1081 catgttcctg gcctggtaag gatgaaaagg aagttgaatt tttaaaaatt ttaaacattg
     1141 ttgtagttac attaatttca gtaatactga tgtcgatact ctttttcaac caacacatca
     1201 taaccttttt aagtgaaatc actttaatat ggttttctga agcctctcta tctgtttacc
     1261 aaagtttatc taacagtctg cataaggtaa agaatatact gtgtcacatt ttctatttgt
     1321 tgaaggaatt tgtgtggaaa atagtttccc attgaaaatg tcaacctgaa ttgtttaaat
     1381 gggcttattc tgtacattgc taaacaaaaa atggggtagc atggataaag agcaaactaa
     1441 gctttattag tgctgcaact aatataaaca aatgtttata tttgttgctt cttttggtta
     1501 gcaatgatat gtcaaagtta tatctgaaat agtcaaatct ttgggaaaca gaatctagta
     1561 acaatttgaa aagtaataca ctatcccatt tttattggct ttatgatggt tgacataatg
     1621 ttgctgtgac atttaaacat tcttgtacca atattgtctt ttaccattat tatatactgc
     1681 agttaattgg ctttacagtt ctttatatat atagcaaaat cctgaaagaa catatacctt
     1741 tattttgatg tggcttgaag cttttgaatg ggtgaataag gatgatagaa aggtttcaaa
     1801 atcaagcaac aaagtcttaa agtgataagg catggcttaa agatcttttg atcaaacata
     1861 cctgtgtttg agatagattt aagagcccta aatgcttatc accattcact ccaaataaaa
     1921 ctattgcttt tggataactg ttagagtaaa gtggcttttt aaaagaaatt tttgagactg
     1981 ggtctcacct tgttgcccag gctggagtgt agttgtctgg tcatgactca ctgcagtttc
     2041 gaccacccag gctcaatcga tcctcccgcc tctgcctctg gagcagctgg gacaaggcac
     2101 acacccccat gcctggctaa ttaaaaaaat tgttttttgt agaaacgagg ttttgccata
     2161 ttgcccaggt tggtctcaaa cttctgggct caagagatct gcccaccttg gcctcccaaa
     2221 gtgctgggat tacagacgtt agccacactg tgcctggggg ccagcatttt ctaatacttg
     2281 tcatattcta tagtttgtgc aaatttaaga ttgttttttt ttctgctcgt cagtcaaatc
     2341 agttcttgga ttaaaaactc attcttatta gaacagaatc atgttggtaa cttggtctgc
     2401 aacaggtttt gatggcatca tgtggacttt attcatctta actcatttaa attttctacc
     2461 acattccctt aagctaatgc aaaagtacca acaacttaat cttttttttt tttttttttt
     2521 tttttttttg agacggagtc ttgctctgtc gcccaggctg gagtgcagtg gcgtgatctc
     2581 ggctcattgc aagccccgcc tcccgggttc acaccattct cctgcctcag cctcccgagt
     2641 agctgggact acaggcatct gctaccacgc ccagctaatt ttctgtattt ttagtagaga
     2701 tggggtttca ctgtgttagc caggatggtc tctatctcct gacctcatga tccactcgcc
     2761 tcagcctccc aaaatgctgg gattataggc gtgagccgcc acgcccggcc caacaactta
     2821 atcttttatt agctttgctt aagagggcca attaaatcaa agccctttag ttccctttaa
     2881 cagggactgg agttatgatg catgtgttac gacttttggc ccactgtcca tgcaactcta
     2941 agtgcaggtt gatttgcttt ccagaaatcc caaaggggct gctcttggat caccgaagag
     3001 ccttacctat atcaaatcaa aaagacattc tgggtcagat tagactatgc tcctggccct
     3061 acagattgca cataaactat cataaataca gctttttcag ggaactagtt ctaaaactct
     3121 tacctgctga gaataagtct taacactaag atgactgtat tatatcaatt tattattaga
     3181 atcagactta tacctagcac aattaactat tgtgtgggca aagaacattt aaagggcata
     3241 gtagaggtaa ggagagacac atactcagct agagataaaa atactaagtt gcactgatta
     3301 cttaaaatac tagtcacacc ataaaagtgc cctgtagttt caaaaacacg taagcaatga
     3361 aatgttagcc attatgtgtt aaactactta atctcatttc tgtgatgtga atatttttaa
     3421 cccccttttt gtagatgagg gaactgacaa gtgacttgtc caaggccata tagctgtgag
     3481 aaaacccatg cattctcttt tcagagttca tgctatcact caactttaaa gtaggccaag
     3541 attaatgttg gtaagggttt gtaatctgta agaatgctaa aaacgtaagt atatatatca
     3601 ttttagattt gacattttgt atcttgccag tttttaggag aacttttcat tttgttaagt
     3661 atgcatgaat atagttgagt atatgagtaa ctggttctta tgctgctgtt ttgtattttt
     3721 accagcagga agattgcaaa agttgatgta tgtaaatctt gaaatatttc taagttttat
     3781 gtataacaaa atatgtattt taataaactt cttttgatat ttta
//
