LOCUS       NM_015431               5170 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens tripartite motif containing 58 (TRIM58), mRNA.
ACCESSION   NM_015431
VERSION     NM_015431.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5170)
  AUTHORS   Hoegenauer,K., An,S., Axford,J., Benander,C., Bergsdorf,C.,
            Botsch,J., Chau,S., Fernandez,C., Gleim,S., Hassiepen,U.,
            Hunziker,J., Joly,E., Keller,A., Lopez Romero,S., Maher,R.,
            Mangold,A.S., Mickanin,C., Mihalic,M., Neuner,P., Patterson,A.W.,
            Perruccio,F., Roggo,S., Scesa,J., Schroder,M., Shkoza,D., Thai,B.,
            Vulpetti,A., Renatus,M. and Reece-Hoyes,J.S.
  TITLE     Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase
  JOURNAL   ACS Med Chem Lett 14 (12), 1631-1639 (2023)
   PUBMED   38116426
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5170)
  AUTHORS   Sun,N., Shen,J., Shi,Y., Liu,B., Gao,S., Chen,Y. and Sun,J.
  TITLE     TRIM58 functions as a tumor suppressor in colorectal cancer by
            promoting RECQL4 ubiquitination to inhibit the AKT signaling
            pathway
  JOURNAL   World J Surg Oncol 21 (1), 231 (2023)
   PUBMED   37516854
  REMARK    GeneRIF: TRIM58 functions as a tumor suppressor in colorectal
            cancer by promoting RECQL4 ubiquitination to inhibit the AKT
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5170)
  AUTHORS   Shang,R., Chen,J., Gao,Y., Chen,J. and Han,G.
  TITLE     TRIM58 Interacts with ZEB1 to Suppress NSCLC Tumor Malignancy by
            Promoting ZEB1 Protein Degradation via UPP
  JOURNAL   Dis Markers 2023, 5899662 (2023)
   PUBMED   36644609
  REMARK    GeneRIF: TRIM58 Interacts with ZEB1 to Suppress NSCLC Tumor
            Malignancy by Promoting ZEB1 Protein Degradation via UPP.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5170)
  AUTHORS   DU,C.K., Jiang,Y., Lu,Y. and Yang,X.
  TITLE     [Correlation between the Promoter Methylation Status of TRIM58 and
            Its mRNA Expression in Acute Myeloid Leukemia]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 30 (5), 1354-1360 (2022)
   PUBMED   36208235
  REMARK    GeneRIF: [Correlation between the Promoter Methylation Status of
            TRIM58 and Its mRNA Expression in Acute Myeloid Leukemia].
REFERENCE   5  (bases 1 to 5170)
  AUTHORS   Chen,X., Wang,Y., Qu,X., Bie,F., Wang,Y. and Du,J.
  TITLE     TRIM58 is a prognostic biomarker remodeling the tumor
            microenvironment in KRAS-driven lung adenocarcinoma
  JOURNAL   Future Oncol 17 (5), 565-579 (2021)
   PUBMED   33406903
  REMARK    GeneRIF: TRIM58 is a prognostic biomarker remodeling the tumor
            microenvironment in KRAS-driven lung adenocarcinoma.
REFERENCE   6  (bases 1 to 5170)
  AUTHORS   Kajiura,K., Masuda,K., Naruto,T., Kohmoto,T., Watabnabe,M.,
            Tsuboi,M., Takizawa,H., Kondo,K., Tangoku,A. and Imoto,I.
  TITLE     Frequent silencing of the candidate tumor suppressor TRIM58 by
            promoter methylation in early-stage lung adenocarcinoma
  JOURNAL   Oncotarget 8 (2), 2890-2905 (2017)
   PUBMED   27926516
  REMARK    GeneRIF: Our findings suggest that aberrant inactivation of TRIM58
            consequent to CGI hypermethylation might stimulate the early
            carcinogenesis of LADC regardless of smoking status; furthermore,
            TRIM58 methylation might be a possible early diagnostic and
            epigenetic therapeutic target in LADC.
REFERENCE   7  (bases 1 to 5170)
  AUTHORS   Thom,C.S., Traxler,E.A., Khandros,E., Nickas,J.M., Zhou,O.Y.,
            Lazarus,J.E., Silva,A.P., Prabhu,D., Yao,Y., Aribeana,C.,
            Fuchs,S.Y., Mackay,J.P., Holzbaur,E.L. and Weiss,M.J.
  TITLE     Trim58 degrades Dynein and regulates terminal erythropoiesis
  JOURNAL   Dev Cell 30 (6), 688-700 (2014)
   PUBMED   25241935
REFERENCE   8  (bases 1 to 5170)
  AUTHORS   van der Harst,P., Zhang,W., Mateo Leach,I., Rendon,A., Verweij,N.,
            Sehmi,J., Paul,D.S., Elling,U., Allayee,H., Li,X.,
            Radhakrishnan,A., Tan,S.T., Voss,K., Weichenberger,C.X.,
            Albers,C.A., Al-Hussani,A., Asselbergs,F.W., Ciullo,M., Danjou,F.,
            Dina,C., Esko,T., Evans,D.M., Franke,L., Gogele,M., Hartiala,J.,
            Hersch,M., Holm,H., Hottenga,J.J., Kanoni,S., Kleber,M.E.,
            Lagou,V., Langenberg,C., Lopez,L.M., Lyytikainen,L.P., Melander,O.,
            Murgia,F., Nolte,I.M., O'Reilly,P.F., Padmanabhan,S., Parsa,A.,
            Pirastu,N., Porcu,E., Portas,L., Prokopenko,I., Ried,J.S.,
            Shin,S.Y., Tang,C.S., Teumer,A., Traglia,M., Ulivi,S., Westra,H.J.,
            Yang,J., Zhao,J.H., Anni,F., Abdellaoui,A., Attwood,A., Balkau,B.,
            Bandinelli,S., Bastardot,F., Benyamin,B., Boehm,B.O., Cookson,W.O.,
            Das,D., de Bakker,P.I., de Boer,R.A., de Geus,E.J., de Moor,M.H.,
            Dimitriou,M., Domingues,F.S., Doring,A., Engstrom,G.,
            Eyjolfsson,G.I., Ferrucci,L., Fischer,K., Galanello,R.,
            Garner,S.F., Genser,B., Gibson,Q.D., Girotto,G., Gudbjartsson,D.F.,
            Harris,S.E., Hartikainen,A.L., Hastie,C.E., Hedblad,B., Illig,T.,
            Jolley,J., Kahonen,M., Kema,I.P., Kemp,J.P., Liang,L.,
            Lloyd-Jones,H., Loos,R.J., Meacham,S., Medland,S.E., Meisinger,C.,
            Memari,Y., Mihailov,E., Miller,K., Moffatt,M.F., Nauck,M.,
            Novatchkova,M., Nutile,T., Olafsson,I., Onundarson,P.T.,
            Parracciani,D., Penninx,B.W., Perseu,L., Piga,A., Pistis,G.,
            Pouta,A., Puc,U., Raitakari,O., Ring,S.M., Robino,A., Ruggiero,D.,
            Ruokonen,A., Saint-Pierre,A., Sala,C., Salumets,A., Sambrook,J.,
            Schepers,H., Schmidt,C.O., Sillje,H.H., Sladek,R., Smit,J.H.,
            Starr,J.M., Stephens,J., Sulem,P., Tanaka,T., Thorsteinsdottir,U.,
            Tragante,V., van Gilst,W.H., van Pelt,L.J., van Veldhuisen,D.J.,
            Volker,U., Whitfield,J.B., Willemsen,G., Winkelmann,B.R.,
            Wirnsberger,G., Algra,A., Cucca,F., d'Adamo,A.P., Danesh,J.,
            Deary,I.J., Dominiczak,A.F., Elliott,P., Fortina,P., Froguel,P.,
            Gasparini,P., Greinacher,A., Hazen,S.L., Jarvelin,M.R., Khaw,K.T.,
            Lehtimaki,T., Maerz,W., Martin,N.G., Metspalu,A., Mitchell,B.D.,
            Montgomery,G.W., Moore,C., Navis,G., Pirastu,M., Pramstaller,P.P.,
            Ramirez-Solis,R., Schadt,E., Scott,J., Shuldiner,A.R., Smith,G.D.,
            Smith,J.G., Snieder,H., Sorice,R., Spector,T.D., Stefansson,K.,
            Stumvoll,M., Tang,W.H., Toniolo,D., Tonjes,A., Visscher,P.M.,
            Vollenweider,P., Wareham,N.J., Wolffenbuttel,B.H., Boomsma,D.I.,
            Beckmann,J.S., Dedoussis,G.V., Deloukas,P., Ferreira,M.A.,
            Sanna,S., Uda,M., Hicks,A.A., Penninger,J.M., Gieger,C.,
            Kooner,J.S., Ouwehand,W.H., Soranzo,N. and Chambers,J.C.
  TITLE     Seventy-five genetic loci influencing the human red blood cell
  JOURNAL   Nature 492 (7429), 369-375 (2012)
   PUBMED   23222517
REFERENCE   9  (bases 1 to 5170)
  AUTHORS   Gieger,C., Radhakrishnan,A., Cvejic,A., Tang,W., Porcu,E.,
            Pistis,G., Serbanovic-Canic,J., Elling,U., Goodall,A.H.,
            Labrune,Y., Lopez,L.M., Magi,R., Meacham,S., Okada,Y., Pirastu,N.,
            Sorice,R., Teumer,A., Voss,K., Zhang,W., Ramirez-Solis,R.,
            Bis,J.C., Ellinghaus,D., Gogele,M., Hottenga,J.J., Langenberg,C.,
            Kovacs,P., O'Reilly,P.F., Shin,S.Y., Esko,T., Hartiala,J.,
            Kanoni,S., Murgia,F., Parsa,A., Stephens,J., van der Harst,P.,
            Ellen van der Schoot,C., Allayee,H., Attwood,A., Balkau,B.,
            Bastardot,F., Basu,S., Baumeister,S.E., Biino,G., Bomba,L.,
            Bonnefond,A., Cambien,F., Chambers,J.C., Cucca,F., D'Adamo,P.,
            Davies,G., de Boer,R.A., de Geus,E.J., Doring,A., Elliott,P.,
            Erdmann,J., Evans,D.M., Falchi,M., Feng,W., Folsom,A.R.,
            Frazer,I.H., Gibson,Q.D., Glazer,N.L., Hammond,C.,
            Hartikainen,A.L., Heckbert,S.R., Hengstenberg,C., Hersch,M.,
            Illig,T., Loos,R.J., Jolley,J., Khaw,K.T., Kuhnel,B.,
            Kyrtsonis,M.C., Lagou,V., Lloyd-Jones,H., Lumley,T., Mangino,M.,
            Maschio,A., Mateo Leach,I., McKnight,B., Memari,Y., Mitchell,B.D.,
            Montgomery,G.W., Nakamura,Y., Nauck,M., Navis,G., Nothlings,U.,
            Nolte,I.M., Porteous,D.J., Pouta,A., Pramstaller,P.P., Pullat,J.,
            Ring,S.M., Rotter,J.I., Ruggiero,D., Ruokonen,A., Sala,C.,
            Samani,N.J., Sambrook,J., Schlessinger,D., Schreiber,S.,
            Schunkert,H., Scott,J., Smith,N.L., Snieder,H., Starr,J.M.,
            Stumvoll,M., Takahashi,A., Tang,W.H., Taylor,K., Tenesa,A., Lay
            Thein,S., Tonjes,A., Uda,M., Ulivi,S., van Veldhuisen,D.J.,
            Visscher,P.M., Volker,U., Wichmann,H.E., Wiggins,K.L.,
            Willemsen,G., Yang,T.P., Hua Zhao,J., Zitting,P., Bradley,J.R.,
            Dedoussis,G.V., Gasparini,P., Hazen,S.L., Metspalu,A., Pirastu,M.,
            Shuldiner,A.R., Joost van Pelt,L., Zwaginga,J.J., Boomsma,D.I.,
            Deary,I.J., Franke,A., Froguel,P., Ganesh,S.K., Jarvelin,M.R.,
            Martin,N.G., Meisinger,C., Psaty,B.M., Spector,T.D., Wareham,N.J.,
            Akkerman,J.W., Ciullo,M., Deloukas,P., Greinacher,A., Jupe,S.,
            Kamatani,N., Khadake,J., Kooner,J.S., Penninger,J., Prokopenko,I.,
            Stemple,D., Toniolo,D., Wernisch,L., Sanna,S., Hicks,A.A.,
            Rendon,A., Ferreira,M.A., Ouwehand,W.H. and Soranzo,N.
  TITLE     New gene functions in megakaryopoiesis and platelet formation
  JOURNAL   Nature 480 (7376), 201-208 (2011)
   PUBMED   22139419
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 5170)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099571.3, AF327057.1, DN998591.1 and BX644877.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015431.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.206945.1,
                                           SRR1803612.21071.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366481.4/ ENSP00000355437.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC099571.3         73296-73307
            13-67               AF327057.1         1-55
            68-527              DN998591.1         55-514
            528-1065            BX644877.1         72-609
            1066-5170           AC099571.3         92143-96247
FEATURES             Location/Qualifiers
     source          1..5170
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..5170
                     /gene="TRIM58"
                     /gene_synonym="BIA2"
                     /note="tripartite motif containing 58"
                     /db_xref="GeneID:25893"
                     /db_xref="HGNC:HGNC:24150"
                     /db_xref="MIM:620527"
     exon            1..480
                     /gene="TRIM58"
                     /gene_synonym="BIA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1521
                     /gene="TRIM58"
                     /gene_synonym="BIA2"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif-containing protein 58; RING-type
                     E3 ubiquitin transferase TRIM58"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM58"
                     /protein_id="NP_056246.3"
                     /db_xref="CCDS:CCDS1636.1"
                     /db_xref="GeneID:25893"
                     /db_xref="HGNC:HGNC:24150"
                     /db_xref="MIM:620527"
                     /translation="MAWAPPGERLREDARCPVCLDFLQEPVSVDCGHSFCLRCISEFC
                     EKSDGAQGGVYACPQCRGPFRPSGFRPNRQLAGLVESVRRLGLGAGPGARRCARHGED
                     LSRFCEEDEAALCWVCDAGPEHRTHRTAPLQEAAGSYQVKLQMALELMRKELEDALTQ
                     EANVGKKTVIWKEKVEMQRQRFRLEFEKHRGFLAQEEQRQLRRLEAEERATLQRLRES
                     KSRLVQQSKALKELADELQERCQRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTA
                     CCIPGRRELLRKFQVDVKLDPATAHPSLLLTADLRSVQDGEPWRDVPNNPERFDTWPC
                     ILGLQSFSSGRHYWEVLVGEGAEWGLGVCQDTLPRKGETTPSPENGVWALWLLKGNEY
                     MVLASPSVPLLQLESPRCIGIFLDYEAGEISFYNVTDGSYIYTFNQLFSGLLRPYFFI
                     CDATPLILPPTTIAGSGNWASRDHLDPASDVRDDHL"
     exon            481..576
                     /gene="TRIM58"
                     /gene_synonym="BIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..807
                     /gene="TRIM58"
                     /gene_synonym="BIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            808..830
                     /gene="TRIM58"
                     /gene_synonym="BIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..931
                     /gene="TRIM58"
                     /gene_synonym="BIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            932..5170
                     /gene="TRIM58"
                     /gene_synonym="BIA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5141..5146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TRIM58"
                     /gene_synonym="BIA2"
                     /note="hexamer: AATAAA"
     polyA_site      5170
                     /gene="TRIM58"
                     /gene_synonym="BIA2"
                     /note="major polyA site"
ORIGIN      
        1 gcagaccgcg aggggagacg gtgcgggcgg ccgggagcgc agccctccgg gaggcgggtc
       61 atggcctggg cgccgcccgg ggagcggctg cgcgaggatg cgcggtgccc ggtgtgcctg
      121 gatttcctgc aggagccggt cagcgtggac tgcggccaca gcttctgcct caggtgcatc
      181 tccgagttct gcgagaagtc ggacggcgcg cagggcggcg tctacgcctg tccgcagtgc
      241 cggggcccct tccggccctc gggctttcgc cccaaccggc agctggcggg cctggtggag
      301 agcgtgcggc ggctggggtt gggcgcgggg cccggggcgc ggcgatgcgc gcggcacggc
      361 gaggacctga gccgcttctg cgaggaggac gaggcggcgc tgtgctgggt gtgcgacgcc
      421 ggccccgagc acaggacgca ccgcacggcg ccgctgcagg aggccgccgg cagctaccag
      481 gtaaagctcc agatggctct ggaacttatg aggaaagagt tggaggacgc cttgactcag
      541 gaggccaacg tggggaaaaa gactgtcatt tggaaggaga aagtggaaat gcagaggcag
      601 cgcttcagat tggagtttga gaagcatcgt ggctttctgg cccaggagga gcaacggcag
      661 ctgaggcggc tggaggcgga ggagcgagcg acgctgcaga gactgcggga gagcaagagc
      721 cggctggtcc agcagagcaa ggccctgaag gagctggcgg atgagctgca ggagaggtgc
      781 cagcgcccgg ccctgggtct gctggagggt gtgagaggag tcctgagcag aagtaaggct
      841 gtcacaaggc tggaagcaga gaacatcccc atggaactga agacagcatg ctgcatccct
      901 gggaggaggg agctcttaag gaagttccaa gtggatgtaa agctggatcc cgccacggcg
      961 cacccgagtc tgctcttgac cgccgacctg cgcagtgtgc aggatggaga accatggagg
     1021 gatgtcccca acaaccctga gcgatttgac acatggccct gcatcctggg tttgcagagc
     1081 ttctcatcag ggaggcatta ctgggaggtt ctggtgggag aaggagcaga gtggggttta
     1141 ggggtctgtc aagacacact gccaagaaag ggggaaacca cgccatctcc tgagaatggg
     1201 gtctgggccc tgtggctgct gaaagggaat gagtacatgg tccttgcctc cccatcagtg
     1261 cctcttctcc aactggaaag tcctcgctgc attgggattt tcttggacta tgaagccggt
     1321 gaaatttcat tctacaatgt cacagatgga tcttatatct acacattcaa ccaactcttc
     1381 tctggtcttc ttcggcctta ctttttcatc tgtgatgcaa ctcctcttat cttgccaccc
     1441 acaacaatag cagggtcagg aaattgggca tccagggatc atttagatcc tgcttctgat
     1501 gtaagagatg atcatctcta aaattctgtt cccaagatgc agtcctagcg tagcgaacgt
     1561 tcctggagtg gggtgaagga tatcaatata ctaagtttta acagataccc catttaggtc
     1621 agcacttgat tcgttgttgc tgtgaaatat gtccatggga caaaagaggg aatatgaaat
     1681 atttgcatat gggaagatta tagagcataa taattttgta aatggagcaa tctcaacctc
     1741 tatttctaga tcacattttc ttgatgtctt ccttcaaatt aatgaccttg gattacataa
     1801 ggatttctat gcattcatta taatttgtta ttcctttcaa tatccttgta tttcaaatct
     1861 tccatataag aattagacat ggcaattctt aaattgattc agaatggtct gatactattc
     1921 cagtatcacc tccttaattc tgtttctcct cgttttcctg attttccttc tcattctctc
     1981 cttccccgct ctgtctctct ctccctgtca ctctctctct cttgttcctt attttttgtt
     2041 tcttacctct tactgtttaa cctgttgctt ccttctggat taatacattt agagccattc
     2101 ctttatatgg tcacatttcc tatgacttta ctcaattact tttaaaatcc tttctattct
     2161 gagactaatt tttaagaatt acaaagctca ttcttctgaa tctaatatca ctaactccta
     2221 gactttttcc gttttctttg gatacacttt aagtaggaat ttatcagaat tttcattcaa
     2281 ctcgttcttt aatgcagata tttactagtt ataagacctt aaggctgggt gcagtggctc
     2341 acgcctgtaa tcccagcact ttgggaggct gaggcgggtg gatcacaagc tcaggagttc
     2401 aagaccagcc tggccaacat ggtgaaaccc tgtctctact aaaaaaaaaa aaaaaataga
     2461 aaaattagct gggcatggtg gcaggagcct gtaatcccag ctattctgga ggtggagaca
     2521 ggagaattgc ttgaaccctg gaggcggagg ttgcagtgag ccaatatctc accactgtac
     2581 tccagcccag tgcgagactc catctcaaaa aagaaaaaag acctcaaaca acacttctct
     2641 ctctctttta gctgcttgtt atggttccta tacatggaac aattatactg gcctcactgt
     2701 gttatggtaa atatttaagg tcatatttga tattgctggt ttgaattcag cttttccatt
     2761 taaatacatt ataatgatga tgatgaaatc atgataatat ttaacttatt tttaaagtat
     2821 attctgtacc tttccaacaa aaaggttaaa agtcattgaa ggctaacctt actgccttct
     2881 ttgtatcact gtcttctaaa taattattat gtctgggtac agtggctcac gcctgtaatc
     2941 ccagcacttt gggaggccga ggtgggcaga tcacgaggtc aggagattga gaccatcctg
     3001 gctaacacag tgaaaccccg tctctactaa aaatacaaaa agaaattagc tgggcgtggt
     3061 ggtgggtgcc tgttgtccca gctacttggg aggctgaggc aggagaatgg catgaaccca
     3121 ggaggcagag cttgtagtga gccgagatcg cgccactgca ctccagccgg ggcaacagag
     3181 caagactcca tctcaaaaat aaataaataa ataaataaat aaataaataa ataaataaat
     3241 attacacaaa tgctaaaatg tttaaatggt aaatgcttca atgctaacca aatattaatt
     3301 aatggcaaat tatttaacat tatctgataa taatctgcag aaggtttaat tttcctcctc
     3361 aatttgaagt tcaagatgtt tttctcttcc agggagattt tttcgactga catctttaac
     3421 ttaccttcca atcatattac taacgtagcc ttcttcctag attttttaat tgtttgatca
     3481 tgagcgaaca cttctactct ctgtgataga tttgcaaaca gaggaaataa cgcatcctcg
     3541 tgtccctctt cttggtgttc cacaggccat gtgtgcccta gccctcgttc atgcaaggtc
     3601 tgtgtaggga aggtggactt cagctcagca acagcatccc ttcccacagg gatcaggtgg
     3661 gtggcttgag ataccccttc catggggcac cacccattca gtgagacggg gaagccctgg
     3721 gtgggaggga gaacacctcc acatgtcttc tactctctcc ataggatgga atgagtgtcc
     3781 cagtcccagg agtatccatt tcccactgtg tagcccagta ctctggtctc actgtctctg
     3841 ctgaatcctg tctcactgtg catattattg tggtttatat cagtcagtaa accaatgtga
     3901 gtcttcatct cttgcattct taggttcata gttttgtgtg tctcctgtaa tgactcttct
     3961 ctttcccttt ccaactcctg aaagattgcc actatttcct ctggaacttt gtttcgttac
     4021 cagcaaaatc ctcgacatcc atacccgttt cctggctttc cctctccttt cctctgaatg
     4081 gtagtctttt atattcagct gtccacttga catcaaaata gacattttga actcaatttg
     4141 cctaaaactt acccacaaat ttctccccaa gtctctccct aactgcaaca acaaaaacca
     4201 caggcttctc cctgtcactg gatggcaact ccattctttt gattgcttaa gccaggcatc
     4261 cgattgagta ctttcttgat ttctccagcc cacatccagt ccatcggcaa gccctgttgg
     4321 tcctaccttc agaatatgtc cggggttcag ttgtcctggc caccctgctg ctgtaaccat
     4381 ggtcagaact ccatcctgcc cctctggatt atgactttcg tttcctcaca gtggtcctgc
     4441 ttgggctcta ggcccttcca ctcccattct ctctacagca gctgggctga ttcctttagc
     4501 acccaaggat atgttggcat cacagtgact tagataccat cacaaagacc tcccattcaa
     4561 cttagagtga aagtcagaat cctcacagtg aatccccagg ccctagagga tgtgaacccc
     4621 caggccctag aggatctgaa cccccatccc tcctctgatt atctctccca cccccacttc
     4681 cctttgcatt ctgctccagc tgccctggcc tcatggctgg gtttccacca aagcaggcac
     4741 ttcccatcac agggccattt ccccgcctgt ggcttctgct tgacattccc ttttccctga
     4801 tatccccttg actcattatt ccctttcttc cttaactctt ctgagatcca gcttctcagt
     4861 gataccacac agccctactc cccccagagc ccatctagag ctcacctttc cagtcgccct
     4921 tgccaggctc agtggaggct ctttgttccc catacagtac gtgtcgtcgt actatattgt
     4981 taggcttatt taatttatgt atgttttgcc tttttgtgct aaatgtaaac accacaaggg
     5041 gaggtatctt tgtctgttga caatgataca ttcaatgttt ctcaagcacc cccaatgctg
     5101 gtttgtatgt ggttatcatt caatctgtat ttgttgaatg aataaatgat tgactatgtg
     5161 gagagcaaaa
//
